The University of Tokyo   Assistant Professor

2012.4 - 2014.3

Japanese society of Medical Oncology

2008.4 - Now

The Japanese Society of Hematology

2008.4 - Now

The Japanese Society of Internal Medicine

2006.4 - Now

Prenatal vitamin D deficiency alters immune cell proportions of young adult offspring through alteration of long-term stem cell fates.

Ueda K, Chin SS, Sato N, Nishikawa M, Yasuda K, Miyasaka N, Bera BS, Chorro L, Doña-Termine R, Koba WR, Reynolds D, Steidl UG, Lauvau G, Greally JM, Suzuki M

bioRxiv : the preprint server for biology   2023.9

Impaired Repopulating Ability of Uhrf2−/− Hematopoietic Progenitor Cells in Mice

Takahiro Sano, Koki Ueda, Keiji Minakawa, Tsutomu Mori, Yuko Hashimoto, Haruhiko Koseki, Yasuchika Takeishi, Kazuhiko Ikeda, Takayuki Ikezoe

Genes   14 ( 8 )   1531   2023.7

Murine double minute X plays a central role in leukemic transformation and may be a promising target for leukemia prevention strategies

Koki Ueda

Experimental Hematology   122   10 - 18   2023.6（ ISSN:0301-472X ）

Gaining MOMENTUM against anaemic myelofibrosis.

Kazuhiko Ikeda, Koki Ueda

Lancet (London, England)   401 ( 10373 )   248 - 249   2023.1（ ISSN:0140-6736 ）

Evaluation of a quantitative PCR-based method for chimerism analysis of Japanese donor/recipient pairs.

Keiji Minakawa, Satoshi Ono, Mao Watanabe, Yuka Sato, Saki Suzuki, Shou Odawara, Kinuyo Kawabata, Koki Ueda, Kenneth E Nollet, Hideki Sano, Takayuki Ikezoe, Atsushi Kikuta, Kazuhiko Ikeda

Scientific reports   12 ( 1 )   21328 - 21328   2022.12

凍害防止剤CP-1の輸注による造血細胞輸注関連有害事象への影響とラットに及ぼす毒性の検討

皆川 敬治, 植田 航希, 山原 研一, 奥山 美樹, 藤原 慎一郎, 長村 登紀子, 大戸 斉, 田野崎 隆二, 池田 和彦, 日本輸血・細胞治療学会造血幹細胞輸注時有害事象ワーキンググループ

日本輸血細胞治療学会誌   68 ( 2 )   313 - 313   2022.4（ ISSN:1881-3011 ）

Comparison of cryoprotectants in hematopoietic cell infusion-related adverse events.

Kazuhiko Ikeda, Keiji Minakawa, Kenichi Yamahara, Minami Yamada-Fujiwara, Yoshiki Okuyama, Shin-Ichiro Fujiwara, Rie Yamazaki, Heiwa Kanamori, Tohru Iseki, Tokiko Nagamura-Inoue, Kazuaki Kameda, Kazuhiro Nagai, Nobuharu Fujii, Takashi Ashida, Asao Hirose, Tsutomu Takahashi, Hitoshi Ohto, Koki Ueda, Ryuji Tanosaki

Transfusion   62 ( 6 )   1280 - 1288   2022.1（ ISSN:00411132 ）

Clonal hematopoiesis with JAK2V617F promotes pulmonary hypertension with ALK1 upregulation in lung neutrophils

Yusuke Kimishima, Tomofumi Misaka, Tetsuro Yokokawa, Kento Wada, Koki Ueda, Koichi Sugimoto, Keiji Minakawa, Kazuhiko Nakazato, Takafumi Ishida, Motohiko Oshima, Shuhei Koide, Kotaro Shide, Kazuya Shimoda, Atsushi Iwama, Kazuhiko Ikeda, Yasuchika Takeishi

Nature Communications   12 ( 1 )   6177 - 6177   2021.12

Myeloproliferative neoplasm-driving Calr frameshift promotes the development of pulmonary hypertension in mice

Minakawa, K., Yokokawa, T., Ueda, K., Nakajima, O., Misaka, T., Kimishima, Y., Wada, K., Tomita, Y., Miura, S., Sato, Y., Mimura, K., Sugimoto, K., Nakazato, K., Nollet, K.E., Ogawa, K., Ikezoe, T., Hashimoto, Y., Takeishi, Y., Ikeda, K.

Journal of Hematology and Oncology   14 ( 1 )   52 - 52   2021.5（ ISSN:1756-8722 ）

Epigenetic Achilles’ heel of AML

Ueda, K., Steidl, U.

Nature Cancer   2 ( 5 )   481 - 483   2021.5（ ISSN:2662-1347 ）

Fueling clonal dominance through TRAFficking of NF-kB signaling

Koki Ueda, Rajni Kumari, Ulrich Steidl

Nature Immunology   489 - 500   2020.5

Calr変異ノックイン(KI)マウスにおけるMPN造血の解析(Analysis of myeloproliferative neoplasm hematopoiesis with knock-in mice with Calr mutants)

皆川 敬治, 植田 航希, 中島 修, 池添 隆之, 竹石 恭知, 池田 和彦

臨床血液   59 ( 9 )   1612 - 1612   2018.9（ ISSN:0485-1439 ）

Lenalidomide as a beneficial treatment option for renal impairment caused by light chain deposition disease

Kimura S., Ohkawara H., Ogawa K., Tanaka M., Sano T., Harada-Shirado K., Takahashi H., Ueda K., Shichishima-Nakamura A., Matsumoto H., Ikeda K., Kazama J.J., Hashimoto Y., Ikezoe T.

Internal Medicine   57 ( 24 )   3651 - 3657   2018.1（ ISSN:09182918 ）

Steroid-resistant autoimmune myelofibrosis in a patient with autoimmune hepatitis and Evans syndrome complicated with increased expression of TGF-β in the bone marrow: a case report

Ohkawara H., Furukawa M., Ikeda K., Shichishima-Nakamura A., Fukatsu M., Sano T., Ueda K., Kimura S., Kanai R., Oka Y., Murakami F., Suzuki O., Hashimoto Y., Ogawa K., Ikezoe T.

International Journal of Hematology   106 ( 5 )   718 - 724   2017.11（ ISSN:09255710 ）

The amelioration of myelofibrosis with thrombocytopenia by a JAK1/2 inhibitor, ruxolitinib, in a post-polycythemia vera myelofibrosis patient with a JAK2 Exon 12 mutation

Ikeda Kazuhiko, Ueda Koki, Sano Takahiro, Ogawa Kazuei, Ikezoe Takayuki, Hashimoto Yuko, Morishita Soji, Komatsu Norio, Ohto Hitoshi, Takeishi Yasuchika

Internal Medicine   56 ( 13 )   1705 - 1710   2017.7

Autocrine and paracrine interactions between multiple myeloma cells and bone marrow stromal cells by growth arrest-specific gene 6 cross-talk with interleukin-6

Furukawa M., Ohkawara H., Ogawa K., Ikeda K., Ueda K., Shichishima-Nakamura A., Ito E., Imai J.I., Yanagisawa Y., Honma R., Watanabe S., Waguri S., Ikezoe T., Takeishi Y.

Journal of Biological Chemistry   292 ( 10 )   4280 - 4292   2017.3（ ISSN:00219258 ）

【造血器腫瘍のゲノム/エピゲノム解析研究と免疫/分子標的療法の進歩】MDSのゲノム/エピゲノム解析研究と治療の進歩

植田 航希, 池添 隆之

血液内科   73 ( 5 )   571 - 579   2016.11（ ISSN:2185-582X ）

Favorable outcome of Epstein-Barr virus-associated B-cell lymphoproliferative disorder complicated by immunoglobulin G4-related disease treated with rituximab-based therapy: a case report

Koki Ueda, Kazuhiko Ikeda, Kazuei Ogawa, Masumi Sukegawa, Takahiro Sano, Satoshi Kimura, Osamu Suzuki, Yuko Hashimoto, Yasuchika Takeishi

Journal of Medical Case Reports   10 ( 1 )   236   2016.8

Acute pericarditis before engraftment in hematopoietic stem cell transplantation

Akihito Shinohara, Akira Honda, Arika Nukina, Kensuke Takaoka, Ayato Tsukamoto, Sho Hangai, Yasunori Kogure, Takashi Kobayashi, Sho Yamazaki, Koki Ueda, Fumihiko Nakamura, Yasuhito Nannya, Mineo Kurokawa

Bone Marrow Transplant   51 ( 3 )   459 - 461   2016.3

Infected pancreatic pseudocyst ruptured into stomach and colon associated with splenic artery pseudoaneurysm

OHKAWARA, Hiroshi*; SHICHISHIMA-NAKAMURA, Akiko*; IKEDA, Kazuhiko*; SUKEGAWA, Masumi*; FURUKAWA, Miki*; SANO, Takahiro*; UEDA, Koki*; KIMURA, Satoshi*; YOSHIHISA, Akiomi*; NOJI, Hideyoshi*; OGAWA, Kazuei*; TAKEISHI, Yasuchika*

Journal of the Pancreas   17 ( 3 )   324 - 327   2016

Modified ESHAP regimen for relapsed/refractory T cell lymphoma: a retrospective analysis

KOGURE, Yasunori; YOSHIMI, Akihide; UEDA, Koki*; NANNYA, Yasuhito; ICHIKAWA, Motoshi; NAKAMURA, Fumihiko; KUROKAWA, Mineo

Annals of Hematology   94 ( 6 )   989 - 994   2015

CD4+ T cells in aged or thymectomized recipients of allogenic stem cell transplantations

TAKAHASHI, Hiroshi*; IKEDA, Kazuhiko*; OGAWA, Kazuei*; SAITO, Syunnichi*; NGOMA, Alain*; MASHIMO, Yumiko*; UEDA, Koki*; FURUKAWA, Miki*; SHICHISHIMA-NAKAMURA, Akiko*; OHKAWARA, Hiroshi*; NOLLET, Kenneth*; OHTO, Hitoshi*; TAKEISHI, Yasuchika*

Biological Research   48   41   2015

Persistent complete remission of acute leukemic-phase CCR4-positive gamma-delta peripheral T-cell lymphoma by autologous stem cell transplantation with mogamulizumab

FURUKAWA, Miki*; IKEDA, Kazuhiko*; OHKAWARA, Hiroshi*; SAITO, Shunichi*; TAKAHASHI, Hiroshi*; UEDA, Koki*; MATSUMOTO, Hayato*; HASHIMOTO, Yuko*; OHTO, Hitoshi*; OGAWA, Kazuei*; TAKEISHI, Yasuchika*

International Journal of Hematology   102 ( 4 )   498 - 505   2015

Post-engraftment blood transfusion and outcomes of bone marrow transplantation

MASHIMO, Yumiko*; IKEDA, Kazuhiko*; OHKAWARA, Hiroshi*; TAKAHASHI, Hiroshi*; SHICHISHIMA-NAKAMURA, Akiko*; FURUKAWA, Miki*; KIMURA, Satoshi*; UEDA, Koki*; NOJI, Hideyoshi*; OGAWA, Kazuei*; NOLLET, Kenneth*; OHTO, Hitoshi*; TAKEISHI, Yasuchika*

ISBT Science Series   10 ( 2 )   93 - 99   2015

Inhibition of histone methyltransferase EZH2 depletes leukemia stem cell of mixed lineage leukemia fusion leukemia through upregulation of p16

UEDA, Koki*; YOSHIMI, Akihide; KAGOYA, Yuki; NISHIKAWA, Satoshi; MARQUEZ, Victor; NAKAGAWA, Masahiro; KUROKAWA, Mineo

Cancer Science   105 ( 5 )   512 - 519   2014

Single-cell gene expression analysis reveals clonal architecture of blast-phase chronic myeloid leukaemia

NUKINA, Arika; KAGOYA, Yuki; WATANABE-OKOCHI, Naoko; ARAI, Shunya; UEDA, Koki*; YOSHIMI, Akihide; NANNYA, Yasuhito; KUROKAWA, Mineo

British Journal of Haematology   165 ( 3 )   414 - 416   2014

Generation of induced pluripotent stem cells derived from primary and secondary myelofibrosis patient samples

HOSOI, Masataka; KUMANO, Keiki; TAOKA, Kazuki; ARAI, Shunya; KATAOKA, Keisuke; UEDA, Koki*; KAMIKUBO, Yasuhiko; TAKAYAMA, Naoya; OTSU, Makoto; ETO, Koji; NAKAUCHI, Hiromitsu; KUROKAWA, Mineo

Experimental Hematology   42 ( 9 )   816 - 825   2014

特集：造血幹細胞移植の合併症とその管理/移植後肺合併症の病態と治療

植田航希*, 黒川峰夫

血液内科   68 ( 3 )   350-355,   2014

Generation of induced pluripotent stem cells from primary chronic myelogenous leukemia patient samples

Keiki Kumano, Shunya Arai, Masataka Hosoi, Kazuki Taoka, Naoya Takayama, Makoto Otsu, Genta Nagae, Koki Ueda*, Kumi Nakazaki, Yasuhiko Kamikubo, Koji Eto, Hiroyuki Aburatani, Hiromitsu Nakauchi, Mineo Kurokawa

Blood   119 ( 26 )   6234 - 6242   2012

A novel MLL-AF1p/Eps15 fusion variant in therapy-related acute lymphoblastic leukemia, lacking the EH-domains

Akihito Shinohara, Motoshi Ichikawa, Koki Ueda*, Tsuyoshi Takahashi, Akira Hangaishi, Mineo Kurokawa

Leukemia Research   34 ( 2 )   e62–e63   2010

Arsenic-induced pericardial and pleural effusion without acute promyelocytic leukemia differentiation syndrome

Koki Ueda*, Sumimasa Nagai, Shin-ich Miyashita, Toshikazu Kaise, Motoshi Ichikawa, Keiki Kumano, Akira Hangaishi, Yasuhito Nannya, Mineo Kurokawa

Leukemia Research   34 ( 1 )   e25–e26   2010

Biliary cast syndrome and benign biliary stricture as complications of allogeneic hematopoietic stem cell transplantation

Masataka Hosoi, Yasuhito Nannya, Takashi Sasaki, Hiroshi I. Suzuki, Koki Ueda*, Takeshi Tsujino, Hiroyuki Isayama, Tsuyoshi Takahashi, Kazuhiko Koike, Mineo Kurokawa

Annals of Hematology   89 ( 12 )   1287 - 1289   2010

FDG-PET is effective in the detection of granulocytic sarcoma in patients with myeloid malignancy

Koki Ueda*, Motoshi Ichikawa, Miwako Takahashi, Toshimitsu Momose, Kuni Ohtomo, Mineo Kurokaw

Leukemia Research   34 ( 9 )   1239 - 1241   2010

T cell acute lymphoblastic leukemia arising from familial platelet disorder

Nahoko Nishimoto, Yoichi Imai, Koki Ueda*, Masahiro Nakagawa, Akihito Shinohara, Motoshi Ichikawa, Yasuhito Nannya, Mineo Kurokawa

International Journal of Hematology   92 ( 1 )   194 - 197   2010

Early onset of acute lymphoblastic leukemia with MLL rearrangement after autologous stem cell transplantation for multiple myeloma

Koki Ueda*, Go Yamamoto, Akihito Shinohara, Akira Hangaishi, Mineo Kurokawa

Annals of Hematology   88 ( 8 )   813 - 814   2009

Monitoring trough concentration of voriconazole is important to ensure successful antifungal therapy and to avoid hepatic damage in patients with hematological disorders

Koki Ueda*, Yasuhito Nannya, Keiki Kumano, Akira Hangaishi, Tsuyoshi Takahashi, Yoichi Imai, Mineo Kurokawa

International Journal of Hematology   89 ( 5 )   592 - 599   2009

Clonal hematopoiesis (CH) with JAK2-V617F mutation promotes pulmonary hypertension (PH) through ALK1 (Acvrl1)

第80回日本癌学会学術総会  

Hematopoietic cells with MPN driver mutations promote pulmonary hypertension

第83回日本血液学会学術集会 The 83rd Annual Meeting of the Japanese Society of Hematology  

MDMX acts as a pervasive preleukemic-to-acute myeloid leukemia switch mechanism.

ISEH (International Society for Experimental Hematology) virtual scientific meeting,  

HMGA2 orchestrates the tumorgenesis of myeloproliferative neoplasms (MPN) in corporation with JAK2V617F

58th American Society of Hematology (ASH) Annual Meeting and Exposition  

同種造血幹細胞移植におけるボリコナゾールおよびキャンディン系抗真菌薬予防投与の有効性に関する後方視的解析

第8回　県北感染症診断・治療研究会  

末梢神経障害で発症した原発性マクログロブリン血症の一例

第32回　悪性リンパ腫（M.L.）研究会  

The role of oncogene HMGA2 in the pathogenesis of myeloproliferative neoplasms (MPN)

The role of oncogene HMGA2 in the pathogenesis of myeloproliferative neoplasms (MPN)

Autocrine and paracrine interactions by Gas 6 signaling pathways via IL-6 between MM cells and BMSCs

同種造血幹細胞移植後の肝障害の診断に肝生検が有用であった二次性ヘモクロマトリーシスの一例

第122回　日本血液学会東北地方会  

同種造血幹細胞移植後の肝障害の診断に肝生検が有用であった二次性ヘモクロマトリーシスの一例

第63回　福島血液研究会  

The role of HMGA2 in the pathogenesis of myeloproliferative neoplasms (MPNs)

The 5th JCA-AACR Special Joint Conference “The Latest Advances in Hematological Cancer Research: From Basic Science to Therapeutics"  

全身の骨病変をきたしたCD5陽性DLBCLの一例

第22回　造血器腫瘍研究会  

Clininal study of CD4+T cell in aged recipients of allogenic stem cell transplantations

非血縁者間同種造血幹細胞移植後に発症した重症筋無力症の一例

第121回　日本血液学会東北地方会  

Expression of HMGA2 collaborates with JAK2V617F to progress myeloproliferative neoplasms

57th American Society of Hematology (ASH) Annual Meeting and Exposition  

EBV関連LPDとIgG4関連疾患を合併しRituximabが有効であった1例

第31回　悪性リンパ腫（M.L.）研究会  

Persistent CR of acute leukemic-phase CCR4+γδ PTCL-NOS by auto-PBSCT with mogamulizumab

Transfusions after engraftment associate with non-relapse mortality in the setting of allo-HSCT

濾胞性リンパ腫と多発性骨髄腫を合併し、VR-CAP療法が奏功した一例

第120回　日本血液学会東北地方会  

モガムリズマブ併用自己末梢血幹細胞移植により長期寛解が得られた末梢性T細胞リンパ腫白血化の一例

第28回 東北ＢＭＴ研究会  

モガムリズマブ併用自己末梢血幹細胞移植により長期寛解が得られている末梢性T細胞リンパ腫白血化の一例

第62回　福島血液研究会  

成人発症の小児EBウイルス (EBV) 陽性T細胞増殖症の1例

第205回　日本内科学会東北地方会  

シタラビン大量療法が奏功し同種移植を施行した混合性白血病の1例

第21回　造血器腫瘍研究会  

白血病化学療法後の真菌感染合併症の2例

血液MEETING in 福島 2015  

治療抵抗性CD20陰性DLBCLの1例

第30回　悪性リンパ腫（M.L.）研究会  

自家末梢血幹細胞移植後再発を疑われた末梢性T細胞リンパ腫

第１3回　福島・新潟・山形　血液スライドカンファレンス  

クローン性造血における好中球・血小板の細胞間相互作用を介した血栓形成機構の解明

Grant number：24K11564  2024.4 - 2027.3

基盤研究(C)

三浦 里織, 三阪 智史, 関亦 正幸, 植田 航希, 池田 和彦

心不全におけるクローン性造血の包括的理解とエクソソームを介した治療応用

Grant number：23H02909  2023.4 - 2026.3

基盤研究(B)

竹石 恭知, 三阪 智史, 植田 航希, 池田 和彦

DNAメチル化を基軸とした炎症ストレスとクローン性造血の相互的役割の解明

Grant number：22K08460  2022.4 - 2025.3

基盤研究(C)

佐藤 友香, 植田 航希, 池田 和彦