基礎生物学研究所　形態形成研究部門　日本学術振興会研究員

1999.10 - 2001.3

MERIT40-dependent recruitment of tankyrase to damaged DNA and its implication for cell sensitivity to DNA-damaging anticancer drugs.

Okamoto K, Ohishi T, Kuroiwa M, Iemura SI, Natsume T, Seimiya H

Oncotarget   9 ( 88 )   35844 - 35855   2018.11

Stratifin regulates stabilization of receptor tyrosine kinases via interaction with ubiquitin-specific protease 8 in lung adenocarcinoma.

Kim Y, Shiba-Ishii A, Nakagawa T, Iemura SI, Natsume T, Nakano N, Matsuoka R, Sakashita S, Lee S, Kawaguchi A, Sato Y, Noguchi M

Oncogene   37 ( 40 )   5387 - 5402   2018.10（ ISSN:0950-9232 ）

β-TrCP-dependent degradation of ASK1 suppresses the induction of the apoptotic response by oxidative stress.

Cheng R, Takeda K, Naguro I, Hatta T, Iemura SI, Natsume T, Ichijo H, Hattori K

Biochimica et biophysica acta. General subjects   1862 ( 10 )   2271 - 2280   2018.10（ ISSN:0304-4165 ）

Serine Phosphorylation by mTORC1 Promotes IRS-1 Degradation through SCFβ-TRCP E3 Ubiquitin Ligase.

Yoneyama Y, Inamitsu T, Chida K, Iemura SI, Natsume T, Maeda T, Hakuno F, Takahashi SI

iScience   5   1 - 18   2018.7

Nuclear export of ubiquitinated proteins via the UBIN-POST system.

Hirayama S, Sugihara M, Morito D, Iemura SI, Natsume T, Murata S, Nagata K

Proceedings of the National Academy of Sciences of the United States of America   115 ( 18 )   E4199 - E4208   2018.5（ ISSN:0027-8424 ）

Endosomal phosphatidylserine is critical for the YAP signalling pathway in proliferating cells.

Matsudaira T, Mukai K, Noguchi T, Hasegawa J, Hatta T, Iemura SI, Natsume T, Miyamura N, Nishina H, Nakayama J, Semba K, Tomita T, Murata S, Arai H, Taguchi T

Nature communications   8 ( 1 )   1246   2017.11

Endoplasmic reticulum proteins SDF2 and SDF2L1 act as components of the BiP chaperone cycle to prevent protein aggregation.

Fujimori T, Suno R, Iemura SI, Natsume T, Wada I, Hosokawa N

Genes to cells : devoted to molecular & cellular mechanisms   22 ( 8 )   684 - 698   2017.8（ ISSN:1356-9597 ）

Tankyrase-binding protein TNKS1BP1 regulates actin cytoskeleton rearrangement and cancer cell invasion

Ohishi T., Yoshida H., Katori M., Migita T., Muramatsu Y., Miyake M., Ishikawa Y., Saiura A., Iemura S., Natsume T., Seimiya H.

Cancer Research   77 ( 9 )   2328 - 2338   2017.5（ ISSN:00085472 ）

USP15 attenuates IGF-I signaling by antagonizing Nedd4-induced IRS-2 ubiquitination.

Fukushima T, Yoshihara H, Furuta H, Hakuno F, Iemura SI, Natsume T, Nakatsu Y, Kamata H, Asano T, Komada M, Takahashi SI

Biochemical and biophysical research communications   484 ( 3 )   522 - 528   2017.3（ ISSN:0006-291X ）

TMED10 Protein Interferes with Transforming Growth Factor (TGF)-β Signaling by Disrupting TGF-β Receptor Complex Formation.

Nakano N, Tsuchiya Y, Kako K, Umezaki K, Sano K, Ikeno S, Otsuka E, Shigeta M, Nakagawa A, Sakata N, Itoh F, Nakano Y, Iemura SI, van Dinther M, Natsume T, Ten Dijke P, Itoh S

The Journal of biological chemistry   292 ( 10 )   4099 - 4112   2017.3（ ISSN:0021-9258 ）

Alternative exon skipping biases substrate preference of the deubiquitylase USP15 for mysterin/RNF213, the moyamoya disease susceptibility factor.

Kotani Y, Morito D, Sakata K, Ainuki S, Sugihara M, Hatta T, Iemura SI, Takashima S, Natsume T, Nagata K

Scientific reports   7   44293   2017.3

Ubiquitylation of Ku80 by RNF126 Promotes Completion of Nonhomologous End Joining-Mediated DNA Repair.

Ishida N, Nakagawa T, Iemura SI, Yasui A, Shima H, Katoh Y, Nagasawa Y, Natsume T, Igarashi K, Nakayama K

Molecular and cellular biology   37 ( 4 )   2017.2（ ISSN:0270-7306 ）

WDR26 is a new partner of Axin1 in the canonical Wnt signaling pathway.

Goto T, Matsuzawa J, Iemura S, Natsume T, Shibuya H.

FEBS Letter   590 ( 9 )   1291 - 1303   2016.5

Distinct types of protease systems are involved in homeostasis regulation of mitochondrial morphology via balanced fusion and fission.

Saita S, Ishihara T, Maeda M, Iemura S, Natsume T, Mihara K, Ishihara N.

Genes to Cells   21 ( 5 )   408 - 424   2016.3

Chaperone complex BAG2-HSC70 regulates localization of Caenorhabditis elegans leucine-rich repeat kinase LRK-1 to the Golgi.

Fukuzono T, Pastuhov SI, Fukushima O, Li C, Hattori A, Iemura S, Natsume T, Shibuya H, Hanafusa H, Matsumoto K, Hisamoto N.

Genes to Cells   21 ( 4 )   311 - 324   2016.2

TBL2 Associates With ATF4 mRNA Via Its WD40 Domain and Regulates Its Translation During ER Stress.

Tsukumo Y, Tsukahara S, Furuno A, Iemura S, Natsume T, Tomida A.

J. Cell. Biochem.   117 ( 2 )   500 - 509   2015.12

The subcellular localization and activity of cortactin is regulated by acetylation and interaction with Keap1.

Ito A, Shimazu T, Maeda S, Shah AA, Tsunoda T, Iemura S, Natsume T, Suzuki T, Motohashi H, Yamamoto M, Yoshida M.

Sci. Signal.   8   2015.11

CACUL1/CAC1 Regulates the Antioxidant Response by Stabilizing Nrf2.

Kigoshi Y, Fukuda T, Endo T, Hayasaka N, Iemura S, Natsume T, Tsuruta F, Chiba T.

Sci Rep.   5   2015.8

The endoplasmic reticulum-localized protein TBL2 interacts with the 60S ribosomal subunit.

Tsukumo Y, Tsukahara S, Furuno A, Iemura S, Natsume T, Tomida A.

Biochem. Biophys. Res. Commun.   462 ( 4 )   383 - 388   2015.6

Nedd4-induced monoubiquitination of IRS-2 enhances IGF signalling and mitogenic activity.

Nat Commun.   6   2015.4

TBL2 is a novel PERK-binding protein that modulates stress-signaling and cell survival during endoplasmic reticulum stress.

Tsukumo Y, Tsukahara S, Furuno A, Iemura S, Natsume T, Tomida A.

PLoS One.   9 ( 11 )   2014.11

ZFP36L1 and ZFP36L2 control LDLR mRNA stability via the ERK-RSK pathway.

Adachi S, Homoto M, Tanaka R, Hioki Y, Murakami H, Suga H, Matsumoto M, Nakayama KI, Hatta T, Iemura S, Natsume T.

Nucleic Acids Res.   42 ( 15 )   10037 - 10049   2014.8

Structure-activity relationship study, target identification, and pharmacological characterization of a small molecular IL-12/23 inhibitor, APY0201.

Hayakawa N, Noguchi M, Takeshita S, Eviryanti A, Seki Y, Nishio H, Yokoyama R, Noguchi M, Shuto M, Shima Y, Kuribayashi K, Kageyama S, Eda H, Suzuki M, Hatta T, Iemura S, Natsume T, Tanabe I, Nakagawa R, Shiozaki M, Sakurai K, Shoji M, Andou A, Yamamoto T.

Bioorg Med Chem.   22 ( 11 )   3021 - 3029   2014.6

IQGAP1 protein regulates nuclear localization of β-catenin via importin-β5 protein in Wnt signaling.

Goto T, Sato A, Adachi S, Iemura S, Natsume T, Shibuya H.

J Biol Chem.   288 ( 51 )   36351 - 36360   2013.12

Mesdc2 plays a key role in cell-surface expression of Lrp4 and postsynaptic specialization in myotubes.

Hoshi T, Tezuka T, Yokoyama K, Iemura S, Natsume T, Yamanashi Y.

FEBS Lett.   587 ( 23 )   3749 - 3754   2013.11

Dynamic regulation of ero1α and peroxiredoxin 4 localization in the secretory pathway.

Kakihana T, Araki K, Vavassori S, Iemura S, Cortini M, Fagioli C, Natsume T, Sitia R, Nagata K.

J Biol Chem.   288 ( 41 )   29586 - 29594   2013.10

Ero1-α and pdis constitute a hierarchical electron transfer network of endoplasmic reticulum oxidoreductases

Araki K., Iemura S., Kamiya Y., Ron D., Kato K., Natsume T., Nagata K.

Journal of Cell Biology   202 ( 6 )   861 - 874   2013.9（ ISSN:00219525 ）

Ero1-α and PDIs constitute a hierarchical electron transfer network of endoplasmic reticulum oxidoreductases.

Araki K, Iemura S, Kamiya Y, Ron D, Kato K, Natsume T, Nagata K.

J Cell Biol.   202 ( 6 )   861 - 874   2013.9

The casein kinase 2-nrf1 axis controls the clearance of ubiquitinated proteins by regulating proteasome gene expression.

Tsuchiya Y, Taniguchi H, Ito Y, Morita T, Karim MR, Ohtake N, Fukagai K, Ito T, Okamuro S, Iemura S, Natsume T, Nishida E, Kobayashi A.

Mol Cell Biol.   33 ( 17 )   3461 - 3472   2013.9

PLEIAD/SIMC1/C5orf25, a novel autolysis regulator for a skeletal-muscle-specific calpain, CAPN3, scaffolds a CAPN3 substrate, CTBP1.

Ono Y, Iemura S, Novak SM, Doi N, Kitamura F, Natsume T, Gregorio CC, Sorimachi H.

J Mol Biol.   425 ( 16 )   2955 - 2972   2013.8

PLEIAD/SIMC1/C5orf25, a novel autolysis regulator for a skeletal-muscle-specific calpain, CAPN3, scaffolds a CAPN3 substrate, CTBP1

Ono Y., Iemura S., Novak S., Doi N., Kitamura F., Natsume T., Gregorio C., Sorimachi H.

Journal of Molecular Biology   425 ( 16 )   2955 - 2972   2013.8（ ISSN:00222836 ）

IQGAP1 Functions as a Modulator of Dishevelled Nuclear Localization in Wnt Signaling.

Goto T, Sato A, Shimizu M, Adachi S, Satoh K, Iemura S, Natsume T, Shibuya H

PLoS One   8 ( 4 )   2013.4

VCP Is an integral component of a novel feedback mechanism that controls intracellular localization of catalase and H2O2 Levels.

Murakami K, Ichinohe Y, Koike M, Sasaoka N, Iemura S, Natsume T, Kakizuka A

PLoS One   8 ( 2 )   2013.2

RPA Assists HSF1 Access to Nucleosomal DNA by Recruiting Histone Chaperone FACT.

Fujimoto M, Takaki E, Takii R, Tan K, Prakasam R, Hayashida N, Iemura S, Natsume T, Nakai A.

Mol Cell.   48 ( 2 )   182 - 194   2012.10

The Kelch Repeat Protein KLHDC10 Regulates Oxidative Stress-Induced ASK1 Activation by Suppressing PP5.

Sekine Y, Hatanaka R, Watanabe T, Sono N, Iemura SI, Natsume T, Kuranaga E, Miura M, Takeda K, Ichijo H.

Mol Cell.   2012.10

Mitochondrial hexokinase HKI is a novel substrate of the Parkin ubiquitin ligase.

Okatsu K, Iemura SI, Koyano F, Go E, Kimura M, Natsume T, Tanaka K, Matsuda N.

Biochem Biophys Res Commun.   2012.10

Insulin/insulin-like growth factor (IGF) stimulation abrogates an association between a deubiquitinating enzyme USP7 and insulin receptor substrates (IRSs) followed by proteasomal degradation of IRSs.

Yoshihara H, Fukushima T, Hakuno F, Saeki Y, Tanaka K, Ito A, Yoshida M, Iemura S, Natsume T, Asano T, Chida K, Girnita L, Takahashi S.

Biochem Biophys Res Commun.   423 ( 1 )   122 - 127   2012.6

Comprehensive predictions of target proteins based on protein-chemical interaction using virtual screening and experimental verifications.

Kobayashi H, Harada H, Nakamura M, Futamura Y, Ito A, Yoshida M, Iemura SI, Shin-Ya K, Doi T, Takahashi T, Natsume T, Imoto M, Sakakibara Y.

BMC Chem. Biol.   12 ( 2 )   2012.4（ ISSN:1472-6769 ）

Identification and functional analysis of Zranb2 as a novel Smad-binding protein that suppresses BMP signaling.

Ohte S, Kokabu S, Iemura S, Sasanuma H, Yoneyama K, Shin M, Suzuki S, Fukuda T, Nakamura Y, Jimi E, Natsume T, Katagiri T.

J. Cell. Biochem.   113 ( 3 )   808 - 814   2012.3

Dual regulation of the transcriptional activity of Nrf1 by β-TrCP- and Hrd1-dependent degradation mechanisms.

Tsuchiya Y, Morita T, Kim M, Iemura S, Natsume T, Yamamoto M, Kobayashi A.

Mol. Cell. Biol.   31 ( 22 )   4500 - 4512   2011.11

Intracellular phosphatidylserine is essential for retrograde membrane traffic through endosomes.

Uchida Y, Hasegawa J, Chinnapen D, Inoue T, Okazaki S, Kato R, Wakatsuki S, Misaki R, Koike M, Uchiyama Y, Iemura S, Natsume T, Kuwahara R, Nakagawa T, Nishikawa K, Mukai K, Miyoshi E, Taniguchi N, Sheff D, Lencer WI, Taguchi T, Arai H.

Proc. Natl. Acad. Sci. U S A.   108 ( 38 )   15846 - 15851   2011.9

Control of AIF-mediated cell death by antagonistic functions of CHIP ubiquitin E3 ligase and USP2 deubiquitinating enzyme.

Oh KH, Yang SW, Park JM, Seol JH, Iemura S, Natsume T, Murata S, Tanaka K, Jeon YJ, Chung CH.

Cell Death Differ.   18 ( 8 )   1326 - 1336   2011.8

Histone chaperone Spt6 is required for class switch recombination but not somatic hypermutation.

Okazaki IM, Okawa K, Kobayashi M, Yoshikawa K, Kawamoto S, Nagaoka H, Shinkura R, Kitawaki Y, Taniguchi H, Natsume T, Iemura S, Honjo T.

Proc. Natl. Acad. Sci U S A.   108 ( 19 )   7920 - 7925   2011.5

Suppression of p53 activity through the cooperative action of Ski and histone deacetylase SIRT1.

Inoue Y, Iemura S, Natsume T, Miyazawa K, Imamura T.

J. Biol. Chem.   286 ( 8 )   6311 - 6320   2011.2

Leucine-rich repeat kinase LRRK1 regulates endosomal trafficking of the EGF receptor.

Hanafusa H, Ishikawa K, Kedashiro S, Saigo T, Iemura S, Natsume T, Komada M, Shibuya H, Nara A, Matsumoto K.

Nat. Commun.   2 ( 158 )   2011.1

A novel human dynactin-associated protein, dynAP, promotes activation of Akt, and ergosterol-related compounds induce dynAP-dependent apoptosis of human cancer cells.

Kunoh T, Noda T, Koseki K, Sekigawa M, Takagi M, Shin-ya K, Goshima N, Iemura S, Natsume T, Wada S, Mukai Y, Ohta S, Sasaki R, Mizukami T.

Mol. Cancer Ther.   9 ( 11 )   2934 - 1942   2010.11

Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1.

Nakada S, Tai I, Panier S, Al-Hakim A, Iemura S, Juang YC, O'Donnell L, Kumakubo A, Munro M, Sicheri F, Gingras AC, Natsume T, Suda T, Durocher D.

Nature   466 ( 7309 )   941 - 946   2010.8

Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly.

Kaizuka T, Hara T, Oshiro N, Kikkawa U, Yonezawa K, Takehana K, Iemura S, Natsume T, Mizushima N.

J. Biol. Chem.   285 ( 26 )   20109 - 20116   2010.6

The PX-RICS-14-3-3zeta/theta complex couples N-cadherin-beta-catenin with dynein-dynactin to mediate its export from the endoplasmic reticulum.

Nakamura T, Hayashi T, Mimori-Kiyosue Y, Sakaue F, Matsuura K, Iemura S, Natsume T, Akiyama T.

J. Biol. Chem.   285 ( 21 )   16145 - 16154   2010.5

Novel thioredoxin-related transmembrane protein TMX4 has reductase activity.

Sugiura Y, Araki K, Iemura S, Natsume T, Hoseki J, Nagata K.

J. Biol. Chem.   285 ( 10 )   7135 - 7142   2010.3

The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1.

Komatsu M, Kurokawa H, Waguri S, Taguchi K, Kobayashi A, Ichimura Y, Sou YS, Ueno I, Sakamoto A, Tong KI, Kim M, Nishito Y, Iemura S, Natsume T, Ueno T, Kominami E, Motohashi H, Tanaka K, Yamamoto M.

Nat. Cell Biol.   12 ( 3 )   213 - 223   2010.3

A novel type of E3 ligase for the Ufm1 conjugation system.

Tatsumi K, Sou YS, Tada N, Nakamura E, Iemura S, Natsume T, Kang SH, Chung CH, Kasahara M, Kominami E, Yamamoto M, Tanaka K, Komatsu M.

J. Biol. Chem.   285 ( 8 )   5417 - 5427   2010.2

Mys protein regulates protein kinase A activity by interacting with regulatory type Ialpha subunit during vertebrate development.

Kotani T, Iemura S, Natsume T, Kawakami K, Yamashita M.

J. Biol. Chem.   285 ( 7 )   5106 - 5116   2010.2

Nemo-like kinase, an essential effector of anterior formation, functions downstream of p38 mitogen-activated protein kinase.

Ohnishi E, Goto T, Sato A, Kim MS, Iemura S, Ishitani T, Natsume T, Ohnishi J, Shibuya H.

Mol. Cell. Biol.   30 ( 3 )   675 - 683   2010.2

SIRT1 Regulates Thyroid-Stimulating Hormone Release by Enhancing PIP5Kgamma Activity through Deacetylation of Specific Lysine Residues in Mammals.

Akieda-Asai S, Zaima N, Ikegami K, Kahyo T, Yao I, Hatanaka T, Iemura S, Sugiyama R, Yokozeki T, Eishi Y, Koike M, Ikeda K, Chiba T, Yamaza H, Shimokawa I, Song SY, Matsuno A, Mizutani A, Sawabe M, Chao MV, Tanaka M, Kanaho Y, Natsume T, Sugimura H, Date Y, McBurney MW, Guarente L, Setou M.

PLoS One   5 ( 7 )   2010

The transmembrane nucleoporin NDC1 is required for targeting of ALADIN to nuclear pore complexes.

Yamazumi Y, Kamiya A, Nishida A, Nishihara A, Iemura S, Natsume T, Akiyama T.

Biochem. Biophys. Res. Commun.   389 ( 1 )   100 - 104   2009.11

Atg101, a novel mammalian autophagy protein interacting with Atg13.

Hosokawa N, Sasaki T, Iemura S, Natsume T, Hara T, Mizushima N.

Autophagy   5 ( 7 )   973 - 979   2009.10

Gasp, a Grb2-associating protein, is critical for positive selection of thymocytes.

Patrick MS, Oda H, Hayakawa K, Sato Y, Eshima K, Kirikae T, Iemura S, Shirai M, Abe T, Natsume T, Sasazuki T, Suzuki H.

Proc. Natl. Acad. Sci. U S A.   106 ( 38 )   16345 - 16350   2009.9

Novel in vitro protein fragment complementation assay applicable to high-throughput screening in a 1536-well format.

Hashimoto J, Watanabe T, Seki T, Karasawa S, Izumikawa M, Seki T, Iemura S, Natsume T, Nomura N, Goshima N, Miyawaki A, Takagi M, Shin-Ya K.

J. Biomol. Screen.   14 ( 8 )   970 - 979   2009.9

Mitochondrial phosphoglycerate mutase 5 uses alternate catalytic activity as a protein serine/threonine phosphatase to activate ASK1.

Takeda K, Komuro Y, Hayakawa T, Oguchi H, Ishida Y, Murakami S, Noguchi T, Kinoshita H, Sekine Y, Iemura S, Natsume T, Ichijo H.

Proc. Natl. Acad. Sci. U S A.   106 ( 30 )   12301 - 12305   2009.7

Assembly pathway of the Mammalian proteasome base subcomplex is mediated by multiple specific chaperones.

Kaneko T, Hamazaki J, Iemura S, Sasaki K, Furuyama K, Natsume T, Tanaka K, Murata S.

Cell   137 ( 5 )   914 - 925   2009.5

Promotion of neurite extension by protrudin requires its interaction with vesicle-associated membrane protein-associated protein.

Saita S, Shirane M, Natume T, Iemura S, Nakayama KI.

J. Biol. Chem.   284 ( 20 )   13766 - 13777   2009.5

Inositol 1,4,5-triphosphate receptor-binding protein released with inositol 1,4,5-triphosphate (IRBIT) associates with components of the mRNA 3' processing machinery in a phosphorylation-dependent manner and inhibits polyadenylation.

Kiefer H, Mizutani A, Iemura S, Natsume T, Ando H, Kuroda Y, Mikoshiba K.

J. Biol. Chem.   284 ( 16 )   10694 - 10705   2009.4

Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy.

Hosokawa N, Hara T, Kaizuka T, Kishi C, Takamura A, Miura Y, Iemura S, Natsume T, Takehana K, Yamada N, Guan JL, Oshiro N, Mizushima N.

Mol. Biol. Cell   20 ( 7 )   1981 - 1991   2009.4

Asef2 and Neurabin2 cooperatively regulate actin cytoskeletal organization and are involved in HGF-induced cell migration.

Sagara M, Kawasaki Y, Iemura SI, Natsume T, Takai Y, Akiyama T.

Oncogene   28 ( 10 )   1357 - 1365   2009.3

Ankyrin repeat domain 28 (ANKRD28), a novel binding partner of DOCK180, promotes cell migration by regulating focal adhesion formation.

Tachibana M, Kiyokawa E, Hara S, Iemura S, Natsume T, Manabe T, Matsuda M.

Exp. Cell Res.   315 ( 5 )   863 - 876   2009.3

CHD8 suppresses p53-mediated apoptosis through histone H1 recruitment during early embryogenesis.

Nishiyama M, Oshikawa K, Tsukada Y, Nakagawa T, Iemura S, Natsume T, Fan Y, Kikuchi A, Skoultchi AI, Nakayama KI.

Nat. Cell Biol.   11 ( 2 )   172 - 182   2009.2

CAATT/enhancer-binding proteins alpha and delta interact with NKX2-1 to synergistically activate mouse secretoglobin 3A2 gene expression.

Tomita T, Kido T, Kurotani R, Iemura S, Sterneck E, Natsume T, Vinson C, Kimura S.

J. Biol. Chem.   283 ( 37 )   25617 - 25627   2008.9

The DHR1 domain of DOCK180 binds to SNX5 and regulates cation-independent mannose 6-phosphate receptor transport.

Hara S, Kiyokawa E, Iemura S, Natsume T, Wassmer T, Cullen PJ, Hiai H, Matsuda M.

Mol. Biol. Cell   19 ( 9 )   3823 - 3835   2008.9

A parallel affinity purification method for selective isolation of polyubiquitinated proteins.

Ota K, Kito K, Iemura S, Natsume T, Ito T.

Proteomics   8 ( 15 )   3004 - 3007   2008.8

FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells.

Hara T, Takamura A, Kishi C, Iemura S, Natsume T, Guan JL, Mizushima N.

J. Cell Biol.   181 ( 3 )   497 - 510   2008.5

タンパク質のネットワーク解析から創薬へ（超高感度質量分析システムをどのように実現したか）

家村俊一郎, 夏目　徹

Synthesiology   1 ( 2 )   123 - 129   2008.4（ ISSN:1882-6229 ）

Mutations causing DOK7 congenital myasthenia ablate functional motifs in Dok-7.

Hamuro J, Higuchi O, Okada K, Ueno M, Iemura S, Natsume T, Spearman H, Beeson D, Yamanashi Y.

J. Biol. Chem.   283 ( 9 )   5518 - 5524   2008.2

Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice.

Komatsu M, Waguri S, Koike M, Sou YS, Ueno T, Hara T, Mizushima N, Iwata J, Ezaki J, Murata S, Hamazaki J, Nishito Y, Iemura S, Natsume T, Yanagawa T, Uwayama J, Warabi E, Yoshida H, Ishii T, Kobayashi A, Yamamoto M, Yue Z, Uchiyama Y, Kominami E, Tanaka K.

Cell   131 ( 6 )   1149 - 1163   2007.12

Nucleocytoplasmic shuttling of the zinc finger protein EZI Is mediated by importin-7-dependent nuclear import and CRM1-independent export mechanisms.

Saijou E, Itoh T, Kim KW, Iemura S, Natsume T, Miyajima A.

J. Biol. Chem.   282 ( 44 )   32327 - 32337   2007.11

Nemo-like kinase-myocyte enhancer factor 2A signaling regulates anterior formation in Xenopus development.

Satoh K, Ohnishi J, Sato A, Takeyama M, Iemura S, Natsume T, Shibuya H.

Mol. Cell. Biol.   27 ( 21 )   7623 - 7630   2007.11

XRab40 and XCullin5 form a ubiquitin ligase complex essential for the noncanonical Wnt pathway.

Lee RH, Iioka H, Ohashi M, Iemura S, Natsume T, Kinoshita N.

EMBO J.   26 ( 15 )   3592 - 3606   2007.8

Wnt signalling regulates paxillin ubiquitination essential for mesodermal cell motility.

Iioka H, Iemura S, Natsume T, Kinoshita N.

Nat. Cell. Biol.   9 ( 7 )   813 - 821   2007.7

質量分析のためのサンプル調製（タンパク質ネットワーク大規模解析）

家村俊一郎, 夏目　徹

J. Mass Spectrom. Soc. Jpn.   55 ( 3 )   165 - 171   2007.6（ ISSN:13408097 ）

Anchoring of the 26S proteasome to the organellar membrane by FKBP38.

Nakagawa T, Shirane M, Iemura S, Natsume T, Nakayama KI.

Genes Cells   12 ( 6 )   709 - 719   2007.6

エピトープタグ発現法（質量分析のためのサンプル調製法）

家村俊一郎

“分子間相互作用解析ハンドブック”実験医学別冊   53 - 57   2007

Protein phosphatase 6 down-regulates TAK1 kinase activation in the IL-1 signaling pathway.

Kajino T, Ren H, Iemura S, Natsume T, Stefansson B, Brautigan DL, Matsumoto K, Ninomiya-Tsuji J.

J. Biol. Chem.   281 ( 52 )   39891 - 39896   2006.12

Cooperation of multiple chaperones required for the assembly of mammalian 20S proteasomes.

Hirano Y, Hayashi H, Iemura S, Hendil KB, Niwa S, Kishimoto T, Kasahara M, Natsume T, Tanaka K, Murata S.

Mol. Cell   24 ( 6 )   977 - 984   2006.12

A novel proteasome interacting protein recruits the deubiquitinating enzyme UCH37 to 26S proteasomes.

Hamazaki J, Iemura S, Natsume T, Yashiroda H, Tanaka K, Murata S.

EMBO J.   25 ( 19 )   4524 - 4536   2006.10

NARF, an nemo-like kinase (NLK)-associated ring finger protein regulates the ubiquitylation and degradation of T cell factor/lymphoid enhancer factor (TCF/LEF).

Yamada M, Ohnishi J, Ohkawara B, Iemura S, Satoh K, Hyodo-Miura J, Kawachi K, Natsume T, Shibuya H.

J. Biol. Chem.   281 ( 30 )   20749 - 20760   2006.7

XGAP, an ArfGAP, is required for polarized localization of PAR proteins and cell polarity in Xenopus gastrulation.

Hyodo-Miura J, Yamamoto TS, Hyodo AC, Iemura S, Kusakabe M, Nishida E, Natsume T, Ueno N.

Dev. Cell.   11 ( 1 )   69 - 79   2006.7

Shugoshin collaborates with protein phosphatase 2A to protect cohesin.

Kitajima TS, Sakuno T, Ishiguro K, Iemura S, Natsume T, Kawashima SA, Watanabe Y.

Nature   441 ( 7089 )   46 - 52   2006.5

Cdc37 interacts with the glycine-rich loop of Hsp90 client kinases.

Terasawa K, Yoshimatsu K, Iemura S, Natsume T, Tanaka K, Minami Y.

Mol. Cell. Biol.   26 ( 9 )   3378 - 3389   2006.5

A novel ubiquitin-binding protein ZNF216 functioning in muscle atrophy.

Hishiya A, Iemura S, Natsume T, Takayama S, Ikeda K, Watanabe K.

EMBO J.   25 ( 3 )   554 - 564   2006.2

Dok-3 sequesters Grb2 and inhibits the Ras-Erk pathway downstream of protein-tyrosine kinases.

Honma M, Higuchi O, Shirakata M, Yasuda T, Shibuya H, Iemura S, Natsume T, Yamanashi Y.

Genes Cells   11 ( 2 )   143 - 151   2006.2

WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1.

Moriguchi T, Urushiyama S, Hisamoto N, Iemura S, Uchida S, Natsume T, Matsumoto K, Shibuya H.

J. Biol. Chem.   280 ( 52 )   42685 - 42693   2005.12

A heterodimeric complex that promotes the assembly of mammalian 20S proteasomes.

Hirano Y, Hendil KB, Yashiroda H, Iemura S, Nagane R, Hioki Y, Natsume T, Tanaka K, Murata S.

Nature   437 ( 7063 )   1381 - 1385   2005.10

DDB2, the xeroderma pigmentosum group E gene product, is directly ubiquitylated by Cullin 4A-based ubiquitin ligase complex.

Matsuda N, Azuma K, Saijo M, Iemura S, Hioki Y, Natsume T, Chiba T, Tanaka K, Tanaka K.

DNA Repair (Amst)   4 ( 5 )   537 - 545   2005.5

STAT3 regulates Nemo-like kinase by mediating its interaction with IL-6-stimulated TGFbeta-activated kinase 1 for STAT3 Ser-727 phosphorylation.

Kojima H, Sasaki T, Ishitani T, Iemura S, Zhao H, Kaneko S, Kunimoto H, Natsume T, Matsumoto K, Nakajima K.

Proc. Natl. Acad. Sci. U S A.   102 ( 12 )   4524 - 4529   2005.3

An RNA-interacting protein, SYNCRIP (heterogeneous nuclear ribonuclear protein Q1/NSAP1) is a component of mRNA granule transported with inositol 1,4,5-trisphosphate receptor type 1 mRNA in neuronal dendrites.

Bannai H, Fukatsu K, Mizutani A, Natsume T, Iemura S, Ikegami T, Inoue T, Mikoshiba K.

J. Biol. Chem.   279 ( 51 )   53427-53434.   2004.12

Physical and functional interaction between Dorfin and Valosin-containing protein that are colocalized in ubiquitylated inclusions in neurodegenerative disorders.

Ishigaki S, Hishikawa N, Niwa J, Iemura S, Natsume T, Hori S, Kakizuka A, Tanaka K, Sobue G.

J. Biol. Chem.   279 ( 49 )   51376 - 51385   2004.12

Skp2-mediated degradation of p27 regulates progression into mitosis.

Nakayama K, Nagahama H, Minamishima YA, Miyake S, Ishida N, Hatakeyama S, Kitagawa M, Iemura S, Natsume T, Nakayama KI.

Dev. Cell.   6 ( 5 )   661 - 672   2004.5

A novel protein-conjugating system for Ufm1, a ubiquitin-fold modifier.

Komatsu M, Chiba T, Tatsumi K, Iemura S, Tanida I, Okazaki N, Ueno T, Kominami E, Natsume T, Tanaka K.

EMBO J.   23 ( 9 )   1977 - 1986   2004.5

質量分析のためのタンパク質複合体プルダウン解析法

家村俊一郎, 夏目　徹

“注目のプロテオミクスの全貌を知る！”実験医学別冊   46 - 53   2003

Sonic hedgehog is involved in osteoblast differentiation by cooperating with BMP-2.

Yuasa T, Kataoka H, Kinto N, Iwamoto M, Enomoto-Iwamoto M, Iemura S, Ueno N, Shibata Y, Kurosawa H, Yamaguchi A.

J. Cell. Physiol.   193 ( 2 )   225 - 232   2002.11

Action range of BMP is defined by its N-terminal basic amino acid core.

Ohkawara B, Iemura S, ten Dijke P, Ueno N.

Curr. Biol.   12 ( 3 )   205 - 209   2002.2

Follistatin inhibits the function of the oocyte-derived factor BMP-15.

Otsuka F, Moore RK, Iemura S, Ueno N, Shimasaki S.

Biochem. Biophys. Res. Commun.   289 ( 5 )   961 - 966   2001.12

Bone morphogenetic protein 2 stimulates osteoclast differentiation and survival supported by receptor activator of nuclear factor-kappaB ligand.

Itoh K, Udagawa N, Katagiri T, Iemura S, Ueno N, Yasuda H, Higashio K, Quinn JM, Gillespie MT, Martin TJ, Suda T, Takahashi N.

Endocrinology   142 ( 8 )   3656 - 3662   2001.8

Ventroptin: a BMP-4 antagonist expressed in a double-gradient pattern in the retina.

Sakuta H, Suzuki R, Takahashi H, Kato A, Shintani T, Iemura Si, Yamamoto TS, Ueno N, Noda M.

Science   293 ( 5527 )   111 - 115   2001.7

Dorsal spinal cord inhibits oligodendrocyte development.

Wada T, Kagawa T, Ivanova A, Zalc B, Shirasaki R, Murakami F, Iemura S, Ueno N, Ikenaka K.

Dev. Biol.   227 ( 1 )   42 - 55   2000.11

Characterization of follistatin isoforms in early Xenopus embryogenesis.

Yamamoto TS, Iemura S, Takagi C, Shimasaki S, Ueno N.

Int. J. Dev. Biol.   44 ( 4 )   341 - 348   2000.6

初期発生におけるBMP活性とその制御メカニズム

家村俊一郎, 澁谷浩司

“サイトカインの新たな機能と生命現象”実験医学増刊号   18   81 - 87   2000

BMP結合タンパク質による負の制御機構

家村俊一郎, 上野直人

Molecular Medicine   37   662 - 669   2000

Isolation and characterization of bone morphogenetic protein-binding proteins from the early Xenopus embryo.

Iemura S, Yamamoto TS, Takagi C, Kobayashi H, Ueno N.

J. Biol. Chem.   274 ( 38 )   26843 - 26849   1999.9

A functional bone morphogenetic protein system in the ovary.

Shimasaki S, Zachow RJ, Li D, Kim H, Iemura S, Ueno N, Sampath K, Chang RJ, Erickson GF.

Proc. Natl. Acad. Sci. U S A.   96 ( 13 )   7282 - 7287   1999.6

Direct binding of follistatin to a complex of bone-morphogenetic protein and its receptor inhibits ventral and epidermal cell fates in early Xenopus embryo.

Iemura S, Yamamoto TS, Takagi C, Uchiyama H, Natsume T, Shimasaki S, Sugino H, Ueno N.

Proc. Natl. Acad. Sci. U S A.   95 ( 16 )   9337 - 9342   1998.8

Interaction between soluble type I receptor for bone morphogenetic protein and bone morphogenetic protein-4.

Natsume T, Tomita S, Iemura S, Kinto N, Yamaguchi A, Ueno N.

J. Biol. Chem.   272 ( 17 )   11535 - 11540   1997.4（ ISSN:0021-9258 ）