Updated on 2024/07/18

写真a

 
FUKABORI Ryouji
 
Organization
Research Facility Attached to the School of Medicine Department of Molecular Genetics Assistant Professor
Title
Assistant Professor

Degree

  • Ph.D. ( 2002.3   Osaka University )

Research Interests

  • Instrumental conditioning, Attention, Memory, Dopamine, Striatum, Transgenic Animals, Motor Learning, Skill Learning

  • Transgenic Animals

  • Instrumental conditioning

  • Motor Learning

  • Memory

  • Striatum

  • Dopamine

  • Skill Learning

  • Attention

Research Areas

  • Life Science / Neuroscience-general  / General Neuroscience

  • Life Science / Animal physiological chemistry, physiology and behavioral biology  / Behavioral Neuroscience

Education

  • Osaka University   Graduate School, Division of Human Science   Human Sciences

    - 2002.3

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    Country: Japan

  • Nara Institute of Science and Technology   Graduate School, Division of Biological Science   Cell Biology

    - 1999.3

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    Country: Japan

  • Teikyo University   Faculty of Literature   Psychology

    - 1997.3

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    Country: Japan

Research History

  • Department of Molecular Genetics, Institute of Biomedical Sciences, Fukushima Medical University

    2007.10 - Now

  • Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency

    2007.2 - 2007.9

  • Department of Behavioral Physiology, Graduate School of Human Sciences, Osaka University

    2006.4 - 2007.1

  • Laboratory of Biophysics, School of Medicine, Teikyo University

    2005.1 - 2006.3

  • Otto-von-Guericke-Universität Magdeburg

    2002.5 - 2005.1

  • Fukushima Medical University   Assistant Professor

    2017.2 - Now

  • Department of Molecular Genetics, Institute of Biomedical Sciences, Fukushima Medical University

    2007.10 - Now

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Professional Memberships

  • Japan Neuroscience Society

    2000.12 - Now

  • Japan Neuroscience Society

Papers

  • Chemogenetic activation of mammalian brain neurons expressing insect Ionotropic Receptors by systemic ligand precursor administration.

    Yoshio Iguchi, Ryoji Fukabori, Shigeki Kato, Kazumi Takahashi, Satoshi Eifuku, Yuko Maejima, Kenju Shimomura, Hiroshi Mizuma, Aya Mawatari, Hisashi Doi, Yilong Cui, Hirotaka Onoe, Keigo Hikishima, Makoto Osanai, Takuma Nishijo, Toshihiko Momiyama, Richard Benton, Kazuto Kobayashi

    Communications biology   7 ( 1 )   547 - 547   2024.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1038/s42003-024-06223-4

    PubMed

  • Chemogenetic activation of target neurons expressing insect Ionotropic Receptors in the mammalian central nervous system by systemic administration of ligand precursors

    Iguchi Y, Fukabori R, Kato S, Takahashi K, Eifuku S, Maejima Y, Shimomura K, Mzuma H, Mawatari A, Doi H, Cui Y, Onoe H, Hikishima K, Osanai M, Nishijo T, Momiyama T, Benton R, Kobayashi K

    bioRxiv   2023.9

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    Language:English  

    DOI : 10.1101/2023.09.11.557081

  • Catecholaminergic cell type-specific expression of Cre recombinase in knock-in transgenic rats generated by the Combi-CRISPR technology

    Natsuki Matsushita, Kayo Nishizawa, Shigeki Kato, Yoshio Iguchi, Ryoji Fukabori, Kosei Takeuchi, Yoshiki Miyasaka, Tomoji Mashimo, Kazuto Kobayashi

    Journal of Neuroscience Methods   381   109707 - 109707   2022.11( ISSN:0165-0270

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1016/j.jneumeth.2022.109707

    PubMed

  • 青斑核ノルアドレナリン神経細胞の活動亢進による情動記憶の想起の促進 新規神経活動活性化ツールによる検討

    井口 善生, 深堀 良二, 加藤 成樹, 高橋 和巳, 永福 智志, 辻 真伍, 挾間 章博, 内ヶ島 基政, 渡辺 雅彦, 水間 広, 崔 翼龍, 尾上 浩隆, 疋島 啓吾, 八十島 安伸, 小山内 実, 稲垣 良, 福永 浩司, 西條 琢真, 籾山 俊彦, リチャード・ベントン, 小林 和人

    日本生理学雑誌   83 ( 2 )   39 - 39   2021.5( ISSN:0031-9341

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    Language:Japanese  

  • The distribution of Cdh20 mRNA demarcates somatotopic subregions and subpopulations of spiny projection neurons in the rat dorsolateral striatum

    Takahashi M., Fukabori R., Kawasaki H., Kobayashi K., Kawakami K.

    Journal of Comparative Neurology   2021.1( ISSN:00219967

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1002/cne.25215

  • Maternal dietary imbalance between omega-6 and omega-3 fatty acids triggers the offspring’s overeating in mice

    Sakayori N., Katakura M., Hamazaki K., Higuchi O., Fujii K., Fukabori R., Iguchi Y., Setogawa S., Takao K., Miyazawa T., Arita M., Kobayashi K.

    Communications Biology   3 ( 1 )   2020.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1038/s42003-020-01209-4

  • Enhanced retrieval of taste associative memory by chemogenetic activation of locus coeruleus norepinephrine neurons

    Fukabori R., Iguchi Y., Kato S., Takahashi K., Eifuku S., Tsuji S., Hazama A., Uchigashima M., Watanabe M., Mizuma H., Cui Y., Onoe H., Hikishima K., Yasoshima Y., Osanai M., Inagaki R., Fukunaga K., Nishijo T., Momiyama T., Benton R., Kobayashi K.

    Journal of Neuroscience   40 ( 43 )   8367 - 8385   2020.10( ISSN:02706474

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1523/JNEUROSCI.1720-20.2020

  • 中枢カテコールアミン細胞選択的にCre酵素を発現する新規ノックインラットのCombi-CRISPR法による作製

    松下夏樹, 西澤佳代, 深堀良二, 橋本裕美, 井口善生, 加藤成樹, 宮坂佳樹, 真下知士, 武内恒成, 小林和人

    日本分子生物学会年会プログラム・要旨集(Web)   43rd   2020

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    Language:English   Publishing type:Research paper (scientific journal)  

    J-GLOBAL

  • Enhanced emotional memory retrieval by chemogenetic activation of locus coeruleus norepinephrine neurons

    Fukabori, R, Iguchi, Y, Kato,S, Takahashi, K, Eifuku,S, Tsuji, S, Hazama, A, Uchigashima, M, Watanabe, M, Mizuma, H, Cui, Y, Onoe, H, Hikishima, K, Yasoshima, Y, Osanai, M, Inagaki, R, Fukunaga, K, Nishijo, T, Momiyama, T, Benton, R, Kobayashi, K

    BioRxive   2019.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1101/831313

  • Action selection and flexible switching controlled by the intralaminar thalamic neurons. Cell Reports

    Kato S, Fukabori R, Nishizawa K, Okada K, Yoshioka N, Sugawara M, Maejima Y, Shimomura K, Okamoto M, Eifuku S, Kobayashi K

    Cell Reports   22 ( 9 )   2370 - 2382   2018.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    PubMed

    Other Link : https://www.sciencedirect.com/science/article/pii/S2211124718301840?via%3Dihub

  • In vivo spiking dynamics of intraand extra-telencephalic projection neurons in rat motor cortex

    Saiki A, Sakai Y, Fukabori R, Soma S, Yoshida J, Yawo H, Kobayashi K, Kimura M, Isomura Y

    Cerebral Cortex   2017.1( ISSN:1047-3211

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  • Close relationship between histamine H1 receptor-expressing neurons and CRH neurons in the mouse hypothalamic paraventricular nucleus.

    Horio S, Kitaike S, Fukabori R, Ueyama T, Kobayashi K

    J Physiol Sci.   65   S293   2015.4

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Enhanced flexibility of place discrimination learning by targeting striatal cholinergic interneurons.

    Okada K, Nishizawa K, Fukabori R, Kai N, Shiota A, Ueda M, Tsutsui Y, Sakata S, Matsushita N, Kobayashi K

    Nature Communications   5 ( 3778 )   2014.5

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    Language:English   Publishing type:Research paper (other academic)  

    PubMed

  • Methylglyoxal (MG) and cerebro-renal interaction: does long-term orally administered MG cause cognitive impairment in normal Sprague-Dawley rats?

    Watanabe K, Okada K, Fukabori R, Hayashi Y, Asahi K, Terawaki H, Kobayashi K, Watanabe T, Nakayama M

    Toxins (Basel)   6 ( 1 )   254 - 269   2014.1

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    Language:English   Publishing type:Research paper (other academic)  

    PubMed

  • Neural circuit mechanism for learning dependent on dopamine transmission. Roles of striatal direct and indirect pathways in sensory discrimination.

    Kobayashi K., Fukabori R., Nishizawa K.

    Advances in Pharmacology   68   143 - 153   2013.9( ISSN:10543589

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1016/B978-0-12-411512-5.00007-5

  • Protocadherin 17 Regulates Presynaptic Assembly in Topographic Corticobasal Ganglia Circuits

    Hoshina N, Tanimura A, Yamasaki M, Inoue T, Fukabori R, Kuroda T, Yokoyama K, Tezuka T, Sagara H, Hirano S, Kiyonari H, Takada M, Kobayashi K, Watanabe M, Kano M, Nakazawa T, and Yamamoto T

    Neuron   78 ( 5 )   839 - 854   2013.6

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    Language:English   Publishing type:Research paper (other academic)  

    DOI : 10.1016/j.neuron.2013.03.031

    PubMed

  • The Ubiquitin Ligase Praja1 Reduces NRAGE Expression and Inhibits Neuronal Differentiation of PC12 Cells

    Teuber J, Mueller B, Fukabori R, Lang D, Albrecht A, and Stork O

    PLOS ONE   8 ( 5 )   e6306-e63067   2013.5

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    Language:English   Publishing type:Research paper (other academic)  

    DOI : 10.1371/journal.pone.0063067

  • Neural circuit mechanism for learning dependent on dopamine transmission: roles of striatal direct and indirect pathways in sensory discrimination.

    Kobayashi K, Fukabori R, Nishizawa K.

    Advances in pharmacology   68   143 - 153   2013

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    Language:English   Publishing type:Research paper (scientific journal)  

    PubMed

    Other Link : http://www.ncbi.nlm.nih.gov/pubmed/?term=24054143

  • Striatal Indirect Pathway Contributes to Selection Accuracy of Learned Motor Actions

    Nishizawa K, Fukabori R, Okada K, Kai N, Uchigashima M, Watanabe M, Shiota A, Ueda M, Tsutsui Y, and Kobayashi K

    Journal of Neuroscience   32 ( 39 )   13421 - 13432   2012.9

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    Language:English   Publishing type:Research paper (other academic)  

    DOI : 10.1523/JNEUROSCI.1969-12.2012

    PubMed

  • Striatal direct pathway modulates response time in execution of visual discrimination

    Fukabori R, Okada K, Nishizawa K, Kai N, Kobayashi K, Uchigashima M, Watanabe M, Tsutsui Y, Kobayashi K

    European Journal of Neuroscience   35 ( 5 )   784 - 797   2012.2

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    Language:English   Publishing type:Research paper (other academic)  

    DOI : 10.1111/j.1460-9568.2012.08005.x

    PubMed

  • Selective neural pathway targeting reveals key roles of thalamostriatal projection in the control of visual discrimination.

    Kato S, Kuramochi M, Kobayashi K, Fukabori R, Okada K, Uchigashima M, Watanabe M, Tsutsui Y, Kobayashi K

    Journal of Neuroscience   31 ( 47 )   17169 - 17179   2011.11

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    Language:English   Publishing type:Research paper (other academic)  

    DOI : 10.1523/JNEUROSCI.4005-11.2011

    PubMed

  • 線条体ニューロン欠損マウス

    小林和人, 深堀良二, 岡田佳奈, 小林とも子

    疾患モデルの作製と利用-脳・神経疾患   90 - 98   2011.11( ISSN:978-4900487505

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    Language:Japanese   Publishing type:Research paper (other academic)  

  • Animal models for the study of instrumental learning and behavioral control

    Kobayashi K, Fkabori R, Kai N, Okada K, Kobayashi T

    61 ( 1 )   47 - 52   2010.2( ISSN:0370-9531

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    Language:Japanese   Publishing type:Research paper (other academic)  

  • イムノトキシン細胞標的法を用いた直接路・間接路の機能解析

    深堀良二, 小林和人

    Brain and Nerve   61 ( 4 )   412 - 441   2009.4

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    Language:Japanese   Publishing type:Research paper (other academic)  

    PubMed

  • 神経回路研究に利用される技術 6.イムノトキシン細胞標的法

    Kobayashi K, Fukabori R

    26 ( 12 )   2001 - 2008   2008.7( ISSN:0288-5514

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    Language:Japanese   Publishing type:Research paper (other academic)  

  • 味覚嗜好性の発現メカニズム--視床下部POMC神経細胞の役割

    深堀良二

    人間科学研究   4   99 - 111   2002( ISSN:13452975

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    Language:Japanese   Publishing type:Research paper (other academic)  

  • The effect of CRF antagonist on saccharin intake behavior.

    Fukabori R, Yamamoto T

    8 ( 3 )   511 - 514   2001( ISSN:13404806

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    Language:Japanese   Publishing type:Research paper (other academic)  

  • Modest neuropsychological deficits caused by reduced noradrenaline metabolism in mice heterozygous for a mutated tyrosine hydroxylase gene

    Kobayashi K, Noda Y, Matsushita N, Nishii K, Sawada H, Nagatsu T, Nakahara D, Fukabori R, Yasoshima Y, Yamamoto T, Miura M, Kano M, Mamiya T, Miyamoto Y and Nabeshima T

    Journal of Neuroscience   20 ( 6 )   2418 - 2426   2000.3

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    Language:English   Publishing type:Research paper (other academic)  

    PubMed

  • POMC gene expression is induced in the hypothalamus by sweet taste stimulation

    Fukabori R, Yamamoto T

    7 ( 3 )   581 - 584   2000( ISSN:13404806

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    Language:Japanese   Publishing type:Research paper (other academic)  

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Presentations

  • Improvement of forelimb motion after long training in the inter-manual transfer model of rat

    The 14th Annual Meeting of the Japanese Society for Neural Repair and Neurorehabilitation   2023.4  

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    Event date: 2023.4

    Country:Japan  

  • High level expression of channelrhodopsin gene in specific neural pathways induced by double transduction system with the HiRet vector

    Neuro2013  

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    Event date: 2013.6

  • Striatonigral pathway from the dorsomedial striatum contributes to the response time in execution of sensory discrimination

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    Event date: 2012

  • Striatal direct pathway modulates response time in execution of conditional discrimination

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    Event date: 2011

  • Role of the striatonigral neurons in basal ganglia in the performance of conditional discrimination task

    Neuro2010  

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    Event date: 2010

  • Behavioral roles of the striatonigral neural pathway in reinforcement learning

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    Event date: 2009

  • Behavioral and physiological roles of the striatonigral neural pathway in motor control

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    Event date: 2008

  • Selective ablation of striatal neuronal type expressing dopamine D1 receptor by immunotoxin cell targeting

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    Event date: 2007

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Research Projects

  • パーキンソン病の認知機能障害を回復させる脳領域

    Grant number:23K10506  2023.4 - 2025.3

    基盤研究(C)(一般)

    深堀良二

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\4810000 ( Direct Cost: \3700000 、 Indirect Cost:\1110000 )

  • New approach for neurorehabilitation with the intermanual transfer

    Grant number:20K11213  2020.4 - 2023.3

    Grant-in-Aid for Scientific Research (C)

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    Grant amount:\3900000 ( Direct Cost: \3000000 、 Indirect Cost:\900000 )

  • Thalamostriatal infomation flow in choice behavior

    Grant number:15K07155  2015.4 - 2020.3

    Grant-in-Aid for Scientific Research (C)

    Ryoji Fukabori

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    Grant amount:\5070000 ( Direct Cost: \3900000 、 Indirect Cost:\1170000 )

    Thalamostriatal projection modulates the dorsal striatum function which mediates learning and performance of appropriate selection. The central lateral nucleus (CL) is the major source of projection originating from the intralaminar thalamic nuclei to the dorsal striatum. Here, we showed the contribution of these nuclei to the selection of behavior by retrograde transgene technique and cell specific ablation. Acquisition process of stimulus-response learning is not distinguishable between the thalamostriatal pathway ablation animal and non-ablation control. Loss of thalamostriatal pathway after acquisition of this behavior induces temporally reduction of performance and long-lasting response delay. Further, it revealed that the thalamostriatal pathway maintain the flexibility and attentional state. The information from the intralaminar thalamic nuclei may contribute to the processing of attention which is mediated by the front-striatal loop of basal ganglia circuit.

Preferred joint research theme

  • The Effect of chemical substances, drug, and exogenous gene on behavior depending on the striatal function

     Cooperative Research with Industry-University research organizations and private agencies. form_gijutsu  Cooperative Research with Industry-University research organizations and private agencies.  others

    After the injection of chemical substances, drug, or viral vectors with exogenous genes to the striatum in the rodents, cognitive effects are assessed by operant chamber.