Updated on 2023/03/23

写真a

 
YOSHIE Susumu
 
Organization
School of Medicine (Life Sciences and Social Medicine) Department of Cellular and Integrative Physiology Assistant Professor
Title
Assistant Professor

Degree

  • 医学博士 ( 2013.3   信州大学 )

Research Interests

  • イオンチャネル、トランスポーター、CFTR、iPS細胞、分化、気道、再生

Research Areas

  • Life Science / Clinical pharmacy  / General Physiology

  • Life Science / Physiology  / General Physiology

  • Life Science / Developmental biology  / Developmental Biology

Education

  • Shinshu University   Graduate School, Division of Medical Sciences

    - 2013.3

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    Country: Japan

  • Shinshu University   Graduate School, Division of Medical Sciences

    - 2009.3

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    Country: Japan

Research History

  • 福島県立医科大学 医学部 細胞統合生理学講座 助教

    2015.10 - Now

  • 福島県立医科大学 医学部 耳鼻咽喉科学講座 研究員

    2013.10 - 2015.9

  • 自治医科大学 分子病態治療研究センター 研究員

    2013.4 - 2013.9

  • 日本学術振興会特別研究員(DC2)

    2011.4 - 2013.3

Papers

  • Dysfunction of Cl - channels promotes epithelial to mesenchymal transition in oral squamous cell carcinoma via activation of Wnt/β-catenin signaling pathway

    Kakinouchi K, Yoshie S, Tsuji S, Murono S, Hazama A

    Biochemical and Biophysical Research Communications   555   95 - 101   2021.4

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Negative chronotropic and inotropic effects of lubiprostone on iPS cell-derived cardiomyocytes via activation of CFTR

    Akita H, Yoshie S, Ishida T, Takeishi Y, Hazama A

    BMC Complementary Medicine and Therapies   20 ( 1 )   118 - 127   2020.4

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Cl- channels regulate lipid droplet formation via Rab8a expression during adipocyte differentiation.

    Ouchi K, Yoshie S, Miyake M, Hazama A

    Bioscience, biotechnology, and biochemistry   84 ( 2 )   247 - 255   2020.2( ISSN:0916-8451

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1080/09168451.2019.1677143

    PubMed

  • Airway regeneration using iPS cell-derived airway epithelial cells with Cl<sup>-</sup> channel function.

    Yoshie S, Omori K, Hazama A

    Channels (Austin, Tex.)   13 ( 1 )   227 - 234   2019.12( ISSN:1933-6950

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1080/19336950.2019.1628550

    PubMed

  • Functional characterization of various channel-expressing central airway epithelial cells from mouse induced pluripotent stem cells.

    Yoshie S, Nakamura R, Kobayashi D, Miyake M, Omori K, Hazama A

    Journal of cellular physiology   234 ( 9 )   15951 - 15962   2019.2( ISSN:0021-9541

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1002/jcp.28254

    PubMed

  • Cytotoxicity and Antiproliferative Activity of Indonesian Red Algae Acanthophora muscoides Crude Ethanol Extracts

    Sunarpi H, Prasedya SE, Ariyana M, Nikmatullah A, Zulkifli L, Yoshie S, Miyake M, Kobayashi D, Hazama A

    Journal of Biological Sciences   18 ( 8 )   425 - 433   2018.12

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Evaluation of Indonesian selected macroalgae for their antitumor and cytoprotective activity

    Prasedya E., Ariyana M., Hamdin C., Nikmatullah A., Yoshie S., Miyake M., Kobayashi D., Hazama A., Sunarpi H.

    Journal of Applied Pharmaceutical Science   8 ( 11 )   123 - 130   2018.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.7324/JAPS.2018.81118

  • Implantation of Induced Pluripotent Stem Cell-Derived Tracheal Epithelial Cells.

    Masakazu Ikeda, Mitsuyoshi Imaizumi, Susumu Yoshie, Ryosuke Nakamura, Koshi Otsuki, Shigeru Murono, Koichi Omori

    Annals of Otology, Rhinology & Laryngology   126 ( 7 )   517 - 524   2017.7

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Heparin cross-linked collagen sponge scaffolds improve functional regeneration of rat tracheal epithelium.

    Ryosuke Nakamura, Akiko Tani, Susumu Yoshie, Masakazu Ikeda, Ikuo Wada, Akihiro Hazama, Yukio Nomoto, Yasuhiro Tada, Tatsuo Nakamura, Koichi Omori.

    Journal of Tissue Engineering and Regenerative Medicine.   2017.1

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  • Generation of airway epithelial cells with natitve characteristics from mouse induced pluripotent stem cells.

    Susumu Yoshie, Mitsuyoshi Imaizumi, Ryosuke Nakamura, Masakazu Ikeda, Koshi Otsuki, Yukio Nomoto, Ikuo Wada, Koichi Omori.

    Cell and Tissue Research   364 ( 2 )   319 - 330   2016.5

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    Language:English   Publishing type:Research paper (other academic)  

  • Regeneration of tracheal epithelium using mouse induced pluripotent stem cells.

    Masakazu Ikeda, Mitsuyoshi Imaizumi, Susumu Yoshie, Koshi Otsuki, Masao Miyake, Akihiro Hazama, Ikuo Wada, Koichi Omori.

    Acta Oto-laryngologica   136 ( 4 )   373 - 378   2016.4

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    Language:English   Publishing type:Research paper (other academic)  

  • Potential of laryngeal muscle regeneration using induced pluripotent stem cell-derived skeletal muscle cells.

    Dirja Bayu Tirta, Susumu Yoshie, Masakazu Ikeda, Mitsuyoshi Imaizumi, Ryosuke Nakamura, Koshi Otsuki, Yukio Nomoto, Ikuo Wada, Akihiro Hazama, Koichi Omori.

    Acta Oto-laryngologica   136 ( 4 )   391 - 396   2016.4

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Visualization of mouse induced pluripotent stem cells for evaluation of tracheal regeneration

    Yoshie S., Ikeda M., Imaizumi M., Otsuki K., Nomoto Y., Wada I., Omori K.

    Acta Oto-Laryngologica   135 ( 4 )   395 - 401   2015.4( ISSN:00016489

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.3109/00016489.2014.990055

  • FGF7 and cell density are required for differentiation of pancreatic amylase-positive cells from human ES cells.

    Sakiko Takizawa-Shirasawa, Susumu Yoshie, Fengming Yue, Akimi Mogi, Tadayuki Yokoyama, Daihachiro Tomotsune, Katsunori Sasaki.

    Cell and Tissue Research   354 ( 3 )   751 - 759   2013.12

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    Language:English   Publishing type:Research paper (other academic)  

  • Gene pathway analysis of the mechanism by which the Rho-associated kinase inhibitor Y-27632 inhibits apoptosis in isolated thawed human embryonic stem cells.

    Hinako Ichikawa, Naohiro Nakata, Youichi Abo, Sakiko Shirasawa, Tadayuki Yokoyama, Susumu Yoshie, Fengming Yue, Daihachiro Tomotsune, Katsunori Sasaki.

    Cryobiology   64 ( 1 )   12 - 22   2012.2

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    Language:English   Publishing type:Research paper (other academic)  

  • Establishment of novel detection system for embryonic stem cell-derived hepatocyte-like cells based on nongenetic manipulation with indocyanine green.

    Susumu Yoshie, Jun Ito, Sakiko Shirasawa, Tadayuki Yokoyama, Yuu Fujimura, Kazuo Takeda, Masahiro Mizuguchi, Ken Matsumoto, Daihachiro Tomotsune, Katsunori Sasaki.

    Tissue Engineering Part C   18 ( 1 )   12 - 20   2012.1

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    Language:English   Publishing type:Research paper (other academic)  

  • In vitro transdifferentiation of HepG2 cells to Pancreatic-like cells by CCl4, D-Galactosamine, and ZnCl2.

    Yoshiya Kanoh, Daihachiro Tomotsune, Sakiko Shirasawa, Susumu Yoshie, Hinako Ichikawa, Tadayuki Yokoyama, Shinichi Mae, Jun Ito, Masahiro Mizuguchi, Ken Matsumoto, Fengming Yue, Katsunori Sasaki.

    Pancreas   40 ( 8 )   1245 - 1252   2011.11

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    Language:English   Publishing type:Research paper (other academic)  

  • Freeze-thawing single human embryonic stem cells induce E-cadherin and actin filament network disruption via G13 signaling.

    Hinako Ichikawa, Susumu Yoshie, Naohiro Nakata, Youichi Abo, Sakiko Shirasawa, Tadayuki Yokoyama, Fengming Yue, Katsunori Sasaki.

    Cryo Letters   32 ( 6 )   516 - 524   2011.11

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  • Pancreatic exocrine enzyme-producing cell differentiation via embryoid bodies from human embryonic stem cells.

    Sakiko Shirasawa, Susumu Yoshie, Fengming Yue, Hinako Ichikawa, Tadayuki Yokoyama, Mika Nagai, Daihachiro Tomotsune, Katsunori Sasaki.

    Biochemical and Biophysical Research Communications   410 ( 3 )   608 - 613   2011.7

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  • A novel stepwise differentiation of functional pancreatic exocrine cells from embryonic stem cells.

    Sakiko Shirasawa, Susumu Yoshie, Tadayuki Yokoyama, Daihachiro Tomotsune, Fengming Yue, Katsunori Sasaki.

    Stem Cells and Development   20 ( 6 )   1071 - 1078   2011.6

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  • Combination of small molecules enhances differentiation of mouse embryonic stem cells into intermediate mesoderm through BMP7-positive cells.

    Shinichi Mae, Sakiko Shirasawa, Susumu Yoshie, Fumi Sato, Yoshiya Kanoh, Hinako Ichikawa, Tadayuki Yokoyama, Fengming Yue, Daihachiro Tomotsune, Katsunori Sasaki.

    Biochemical and Biophysical Research Communications   393 ( 4 )   877 - 882   2010.3

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  • Lanford medium induces high quality hepatic lineage cell differentiation directly from mouse embryonic stem cell-derived mesendoderm.

    Susumu Yoshie, Sakiko Shirasawa, Tadayuki Yokoyama, Yoshiya Kanoh, Shunsuke Takei, Masahiro Mizuguchi, Ken Matsumoto, Daihachiro Tomotsune, Katsunori Sasaki.

    Biochemical and Biophysical Research Communications   391 ( 3 )   1477 - 1482   2010.1

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  • Hepatocyte differentiation from human ES cells using the simple embryoid body formation method and the staged-additional cocktail.

    Katsunori Sasaki, Hinako Ichikawa, Shunsuke Takei, Heesung No, Daihachiro Tomotsune, Yoshiya Kano, Tadayuki Yokoyama, Sakiko Shirasawa, Akimi Mogi, Susumu Yoshie, Shujiro Sakaki, Satoshi Yamada, Ken Matsumoto, Masahiro Mizuguchi, Fengming Yue, Yoshiki Tanaka.

    TheScientificWorldJournal   1 ( 9 )   884 - 890   2009.9

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  • Bone morphogenetic protein-4 promotes induction of cardiomyocytes from human embryonic stem cells in serum-based embryoid body development.

    Shunsuke Takei, Hinako Ichikawa, Kohei Johkura, Akimi Mogi, Heesung No, Susumu Yoshie, Daihachiro Tomotsune, Katsunori Sasaki.

    Am J Physiol Heart Circ Physiol   296 ( 6 )   1793 - 1803   2009.6

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  • Localization of Liv2 as an immature hepatocyte marker in EB outgrowth.

    Ikkei Takashimizu, Yoshiki Tanaka, Susumu Yoshie, Yoshiya Kanoh, Hinako Ichikawa, Naoko Ogiwara, Kohei Johkura, Katsunori Sasaki.

    TheScientificWorldJournal   1 ( 9 )   190 - 199   2009.3

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Books

  • Recent Advances in iPSC-Derived Cell Types

    Alexander Birbrair(Application of iPS cell-derived airway epithelial cells for cell-based therapy and disease models)

    ELSEVIER  2021.1 

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    Responsible for pages:121-132   Language:English   Book type:Scholarly book

    Authors name of the chapter and paper which it took charge of:Susumu Yoshie and Akihiro Hazama   Publication place:  

  • Regenerative Medicine and Tissue Engineering.

    (Induce differentiation of ESCs by coculture system.)

    2013  ( ISBN:978-953-51-1108-5

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    Language:English  

    Authors name of the chapter and paper which it took charge of:Fengming Yue, Sakiko Shirasawa, Hinako Ichikawa, Susumu Yoshie, Akimi Mogi, Mika Nagai, Shoko Masuda, Tadayuki Yokoyama, Daihachiro Tomotsune, Katsunori Sasaki.  

  • Advances in Regenerative Medicine.

    (A strategy using pluripotent stem cell-derived hepatocytes for stem cell-based therapies.)

    2011  ( ISBN:978-953-307-732-1

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    Language:English  

    Authors name of the chapter and paper which it took charge of:Daihachiro Tomotsune, Fumi Sato, Susumu Yoshie, Sakiko Shirasawa, Tadayuki Yokoyama, Yoshiya Kanoh, Hinako Ichikawa, Akimi Mogi, Fengming Yue, Katsunori Sasaki.  

Industrial property rights

  • 特定の細胞内に選択的に取り込まれる蛍光色素を利用して多種類の細胞から特定の細胞を純化濃縮する方法

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    Property type:Patent

    Application no:2010-229521  Date applied:2010.10

    Announcement no:2012-80819  Date announced:2012.4

    Patent/Registration no:5845533  Date registered:2015.12  Date issued:2015.12

Research Projects

  • 気道上皮膜輸送体とiPS細胞から明らかにする喘息気道における杯細胞化生の病態解明

    2022.4 - 2025.3

    吉江 進

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    科学研究費補助金 基盤研究(C)

  • ヒトiPS細胞とたばこ煙を利用した杯細胞過形成機構の解明に関する研究

    2021.4 - 2024.3

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    公益財団法人喫煙科学研究財団 若手研究助成

  • iPS細胞を利用した気道リモデリングに伴う杯細胞過形成機構の解明

    2017.10 - 2020.10

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    公益財団法人武田科学振興財団 医学系研究奨励金

  • iPS細胞とたばこ煙を利用した杯細胞過形成機構の解明に関する研究

    2017.4 - 2020.3

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    公益財団法人喫煙科学研究財団 若手研究助成金

  • iPS細胞を利用した杯細胞過形成機構の解明に関する研究

    2017.4 - 2020.3

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    科学研究費補助金 若手研究(B)

  • ヒトiPS細胞を利用した次世代型気管再生技術の開発

    2016.3 - 2017.3

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    公益財団法人上原記念生命科学財団 研究奨励金

  • マウスおよびヒトiPS細胞を用いた頭頸部組織の再生技術開発

    2015.4 - 2017.3

    大森孝一、今泉光雅、吉江 進

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    科学研究費補助金 基盤研究(B)

  • ヒトiPS細胞由来気管軟骨細胞とIn situ Tissue Engineeringを組み合わせた小児気管再生の基盤技術開発に関する研究

    2014.12 - 2015.11

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    公益財団法人母子健康協会 小児医学研究助成金

  • ヒトiPS細胞を用いた気管軟骨への分化誘導に関する研究

    2014.4 - 2017.3

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    科学研究費補助金 若手研究(B)

  • ES細胞、iPS細胞を用いた時空間的制御による肝細胞分化誘導に関する研究

    2011.4 - 2013.3

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    科学研究費補助金 特別研究員奨励費

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