Unprecedented Cyclization Catalyzed by a Cytochrome P450 in Benzastatin Biosynthesis.

Tsutsumi H, Katsuyama Y, Izumikawa M, Takagi M, Fujie M, Satoh N, Shin-Ya K, Ohnishi Y.

J Am Chem Soc.   140 ( 21 )   6631 - 6639   2018.5

A small-molecule compound inhibits a collagen-specific molecular chaperone and could represent a potential remedy for fibrosis.

Ito S, Ogawa K, Takeuchi K, Takagi M, Yoshida M, Hirokawa T, Hirayama S, Shin-ya K, Shimada I, Doi T, Goshima N, Natsume T, Nagata K.

The Journl of Biological Chemistry.   292 ( 49 )   20076 - 20085   2017.12

ヒトiPS細胞由来心筋細胞と遺伝子発現解析を用いた薬物の催不整脈能の評価系(Evaluation system for arrhythmogenic potential of drugs using human-induced pluripotent stem cell-derived cardiomyocytes and gene expression analysis)

Higa Arisa, Hoshi Hirotaka, Yanagisawa Yuka, Ito Emi, Morisawa Gaku, Imai Jun-ichi, Watanabe Shinya, Takagi Motoki

The Journal of Toxicological Sciences   42 ( 6 )   755 - 761   2017.12（ ISSN:0388-1350 ）

Construction of a novel cell-based assay for the evaluation of anti-EGFR drug efficacy against EGFR mutation.

Hoshi H, Hiyama G, Ishikawa K, Inageda K, Fujimoto J, Wakamatsu A, Togashi T, Kawamura Y, Takahashi N, Higa A, Goshima N, Semba K, Watanabe S, Takagi M

Oncology reports   37 ( 1 )   66 - 76   2017.1（ ISSN:1021-335X ）

Streptomyces sp. RI-77から単離した改変ナフトキノン類JBIR-76とJBIR-77(JBIR-76 and JBIR-77, modified naphthoquinones from Streptomyces sp. RI-77)

Motohashi Keiichiro, Izumikawa Miho, Kagaya Noritaka, Takagi Motoki, Shin-ya Kazuo

The Journal of Antibiotics   69 ( 9 )   707 - 708   2016.9（ ISSN:0021-8820 ）

インピーダンス測定を用いて決定したヒト幹細胞由来心筋細胞の催不整脈薬に対する種々の応答(Differing responses of human stem cell-derived cardiomyocytes to arrhythmogenic drugs, determined using impedance measurements)

Higa Arisa, Hoshi Hirotaka, Takagi Motoki

Fundamental Toxicological Sciences   3 ( 2 )   47 - 53   2016.3

Involvement of the Baeyer-Villiger Monooxygenase IfnQ in the Biosynthesis of Isofuranonaphthoquinone Scaffold of JBIR-76 and -77.

Katsuyama Y, Sone K, Satou R, Izumikawa M, Takagi M, Fujie M, Satoh N, Shin-Ya K, Ohnishi Y.

Chembiochem   2016

Synthesis of marine oxylipin topsentolide A<inf>1</inf>and its stereoisomers, and determination of the absolute configuration of the natural product

Ishigami K., Kobayashi M., Takagi M., Shin-Ya K., Watanabe H.

Tetrahedron   71 ( 44 )   8436 - 8443   2015.11（ ISSN:00404020 ）

新規チオビリダミド誘導体JBIR-140　チオビリダミド生合成のための遺伝子クラスターの異種発現(Novel thioviridamide derivative: JBIR-140: heterologous expression of the gene cluster for thioviridamide biosynthesis)

Izumikawa Miho, Kozone Ikuko, Hashimoto Junko, Kagaya Noritaka, Takagi Motoki, Koiwai Hanae, Komatsu Mamoru, Fujie Manabu, Satoh Noriyuki, Ikeda Haruo, Shin-ya Kazuo

The Journal of Antibiotics   68 ( 8 )   533 - 536   2015.8（ ISSN:0021-8820 ）

Total synthesis and structure elucidation of JBIR-39: A linear hexapeptide possessing piperazic acid and γ-hydroxypiperazic acid residues

Yoshida M., Sekioka N., Izumikawa M., Kozone I., Takagi M., Shin-ya K., Doi T.

Chemistry - A European Journal   21 ( 7 )   3031 - 3041   2015.2（ ISSN:09476539 ）

Identification and Characterization of the Streptazone E Biosynthetic Gene Cluster in Streptomyces sp. MSC090213JE08.

Ohno S, Katsuyama Y, Tajima Y, Izumikawa M, Takagi M, Fujie M, Satoh N, Shin-ya K, Ohnishi Y.

Chembiochem   16   2385 - 2391   2015

Total synthesis and structure elucidation of JBIR-39: a linear hexapeptide possessing piperazic acid and γ-hydroxypiperazic acid residues.

Yoshida M, Sekioka N, Izumikawa M, Kozone I, Takagi M, Shin-ya K, Doi T.

Chemistry   21   3031 - 3041   2015

Biosynthesis of the 4-methyloxazoline-containing nonribosomal peptides, JBIR-34 and -35, in Streptomyces sp. Sp080513GE-23.

Muliandi A, Katsuyama Y, Sone K, Izumikawa M, Moriya T, Hashimoto J, Kozone I, Takagi M, Shin-ya K, Ohnishi Y

Chem Biol.   21   923 - 934   2015

Total synthesis and structure determination of JBIR-108-a 2-Hydroxy-2-(1-hydroxyethyl)-2,3-dihydro-3(2H)-furanone isolated from Streptomyces gramineus IR087Pi-4.

Fujiwara K, Tsukamoto H, Izumikawa M, Hosoya T, Kagaya N, Takagi M, Yamamura H, Hayakawa M, Shin-ya K, Doi T

J Org Chem.   80   114 - 132   2015

Pyrrolidine-containing peptides, JBIR-126, -148, and -149, from Streptomyces sp. NBRC 111228.

Izumikawa M, Kawahara T, Kagaya N, Yamamura H, Hayakawa M, Takagi M, Yoshida M, Doi T, Shin-ya K.

Tetrahedron Lett.   56   5333 - 5336   2015

海洋由来の放線菌が産生する二次代謝産物の新規薬剤探索ライブラリーの構築

高木　基樹、新家　一男

バイオサイエンスとインダストリー   72 ( 2 )   208 - 212   2014.5

Actinoplanes missouriensisからの新規プレニル化インドール誘導体3-hydroxy-6-dimethylallylindolin-2-oneの単離、構造決定および生合成(Isolation, structural elucidation and biosynthesis of 3-hydroxy-6-dimethylallylindolin-2-one, a novel prenylated indole derivative from Actinoplanes missouriensis)

Satou Ryutaro, Izumikawa Miho, Katsuyama Yohei, Matsui Misato, Takagi Motoki, Shin-ya Kazuo, Ohnishi Yasuo

The Journal of Antibiotics   67 ( 3 )   231 - 236   2014.3（ ISSN:0021-8820 ）

Total synthesis and characterization of thielocin B1 as a protein–protein interaction inhibitor of PAC3 homodimer.

Doi T, Yoshida M, Ohsawa K, Shin-ya K, Takagi M, Uekusa Y, Yamaguchi T, Kato K, Hirokawa T, Natsume T.

Chem Sci.   5   1860 - 1868   2014

Isolation, structural elucidation and biosynthesis of 3-hydroxy-6-dimethylallylindolin-2-one, a novel prenylated indole derivative from Actinoplanes missouriensis.

Satou R, Izumikawa M, Katsuyama Y, Matsui M, Takagi M, Shin-ya K, Ohnishi Y.

J Antibiot.   67   231 - 236   2014

Synthesis of heptaoxazole macrocyclic analogues of telomestatin and evaluation of their telomerase inhibitory activities

Shibata K., Yoshida M., Takahashi T., Takagi M., Shin-Ya K., Doi T.

Bulletin of the Chemical Society of Japan   86 ( 12 )   1453 - 1465   2013.12（ ISSN:00092673 ）

Spectomycin B1 as a novel sumoylation inhibitor that directly binds to SUMO E2

Hirohama M., Kumar A., Fukuda I., Matsuoka S., Igarashi Y., Saitoh H., Takagi M., Shin-Ya K., Honda K., Kondoh Y., Saito T., Nakao Y., Osada H., Zhang K., Yoshida M., Ito A.

ACS Chemical Biology   8 ( 12 )   2635 - 2642   2013.12（ ISSN:15548929 ）

Isaria種NBRC 104353由来の新規ピリドンアルカロイドJBIR-130、JBIR-131、JBIR-132(New pyridone alkaloids JBIR-130, JBIR-131 and JBIR-132 from Isaria sp. NBRC 104353)

Hosoya Takahiro, Takagi Motoki, Shin-ya Kazuo

The Journal of Antibiotics   66 ( 4 )   235 - 238   2013.4（ ISSN:0021-8820 ）

Total Synthesis of Destruxin E and its Derivatives

YOSHIDA Masahito, ISHIDA Yoshitaka, TAKEUCHI Hisayuki, NAKAGAWA Hiroshi, YASHIRODA Yoko, YOSHIDA Minoru, TAKAGI Motoki, SHIN-YA Kazuo, DOI Takayuki

Peptide science : proceedings of the ... Japanese Peptide Symposium   2012   95 - 96   2013.3（ ISSN:13447661 ）

Synthesis of hepta-oxazole macrocyclic analogues of telomestatin and evaluation of their telomerase inhibitory activities.

Shibata K, Yoshida M, Takahashi T, Takagi M, Shin-ya K, Doi T.

Bull. Chem. Soc. Jpn   86   1453 - 1465   2013

Design and synthesis of 2-phenyl-1,4-dioxa-spiro[4.5]deca-6,9-dien-8-ones as potential anticancer agents starting from cytotoxic spiromamakone A.

Fuse S, Inaba K, Takagi M, Tanaka M, Hirokawa T, Johmoto K, Uekusa H, Shin-ya K, Takahashi T, Doi T.

Eur J Med Chem.   66   180 - 184   2013

Spectomycin B1 as a Novel SUMOylation Inhibitor That Directly Binds to SUMO E2.

Hirohama M, Kumar A, Fukuda I, Matsuoka S, Igarashi Y, Saitoh H, Takagi M, Shin-ya K, Honda K, Kondoh Y, Saito T, Nakao Y, Osada H, Zhang KY, Yoshida M, Ito A.

ACS Chem Biol.   8   2635 - 2642   2013

JBIR-107, a new metabolite from the marine-sponge-derived actinomycete, Streptomyces tateyamensis NBRC 105047.

Izumikawa M, Kawahara T, Hwang JH, Takagi M, Shin-ya K.

Biosci Biotechnol Biochem.   77   663 - 665   2013

Engineered Streptomyces avermitilis Host for Heterologous Expression of Biosynthetic Gene Cluster for Secondary Metabolites.

Komatsu M, Komatsu K, Koiwai H, Yamada Y, Kozone I, Izumikawa M, Hashimoto J, Takagi M, Omura S, Shin-ya K, Cane DE, Ikeda H.

ACS Synth Biol.   2   384 - 396   2013

A stand-alone adenylation domain forms amide bonds in streptothricin biosynthesis.

Maruyama C, Toyoda J, Kato Y, Izumikawa M, Takagi M, Shin-ya K, Katano H, Utagawa T, Hamano Y.

Nat Chem Biol   8 ( 9 )   791 - 797   2012.9

Construction of a natural product library containing secondary metabolites produced by actinomycetes.

Takagi M, Shin-ya K.

J Antibiot.   65   443 - 447   2012

JBIR-78 and JBIR-95: Phenylacetylated peptides isolated from Kibdelosporangium sp. AK-AA56.

Izumikawa M, Takagi M and Shin-ya K

J Nat Prod   75   280 - 284   2012

Trichostatin Analogues JBIR-109, JBIR-110, and JBIR-111 from the marine sponge-derived Streptomyces sp. RM72.

Hosoya T, Hirokawa T, Takagi M and Shin-ya K

J Nat Prod   75   285 - 289   2012

Analysis of the biological activity of a novel 24-membered macrolide JBIR-19 in Saccharomyces cerevisiae by the morphological imaging program CalMorph.

Ohnuki S, Kobayashi T, Ogawa H, Kozone I, Ueda JY, Takagi M, Shin-Ya K, Hirata D, Nogami S and Ohya Y

FEMS Yeast Res   12   293 - 304   2012

Actinobacteria Associated with the Marine Sponges Cinachyra sp., Petrosia sp., and Ulosa sp. and Their Culturability.

Khan ST, Takagi M and Shin-ya K

Microbes Environ   27   99 - 104   2012

Three new depsipeptides, JBIR-113, JBIR-114 and JBIR-115, isolated from a marine sponge-derived Penicillium sp. fS36.

Kawahara T, Takagi M and Shin-ya K

J Antibiot   65   147 - 150   2012

Inhibition of histone H3K9 methyltransferases by gliotoxin and related epipolythiodioxopiperazines.

Takahashi M, Takemoto Y, Shimazu T, Kawasaki H, Tachibana M, Shinkai Y, Takagi M, Shin-ya K, Igarashi Y, Ito A and Yoshida M.

J Antibiot.   65   263 - 265   2012

JBIR-120: a new growth inhibitor of hormone-refractory prostate cancer cells.

Kawahara T, Hosoya T, Tsukamoto M, Okabe S, Yamamura H, Hayakawa M, Seimiya H, Takagi M* and Shin-ya K.

J Antibiot.   65   373 - 375   2012

JBIR-137 and JBIR-138, new secondary metabolites from Aspergillus sp. fA75.

Kawahara T, Nagai A, Takagi M, Shin-ya K.

J Antibiot.   65   535 - 538   2012

Relative configuration of JBIR-129, a cytotoxic 34-membered glycosidic polyol macrolide from Streptomyces sp. RK74.

Kawahara T, Izumikawa M, Takagi M, Shin-ya K.

Org Lett.   14   4434 - 4437   2012

A new furaquinocin derivative, JBIR-136, from Streptomyces sp. 4963H2.

Kawahara T, Nagai A, Takagi M, Shin-ya K.

J Antibiot.   65   579 - 581   2012

JBIR-129 and -139, Cytotoxic 34-membered polyol macrolides of microbial origin.

Kawahara T, Hwang JH, Izumikawa M, Hashimoto J, Takagi M, Shin-ya K.

J Nat Prod.   75   1814−1818   2012

JBIR-94 and JBIR-125, Antioxidative Phenolic Compounds from Streptomyces sp. R56-07.

Kawahara T, Izumikawa M, Otoguro M, Yamamura H, Hayakawa M, Takagi M and Shin-ya K

J Nat Prod   75   107 - 110   2012

Tyrosyl-DNA Phosphodiesterase 1 Inhibitor from an Anamorphic Fungus.

Takagi M, Ueda JY, Hwang JH, Hashimoto J, Izumikawa M, Murakami H, Sekido Y and Shin-ya K.

J Nat Prod   75   764 - 767   2012

JBIR-124: a novel antioxidative agent from a marine sponge-derived fungus Penicillium citrinum SpI080624G1f01.

Kawahara T, Takagi M and Shin-ya K

J Antibiot   65   45 - 47   2012

A new cyclizidine analog-JBIR-102-from Saccharopolyspora sp. RL78 isolated from mangrove soil.

Izumikawa M, Hosoya T, Takagi M and Shin-ya K

J Antibiot   65   41 - 43   2012

がんオルガノイド（F-PDO）を用いた抗がん剤やがん免疫療法の評価システム

ゲノム創薬・創発フォーラム第7回シンポジウム