Organization
Research Facility Attached to the School of Medicine Department of Molecular Genetics Assistant Professor
Title
Assistant Professor
FUKABORI Ryouji
Degree
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Ph.D. ( 2002.3 Osaka University )
Research Interests
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Instrumental conditioning, Attention, Memory, Dopamine, Striatum, Transgenic Animals, Motor Learning, Skill Learning
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Transgenic Animals
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Instrumental conditioning
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Motor Learning
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Memory
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Striatum
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Dopamine
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Skill Learning
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Attention
Research Areas
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Life Science / Neuroscience-general / General Neuroscience
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Life Science / Animal physiological chemistry, physiology and behavioral biology / Behavioral Neuroscience
Education
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Osaka University Graduate School, Division of Human Science Human Sciences
- 2002.3
Country： Japan
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Nara Institute of Science and Technology Graduate School, Division of Biological Science Cell Biology
- 1999.3
Country： Japan
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Teikyo University Faculty of Literature Psychology
- 1997.3
Country： Japan
Research History
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Department of Molecular Genetics, Institute of Biomedical Sciences, Fukushima Medical University
2007.10 - Now
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Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency
2007.2 - 2007.9
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Department of Behavioral Physiology, Graduate School of Human Sciences, Osaka University
2006.4 - 2007.1
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Laboratory of Biophysics, School of Medicine, Teikyo University
2005.1 - 2006.3
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Otto-von-Guericke-Universität Magdeburg
2002.5 - 2005.1
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Fukushima Medical University Assistant Professor
2017.2 - Now
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Department of Molecular Genetics, Institute of Biomedical Sciences, Fukushima Medical University
2007.10 - Now
Professional Memberships
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Japan Neuroscience Society
2000.12 - Now
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Japan Neuroscience Society
Papers
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Yoshio Iguchi, Ryoji Fukabori, Shigeki Kato, Kazumi Takahashi, Satoshi Eifuku, Yuko Maejima, Kenju Shimomura, Hiroshi Mizuma, Aya Mawatari, Hisashi Doi, Yilong Cui, Hirotaka Onoe, Keigo Hikishima, Makoto Osanai, Takuma Nishijo, Toshihiko Momiyama, Richard Benton, Kazuto Kobayashi
Communications biology 7 ( 1 ) 547 - 547 2024.5
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Iguchi Y, Fukabori R, Kato S, Takahashi K, Eifuku S, Maejima Y, Shimomura K, Mzuma H, Mawatari A, Doi H, Cui Y, Onoe H, Hikishima K, Osanai M, Nishijo T, Momiyama T, Benton R, Kobayashi K
bioRxiv 2023.9
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Natsuki Matsushita, Kayo Nishizawa, Shigeki Kato, Yoshio Iguchi, Ryoji Fukabori, Kosei Takeuchi, Yoshiki Miyasaka, Tomoji Mashimo, Kazuto Kobayashi
Journal of Neuroscience Methods 381 109707 - 109707 2022.11（ ISSN:0165-0270 ）
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青斑核ノルアドレナリン神経細胞の活動亢進による情動記憶の想起の促進 新規神経活動活性化ツールによる検討
井口 善生, 深堀 良二, 加藤 成樹, 高橋 和巳, 永福 智志, 辻 真伍, 挾間 章博, 内ヶ島 基政, 渡辺 雅彦, 水間 広, 崔 翼龍, 尾上 浩隆, 疋島 啓吾, 八十島 安伸, 小山内 実, 稲垣 良, 福永 浩司, 西條 琢真, 籾山 俊彦, リチャード・ベントン, 小林 和人
日本生理学雑誌 83 ( 2 ) 39 - 39 2021.5（ ISSN:0031-9341 ）
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Takahashi M., Fukabori R., Kawasaki H., Kobayashi K., Kawakami K.
Journal of Comparative Neurology 2021.1（ ISSN:00219967 ）
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Sakayori N., Katakura M., Hamazaki K., Higuchi O., Fujii K., Fukabori R., Iguchi Y., Setogawa S., Takao K., Miyazawa T., Arita M., Kobayashi K.
Communications Biology 3 ( 1 ) 2020.12
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Fukabori R., Iguchi Y., Kato S., Takahashi K., Eifuku S., Tsuji S., Hazama A., Uchigashima M., Watanabe M., Mizuma H., Cui Y., Onoe H., Hikishima K., Yasoshima Y., Osanai M., Inagaki R., Fukunaga K., Nishijo T., Momiyama T., Benton R., Kobayashi K.
Journal of Neuroscience 40 ( 43 ) 8367 - 8385 2020.10（ ISSN:02706474 ）
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中枢カテコールアミン細胞選択的にCre酵素を発現する新規ノックインラットのCombi-CRISPR法による作製
松下夏樹, 西澤佳代, 深堀良二, 橋本裕美, 井口善生, 加藤成樹, 宮坂佳樹, 真下知士, 武内恒成, 小林和人
日本分子生物学会年会プログラム・要旨集(Web) 43rd 2020
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Fukabori, R, Iguchi, Y, Kato,S, Takahashi, K, Eifuku,S, Tsuji, S, Hazama, A, Uchigashima, M, Watanabe, M, Mizuma, H, Cui, Y, Onoe, H, Hikishima, K, Yasoshima, Y, Osanai, M, Inagaki, R, Fukunaga, K, Nishijo, T, Momiyama, T, Benton, R, Kobayashi, K
BioRxive 2019.11
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Action selection and flexible switching controlled by the intralaminar thalamic neurons. Cell Reports
Kato S, Fukabori R, Nishizawa K, Okada K, Yoshioka N, Sugawara M, Maejima Y, Shimomura K, Okamoto M, Eifuku S, Kobayashi K
Cell Reports 22 ( 9 ) 2370 - 2382 2018.2
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In vivo spiking dynamics of intraand extra-telencephalic projection neurons in rat motor cortex
Saiki A, Sakai Y, Fukabori R, Soma S, Yoshida J, Yawo H, Kobayashi K, Kimura M, Isomura Y
Cerebral Cortex 2017.1（ ISSN:1047-3211 ）
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Close relationship between histamine H1 receptor-expressing neurons and CRH neurons in the mouse hypothalamic paraventricular nucleus.
Horio S, Kitaike S, Fukabori R, Ueyama T, Kobayashi K
J Physiol Sci. 65 S293 2015.4
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Enhanced flexibility of place discrimination learning by targeting striatal cholinergic interneurons.
Okada K, Nishizawa K, Fukabori R, Kai N, Shiota A, Ueda M, Tsutsui Y, Sakata S, Matsushita N, Kobayashi K
Nature Communications 5 ( 3778 ) 2014.5
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Methylglyoxal (MG) and cerebro-renal interaction: does long-term orally administered MG cause cognitive impairment in normal Sprague-Dawley rats?
Watanabe K, Okada K, Fukabori R, Hayashi Y, Asahi K, Terawaki H, Kobayashi K, Watanabe T, Nakayama M
Toxins (Basel) 6 ( 1 ) 254 - 269 2014.1
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Kobayashi K., Fukabori R., Nishizawa K.
Advances in Pharmacology 68 143 - 153 2013.9（ ISSN:10543589 ）
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Protocadherin 17 Regulates Presynaptic Assembly in Topographic Corticobasal Ganglia Circuits
Hoshina N, Tanimura A, Yamasaki M, Inoue T, Fukabori R, Kuroda T, Yokoyama K, Tezuka T, Sagara H, Hirano S, Kiyonari H, Takada M, Kobayashi K, Watanabe M, Kano M, Nakazawa T, and Yamamoto T
Neuron 78 ( 5 ) 839 - 854 2013.6
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The Ubiquitin Ligase Praja1 Reduces NRAGE Expression and Inhibits Neuronal Differentiation of PC12 Cells
Teuber J, Mueller B, Fukabori R, Lang D, Albrecht A, and Stork O
PLOS ONE 8 ( 5 ) e6306-e63067 2013.5
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Neural circuit mechanism for learning dependent on dopamine transmission: roles of striatal direct and indirect pathways in sensory discrimination.
Kobayashi K, Fukabori R, Nishizawa K.
Advances in pharmacology 68 143 - 153 2013
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Striatal Indirect Pathway Contributes to Selection Accuracy of Learned Motor Actions
Nishizawa K, Fukabori R, Okada K, Kai N, Uchigashima M, Watanabe M, Shiota A, Ueda M, Tsutsui Y, and Kobayashi K
Journal of Neuroscience 32 ( 39 ) 13421 - 13432 2012.9
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Striatal direct pathway modulates response time in execution of visual discrimination
Fukabori R, Okada K, Nishizawa K, Kai N, Kobayashi K, Uchigashima M, Watanabe M, Tsutsui Y, Kobayashi K
European Journal of Neuroscience 35 ( 5 ) 784 - 797 2012.2
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Selective neural pathway targeting reveals key roles of thalamostriatal projection in the control of visual discrimination.
Kato S, Kuramochi M, Kobayashi K, Fukabori R, Okada K, Uchigashima M, Watanabe M, Tsutsui Y, Kobayashi K
Journal of Neuroscience 31 ( 47 ) 17169 - 17179 2011.11
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線条体ニューロン欠損マウス
小林和人, 深堀良二, 岡田佳奈, 小林とも子
疾患モデルの作製と利用－脳・神経疾患 90 - 98 2011.11（ ISSN:978-4900487505 ）
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Animal models for the study of instrumental learning and behavioral control
Kobayashi K, Fkabori R, Kai N, Okada K, Kobayashi T
61 ( 1 ) 47 - 52 2010.2（ ISSN:0370-9531 ）
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イムノトキシン細胞標的法を用いた直接路・間接路の機能解析
深堀良二, 小林和人
Brain and Nerve 61 ( 4 ) 412 - 441 2009.4
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神経回路研究に利用される技術 6.イムノトキシン細胞標的法
Kobayashi K, Fukabori R
26 ( 12 ) 2001 - 2008 2008.7（ ISSN:0288-5514 ）
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味覚嗜好性の発現メカニズム--視床下部POMC神経細胞の役割
深堀良二
人間科学研究 4 99 - 111 2002（ ISSN:13452975 ）
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The effect of CRF antagonist on saccharin intake behavior.
Fukabori R, Yamamoto T
8 ( 3 ) 511 - 514 2001（ ISSN:13404806 ）
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Modest neuropsychological deficits caused by reduced noradrenaline metabolism in mice heterozygous for a mutated tyrosine hydroxylase gene
Kobayashi K, Noda Y, Matsushita N, Nishii K, Sawada H, Nagatsu T, Nakahara D, Fukabori R, Yasoshima Y, Yamamoto T, Miura M, Kano M, Mamiya T, Miyamoto Y and Nabeshima T
Journal of Neuroscience 20 ( 6 ) 2418 - 2426 2000.3
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POMC gene expression is induced in the hypothalamus by sweet taste stimulation
Fukabori R, Yamamoto T
7 ( 3 ) 581 - 584 2000（ ISSN:13404806 ）
Presentations
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Improvement of forelimb motion after long training in the inter-manual transfer model of rat
The 14th Annual Meeting of the Japanese Society for Neural Repair and Neurorehabilitation 2023.4
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High level expression of channelrhodopsin gene in specific neural pathways induced by double transduction system with the HiRet vector
Neuro2013
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Striatonigral pathway from the dorsomedial striatum contributes to the response time in execution of sensory discrimination
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Striatal direct pathway modulates response time in execution of conditional discrimination
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Role of the striatonigral neurons in basal ganglia in the performance of conditional discrimination task
Neuro2010
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Behavioral roles of the striatonigral neural pathway in reinforcement learning
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Behavioral and physiological roles of the striatonigral neural pathway in motor control
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Selective ablation of striatal neuronal type expressing dopamine D1 receptor by immunotoxin cell targeting
Research Projects
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パーキンソン病の認知機能障害を回復させる脳領域
Grant number：23K10506 2023.4 - 2025.3
基盤研究(C)（一般）
深堀良二
Authorship：Principal investigator Grant type：Competitive
Grant amount：\4810000 （ Direct Cost: \3700000 、 Indirect Cost：\1110000 ）
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New approach for neurorehabilitation with the intermanual transfer
Grant number：20K11213 2020.4 - 2023.3
Grant-in-Aid for Scientific Research (C)
Grant amount：\3900000 （ Direct Cost: \3000000 、 Indirect Cost：\900000 ）
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Thalamostriatal infomation flow in choice behavior
Grant number：15K07155 2015.4 - 2020.3
Grant-in-Aid for Scientific Research (C)
Ryoji Fukabori
Grant amount：\5070000 （ Direct Cost: \3900000 、 Indirect Cost：\1170000 ）
Thalamostriatal projection modulates the dorsal striatum function which mediates learning and performance of appropriate selection. The central lateral nucleus (CL) is the major source of projection originating from the intralaminar thalamic nuclei to the dorsal striatum. Here, we showed the contribution of these nuclei to the selection of behavior by retrograde transgene technique and cell specific ablation. Acquisition process of stimulus-response learning is not distinguishable between the thalamostriatal pathway ablation animal and non-ablation control. Loss of thalamostriatal pathway after acquisition of this behavior induces temporally reduction of performance and long-lasting response delay. Further, it revealed that the thalamostriatal pathway maintain the flexibility and attentional state. The information from the intralaminar thalamic nuclei may contribute to the processing of attention which is mediated by the front-striatal loop of basal ganglia circuit.
Preferred joint research theme
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The Effect of chemical substances, drug, and exogenous gene on behavior depending on the striatal function
Cooperative Research with Industry-University research organizations and private agencies. form_gijutsu Cooperative Research with Industry-University research organizations and private agencies. others
After the injection of chemical substances, drug, or viral vectors with exogenous genes to the striatum in the rodents, cognitive effects are assessed by operant chamber.