日本学術振興会   特別研究員

1997.4 - 1997.10

RIKEN   postdoctoral fellowship

1996.4 - 1997.3

New small wireless optical stimulator for controlling a movement of a conscious mouse

44 ( 4 )   1 - 5   2016.4

Cell-cycle-independent transitions in temporal identity of mammalian neural progenitor cells

OKAMOTO M,MIYATA T,Konno D,UEDA RH,KASUKAWA T,HASHIMOTO M*,MATSUZAKI F,KAWAGUCHI A

NATURE COMMUNICATIONS   20 ( 7 )   11349   2016.3

New Small Wireless Optical Stimulator for Controlling a Movement of a Conscious Mouse

HASHIMOTO Mitsuhiro

The Review of Laser Engineering   44 ( 4 )   2016（ ISSN:0387-0200 ）

Programmable wireless light-emitting diode stimulator for chronic stimulation of optogenetic molecules in freely moving mice

Mitsuhiro Hashimoto

Neurophotonics   1 ( 1 )   2014.7（ ISSN:2329-423X ）

【小脳の神経学】 小脳の発生・分化機構

橋本 光広

神経内科   78 ( 6 )   619 - 626   2013.6（ ISSN:0386-9709 ）

Mechanisms of cerebellar development and differentiation.

Mitsuhiro Hashimoto

Neurological Medicine   78 ( 6 )   619 - 626   2013.6

Epha4 controls the midline crossing and contralateral axonal projections of inferior olive neurons

Mitsuhiro Hashimoto, Rie Ito, Naohito Kitamura, Kazunori Namba, Yasuko Hisano

JOURNAL OF COMPARATIVE NEUROLOGY   520 ( 8 )   1702 - 1720   2012.6（ ISSN:0021-9967 ）

Development and evolution of cerebellar neural circuits

Mitsuhiro Hashimoto, Masahiko Hibi

DEVELOPMENT GROWTH & DIFFERENTIATION   54 ( 3 )   373 - 389   2012.4（ ISSN:0012-1592 ）

Close Correlation Between the Birth Date of Purkinje Cells and the Longitudinal Compartmentalization of the Mouse Adult Cerebellum

Kazunori Namba, Izumi Sugihara, Mitsuhiro Hashimoto

JOURNAL OF COMPARATIVE NEUROLOGY   519 ( 13 )   2594 - 2614   2011.9（ ISSN:0021-9967 ）

Quantitative comparison of genetically encoded Ca2+ indicators in cortical pyramidal cells and cerebellar Purkinje cells

Yoshiyuki Yamada, Takayuki Michikawa, Mitsuhiro Hashimoto, Kazuki Horikawa, Takeharu Nagai, Atsushi Miyawaki, Michael Haeusser, Katsuhiko Mikoshiba

FRONTIERS IN CELLULAR NEUROSCIENCE   5   18   2011.9（ ISSN:1662-5102 ）

A simple head-mountable LED device for chronic stimulation of optogenetic molecules in freely moving mice

Youichi Iwai, Shinzou Honda, Hirofumi Ozeki, Mitsuhiro Hashimoto, Hajime Hirase

NEUROSCIENCE RESEARCH   70 ( 1 )   124 - 127   2011.5（ ISSN:0168-0102 ）

Directional gene-transfer into the brain by an adenoviral vector tagged with magnetic nanoparticles

Mitsuhiro Hashimoto, Yasuko Hisano

JOURNAL OF NEUROSCIENCE METHODS   194 ( 2 )   316 - 320   2011.1（ ISSN:0165-0270 ）

Ptch1-mediated dosage-dependent action of Shh signaling regulates neural progenitor development at late gestational stages

Yayoi Shikata, Toshiaki Okada, Mitsuhiro Hashimoto, Tammy Ellis, Daisuke Matsumaru, Toshihiko Shiroishi, Masaharu Ogawa, Brandon Wainwright, Jun Motoyama

DEVELOPMENTAL BIOLOGY   349 ( 2 )   147 - 159   2011.1（ ISSN:0012-1606 ）

Close correlation between the birthdate of Purkinje cells and the longitudinal compartmentalization of the mouse adult cerebellum

Mitsuhiro Hashimoto, Izumi Sugihara

NEUROSCIENCE RESEARCH   71   E247 - E247   2011（ ISSN:0168-0102 ）

Migration, early axonogenesis, and Reelin-dependent layer-forming behavior of early/posterior-born Purkinje cells in the developing mouse lateral cerebellum

Takaki Miyata, Yuichi Ono, Mayumi Okamoto, Makoto Masaoka, Akira Sakakibara, Ayano Kawaguchi, Mitsuhiro Hashimoto, Masaharu Ogawa

NEURAL DEVELOPMENT   5   23   2010.9（ ISSN:1749-8104 ）

Spontaneous network activity visualized by ultrasensitive Ca2+ indicators, yellow Cameleon-Nano

Kazuki Horikawa, Yoshiyuki Yamada, Tomoki Matsuda, Kentarou Kobayashi, Mitsuhiro Hashimoto, Toru Matsu-ura, Atsushi Miyawaki, Takayuki Michikawa, Katsuhiko Mikoshiba, Takeharu Nagai

NATURE METHODS   7 ( 9 )   729 - U88   2010.9（ ISSN:1548-7091 ）

Transient and permanent gene transfer into the brain of the teleost fish medaka (Oryzias latipes) using human adenovirus and the Cre-loxP system.

Yuji Suehiro, Masato Kinoshita, Teruhiro Okuyama, Atsuko Shimada, Kiyoshi Naruse, Hiroyuki Takeda, Takeo Kubo, Mitsuhiro Hashimoto, Hideaki Takeuchi

FEBS letters   584 ( 16 )   3545 - 9   2010.8（ ISSN:0014-5793 ）

Evaluating the performance of genetically encoded calcium indicators expressed in mammalian neurons

Yoshiyuki Yamada, Takayuki Michikawa, Mitsuhiro Hashimoto, Atsushi Miyawaki, Katsuhiko Mikoshiba

NEUROSCIENCE RESEARCH   68   E334 - E334   2010（ ISSN:0168-0102 ）

The birthdate of Purkinje cells is essential for the compartmentalization of the cerebellum

Mitsuhiro Hashimoto

NEUROSCIENCE RESEARCH   68   E47 - E47   2010（ ISSN:0168-0102 ）

An adenovirus-based novel experimental system for introduction of genetically encoded tools

Yoshiyuki Yamada, Takayuki Michikawa, Mitsuhiro Hashimoto, Atsushi Miyawaki, Katsuhiko Mikoshiba

NEUROSCIENCE RESEARCH   65   S132 - S132   2009（ ISSN:0168-0102 ）

Mediolateral compartments determined by the birthdate of Purkinje cells correlates closely with Zebrin II-pattern in adult cerebellum

Mitsuhiro Hashimoto, Kazunori Namba, Izumi Sugihara

NEUROSCIENCE RESEARCH   65   S161 - S161   2009（ ISSN:0168-0102 ）

Correlation between the mediolateral compartments formed by birthdate-related Purkinje cells andzebrin II-bands

Mitsuhiro Hashimoto, Kazunori Namba, Izurni Sugihara

NEUROSCIENCE RESEARCH   61   S155 - S155   2008（ ISSN:0168-0102 ）

Role of Ptch1 in neural stem cell maintenance during mouse brain development

Jun Motoyama, Yayoi Shikata, Mitsuhiro Hashimoto, Toshiaki Okada, Masaharu Ogawa

NEUROSCIENCE RESEARCH   61   S156 - S156   2008（ ISSN:0168-0102 ）

Target regulation of V2R expression and functional maturation in vomeronasal sensory neurons in vitro

Kazuyo Muramoto, Mitsuhiro Hashimoto, Hideto Kaba

EUROPEAN JOURNAL OF NEUROSCIENCE   26 ( 12 )   3382 - 3394   2007.12（ ISSN:0953-816X ）

Cdk5 is required for multipolar-to-bipolar transition during radial neuronal migration and proper dendrite development of pyramidal neurons in the cerebral cortex

Toshio Ohshima, Motoyuki Hirasawa, Hidenori Tabata, Tetsuji Mutoh, Tomoko Adachi, Hiromi Suzuki, Keiko Saruta, Takuji Iwasato, Shigeyoshi Itohara, Mistuhiro Hashimoto, Kazunori Nakajima, Masaharu Ogawa, Ashok B. Kulkarni, Katsuhiko Mikoshiba

DEVELOPMENT   134 ( 12 )   2273 - 2282   2007.6（ ISSN:0950-1991 ）

Pak1 regulates dendritic branching and spine formation

Kanehiro Hayashi, Toshio Ohshima, Mitsuhiro Hashimoto, Katsuhiko Mikoshiba

DEVELOPMENTAL NEUROBIOLOGY   67 ( 5 )   655 - 669   2007.4（ ISSN:1932-8451 ）

Modulatory effects of the accessory olfactory bulb on V2R family pheromone receptor expression in cultured vomeronasal neurons

K. Muramoto, M. Hashimoto, H. Kaba

CHEMICAL SENSES   32 ( 2 )   J22 - J22   2007.2（ ISSN:0379-864X ）

小脳の発生

橋本光広

BRAIN MEDICAL   19 ( 1 )   21 - 26   2007

副嗅球との相互作用による鋤鼻ニューロンでのV2Rファミリー受容体の発現調節(ポスターセッション, 2006年度日本味と匂学会第40回大会)

村本 和世, 橋本 光広, 椛 秀人

日本味と匂学会誌   13 ( 3 )   565 - 568   2006.12（ ISSN:1340-4806 ）

Modulation of V2R receptor expression in cultured vomeronasal neurons by the interaction with cocultured accessory olfactory bulb neurons

K. Muramoto, M. Hashimoto, H. Kaba

CHEMICAL SENSES   31 ( 8 )   E45 - E45   2006.10（ ISSN:0379-864X ）

Neuronal birthdate-specific gene transfer with adenoviral vectors

M Hashimoto, K Mikoshiba

JOURNAL OF NEUROSCIENCE   24 ( 1 )   286 - 296   2004.1（ ISSN:0270-6474 ）

Mediolateral compartmentalization of the cerebellum is determined on the "birth date" of Purkinje cells.

Hashimoto M, Mikoshiba K

The Journal of neuroscience : the official journal of the Society for Neuroscience   23 ( 36 )   11342 - 11351   2003.12（ ISSN:0270-6474 ）

CrmA gene expression protects mice against concanavalin-A-induced hepatitis by inhibiting IL-18 secretion and hepatocyte apoptosis

M Fujino, M Kawasaki, N Funeshima, Y Kitazawa, M Kosuga, K Okabe, M Hashimoto, H Yaginuma, K Mikoshiba, T Okuyama, S Suzuki, XK Li

GENE THERAPY   10 ( 20 )   1781 - 1790   2003.9（ ISSN:0969-7128 ）

小脳の縦縞状区画化と皮質形成：Purkinje細胞の誕生日・移動・配置の分子機構

橋本光広, 宮田卓樹

脳の科学   25   543 - 549   2003

Prolongation of transgene expression by coexpression of cytokine response modifier A in rodent liver after adenoviral gene transfer

XK Li, M Kosuga, K Tokieda, A Kanaji, Y Fukuhara, M Hashimoto, K Okabe, H Yaginuma, M Yamada, S Suzuki, T Okuyama

MOLECULAR THERAPY   5 ( 3 )   262 - 268   2002.3（ ISSN:1525-0016 ）

アデノウイルスベクターを用いた神経機能解析 シリーズ・バイオサイエンスの新世紀

橋本光広, 御子柴克彦

シリーズ・バイオサイエンスの新世紀 日本生化学会編 「感覚器官と脳内情報処理」 御子柴克彦、清水孝雄 編   12   2002

Prolonged Survival of Rat Liver Allografts Transfected with Adenovirus Vectors Containning Fas-Ligand and CrmA a Genes

LI Xiao-Kang, FUJINO Masayuki, ADACHI Kensuke, GUO Lei, KAWASAKI Mikiko, FUNESHIMA Naoko, KITAZAWA Yusuke, HASHIMOTO Mitsuhiro, OKUYAMA Torayuki, SUZUKI Seiichi

36 ( 5 )   304 - 315   2001.10（ ISSN:0578-7947 ）

High-yield selection and extraction of two promoter-defined phenotypes of neural stem cells from the fetal human brain.

Keyoung H M, Roy N S, Benraiss A, Louissaint A, Suzuki A, Hashimoto M, Rashbaum W K, Okano H, Goldman S A

Nature Biotechnol.   19 ( 9 )   843 - 850   2001（ ISSN:1087-0156 ）

The neural RNA-binding protein Musashi1 translationally regulation the m-numb gene expression by interaction with its mRNA.

Imai T, Tokunaga A, Yoshida T, Hashimoto M, Mikoshiba K, Weinmaster G, Nakafuku M, Okano H

Molecular Cellular Biology   21 ( 12 )   3888 - 3900   2001（ ISSN:0270-7306 ）

Promoter structure and gene expression of the mouse inositol 1,4,5-trisphosphate receptor type 3 gene.

Tamura T, Hashimoto M, Aruga J, Konishi Y, Nakagawa M, Ohbayashi T, Shimada, M, Mikoshiba K

Gene   275 ( 1 )   169 - 176   2001（ ISSN:0378-1119 ）

In vitro prevention of cell-mediated xeno-graft rejection via the Fas/FasL-pathway in CrmA-transducted porcine kidney cells.

Fujino M, Li X K, Suda T, Hashimoto M, Okabe K, Yaginuma H, Mikoshiba K, Guo L, Okuyama T, Enosawa S, Amemiya H, Amano T, Suzuki S

XENOTRANSPLANTATION   8 ( 2 )   115 - 124   2001（ ISSN:0908-665X ）

In vitro prevention of cell-mediated xeno-graft rejection via the Fas/FasL-pathway in CrmA-transducted porcine kidney cells.

Fujino M, Li X K, Suda T, Hashimoto M, Okabe K, Yaginuma H, Mikoshiba K, Guo L, Okuyama T, Enosawa S, Amemiya H, Amano T, Suzuki S

Xenotransplantation   8   115 - 124   2001

Inhibition of Fas-mediated fulminant hepatitis in CrmA gene-transfected mice

Li XK, Fujino M, Guo L, Okuyama T, Funeshima N, Hashimoto M, Okabe K, Yaginuma H, Mikoshiba K, Enosawa S, Amemiya H, Suzuki S

Biochem Biophys Res Commun.   273 ( 1 )   101 - 109   2000.6（ ISSN:0006-291X ）

Adenovirus-mediated transfer of Bax with caspase-8 controlled by myelin basic protein promoter exerts an enhanced cytotoxic effect in gliomas

N Shinoura, K Saito, Y Yoshida, M Hashimoto, A Asai, T Kirino, H Hamada

CANCER GENE THERAPY   7 ( 5 )   739 - 748   2000.5（ ISSN:0929-1903 ）

Adenovirus-mediated transfer of caspase-8 augments cell death in gliomas: Implication for gene therapy

N Shinoura, H Koike, T Furitu, M Hashimoto, A Asai, T Kirino, H Hamada

HUMAN GENE THERAPY   11 ( 8 )   1123 - 1137   2000.5（ ISSN:1043-0342 ）

Pig kidney target cell PK15 apoptosis was inhibited by the cytokine response modifier A gene via suppression of caspase activity.

Fujino M, Li X, Funeshima N, Kimura H, Amano T, Hashimoto M, Okabe K, Yaginuma H, Mikoshiba K, Shinomiya T, Enosawa S, Amemiya H, Suzuki S

Transplantation Proceedings   32 ( 9 )   291 - 292   2000.4（ ISSN:0041-1345 ）

Adenovirus-mediated overexpression of Fas induces apoptosis of gliomas.

Shinoura N, Ohashi M, Yoshida Y, Kirino T, Asai A, Hashimoto M, Hamada H

Cancer Gene Therapy   7 ( 2 )   224 - 232   2000.3（ ISSN:0929-1903 ）

Adenovirus-mediated transfer of p33(ING1) with p53 drastically augments apoptosis in gliomas

N Shinoura, Y Muramatsu, M Nishimura, Y Yoshida, A Saito, T Yokoyama, T Furukawa, A Horii, M Hashimoto, A Asai, T Kirino, H Hamada

CANCER RESEARCH   59 ( 21 )   5521 - 5528   1999.11（ ISSN:0008-5472 ）

Dopa-producing astrocytes generated by adenoviral transduction of human tyrosine hydroxylase gene: in vitro study and transplantation to hemiparkinsonian model rats

H Hida, M Hashimoto, Fujimoto, I, K Nakajima, Y Shimano, T Nagatsu, K Mikoshiba, H Nishino

NEUROSCIENCE RESEARCH   35 ( 2 )   101 - 112   1999.11（ ISSN:0168-0102 ）

Gene expression of oligodendrocyte markers in human amniotic epithelial cells using neural cell-type-specific expression system

Ishii T, Ohsugi K, Nakamura S, Sato K, Hashimoto M, Mikoshiba K, Sakuragawa N

Neurosci Lett.   268 ( 3 )   131 - 134   1999.6（ ISSN:0304-3940 ）

MY TECHNOLOGY アデノウイルスベクタ-系を用いた脳機能の解析(2)小脳細胞特異的に遺伝子を発現させる系の完成

橋本 光広

細胞工学   17 ( 11 )   1756 - 1764   1998.11（ ISSN:0287-3796 ）

(MY TECHNOLOGY)アデノウイルスベクタ-系を用いた脳機能の解析(1)神経組織に効率良く遺伝子を導入するベクタ-の開発

橋本 光広

細胞工学   17 ( 10 )   1585 - 1593   1998.10（ ISSN:0287-3796 ）

A novel strategy for introducing exogenous Bcl-2 into neuronal cells: The Cre/loxP system-mediated activation of Bcl-2 for preventing programmed cell death using recombinant adenoviruses

N Sato, SW Wang, L Li, K Okabe, M Hashimoto, H Yaginuma, K Mikoshiba, Y Uchiyama, T Uetsuki, K Yoshikawa, CE Milligan, RW Oppenheim

MOLECULAR AND CELLULAR NEUROSCIENCE   12 ( 1-2 )   65 - 78   1998.9（ ISSN:1044-7431 ）

TH gene transfected astrocytes release DOPA stably in culture and meliorate methamphetamine rotation after grafting in hemiparkinsonian model rats

NISHINO H., HASHIMOTO M., SHIMANO Y., HIDA H., NAGATSU T., MIKOSHIBA K.

10 ( 1 )   19 - 20   1998.6（ ISSN:0915-3896 ）

Functional expression of a mammalian odorant receptor

HQ Zhao, L Ivic, JM Otaki, M Hashimoto, K Mikoshiba, S Firestein

SCIENCE   279 ( 5348 )   237 - 242   1998.1（ ISSN:0036-8075 ）

損傷神経の再生と機能修復

島野泰暢, 飛田秀樹, 西野仁雄, 橋本光広, 御子柴克彦, 永津俊治

神経移植による脳機能の再建   29 - 37   1998

Advantage of adenovirus to study the cell specificity and the function of a gene.

K Mikoshiba, M Hashimoto

JOURNAL OF NEUROCHEMISTRY   70   S9 - S9   1998（ ISSN:0022-3042 ）

Improvement of motor disturbance after introduction of recombinant adenovirus carring hTH-1 gene in hemiparkinson model rats

NISHINO H., SHIMANO Y., HASHIMOTO M., NAGATSU T., MIKOSHIBA K.

9 ( 1 )   23 - 24   1997.6（ ISSN:0915-3896 ）

神経系に於ける遺伝子の発現と制御 : アデノウイルスベクターを用いた特異的遺伝子導入

御子柴 克彦, 橋本 光広, 有賀 純, 齋藤 泉

日本先天代謝異常学会雑誌   12 ( 2 )   1996.10（ ISSN:0912-0122 ）

アデノウイルスペクターを用いたシバラーマウスへのMBP遺伝子導入の試み

徳山 勤, 橋本 光広, 永井 健治, 有賀 純, 御子柴 克彦

日本分子生物学会年会プログラム・講演要旨集   19   1996.8

アデノウイルスペクターを用いた神経細胞型特異的遺伝子導入法の開発とその応用

橋本 光広, 有賀 純, 御子柴 克彦

日本分子生物学会年会プログラム・講演要旨集   19   1996.8

A Neural Cell-Type-Specific Expression System Using Recombinant Adenovirus Vecters.

Hashimoto M, Aruga J, Hosoya Y, Kanegae Y, Saito I, Mikoshiba K

Human Gene Therapy   7 ( 2 )   149 - 158   1996（ ISSN:1043-0342 ）

A NOVEL ZINC-FINGER PROTEIN, ZIC, IS INVOLVED IN NEUROGENESIS, ESPECIALLY IN THE CELL LINEAGE OF CEREBELLAR GRANULE CELLS

J ARUGA, N YOKOTA, M HASHIMOTO, T FURUICHI, M FUKUDA, K MIKOSHIBA

JOURNAL OF NEUROCHEMISTRY   63 ( 5 )   1880 - 1890   1994.11（ ISSN:0022-3042 ）

Molecular cloning of human ZIC cDNA and its expression in the cerebella and medulloblastomas

Naoki Yokota, Jun Aruga, Mitsuhiro Hashimoto

Neuroscience Research Supplements   19   S138   1994.1（ ISSN:0921-8696 ）

1107 Highly restricted expression pattern of a novel zinc finger protein, zic, in cerebellar granule cell lineage

Naoki Yokota, Jun Aruga, Mitsuhiro Hashimoto, Mitsunori Fukuda, Katsuhiko Mikoshiba

Neuroscience Research Supplements   18   S106   1993.1（ ISSN:0921-8696 ）

Immunohistochemical study of inositol 1,3,4,5-tetrakisphosphate binding protein in neural tissue

Mitsuhiro Hashimoto, Michio Niinobe, Jun Aruga, Yoshihide Yamaguchi, Mitsunori Fukuda, Katsuhiko Mikoshiba

Neuroscience Research Supplements   17   70   1992.1（ ISSN:0921-8696 ）

視床下部外側野から小脳へのオレキシン入力

第125回日本解剖学会総会・全国学術集会  

Orexinergic inputs from lateral hypothalamus to cerebellar vermis.

NEURO2019  

ウイルスベクターを用いた、新たな小脳の神経回路の解明

福島医学会第476回学術研究集会  

ウイルスベクターを用いた、新たな小脳の神経回路の解析

第124回日本解剖学会総会・全国学術集会  

神経科学でＤＩＹ

第2回BIRD公開シンポジウム「脳の理科（サイエンス）～脳の謎に挑む」  

Anatomical evidence for a direct projection from Purkinje cell in the mouse cerebellar vermis to medial parabrachial nucleus

Neuroscience2018  

ウイルスベクターを用いた、小脳から内側傍小脳脚核への直接投射の解明

第123回日本解剖学会全国学術集会  

小脳と睡眠制御を関連付ける、小脳から内側傍小脳脚核への直接投射

第１回BIRDシンポジウム「脳の理科（サイエンス）～脳の謎に挑む」  

小脳と睡眠-覚醒サイクルの制御を関連付ける、小脳から内側傍小脳脚核（内側結合腕傍核）への直接投射

日本解剖学会　第63回東北・北海道連合支部学術集会  

Wnt7b-suppression in neurons born on embryonic day 11.5 of mouse brain causes brain malformation like human 22q13.3 deletion syndrome

第40回日本神経科学大会  

Wnt7b欠損と、小脳変性・自閉症様病態・22q13欠損症候群（Phelan-McDermid syndrome）との 関連

第１２２回日本解剖学会全国学術集会  

Wireless EEG recording and optical stimulation by iPad

Neuroscience2016  

小型・無線脳波解析装置の開発

東京理科大　第1回脳学際研究部門ミーティング＆キックオフミーティング  

小脳プルキンエ細胞の発生時期（誕生日）を指標とすることで明らかとなった、マウス小脳内領域の形成過程

第121回日本解剖学会総会・全国学術集会  

マウス胎生11.5日生まれの神経細胞に発現しているWnt7bは、正常な脳の形態形成において必要である

日本解剖学会第61回東北・北海道連合支部学術集会  

Wnt7b expressed by neurons born on embryonic day 11.5 of mouse brain is necessary for the normal brain morphogenesis

Wnt7b expressed by neurons born on embryonic day 11.5 of mouse brain is necessary for the normal brain morphogenesis

48th Japanse Society of Dvelopmental Biologists  

臨界期機構の脳内イメージングによる解析と統合的解明

2004 - 2009

ヘンシュ貴雄

アデノウイルスベクターを用いた神経幹細胞への遺伝子導入ならびに神経発生に関する分化誘導因子の機能に関する研究

1999 - 2002

橋本光広

アデノウイルスベクターを用いた匂い受容体、フェロモン受容体の機能解析

Grant number：11780570  1999 - 2000

奨励研究(A)

橋本光廣