Life Science / Functional biochemistry  / Functional Biochemistry

東京医科歯科大学医学部　文部教官・助手

1989.4 - 1997.1

日本学術振興会特別研究員

1987.4 - 1989.3

Japanese Cancer Association

Japan Biochemical Society

日本分子生物学会

その他   日本学術振興会　科研費専門委員  

2019.7 - 2022.7   

  文部科学省審議会委員  

2017.4 - Now   

米国薬理学会   Molecular Pharmacology, Editorial Associate Board  

2016.11 - Now   

  日本学術振興会 科研費専門委員  

2016.10 - Now   

その他   日本学術振興会　科研費専門委員  

2016.7 - 2018.6   

日本分子生物学会   理事会 執行部（庶務幹事）  

2013.1 - 2016.12   

その他   日本学術振興会　科研費専門委員  

2011.10 - 2014.3   

その他   日本女性科学者の会　理事(提言委員長)  

2010.1 - 2023.5   

日本分子生物学会   男女共同参画委員  

2007.4 - Now   

日本分子生物学会   男女共同参画委員  

2007.4 - 2012.12   

CK2 phosphorylation of eukaryotic translation initiation factor 5 potentiates cell cycle progression.

Proc Natl Acad Sci USA   102 ( 43 )   15688 - 15693   2005.10

Association and regulation of casein kinase 2 activity by adenomatous polyposis coli protein

Proc. Natl. Acad. Sci, U.S.A.   99 ( 9 )   5959 - 5964   2002

Assessing the components of the CK2 complex in the nucleus during the cell cycle progression.

Miwako K. Homma, Takeshi Shibata, Toshiyuki Suzuki, Masato Ogura, Hiroko Kozuka-Hata, Masaaki Oyama and Yoshimi Homma.

Advances in Biochemistry in Health and Disease   12   197 - 226   2015.1

Weight loss by a novel small-molecule, Ppc-1, derived from slime mold

Toshiyuki Suzuki, Haruhisa Kikuchi, Masato Ogura, Miwako K Homma, Yoshiteru Oshima and Yoshimi Homma.

PLOS One   10 ( 2 )   e0117088   2015

Dysregulation of very long chain acyl-CoA dehydrogenase coupled with lipid peroxidation.

Kabuyama Y., Nakazawa N., Yamaki J., Homma M.K., and Homma Y.

Am. J. Physiol. Cell Physiol.   298 ( 1 )   107 - 113   2010

Cell Cycle and activation of CK2

Miwako K. Homma and Yoshimi Homma.

Mol.Cell.Biochem.   316 ( 1-2 )   49 - 55   2008.4

Phosphorylation of flotillin-1 by mitochondrial c-Src is required to prevent the production of reactive oxygen species.

Ogura M, Yamaki J, Homma MK and Homma Y.

FEBS Lett   588   2837 - 2843   2014.8

Enhancement of lymphocyte migration and cytokine production by ephrinB1 system in rheumatoid arthritis.

Takuya Kitamura, Yukihito Kabuyama, Akihisa Kamataki, Miwako K. Homma, Hideo Kobayashi, Shigeo Aota, Shin-ichi Kikuchi and Yoshimi Homma.

Am. J. Physiol. Cell Physiol.   294   C189-C196   2008

Mitochondrial c-Src regulates cell survival through phosphorylation of respiratory chain components.

Ogura M, Yamaki J, Homma MK and Homma Y.

Biochem J   447   281 - 289   2012

Involvemnet of selenoprotein P in the regulation of redox balance and myofibroblast viability in idiopathic pulmonary fibrosis.

Yukihito Kabuyama, Kengo Oshima, Takuya Kitamura, Miwako K. Homma, Junko Yamaki, Mitsuru Munakata, and Yoshimi Homma.

Genes to Cells   12   1235 - 1244   2007

Opsonic complement component C3 in the solitary Ascidian, Halocynthia roretzi.

Journal of Immunology   162   387 - 391   1999

Involvement of EphB1 receptor/ephrinB2 in chronic neuropathic pain

Kobayashi H, Kitamura T, Sekiguchi M, Kabuyama Y, Homma MK, Konno S, Kikuchi S and Homma Y

Spine   in press   2007

Regulatory role of CK2 during the progression of cell cycle.

Homma MK,and Homma Y

Mol Cell Biochem   274 ( 1-2 )   47 - 52   2005.4

Early signaling events induced by 280-nm UV irradiation

Eur. J. Biochem   269   664 - 670   2002

Wavelength-specific activation of MAP kinase family proteins by monochromatic ultraviolet irradiation.

Photochem. Photobiol.   73 ( 3 )   147 - 152   2001

Involvement of ErbB-2 in rheumatoid synovial cell growth.

Arthritis Rheum.   44 ( 2 )   260 - 265   2001

Inhibition of phosphoinositide hydrolysis and cell growth of Swiss 3T3 cells by myristoylated phosphoinositide phospholipase C inhibitor peptides.

Miwako K. Homma, Motoo Yamasaki, Shinobu Ohmi-Imajoh, and Yoshimi Homma

J. Biochem.   122   738   1997

Growth inhibition by phospholipase C inhibitor peptides of colorectal carunoma cells derived from familial adenomatous

Miwako K. Homma, Yoshimi Homma, Moto-o Yamasaki, Shinobu Ohmi-Imajoh, and Yasuhito Yuasa

Cell Growth & Differentiation   7   281 - 288   1996

Sequential activation of MAP kinase cascade by angiotensin Ⅱ in opossum kidney cells.(共著)

Yoshio Terada, Kimio Tomita, Miwako K. Homma, Hiroshi Nonoguchi, Tianxin Yang, Takehisa Yamada, Yasuhito Yuasa, Edwin G. Krebs, and Fumiaki Marumo

kidney international   48   1801 - 1809   1995

AVP-inhibits EGF-stimulated MAP kinase cascade in Madin-Darby canine kidney cells(共著)

Takehisa Yamada, Yoshio Terada, Miwako K. Homma, Hiroshi Nonoguchi, Sei Sasaki, Kimio Tomita, Yasuhito Yuasa, and Fumiaki Marumo

kidney international   48   745 - 752   1995

Enhanced phosphoinositide metabolism in colorectal carcinoma cells derived from familial adenomarous polyposis patients

Miwako K. Homma, Yoshimi Homma, Masayoshi Namba, and Yasuhito Yuasa

J. Cellular Biochemistry   55   477 - 485   1994

Sequential activation of Raf-1 kinase, MAP kinase, MAP kinase, and S6 kinase by hyperosmolality in renal cells. (共著)

Yoshio Terada, Kimio Tomita, Miwako K. Homma, Hiroshi Nonoguchi, Tianxin Yang, Takehisa Yamada, Yasuhito Yuasa, Edwin G. Krebs, and Fumiaki Marumo

Journal of Biological Chemistry   269   31296 - 31301   1994

Enhancement of PLC activity by tyrosine phosphorylation in human colorectal carcinomas.

Miwako K. Homma, Yoshimi Homma, Masayoshi Namba, and Yasuhito Yuasa

J. Cellular Biochemistry   17 ( A )   318   1993

Effects of phorbor ester on mitogen-activated protein kinase kinase activity in wild-type and phorbor ester-resisitant EL4 thymoma cells.

Journal of Biological Chemistry   268   16124 - 16129   1993

Purification and characterization of membrane-bound and cytosolic forms of diacylglycerol kinase from rat brain

Journal of Biological Chemistry   265   794 - 800   1990

Transforming genes from familial adenomatous polyposis patient cells detected by a tumorigenicity assay

Oncogene   5   589 - 596   1990

Dissapearance of phorbol acetate-induced translocation of diacylglycerol kinase in erbB-transformed cells

Miwako Kato, Sadaaki Kawai, and Tadaomi Takenawa

FEBS Letters   247   247 - 250   1989

Enhancement of inositol phospholipid metabolism and activation of protein kinase C in ras-transformed fibroblasts

Journal of Biological Chemistry   263   17975 - 17980   1988

Effect of transforming growth factor-alpha on inositol phospholipid metabolism in human epidermal carcinoma cells

Miwako Kato, Tadaomi Takenawa, and Daniel R.Twardzik

Journal of Cellular Biochemistry   37   339 - 346   1988

Altered signal transduction in erbB-transformed cells. An implication of enhanced inositol phospholipid metabolism in erbB-induced transformation

Miwako Kato, Sadaaki Kawai, and Tadaomi Takenawa

Journal of Biological Chemistry   262   5696 - 5704   1987

Epidermal growth factor stimulates diacylglycerol kinase activity in isolated plasma membrane vesicles from A431 cells

Miwako Kato, Yoshimi Homma, Yoshitaka Nagai,and Tadaomi Takenawa

Biochem. Biophys. Res. Commun.   129   375 - 380   1985

Role of enhanced inositol phospholipid metabolism in neutrophil activation.

Tadaomi Takenawa, Jun-ichi Ishitoya, Yoshimi Homma, Miwako Kato, and Yoshitaka Nagai.

Biochem. Pharmacol.   34   1931 - 1936   1985

Maximizing the Potential of Scientists in Japan: Promoting equal participation for women scientists through leadership development

Homma M., Motohashi R., Ohtsubo H.

Genes to Cells   18 ( 7 )   529 - 532   2013.7（ ISSN:13569597 ）

Japan's lagging gender equality

Homma M., Motohashi R., Ohtsubo H.

Science   340 ( 6131 )   428 - 429   2013.4（ ISSN:00368075 ）

Realizing a research environment where both women and men can fully demonstrate their abilities in the era of 100-year life

Noriko Shiomitsu, Miwako Kato Homma, Keioko Yamada, Miho Shimizu, Yoriko Atomi

Journal of the Society of Japanese Womesn Scientists   22 ( 1 )   86 - 106   2022.7（ ISSN:1349-4449 ）

Development of a prognostic cancer marker and monoclonal antibodies that contribute to higher sensitivity

So Yamamoto, Miwako Kato Homma

Bio R&D   41 ( 7 )   27 - 33   2024.7

Primary pituitary malignant lymphoma that was difficult to differentiate from nonfunctioning pituitary adenoma: A case report

Murakami Y., Sato T., Jinguji S., Kjshida Y., Watanabe T., Suzuki O., Ikeda K., Homma M., Midorikavva S., Saito K.

Neurological Surgery   44 ( 9 )   779 - 784   2016.9（ ISSN:03012603 ）

Prenylated quinolinecarboxylic acid derivative suppresses immune response through inhibition of PAK2

Masato Ogura, Haruhisa Kikuchi, Toshiyuki Suzuki, Junko Yamaki, Miwako K. Homma, Yoshiteru Oshima, Yoshimi Homma.

Biochem Pharmacol   105   55 - 65   2016

Mitochondrial reactive oxygen species suppress humoral immune response through reduction of CD19 expression in B cells.

Masato Ogura, Takeshi Inoue, Junko Yamaki, Miwako K. Homma, Tomohiro Kurosaki, Yoshimi Homma

Eur J Immunol   2016

Synthesis of plenylated quinolinecarboxylic acid derivatives and their anti-obesity activities.

Kikuchi H, Suzuki T, Ogura M, Homma MK, Homma Y and Oshima Y.

Bioorg Med Chem   23   66 - 72   2015.1

KEY WORD炎症・免疫系

（ジアシルグリセロール）

先端医学社  1994 

新生化学実験講座 第4巻 脂質II

日本生化学会（イノシトールリン酸産生反応）

東京化学同人  1991 

臨床免疫

（細胞増殖とイノシトールリン脂質シグナル伝達系）

科学評論社  1991 

神経精神薬理

（細胞内情報伝達とイノシトールリン脂質代謝の機能）

星和書店  1989 

実験医学　増刊号

（リン脂質代謝異常と細胞癌化）

羊土社  1989 

Phosphatidylinositol kinase and cell transformation

Adv. Second Messenger and Phosphoprotein Research  1989 

癌と化学療法 PartII別冊

（発癌遺伝子産物のシグナルトランスダクションにおけるイノシトールリン脂質代謝の役割　,）

癌と化学療法社  1986 

日本女性科学者の会学術誌

一般社団法人　日本女性科学者の会（例会シンポジウム2021「女性科学者への期待・女性科学者はなぜ増えないか」アンコンシャス・バイアスの解消とジェンダード・イノベーション）

一般社団法人　日本女性科学者の会  2022.3 

Dry analysis of RNA-Seq data targeting CK2.

The 81th Annual Meeting of Japan Cancer Association  

CK2α as a prognostic factor in invasive ductal carcinomas of the breast: cancer recurrence prognosis by surgical sampling

The Lancet Summit: Cancer Care in Asia and Latin America  

Inhibition of CK2 activity by adenomatous polyposis coli (APC) protein.

Cold Spring Harbor Laboratory Meeting on Phosphorylation, Signaling and Disease   2007.5  

Cell cycle-regulated phosphorylation and nuclear translocation of CK2

IUBMB  

Cell cycle-regulated phosphorylation and nuclear localization of CK2.

Cold Spring Harbor Laboratory Meeting on Cell Cycle  

Role of CK2 during the progression of cell cycle

Miami Nature Biotechnology Winter Symposium  

Regulatory role of CK2 during progression of cell cycle

The 4th International Conference on Protein Kinase CK2  

Evaluation of nucleolar CK2a-positive staining as a new prognostic factor for invasive ductal carcinoma of the breast.

ASBMB Sympojiumu: Emerging roles of the nucleolus  

The molecular functions of protein kinase CK2 in association with nuclear localization.

The 81th Annual Meeting of Japan Cancer Association  

Association of nucleolar CKa with poor prognosis for breast carcinomas.

Cell Press Symposium  

Intracellular localization of CK2a as a prognostic factor in invasive breast carcinomas.

第80回日本癌学会学術総会  

Nuclear localization of protein kinase CK2 as a prognostic factor for breast cancer.

The 79th Annual Meeting of Japan Cancer Association (Oral English Session)  

Alterations of intracellular signal transduction system in a rare liver carcinoma

The 78th Annual Meeting of the Japanese Cancer Association  

Phosphoproteomics analysis of nuclear protein kinase complexes associating with growth-related gene expression

The 77th Annual Meeting of the Japanese Cancer Association  

Phosphoproteomics analysis of nuclear protein kinase complexes associating with growth-related gene expression

The 77th Annual Meeting of the Japanese Cancer Association  

Protein Kinase Signaling System: Integrative studies of physiological approach and phosphoprotein analysis

ConBio 2017  

Protein Kinase Signaling System: Integrative studies of physiological approach and phosphoprotein analysis

ConBio 2017  

ゲノム編集細胞株を用いたCK2機能の解析

第39回日本分子生物学会年会  

ゲノム編集細胞株を用いたCK2機能の解析

第39回日本分子生物学会年会  

ゲノム編集細胞株を用いたCK2機能の解析

第39回日本分子生物学会年会  

Proteomic analysis implicates protein kinase CK2 in the nuclear signaling in the cell cycle.

The 8th International Conference on Protein Kinase CK2  

Proteomic analysis implicates protein kinase CK2 in the nuclear signaling in the cell cycle.

The 8th International Conference on Protein Kinase CK2  

Proteomic analysis implicates protein kinase CK2 in the nuclear signaling in the cell cycle.

The 8th International Conference on Protein Kinase CK2  

Function of protein kinase CK2 on cell cycle progression.

The 21st International Charles Heidelberger Symposium on Carcinogenesis,  

Function of protein kinase CK2 on cell cycle progression.

The 21st International Charles Heidelberger Symposium on Carcinogenesis,  

Function of protein kinase CK2 on cell cycle progression.

The 21st International Charles Heidelberger Symposium on Carcinogenesis,  

Role of protein kinase CK2 on cell cycle progression

University of Washington and Kobe University International Joint Symposium  

Role of protein kinase CK2 on cell cycle progression

University of Washington and Kobe University International Joint Symposium  

Role of protein kinase CK2 on cell cycle progression

University of Washington and Kobe University International Joint Symposium  

細胞周期進行と関連する核内CK2複合体解析

３７回日本分子生物学会年会   2014.11  

細胞周期進行と関連する核内CK2複合体解析

３７回日本分子生物学会年会  

細胞周期進行と関連する核内CK2複合体解析

３７回日本分子生物学会年会  

Protein kinase CK2: its role in cell proliferation and cell cycle progression.

The 20th International Charles Heidelberger Symposium on Carcinogenesis  

Protein kinase CK2: its role in cell proliferation and cell cycle progression.

The 20th International Charles Heidelberger Symposium on Carcinogenesis  

Protein kinase CK2: its role in cell proliferation and cell cycle progression.

The 20th International Charles Heidelberger Symposium on Carcinogenesis  

Proteomics analysis of CK2 interacting proteins during the progression of cell cycle

The 7th International Conference on Protein Kinase CK2  

Important role of intramolecular phosphorylation for CK2 activity

The 7th International Conference on Protein Kinase CK2  

Important role of intramolecular phosphorylation for CK2 activity

The 7th International Conference on Protein Kinase CK2  

Proteomics analysis of CK2 interacting proteins during the progression of cell cycle

The 7th International Conference on Protein Kinase CK2  

Important role of intramolecular phosphorylation for CK2 activity

The 7th International Conference on Protein Kinase CK2  

Proteomics analysis of CK2 interacting proteins during the progression of cell cycle

The 7th International Conference on Protein Kinase CK2  

Autophosphorylation of CK2 at the N-terminal region is required for its catalytic activity.

Cold Spring Harbor Laboratory Symposium“Protein Data Bank 40th"  

Involvement of CK2 phosphorylation for its activity and nuclear localiztion during the cell cycle progression of normal human fibroblasts.

Keystone Symposia on “The Evolution of Protein Phosphorylation"   2011.1  

Regulatory mechanisms involved in the activation of nuclear CK2

The 14th Meeting on Protein Phosphorylation and Cell Signaling  

CK2 changes its cellular localization during the progression of cell cycle

Cold Spring Harbor Laboratory Meeting on Cell Cycle  

Cell cycle-regulated phosphorylation and nuclear translocation of CK2.

5th International Conference on Protein Kinase CK2, Protien Kinase CK2 and Disease  

EPIMEWS

2010.3 - 2013.12

先端技術の広報活動

2008.10 - 2010.3