Updated on 2022/03/28

写真a

 
ITO Hiromi
 
Organization
School of Medicine (Life Sciences and Social Medicine) Department of Biochemistry Associate Professor
Title
Associate Professor
Contact information
メールアドレス

Research History

  • Fukushima Medical University   Associate Professor

    2017.2 - Now

Papers

  • Transferrin Biosynthesized in the Brain Is a Novel Biomarker for Alzheimer's Disease.

    Hoshi K, Ito H, Abe E, Fuwa TJ, Kanno M, Murakami Y, Abe M, Murakami T, Yoshihara A, Ugawa Y, Saito T, Saido TC, Matsumoto K, Yamaguchi Y, Furukawa K, Arai H, Kanai M, Miyajima M, Arai H, Ogawa N, Akatsu H, Hashizume Y, Tateno H, Honda T, Hashimoto Y

    Metabolites   11 ( 9 )   2021.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.3390/metabo11090616

    PubMed

  • Total transferrin in cerebrospinal fluid is a novel biomarker for spontaneous intracranial hypotension.

    Iijima J, Hoshi K, Ito H, Kanno M, Murakami Y, Takahashi K, Matsumoto K, Yamaguchi Y, Nakajima M, Miyajima M, Arai H, Kanai M, Kitazume S, Honda T, Hashimoto Y

    Fukushima journal of medical science   67 ( 2 )   64 - 70   2021.8( ISSN:0016-2590

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    DOI : 10.5387/fms.2020-19

    PubMed

  • 認知症のバイオマーカーと早期診断update 認知症における髄液バイオマーカー 特発性正常圧水頭症マーカーとしての髄液中の"脳型"トランスフェリン

    橋本 康弘, 伊藤 浩美, 星 京香, 本多 たかし

    神経治療学   37 ( 3 )   331 - 334   2020.5( ISSN:0916-8443

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  • 【脳脊髄液減少症と体位性頻脈症候群】脳脊髄液減少症における髄液バイオマーカー

    村上 友太, 星 京香, 伊藤 浩美, 橋本 康弘

    脳神経内科   92 ( 4 )   397 - 404   2020.4( ISSN:2434-3285

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  • Glycoform-Specific Visualization in Immunohistochemistry by "Lectin Inhibition".

    Ito H, Hoshi K, Hashimoto Y, Honda T

    Methods in molecular biology (Clifton, N.J.)   2132   173 - 181   2020( ISSN:1064-3745

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1007/978-1-0716-0430-4_18

    PubMed

  • Simple and Rapid Detection of Glycoforms by "Lectin Inhibition" Assay.

    Hoshi K, Hashimoto Y, Ito H

    Methods in molecular biology (Clifton, N.J.)   2132   165 - 171   2020( ISSN:1064-3745

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    DOI : 10.1007/978-1-0716-0430-4_17

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  • Ratio of Alpha 2-Macroglobulin Levels in Cerebrospinal Fluid and Serum: An Expression of Neuroinflammation in Acute Disseminated Encephalomyelitis.

    Suzuki Y, Hashimoto K, Hoshi K, Ito H, Kariya Y, Miyazaki K, Sato M, Kawasaki Y, Yoshida M, Honda T, Hashimoto Y, Hosoya M

    Pediatric neurology   98   61 - 67   2019.9( ISSN:0887-8994

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    DOI : 10.1016/j.pediatrneurol.2019.04.020

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  • 脳脊髄液におけるトランスフェリンアイソフォームとそれらの神経学的疾患との関連性(Transferrin isoforms in cerebrospinal fluid and their relation to neurological diseases)

    Murakami Yuta, Saito Kiyoshi, Ito Hiromi, Hashimoto Yasuhiro

    Proceedings of the Japan Academy Series B, Physical and Biological Sciences   95 ( 5 )   198 - 210   2019.5( ISSN:0386-2208

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  • Transferrin metabolism in CSF and its relation to neurological diseases.

    Murakami Yuta, Saito Kiyoshi, Hashimoto Yasuhiro

    Proceedings of the Japan Academy, Series B   in press   2019

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  • "脳型"トランスフェリンは特発性正常圧水頭症の診断及び認知症の予後マーカーとなる

    橋本 康弘, 星 京香, 伊藤 浩美

    神経治療学   36 ( 6 )   S113 - S113   2019( ISSN:0916-8443

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    DOI : 10.15082/jsnt.36.6_S113

  • Transferrin isoforms in cerebrospinal fluid and their relation to neurological diseases.

    Murakami Y, Saito K, Ito H, Hashimoto Y

    Proceedings of the Japan Academy. Series B, Physical and biological sciences   95 ( 5 )   198 - 210   2019( ISSN:0386-2208

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    DOI : 10.2183/pjab.95.015

    PubMed

  • 特発性正常圧水頭症に対するシャント手術後の脳脊髄液における脳型トランスフェリンの急速な増加 認知機能改善のための予後マーカー(Rapid increase of 'brain-type' transferrin in cerebrospinal fluid after shunt surgery for idiopathic normal pressure hydrocephalus: a prognosis marker for cognitive recovery)

    Murakami Yuta, Matsumoto Yuka, Hoshi Kyoka, Ito Hiromi, Fuwa Takashi J., Yamaguchi Yoshiki, Nakajima Madoka, Miyajima Masakazu, Arai Hajime, Nollet Kenneth, Kato Naho, Nishikata Rie, Kuroda Naohito, Honda Takashi, Sakuma Jun, Saito Kiyoshi, Hashimoto Yasuhiro

    The Journal of Biochemistry   164 ( 3 )   205 - 213   2018.9( ISSN:0021-924X

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  • 脳脊髄液減少症(特発性低髄液圧症候群)と脳型トランスフェリン

    村上 友太, 高橋 浩一, 星 京香, 伊藤 浩美, 齋藤 清, 宮嶋 雅一, 新井 一, 美馬 達夫, 橋本 康弘

    日本頭痛学会誌   45 ( 1 )   25 - 33   2018.8( ISSN:1345-6547

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  • Spontaneous intracranial hypotension is diagnosed by a combination of lipocalin-type prostaglandin D synthase and brain-type transferrin in cerebrospinal fluid.

    Murakami Y, Takahashi K, Hoshi K, Ito H, Kanno M, Saito K, Nollet K, Yamaguchi Y, Miyajima M, Arai H, Hashimoto Y, Mima T

    Biochimica et biophysica acta. General subjects   1862 ( 8 )   1835 - 1842   2018.8( ISSN:0304-4165

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    DOI : 10.1016/j.bbagen.2018.03.027

    PubMed

  • Rapid increase of “brain-type” transferrin in cerebrospinal fluid after shunt surgery for idiopathic normal pressure hydrocephalus: a prognosis marker for cognitive recovery.

    Murakami Yuta, Matsumoto Yuka, Hoshi Kyoka, Ito Hiromi, Fuwa Takashi J., Yamaguchi Yoshiki, Nakajima Madoka, Miyajima Masakazu, Arai Hajime, Nollet Kenneth, Kato Naho, Nishikata Rie, Kuroda Naohito, Honda Takashi, Sakuma Jun, Saito Kiyoshi, Hashimoto Yasuhiro

    Journal of Biochemistry   164 ( 3 )   206 - 213   2018

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1093/jb/mvy043

  • Spontaneous intracranial hypotension is diagnosed by a combination of lipocalin-type prostaglandin D synthase and brain-type transferrin in cerebrospinal fluid.

    Murakami Yuta, Takahashi Koichi, Hoshi Kyoka, Ito Hiromi, Kanno Mayumi, Saito Kiyoshi, Nollet Kenneth, Yamaguchi Yoshiki, Miyajima Masakazu, Arai Hajime, Hashimoto Yasuhiro, Mima Tatsuo

    BBA General Subjects   1862   1835 - 1842   2018

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  • Lectin-based assay for glycoform-specific detection of alpha2,6sialylated transferrin and carcinoembryonic antigen in tissue and body fluid.

    Ito Hiromi, Hoshi Kyoka, Honda Takashi, Hashimoto Yasuhiro

    Molecules   23   1314 - 1314   2018

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.3390/molecules23061314

  • A unique glycan-isoform of transferrin in cerebrospinal fluid: A potential diagnostic marker for neurological diseases.

    Hoshi K, Matsumoto Y, Ito H, Saito K, Honda T, Yamaguchi Y, Hashimoto Y

    Biochimica et biophysica acta. General subjects   1861 ( 10 )   2473 - 2478   2017.10( ISSN:0304-4165

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    DOI : 10.1016/j.bbagen.2017.07.005

    PubMed

  • A unique glycan-isoform of transferrin in cerebrospinal fluid: A potential diagnostic marker for neurological diseases

    Kyoka Hoshi, Yuka Matsumoto, Hiromi Ito, Kiyoshi Saito, Takashi Honda, Yoshiki Yamaguchi, Yasuhiro Hashimoto

    BBA-General Subjects   1861   2473 - 2478   2017

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    DOI : 10.1016/j.bbagen. 2017.07.005

  • Evaluation of blood-brain barrier function by quotient alpha2macroglobulin and its relationship with interlwukin-6 and complement component 3 levels in neuropsychiatric systemic lupus erythematosus

    Tomoyuki Asano, Hiromi Ito, Yoshinobu Kariya, Kyoka Hoshi, Akioh Yoshihara, Yoshikazu Ugawa, Hideharu Sekine, Shunsei Hirohata, Yoshiki Yamaguchi, Shuzo Sato, Hiroko Kobayashi, Kiyoshi Migita, Hiromasa Ohira, Yasuhiro Hashimoto, Hiroshi Wwatanabe

    PlosOne   12 ( 10 )   e0186414   2017

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    DOI : 10.1371/journal.pone.0186414. eCollection 2017

  • Evaluation of blood-brain barrier function by quotient alpha2 macroglobulin and its relationship with interleukin-6 and complement component 3 levels in neuropsychiatric systemic lupus erythematosus.

    Asano T, Ito H, Kariya Y, Hoshi K, Yoshihara A, Ugawa Y, Sekine H, Hirohata S, Yamaguchi Y, Sato S, Kobayashi H, Migita K, Ohira H, Hashimoto Y, Watanabe H

    PloS one   12 ( 10 )   e0186414   2017

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    DOI : 10.1371/journal.pone.0186414

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  • 認知症における糖鎖バイオマーカー

    星 京香, 伊藤 浩美, 橋本 康弘, 吉原 章王, 宇川 義一, 宮嶋 雅一, 新井 一, 古川 勝敏, 荒井 啓行

    老年期認知症研究会誌   21 ( 2 )   17 - 19   2016.12

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  • Lectin inhibits antigen-antibody reaction in a glycoform-specific manner: Application for detecting α2,6sialylated-carcinoembryonic antigen.

    Ito H, Hoshi K, Osuka F, Gotoh M, Saito T, Hojo H, Suzuki R, Ohira H, Honda T, Hashimoto Y

    Proteomics   16 ( 24 )   3081 - 3084   2016.12( ISSN:1615-9853

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    DOI : 10.1002/pmic.201600117

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  • 【病態バイオマーカーの"いま"】精神・神経疾患 特発性正常圧水頭症 糖鎖バイオマーカーによる特発性正常圧水頭症と神経変性疾患の鑑別

    星 京香, 吉原 章王, 深津 真彦, 金子 知香子, 伊藤 浩美, 橋本 康弘

    生体の科学   67 ( 5 )   498 - 499   2016.10( ISSN:0370-9531

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  • A case of lymphomatosis cerebri mimicking inflammatory diseases

    Murakami T., Yoshida K., Segawa M., Yoshihara A., Hoshi A., Nakamura K., Ichikawa M., Suzuki O., Yokoyama Y., Toyoshima Y., Sugiura Y., Ito H., Saito K., Hashimoto Y., Kakita A., Takahashi H., Ugawa Y.

    BMC Neurology   16 ( 1 )   2016.8

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    DOI : 10.1186/s12883-016-0655-7

  • パーキンソン病と多系統萎縮における"脳型"トランスフェリンとα-シヌクレイン発現に関するサブグループの存在(Subgroup differences in 'brain-type' transferrin and α-synuclein in Parkinson's disease and multiple system atrophy)

    Yoshihara Akioh, Fukatsu Masahiko, Hoshi Kyoka, Ito Hiromi, Nollet Kenneth, Yamaguchi Yoshiki, Ishii Ryotaro, Tokuda Takahiko, Miyajima Masakazu, Arai Hajime, Kato Takeo, Furukawa Katsutoshi, Arai Hiroyuki, Kikuchi Akio, Takeda Atsushi, Ugawa Yoshikazu, Hashimoto Yasuhiro

    The Journal of Biochemistry   160 ( 2 )   87 - 91   2016.8( ISSN:0021-924X

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  • Comparison of analytical methods for profiling N- and O-linked glycans from cultured cell lines: HUPO Human Disease Glycomics/Proteome Initiative multi-institutional study

    Ito H., Kaji H., Togayachi A., Azadi P., Ishihara M., Geyer R., Galuska C., Geyer H., Kakehi K., Kinoshita M., Karlsson N., Jin C., Kato K., Yagi H., Kondo S., Kawasaki N., Hashii N., Kolarich D., Stavenhagen K., Packer N., Thaysen-Andersen M., Nakano M., Taniguchi N., Kurimoto A., Wada Y., Tajiri M., Yang P., Cao W., Li H., Rudd P., Narimatsu H.

    Glycoconjugate Journal   33 ( 3 )   405 - 415   2016.6( ISSN:02820080

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    DOI : 10.1007/s10719-015-9625-3

  • Comparison of analytical methods for profiling N- and O-linked glycans from cultured cell lines HUPO Human Disease Glycomics/Proteome Initiative Multi-institutional Study.

    Ito H, Kaji H, Togayachi A, Azadi P, Ishihara M, Geyer R, Galuska C, Geyer H, Kakehi K, Kinoshita M, Karlsson NG, Jin C, Kato K, Yagi H, Kondo S, Kawasaki N, Hashii N, Kolarich D, Stavenhagen K, Packer NH, Thaysen-Andersen M, Nakano M, Taniguchi N, Kurimoto A, Wada Y, Tajiri M, Yang P, Cao W, Li H, Rudd PM, Narimatsu H

    Glycoconj J   33   405 - 415   2016

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  • Lectin inhibits antigen-antibody reactioon in a glycoform-specific manner: Application for detecting alpha2,6sialylated-carcinoembryonic antigen

    Ito Hiromi*, Hoshi Kyoka*, Osuka Fumihiko*, Gotoh Mitsukazu*, Saito Takuro*, Hojo Hiroshi*, Suzuki Rei*, Ohira Hiromasa*, Honda Takashi*, Hashimoto Yasuhiro*

    PROTEOMICS   16 ( 24 )   3081 - 3084   2016

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  • Subgroup differences in "brain-type" transferrin and alpha-synuclein in Parkinson's disease

    Yoshihara Akioh*, Fukatsu Masahiko*, Hoshi Kyoka*, Ito Hiromi*, Nollet Kenneth*, Yamaguchi Yoshiki, Ishii Ryotaro, Tokuda Takahiko, Miyajima Masakazu, Arai Hajime, Kato Takeo, Furukawa Katsutoshi, Arai Hiroyuki, Kikuchi Akio, Takeda Atsushi, Ugawa Yoshikazu* and Hashimoto Yasuhiro*

    Journal of Biochemistry   160 ( 2 )   87 - 91   2016

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    DOI : 10.1093/jb/mvw015

  • 糖鎖バイオマーカーによる特発性正常圧水頭症と神経変性疾患の鑑別

    星京香*, 吉原章王*, 深津真彦*, 金子知香子, 伊藤浩美*, 橋本康弘*

    生体の科学   67 ( 5 )   498 - 499   2016

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

  • 認知症における糖鎖バイオマーカー

    星京香*, 吉原章王*, 伊藤浩美*, 宮嶋雅一, 新井一, 宇川義一*, 橋本康弘*

    老年期認知症研究会誌   21 ( 7 )   17 - 19   2016

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  • トランスフェリンの糖型のin situでの可視化 肝臓におけるα2,6-シアル化トランスフェリンの局在確認(In situ visualization of a glycoform of transferrin: localization of α2,6-sialylated transferrin in the liver)

    Matsumoto Yuka, Saito Toshie, Hoshi Kyoka, Ito Hiromi, Kariya Yoshinobu, Nagae Masamichi, Yamaguchi Yoshiki, Hagiwara Yoshiaki, Kinoshita Noriaki, Wada Ikuo, Saito Kiyoshi, Honda Takashi, Hashimoto Yasuhiro

    The Journal of Biochemistry   157 ( 4 )   211 - 216   2015.4( ISSN:0021-924X

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  • In situ visualization of a glycoform of transferrin: localization of α2,6-sialylated transferrin in the liver.

    Matsumoto Y, Saito T, Hoshi K, Ito H, Kariya Y, Nagae M, Yamaguchi Y, Hagiwara Y, Kinoshita N, Wada I, Saito K, Honda T, Hashimoto Y

    Journal of biochemistry   157 ( 4 )   211 - 6   2015.4( ISSN:0021-924X

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    DOI : 10.1093/jb/mvu071

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  • Glycan Marker for Idiopathic Normal Pressure Hydrocephalus

    Hoshi K., Matsumoto Y., Saito T., Ito H., Kariya Y., Yamaguchi Y., Furukawa K., Arai H., Miyajima M., Arai H., Narimatsu H., Saito K., Honda T., Hashimoto Y.

    Glycoscience: Biology and Medicine   1289 - 1295   2015.1

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    DOI : 10.1007/978-4-431-54841-6_177

  • 肝疾患病態指標血清マーカーの開発と低侵襲かつ効率的に評価・予測する新規検査系の実用化 病態病理・分子病理に基づいた肝がん特徴的な糖鎖変化の検出および肝がんマーカー候補糖タンパク質探索・検証のための技術開発

    梶裕之, 久野敦, 佐藤隆, 栂谷内晶, 調憲, 末松誠, 坂元亨宇, 伊藤浩美, 是永匡紹

    肝疾患病態指標血清マーカーの開発と低侵襲かつ効率的に評価・予測する新規検査系の実用化 平成26年度 委託業務成果報告書   2015

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  • B型肝炎ウイルスにおける糖鎖の機能解析と医用応用技術の実用化へ HBV感染可能細胞の糖鎖解析

    栂谷内晶, 梶裕之, 伊藤浩美, 安形清彦, 尾曲克己, 飯島沙幸

    B型肝炎ウイルスにおける糖鎖の機能解析と医用応用技術の実用化へ 平成26年度 総括・分担研究報告書   2015

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  • High throughput detection of an alpha2,6-sialylated glycoform of transferrin in cerebrospinal fluid: Application for dementia diagnosis

    Yasuhiro Hashimoto, Kyoka Hoshi, Toshie Saito, Hiromi Ito, Yoshinobu Kariya, Takashi Honda, Yoshiki Yamaguchi

    GLYCOBIOLOGY   24 ( 11 )   1219 - 1220   2014.11( ISSN:0959-6658

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  • IgA nephropathy caused by unusual polymerization of IgA1 with aberrant N-glycosylation in a patient with monoclonal immunoglobulin deposition disease.

    Narimatsu Y, Kuno A, Ito H, Kaji H, Kaneko S, Usui J, Yamagata K, Narimatsu H

    PLoS One.   9   e91079   2014

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  • In situ visualization of a glycoform of transferrin: Localization of α2,6-sialylated transferrin in the liver

    Yuka Matsumoto*, Toshie Saito*, Kyoka Hoshi*, Hiromi Ito*, Yoshinobu Kariya*, Masamichi Nagae, Yoshiki Yamaguchi, Yoshiaki Hagiwara, Noriaki Kinoshita, Ikuo Wada*, Kiyoshi Saito*, Takashi Honda* and Yasuhiro Hashimoto*

    Journal of Biochemistry   157 ( 4 )   211 - 6   2014

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    DOI : 10.1093/jb/mvu071.

  • IgA nephropathy caused by unusual polymerization of IgA1 with aberrant N-glycosylation in a patient with monoclonal immunoglobulin deposition disease.

    Narimatsu Y, Kuno A, Ito H, Kaji H, Kaneko S, Usui J, Yamagata K, Narimatsu H

    PloS one   9 ( 3 )   e91079   2014

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    DOI : 10.1371/journal.pone.0091079

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  • 髄液中α2,6-シアル酸化トランスフェリンの迅速測定

    星京香, 苅谷慶喜, 伊藤浩美, 松本加奈, 長江雅倫, 山口芳樹, 中島円, 宮嶋雅一, 新井一, 久野敦, 成松久, 城谷圭朗, 橋本康弘

    日本正常圧水頭症学会プログラム・抄録集   15th   2014

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  • 肝疾患病態指標血清マーカーの開発と迅速,簡便かつ安価な測定法の実用化 新規肝疾患病態指標マーカーの簡易測定系開発

    成松久, 梶裕之, 久野敦, 栂谷内晶, 佐藤隆, 田中靖人, 伊藤浩美, 池原譲, 雄長誠, 後藤雅式

    肝疾患病態指標血清マーカーの開発と迅速、簡便かつ安価な測定法の実用化 平成25年度 総括・分担研究報告書   2014

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  • レクチンによる抗体抗原反応の阻害を利用した糖タンパク質迅速測定法の開発

    城谷圭朗, 城谷圭朗, 星京香, 苅谷慶喜, 奈良清光, 伊藤浩美, 松本加奈, 長江雅倫, 山口芳樹, 中島円, 宮嶋雅一, 新井一, 久野敦, 成松久, 橋本康弘, 岩田修永

    日本薬学会年会要旨集(CD-ROM)   134th   2014

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  • B型肝炎ウイルスにおける糖鎖の機能解析と医用応用技術の実用化へ HBV感染可能細胞の糖鎖解析

    栂谷内晶, 梶裕之, 伊藤浩美, 安形清彦, 飯島沙幸

    B型肝炎ウイルスにおける糖鎖の機能解析と医用応用技術の実用化へ 平成25年度 総括・分担研究報告書   2014

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    J-GLOBAL

  • Lectin-dependent inhibition of antigen-antibody reaction: application for measuring α2,6-sialylated glycoforms of transferrin.

    Hoshi K, Kariya Y, Nara K, Ito H, Matsumoto K, Nagae M, Yamaguchi Y, Nakajima M, Miyajima M, Arai H, Kuno A, Narimatsu H, Shirotani K, Hashimoto Y

    Journal of biochemistry   154 ( 3 )   229 - 32   2013.9( ISSN:0021-924X

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    DOI : 10.1093/jb/mvt065

    PubMed

  • レクチン依存的な抗原抗体反応の阻害 α2,6-シアリル化された糖型トランスフェリンの定量への応用(Lectin-dependent inhibition of antigen-antibody reaction: application for measuringα2,6-sialylated glycoforms of transferrin)

    Hoshi Kyoka, Kariya Yoshinobu, Nara Kiyomitsu, Ito Hiromi, Matsumoto Kana, Nagae Masamichi, Yamaguchi Yoshiki, Nakajima Madoka, Miyajima Masakazu, Arai Hajime, Kuno Atsushi, Narimatsu Hisashi, Shirotani Keiro, Hashimoto Yasuhiro

    The Journal of Biochemistry   154 ( 3 )   229 - 232   2013.9( ISSN:0021-924X

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  • Lectin-dependent inhibition of antigen-antibody reaction: application for measuring α2,6-sialylated glycoforms of transferrin.

    Hoshi K, Kariya Y, Nara K, Ito H, Matsumoto K, Nagae M, Yamaguchi Y, Nakajima M, Miyajima M, Arai H, Kuno A, Narimatsu H, Shirotani K, Hashimoto Y

    J Biochem.   154   229 - 232   2013

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  • 髄液型糖鎖と中枢神経疾患

    橋本康弘, 星京香, 苅谷慶喜, 伊藤浩美, 本田たかし, 松本由香, 齋藤清, 長江雅倫, 山口芳樹, 松崎英樹, 久野敦, 成松久

    生命科学における糖鎖の底力-生活習慣病と糖鎖科学 第11回 糖鎖科学コンソーシアムシンポジウム 理研シンポジウム 平成25年   2013

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    J-GLOBAL

  • 認知症マーカーとしてのα2,6シアル酸化トランスフェリンの新規測定法

    星京香, 苅谷慶喜, 奈良清光, 伊藤浩美, 松本加奈, 長江雅倫, 山口芳樹, 中島円, 宮嶋雅一, 新井一, 久野敦, 成松久, 城谷圭朗, 橋本康弘

    日本生化学会大会(Web)   86th   2013

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    J-GLOBAL

  • 肝疾患病態指標血清マーカーの開発と迅速,簡便かつ安価な測定法の実用化 新規肝疾患病態指標マーカーの簡易測定系開発

    成松久, 梶裕之, 久野敦, 栂谷内晶, 佐藤隆, 伊藤浩美, 池原譲, 雄長誠, 後藤雅式

    肝疾患病態指標血清マーカーの開発と迅速、簡便かつ安価な測定法の実用化 平成24年度 総括・分担研究報告書   2013

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    J-GLOBAL

  • B型肝炎ウイルスにおける糖鎖の機能解析と医用応用技術の実用化へ 2.HBV感染可能細胞の糖鎖解析

    栂谷内晶, 梶裕之, 伊藤浩美, 安形清彦

    B型肝炎ウイルスにおける糖鎖の機能解析と医用応用技術の実用化へ 平成24年度 総括・分担研究報告書   2013

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    J-GLOBAL

  • A unique N-glycan on human transferrin in CSF: a possible biomarker for iNPH.

    Futakawa S, Nara K, Miyajima M, Kuno A, Ito H, Kaji H, Shirotani K, Honda T, Tohyama Y, Hoshi K, Hanzawa Y, Kitazume S, Imamaki R, Furukawa K, Tasaki K, Arai H, Yuasa T, Abe M, Arai H, Narimatsu H, Hashimoto Y

    Neurobiol Aging.   33   1807 - 1815   2012

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  • Structural basis for the recognition of Lewis antigens by genogroup I norovirus.

    Kubota T, Kumagai A, Ito H, Furukawa S, Someya Y, Takeda N, Ishii K, Wakita T, Narimatsu H, Shirato H

    J Virol.   86   11138 - 11150   2012

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  • A chemoenzymatic approach toward the identification of fucosylated glycoproteins and mapping of N-glycan sites.

    Liu TW, Kaji H, Togayachi A, Ito H, Sato T, Narimatsu H

    Glycobiology   22   630 - 637   2012

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  • Bovine Milk Whey for Preparation of Natural N-glycans: Structural and Quantitative Analysis.

    Sriwilaijaroen N, Kondo S, Yagi H, Hiramatsu H, Nakakita S, Yamada K, Ito H, Hirabayashi J, Narimatsu H, Kato K, Suzuki Y

    Open Glycoscience   5   41 - 50   2012

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  • Functional expression of L-fucokinase/GDP-L-fucose pyrophosphorylase from Bacteroides fragilis in Saccharomyces cerevisiae for the production of nucleotide sugars from exogenous monosaccharides.

    Liu TW, Ito H, Chiba Y, Kubota T, Sato T, Narimatsu H

    Glycobiology   21   1228 - 1236   2011

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  • Lack of lacto/neolacto-glycolipids enhances the formation of glycolipid-enriched microdomains, facilitating B cell activation.

    Togayachi A, Kozono Y, Ikehara Y, Ito H, Suzuki N, Tsunoda Y, Abe S, Sato T, Nakamura K, Suzuki M, Goda HM, Ito M, Kudo T, Takahashi S, Narimatsu H

    Proc Natl Acad Sci USA.   107   11900 - 11905   2010

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  • Identification of a novel human UDP-GalNAc transferase with unique catalytic activity and expression profile.

    Peng C, Togayachi A, Kwon YD, Xie C, Wu G, Zou X, Sato T, Ito H, Tachibana K, Kubota T, Noce T, Narimatsu H, Zhang Y.

    Biochem Biophys Res Commun.   402   680 - 686   2010

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  • Renal involvement of monoclonal immunoglobulin deposition disease associated with an unusual monoclonal immunoglobulin A glycan profile.

    Kaneko S, Usui J, Narimatsu Y, Ito H, Narimatsu H, Hagiwara M, Tsuruoka S, Nagata M, Yamagata K

    Clin Exp Nephrol.   14   389 - 395   2010

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  • Comparison of Methods for Profiling O-glycosylation: HUPO Human Disease Glycomics/Proteome Initiative Multi-Institutional Study of IgA1.

    Wada Y, Dell A, Haslam SM, Tissot B, Canis K, Azadi P, Bäckström M, Costello CE, Hansson GC, Hiki Y, Ishihara M, Ito H, Kakehi K, Karlsson N, Kato K, Kawasaki N, Khoo KH, Kobayashi K, Kolarich D, Kondo A, Lebrilla C, Nakano M, Narimatsu H, Novak J, Novotny MV, Ohno E, Packer NH, Renfrow MB, Tajiri M, Thomsson KA, Yagi H, Yu SY, Taniguchi N

    Mol Cell Proteomics.   9   719 - 727   2010

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  • Expression system for human glycosyltransferases and its application.

    Chiba Y, Ito H, Sato T, Takahashi Y, Jigami Y, Narimatsu H

    J. Appl. Glycosci.   57   131 - 136   2010

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  • A strategy for discovery of cancer glyco-biomarkers in serum using newly developed technologies for glycoproteomics.

    Narimatsu H, Sawaki H, Kuno A, Kaji H, Ito H, Ikehara Y

    FEBS J.   277   95 - 105   2010

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  • Strategy for glycoproteomics: identification of glyco-alteration using multiple glycan profiling tools

    Ito H, Kuno A, Sawaki H, Sogabe M, Ozaki H, Tanaka Y, Mizokami M, Shoda J, Angata T, Sato T, Hirabayashi J, Ikehara Y, Narimatsu H

    J Proteome Res.   8   1358 - 1367   2009

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  • Focused differential glycan analysis with the platform antibody-assisted lectin profiling (ALP) for glycan-related biomarker verification

    Kuno A, Kato Y, Matsuda A, Kaneko MK, Ito H, Amano K, Chiba Y, Narimatsu H, Hirabayashi J

    Mol Cell Proteomics.   8   99 - 108   2009

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  • Molecular cloning, expression, and characterization of a novel endo-alpha-N-acetylgalactosaminidase from Enterococcus faecalis

    Goda HM, Ushigusa K, Ito H, Okino N, Narimatsu H, Ito M

    Biochem Biophys Res Commun.   375   541 - 546   2008

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  • Identification of further elongation and branching of dimeric type 1 chain on lactosylceramides from colonic adenocarcinoma by tandem mass spectrometry sequencing analyses.

    Fan YY, Yu SY, Ito H, Kameyama A, Sato T, Lin CH, Yu LC, Narimatsu H, Khoo KH

    J Biol Chem   283   16455 - 16468   2008

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  • Quantitative derivatization of sialic acids for the detection of sialoglycans by MALDI MS

    Toyoda M, Ito H, Matsuno YK, Narimatsu H, Kameyama A

    Anal Chem.   80   5211 - 5218   2008

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  • Engineering of mucin-type human glycoproteins in yeast cells.

    Amano K, Chiba Y, Kasahara Y, Kato Y, Kaneko MK, Kuno A, Ito H, Kobayashi K, Hirabayashi J, Jigami Y, Narimatsu H

    Proc Natl Acad Sci USA.   105   3232 - 3237   2008

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  • Molecular analysis of pathophysiological binding of the platelet aggregation-inducing factor podoplanin to the C-type lectin-like receptor CLEC-2

    Kato Y, Kaneko M, Kunita A, Ito H, Kameyama A, Ogasawara S, Matsuura N, Hasegawa Y, Suzuki-Inoue K, Inoue O, Ozaki Y, Narimatsu H

    Cancer Science   99   2488 - 2494   2008

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  • Noroviruses distinguish between type 1 and type 2 histo-blood group antigens for binding

    Shirato H, Ogawa S, Ito H, Sato T, Kameyama A, Narimatsu H, Xiaofan Z, Miyamura T, Wakita T, Ishii K, Takeda N

    J Virol.   82   10756 - 10767   2008

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  • Direct On-Membrane Glycoproteomic Approach Using MALDI-TOF Mass Spectrometry Coupled with Microdispensing of Multiple Enzymes

    Kimura S, Kameyama A, Nakaya S, Ito H, Narimatsu H

    J Proteome Res.   6   2488 - 2494   2007

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  • Strategy for the fine characterization of glycosyltransferase specificity using isotopomer assembly

    Ito H, Kameyama A, Sato T, Sukegawa M, Ishida HK, Narimatsu H

    Nat Methods.   4   577 - 582   2007

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  • Functional glycosylation of human podoplanin: glycan structure of platelet aggregation-inducing factor

    Kaneko MK, Kato Y, Kameyama A, Ito H, Kuno A, Hirabayashi J, Kubota T, Amano K, Chiba Y, Hasegawa Y, Sasagawa I, Mishima K, Narimatsu H

    FEBS Lett   581   331 - 336   2007

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  • Molecular cloning and characterization of a novel human beta1,3-glucosyltransferase, which is localized at the endoplasmic reticulum and glucosylates O-linked fucosylglycan on thrombospondin type 1 repeat domain

    Molecular cloning and characterization of a novel human Sato T, Sato M, Kiyohara K, Sogabe M, Shikanai T, Kikuchi N, Togayachi A, Ishida H, Ito H, Kameyama A, Gotoh M, Narimatsu H

    Glycobiology   16   1194 - 1206   2006

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  • Strategy for simulation of CID spectra of N-linked oligosaccharides toward glycomics

    Kameyama A, Nakaya S, Ito H, Kikuchi N, Angata T, Nakamura M, Ishida HK, Narimatsu H

    J Proteome Res.   5   808 - 814   2006

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  • A Strategy for Identification of Oligosaccharide Structures Using Observational Multistage Mass Spectral Library

    Kameyama A, Kikuchi N, Nakaya S, Ito H, Sato T, Shikanai T, Takahashi Y, Takahashi K, Narimatsu H

    Anal Chem   77   4179 - 4725   2005

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  • Molecular-weight-tagged glycopeptide library: efficient construction and applications

    Ito H, Kameyama A, Sato T, Kiyohara K, Nakahara Y, Narimatsu H

    Angew Chem Int Ed.   44   4547 - 4579   2005

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  • The carbohydrate sequence markup language (CabosML): an XML description of carbohydrate structures

    Kikuchi N, Kameyama A, Nakaya S, Ito H, Sato T, Shikanai T, Takahashi Y, Narimatsu H

    Bioinformatics   21   1717 - 1718   2004

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  • Systematic synthesis and MAG-binding activity of novel sulfated GM1b analogues as mimics of Chol-1 (alpha-series) gangliosides: highly active ligands for neural siglecs

    Ito H, Ishida H, Collins BE, Fromholt SE, Schnaar RL, Kiso M

    Carbohydr Res.   338   1621 - 1639   2003

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  • Novel sulfated gangliosides, high-affinity ligands for neural siglecs, inhibit NADase activity of leukocyte cell surface antigen CD38

    Hara-Yokoyama M, Ito H, Ueno-Noto K, Takano K, Ishida H, Kiso M

    Bioorg Med Chem Lett   13   3441 - 3445   2003

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  • Immunoglobulin G-class mouse monoclonal antibodies to major brain gangliosides

    Schnaar RL, Fromholt SE, Gong Y, Vyas AA, Laroy W, Wayman DM, Heffer-Lauc M, Ito H, Ishida H, Kiso M, Griffin JW, Shiekh KA

    Anal Biochem   302   276 - 284   2002

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  • The aglycone of sulfogalactolipids can alter the sulfate ester substitution position required for hsc70 recognition

    Mamelak D, Mylvaganam M, Tanahashi E, Ito H, Ishida H, Kiso M, Lingwood C

    Carbohydr Res   335   91 - 100   2001

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  • A highly efficient total synthetic route to alpha-series gangliosides: GM1alpha, GD1alpha, and GT1alpha

    Ito H, Ishida H, Kiso M, Hasegawa A

    J Carbohydr Chem   20   207 - 225   2001

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  • Molecular cloning and expression of mouse GD1alpha/GT1aalpha/GQ1balpha synthase (ST6GalNAc VI) gene

    Okajima T, Chen HH, Ito H, Kiso M, Tai T, Furukawa K, Urano T, Furukawa K

    J Biol Chem   275   6717 - 6723   2000

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  • Molecular cloning of brain-specific GD1alpha synthase (ST6GalNAc V) containing CAG/Glutamine repeats

    Okajima T, Fukumoto S, Ito H, Kiso M, Hirabayashi Y, Urano T, Furukawa K

    J Biol Chem   274   30557 - 30562   1999

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  • Total synthesis of a cholinergic neuron-specific ganglioside GT1a alpha: a high affinity ligand for myelin-associated glycoprotein (MAG)

    Ito H, Ishida H, Waki H, Ando S, Kiso M

    Glycoconj J.   16   585 - 598   1999

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  • Enhanced binding of the neural siglecs, myelin-associated glycoprotein and Schwann cell myelin protein, to Chol-1 (alpha-series) gangliosides and novel sulfated Chol-1 analogs

    Collins BE, Ito H, Sawada N, Ishida H, Kiso M, Schnaar RL

    J Biol Chem   274   37637 - 37643   1999

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  • First total synthesis of ganglioside GT1a alpha

    Ito H, Ishida H, Kiso M, Hasegawa A

    Carbohydr Res.   306   581 - 585   1998

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  • Total synthesis of ganglioside GD1c and GT1a

    Ishida HK, Ando H, Ito H, Ishida H, Kiso M, Hasegawa A

    J Carbohydr Chem   16   413 - 428   1997

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Books

  • Glycoscience: Biology and Medicine

    Naoyuki Taniguchi, Tamao Endo, Gerald Hart, Peter Seeberger, Chi-Huey Wong(A Glycan Marker for Idiopathic Normal Pressure Hydrocephalus)

    Springer Verlag Tokyo  2014 

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    Responsible for pages:1-7   Language:English  

    Authors name of the chapter and paper which it took charge of:Kyoka Hoshi*, Yuka Matsumoto*, Toshie Saito*, Hiromi Ito*, Yoshinobu Kariya*, Yoshiki Yamaguchi, Katsutoshi Furukawa, Hiroyuki Arai, Masakazu Miyajima, Hajime Arai, Hisashi Narimatsu, Kiyoshi Saito*, Takashi Honda* and Yasuhiro Hashimoto*   Publication place:Tokyo  

  • Glycoscience: Biology and Medicine

    Springer Verlag Tokyo  2014 

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    Responsible for pages:1-7   Language:Japanese   Book type:Scholarly book

    Publication place:  

  • 実験医学別冊「創薬・タンパク質研究のためのプロテオミクス解析」

    (グライコプロテオミクスによるがんの血清バイオマーカー探索)

    羊土社  2010 

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    Responsible for pages:112-118   Language:Japanese  

    Authors name of the chapter and paper which it took charge of:梶 裕之, 池原 譲, 久野 敦, 澤木弘道, 伊藤浩美, 成松 久   Publication place:  

  • Methods in Enzymology

    (In vitro and in vivo enzymatic syntheses and mass spectrometric database for N-glycans and o-glycans.)

    2010 

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    Responsible for pages:127-149   Language:English  

    Authors name of the chapter and paper which it took charge of:Ito H, Chiba Y, Kameyama A, Sato T, Narimatsu H   Publication place:  

  • Methods in Molecular Biology

    Packer NH et al. eds.(Preparation of a Glycan Library Using a Variety of Glycosyltransferases)

    The Humana Press Inc.  2009 

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    Responsible for pages:1-10   Language:English  

    Authors name of the chapter and paper which it took charge of:Ito H, Kameyama A, Sato T, Narimatsu H   Publication place:  

  • シリーズ最新医学講座・I 糖鎖と臨床検査・3

    (糖鎖遺伝子ライブラリーの構築と糖鎖合成)

    医学書院  2008 

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    Responsible for pages:343-348   Language:Japanese  

    Authors name of the chapter and paper which it took charge of:清原克恵,佐藤 隆,伊藤浩美,成松 久   Publication place:  

  • Glycoscience Lab Manual

    Taniguchi N. et al. eds.(Experimental Glycoscience, Glycochemistry: Construction of O-linked glycopeptide library using human glycosyltransferases)

    Springer Verlag  2008 

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    Responsible for pages:155-157   Language:English  

    Authors name of the chapter and paper which it took charge of:Ito H.   Publication place:  

  • 実験医学増刊「波及・深化する糖鎖研究」

    古川鋼一、遠藤玉夫、川嵜敏祐 監修(糖鎖遺伝子ライブラリーの構築と糖鎖構造解析への応用)

    羊土社  2007 

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    Responsible for pages:239-244   Language:Japanese  

    Authors name of the chapter and paper which it took charge of:佐藤 隆,伊藤浩美,亀山昭彦,成松 久   Publication place:  

  • バイオテクノロジージャーナル「糖鎖解析〜基盤技術の整備と最新動向」

    羊土社(酵素による糖鎖合成技術の動向)

    羊土社  2006 

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    Responsible for pages:294-298   Language:Japanese  

    Authors name of the chapter and paper which it took charge of:伊藤浩美   Publication place:  

  • 糖鎖科学の新展開

    谷口直之、伊藤幸成 監修(糖鎖遺伝子を用いる糖鎖合成法)

    NTS社  2005 

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    Responsible for pages:410-415   Language:Japanese  

    Authors name of the chapter and paper which it took charge of:伊藤浩美, 亀山昭彦, 成松 久   Publication place:  

  • 未来を拓く糖鎖科学

    永井克孝 監修(ヒト糖転移酵素を用いたO-結合型糖ペプチドライブラリーの構築)

    金芳堂  2005 

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    Responsible for pages:91-93   Language:Japanese  

    Authors name of the chapter and paper which it took charge of:伊藤浩美, 亀山昭彦, 佐藤 隆, 成松 久   Publication place:  

  • Special problems in glycosylation reactions: Sialidations in Carbohydrates in Chemistry and Biology

    Ernst B, Sinay P, and Hart H, Eds.

    Wiley-VCH, Weinheim  2000 

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    Responsible for pages:345-365   Language:English  

    Authors name of the chapter and paper which it took charge of:Ishida H, Kiso M, and Ito H   Publication place:  

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Presentations

  • 脳脊髄液減少症における髄液バイオマーカー

    第71回日本自律神経学会総会  

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    Event date: 2018.10

  • 脳脊髄液減少症における髄液バイオマーカー

    第71回日本自律神経学会総会  

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    Event date: 2018.10

  • 新しい脳脊髄液代謝マーカーによる脳脊髄液漏出症の診断

    BIO Japan 2018  

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    Event date: 2018.10

  • 新しい脳脊髄液代謝マーカーによる脳脊髄液漏出症の診断

    BIO Japan 2018  

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    Event date: 2018.10

  • 髄液糖鎖マーカーとしての脳型トランスフェリン

    第12回東北糖鎖研究会  

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    Event date: 2018.9

  • 髄液糖鎖マーカーとしての脳型トランスフェリン

    第12回東北糖鎖研究会  

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    Event date: 2018.9

  • 髄液代謝異常症とトランスフェリン糖鎖異性体

    第37回日本糖質学会年会  

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    Event date: 2018.8

  • 髄液代謝異常症とトランスフェリン糖鎖異性体

    第37回日本糖質学会年会  

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    Event date: 2018.8

  • 髄液産生マーカーとしてのトランスフェリン

    京都髄液フォーラム2018  

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    Event date: 2018.8

  • 髄液産生マーカーとしてのトランスフェリン

    京都髄液フォーラム2018  

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    Event date: 2018.8

  • 新しい髄液代謝マーカー:髄液過剰による認知症及び髄液漏出症の診断

    BIO tech 2018  

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    Event date: 2018.6

  • 新しい髄液代謝マーカー:髄液過剰による認知症及び髄液漏出症の診断

    BIO tech 2018  

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    Event date: 2018.6

  • 脈絡叢組織に対するレクチン染色を用いた形態学的検討

    第19回日本正常圧水頭症学会  

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    Event date: 2018.2

  • 脈絡叢組織に対するレクチン染色を用いた形態学的検討

    第19回日本正常圧水頭症学会  

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    Event date: 2018.2

  • 特発性正常圧水頭症における髄液トランスフェリンの定量及び形態学的検討

    第10回日本水頭症脳脊髄液学会  

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    Event date: 2017.11

  • 特発性正常圧水頭症における髄液トランスフェリンの定量及び形態学的検討

    第10回日本水頭症脳脊髄液学会  

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    Event date: 2017.11

  • レクチン阻害法による糖鎖アイソフォームの測定

    東北糖鎖研究会・東京糖鎖研究会合同シンポジウム(第11回東北糖鎖研究会・GlycoTOKYO 2017)  

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    Event date: 2017.11

  • レクチン阻害法による糖鎖アイソフォームの測定

    東北糖鎖研究会・東京糖鎖研究会合同シンポジウム(第11回東北糖鎖研究会・GlycoTOKYO 2017)  

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    Event date: 2017.11

  • A CSF biomarker for diagnosing spontaneous intracranial hypotension

    The 9th Meeting of the Internaional Society for Hydrocephalus and Cerebrospinal Fluid Disorders (Hydrocephalus 2017)  

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    Event date: 2017.9

  • 髄液バイオマーカーによる特発性低髄液圧症候群の診断

    第18回日本正常圧水頭症学会  

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    Event date: 2017.2

  • 髄液バイオマーカーによる特発性低髄液圧症候群の診断

    第18回日本正常圧水頭症学会  

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    Event date: 2017.2

  • 特発性低髄液圧症候群の診断における新たな髄液バイオマーカーの模索

    第9回日本水頭症脳脊髄液学会  

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    Event date: 2016.11

  • 特発性低髄液圧症候群の診断における新たな髄液バイオマーカーの模索

    第9回日本水頭症脳脊髄液学会  

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    Event date: 2016.11

  • 特発性低髄液圧症候群の診断における髄液中バイオマーカー

    日本脳神経外科学会 第75回学術総会  

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    Event date: 2016.9 - 2016.10

  • 特発性低髄液圧症候群の診断における髄液中バイオマーカー

    日本脳神経外科学会 第75回学術総会  

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    Event date: 2016.9

  • ホルマリン固定大腸癌由来のα2,6シアリル化癌胎児性抗原の検出

    第89回日本生化学会大会  

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    Event date: 2016.9

  • 髄液中トランスフェリン糖鎖アイソフォームと疾患

    第89回日本生化学会大会  

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    Event date: 2016.9

  • ホルマリン固定大腸癌由来のα2,6シアリル化癌胎児性抗原の検出

    第89回日本生化学会大会  

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    Event date: 2016.9

  • 髄液中トランスフェリン糖鎖アイソフォームと疾患

    第89回日本生化学会大会  

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    Event date: 2016.9

  • Subgroup differences in "brain-type transferrin and alpha-synuclein in Parkinson's disease and multiple system atrophy

    7th Asian Community of Glycoscience and Glycotechnology Conference (ACGG)  

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    Event date: 2015.11

  • Subgroup differences in "brain-type transferrin and alpha-synuclein in Parkinson's disease and multiple system atrophy

    7th Asian Community of Glycoscience and Glycotechnology Conference (ACGG)  

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    Event date: 2015.11

  • Upregulation of C3 and alpha-2-Macroglobulin in cerebrospinal fluid of neuropsychiatric systemic lupus erythematosus

    18th Annual Meeting of American College of Rheumatology  

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    Event date: 2015.11

  • Upregulation of C3 and alpha-2-Macroglobulin in cerebrospinal fluid of neuropsychiatric systemic lupus erythematosus

    18th Annual Meeting of American College of Rheumatology  

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    Event date: 2015.11

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