Overview of green tea interaction with cardiovascular drugs.

Werba JP, Misaka S, Giroli MG, Yamada S, Cavalca V, Kawabe K, Squellerio I, Laguzzi F, Onoue S, Veglia F, Myasoedova V, Takeuchi K, Adachi E, Inui N, Tremoli E, Watanabe H.

Current Pharmaceutical Design   21   1213 - 1219   2015

Green tea ingestion greatly reduces plasma concentrations of nadolol in healthy subjects.

Shingen Misaka, Junichi Yatabe, Fabian Müller, Kozue Takano, Keisuke Kawabe, Hartmut Glaeser, Midori S. Yatabe, Satomi Onoue, José P. Werba, Hiroshi Watanabe, Shizuo Yamada, Martin F. Fromm, Junko Kimura

Clinical Pharmacology & Therapeutics   95 ( 4 )   432 - 438   2014

Effects of green tea extract and (-)-epigallocatechin-3-gallate on pharmacokinetics of nadolol in rats.

Shingen Misaka, Nozomu Miyazaki, Tetsuhito Fukushima, Shizuo Yamada, Junko Kimura

Phytomedicine   20 ( 14 )   1247 - 1250   2013

Clinical relevance of drug efflux pumps in the gut.

Shingen Misaka, Fabian Müller, Martin F. Fromm

Current Opinion in Pharmacology   13   847 - 852   2013

Pharmacokinetic and pharmacodynamic interactions of nadolol with itraconazole, rifampicin and grapefruit juice in healthy volunteers.

Shingen Misaka, Nozomu Miyazaki, Midori S. Yatabe, Tomoyuki Ono, Yayoi Shikama, Tetsuhito Fukushima, Junko Kimura

Journal of Clinical Pharmacology   53 ( 7 )   738 - 745   2013

Effects of itraconazole, dexamethasone and naringin on pharmacokinetics of nadolol in rats.

Nozomu Miyazaki, Shingen Misaka, Hiroshi Ogata, Tetsuhito Fukushima, Junko Kimura

Drug Metabolism and Pharmacokinetics   28 ( 4 )   356 - 361   2013

Effects of green tea catechins on cytochrome P450 2B6, 2C8, 2C19, 2D6 and 3A activities in human liver and intestinal microsomes.

Shingen Misaka, Keisuke Kawabe, Satomi Onoue, José P. Werba, Monica Giroli, Sekihiro Tamaki, Toshiyuki Kan, Junko Kimura, Hiroshi Watanabe, Shizuo Yamada

Drug Metabolism and Pharmacokinetics   28 ( 3 )   244 - 249   2013

Green tea extract affects cytochrome P450 3A activity and pharmacokinetics of simvastatin in rats.

Shingen Misaka, Keisuke Kawabe, Satomi Onoue, Monica Giroli, José P. Werba, Hiroshi Watanabe, Shizuo Yamada

Drug Metabolism and Pharmacokinetics   28 ( 6 )   514 - 518   2013

Novel vasoactive intestinal peptide derivatives with improved stability protect rat alveolar L2 cells from cigarette smoke-induced cytotoxicity and apoptosis

Shingen Misaka, Hideyuki Sato, Yosuke Aoki, Takahiro Mizumoto, Satomi Onoue, Shizuo Yamada

Peptides   32   401 - 407   2011

Formulation design and in vivo evaluation of dry powder inhalation system of new vasoactive intestinal peptide derivative ([R^{15, 20, 21}, L¹⁷, A^24,25, des-N²⁸]-VIP-GRR) in experimental asthma/COPD model rats

Satomi Onoue, Yosuke Aoki, Takuya Matsui, Yoshiki Kojo, Shingen Misaka, Takahiro Mizumoto, Shizuo Yamada

International Journal of Pharmaceutics   410   54 - 60   2011

Evaluation of pharmacodynamic interaction of midazolam with ursodeoxycholic acid, ketoconazole and dexamethasone by brain benzodiazepine receptor occupancy

Shingen Misaka, Souhei Kurosawa, Shinya Uchida, Akira Yoshida, Yoshihisa Kato, Yoshiyuki Kagawa, Shizuo Yamada

Journal of Pharmacy and Pharmacology   63   58 - 64   2011

Benzbromarone pharmacokinetics and pharmacodynamics in different cytochrome P450 2C9 genotypes

Shinya Uchida, Kayoko Shimada, Shingen Misaka, Hiromitsu Imai, Naoki Inui, Kazuhiko Takeuchi, Noriyuki Namiki, Takashi Ishizaki, Kyoichi Ohashi, Shizuo Yamada, Hiroshi Watanabe

Drug Metabolism and Pharmacokinetics   25   605 - 610   2010

Effects of a stabilized vasoactive intestinal peptide derivative, [R^{15, 20, 21}, L¹⁷]-VIP-GRR (IK312532), on cigarette smoke-induced lung inflammation in rats

Satomi Onoue, Shingen Misaka, Yosuke Aoki, Shin-ichiro Karaki, Atsukazu Kuwahara, Takahiro Mizumoto, Shizuo Yamada

European Journal of Pharmaceutical Sciences   41   508 - 514   2010

Inhalable powder formulation of a stabilized vasoactive intestinal peptide (VIP) derivative: Anti-inflammatory effect in experimental asthmatic rats

Shingen Misaka, Yosuke Aoki, Shin-ichiro Karaki, Atsukazu Kuwahara, Takahiro Mizumoto, Satomi Onoue, Shizuo Yamada

Peptides   31   72 - 78   2010

Effect of lemborexant on pharmacokinetics of clozapine: A potential drug-drug interaction mediated by time-dependent inhibition of CYP3A4.

Watanabe K, Misaka S, Kanno-Nozaki K, Chiyoda T, Suzuki Y, Sato A, Suto T, Kuroda J, Shimomura K, Miura I, Yabe H

British journal of clinical pharmacology   2023.8（ ISSN:0306-5251 ）

Exposure of Fexofenadine, but Not Pseudoephedrine, Is Markedly Decreased by Green Tea Extract in Healthy Volunteers.

Misaka S, Ono Y, Taudte RV, Hoier E, Ogata H, Ono T, König J, Watanabe H, Fromm MF, Shimomura K

Clinical pharmacology and therapeutics   112 ( 3 )   627 - 634   2022.9（ ISSN:0009-9236 ）

C188-9, a specific inhibitor of STAT3 signaling, prevents thermal burn-induced skeletal muscle wasting in mice.

Ono Y, Saito M, Sakamoto K, Maejima Y, Misaka S, Shimomura K, Nakanishi N, Inoue S, Kotani J

Frontiers in pharmacology   13   1031906   2022（ ISSN:1663-9812 ）

Identification of oxytocin receptor activating chemical components from traditional Japanese medicines.

Maejima Y, Horita S, Yokota S, Ono T, Proks P, Yoshida-Komiya H, Ueta Y, Nishimori K, Misaka S, Shimomura K

Journal of food and drug analysis   29 ( 4 )   653 - 675   2021.12（ ISSN:1021-9498 ）

Urinary Excretion of Nadolol as a Possible In Vivo Probe for Drug Interactions Involving P-Glycoprotein.

Shimazaki S, Kuroda J, Shimomura K, Misaka S

Journal of clinical pharmacology   61 ( 6 )   799 - 805   2021.6（ ISSN:0091-2700 ）

Impact of Green Tea Catechin Ingestion on the Pharmacokinetics of Lisinopril in Healthy Volunteers.

Misaka S, Ono Y, Uchida A, Ono T, Abe O, Ogata H, Sato H, Suzuki M, Onoue S, Shikama Y, Shimomura K

Clinical and translational science   14 ( 2 )   476 - 480   2021.3（ ISSN:1752-8054 ）

Atorvastatin-Green Tea Interaction: Possible Mechanisms are Complicated, But Clinical Relevance is Not?

Misaka S, Shimomura K

European journal of drug metabolism and pharmacokinetics   45 ( 3 )   423 - 425   2020.6（ ISSN:0378-7966 ）

Effects of single green tea ingestion on pharmacokinetics of nadolol in healthy volunteers.

Misaka S, Abe O, Ono T, Ono Y, Ogata H, Miura I, Shikama Y, Fromm MF, Yabe H, Shimomura K

British journal of clinical pharmacology   2020.4（ ISSN:0306-5251 ）

【緑茶の機能性と薬理】緑茶と薬物の相互作用

三坂 眞元

機能性食品と薬理栄養   13 ( 1 )   35 - 43   2019.8（ ISSN:1348-2564 ）

【緑茶の機能性と薬理】緑茶と薬物の相互作用

三坂 眞元

機能性食品と薬理栄養   13 ( 1 )   35 - 43   2019.8（ ISSN:1348-2564 ）

Memantine has no effect on K_ATP channels in pancreatic β cells.

Imai R, Misaka S, Horita S, Yokota S, O'hashi R, Maejima Y, Shimomura K

BMC research notes   11 ( 1 )   614   2018.8

Similar effect of quercetin on CYP2E1 and CYP2C9 activities in humans?

Misaka S, Shimomura K

European journal of clinical pharmacology   1 - 2   2018.5（ ISSN:0031-6970 ）

Cardio-protective effects of pentraxin 3 produced from bone marrow-derived cells against ischemia/reperfusion injury.

Shimizu T, Suzuki S, Sato A, Nakamura Y, Ikeda K, Saitoh S, Misaka S, Shishido T, Kubota I, Takeishi Y

Journal of molecular and cellular cardiology   89 ( Pt B )   306 - 13   2015.12（ ISSN:0022-2828 ）

Effects of natural products on pharmacokinetics and pharmacodynamics of drugs

Yamada S., Misaka S., Ito Y., Watanabe H., Umegaki K.

AAPS Advances in the Pharmaceutical Sciences Series   12   189 - 211   2014.1（ ISSN:22107371 ）

Effect of oral L-arginine administration on exhaled nitric oxide (NO) concentration in healthy volunteers.

Ogata H., Yatabe M., Misaka S., Shikama Y., Sato S., Munakata M., Kimura J.

Fukushima journal of medical science   59 ( 1 )   43 - 48   2013.1

Development of rapid and simultaneous quantitative method for green tea catechins on the bioanalytical study using UPLC/ESI-MS.

Shingen Misaka, Keisuke Kawabe, Satomi Onoue, José P. Werba, Monica Giroli, Junko Kimura, Hiroshi Watanabe, Shizuo Yamada

Biomedical Chromatography   27 ( 1 )   1 - 6   2013

Effect of two weeks consumption of pomegranate juice on the pharmacokinetics of single dose of midazolam: an open-label, randomized, single-center, two-period crossover study in healthy Japanese volunteers.

Shingen Misaka, Reiko Nakamura, Shinya Uchida, Kazuhiko Takeuchi, Norio Takahashi, Naoki Inui, Kazuhiro Kosuge, Shizuo Yamada, Hiroshi Watanabe

Clinical Therapeutics   33   246 - 252   2011

Pharmacokinetics and pharmacodynamics of midazolam administered intravenously and orally at low doses to healthy volunteers

Shingen Misaka, Shinya Uchida, Hiromitsu Imai, Naoki Inui, Shinichiro Nishio, Kyoichi Ohashi, Hiroshi Watanabe, Shizuo Yamada

Clinical and Experimental Pharmacology and Physiology   37   290 - 295   2010

New treatments for COPD and viable formulation/device options for inhalation therapy

Satomi Onoue, Shingen Misaka, Yohei Kawabata, Shizuo Yamada

Expert Opinion on Drug Delivery   6 ( 8 )   793 - 811   2009

Physicochemical and pharmacological characterization of novel vasoactive intestinal peptide derivatives with improved stability

Satomi Onoue, Shingen Misaka, Yuki Ohmori, Hideyuki Sato, Takahiro Mizumoto, Mariko Hirose, Sumiko Iwasa, Takehiko Yajima, Shizuo Yamada

European Journal of Pharmaceutics and Biopharmaceutics   73   95 - 101   2009

Novel dry powder formulation of ovalbumin for development of COPD-like animal model: physicochemical characterization and biomarker profiling in rats

Shingen Misaka, Hideyuki Sato, Yukinori Yamauchi, Satomi Onoue, Shizuo Yamada

European Journal of Pharmaceutical Sciences   37   469 - 476   2009

Maintenance time of sedative effects after an intravenous infusion of diazepam: a guide for endoscopy using diazepam

Mitsushige Sugimoto, Takahisa Furuta, Akiko Nakamura, Naohito Shirai, Mutsuhiro Ikuma, Shingen Misaka, Shinya Uchida, Hiroshi Watanabe, Kyoichi Ohashi, Takashi Ishizaki, Akira Hishida

World Journal of Gastroenterology   14   5197 - 5203   2008

Structure-activity relationship of vasoactive intestinal peptide (VIP): potent agonists and potential clinical applications

Satomi Onoue, Shingen Misaka, Shizuo Yamada

Naunyn-Schmiedeberg's Archives of Pharmacology   377   579 - 590   2008

Effects of ursodeoxycholic acid on the pharmacokinetics and pharmacodynamics of intravenous and oral midazolam in healthy volunteers

Dongmei Yan, Yingbao Yang, Shinya Uchida, Shingen Misaka, Jinghui Luo, Kazuhiko Takeuchi, Naoki Inui, Shizuo Yamada, Kyoichi Ohashi, Hiroshi Watanabe

Naunyn-Schmiedeberg's Archives of Pharmacology   377   629 - 636   2008