Updated on 2023/12/12

写真a

 
MORI Tsutomu
 
Organization
School of Nursing Department of Human Life Sciences Associate Professor
Title
Associate Professor
Contact information
メールアドレス

Degree

  • 博士(医学) ( その他の授与機関 )

Research Interests

  • Development of the Ab Initio Genetic Orbital Method

  • Identification of a novel immune checkpoint #IKYNU”IR

  • Formulation of the Influential Force

  • Development of infinite dimensional information theory

  • Systems Biology towards the Cell Cycle Control by the NIRF Ubiquitin Ligase

Research Areas

  • Manufacturing Technology (Mechanical Engineering, Electrical and Electronic Engineering, Chemical Engineering) / Biofunction and bioprocess engineering  / Systems Biology

  • Life Science / Molecular biology  / Molecular Biology

  • Life Science / Medical biochemistry  / Medical Chemistry in General

Research History

  • Fukushima Medical University   Associate Professor

    2017.2 - Now

Professional Memberships

  • NIRF Project

    2010.8 - Now

  • 日本トリプトファン研究会

    2023.10 - Now

  • 日本バイオインフォマティクス学会

  • 日本分子生物学会

Committee Memberships

  • NIRF Project   Project Leader  

    2010.8 - Now   

Papers

  • Equivalence Principle of the P-value and Mutual Information

    Tsutomu Mori, Takashi Kawamura

    arXiv   2023.8

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.48550/arXiv.2308.14735

    Other Link : https://doi.org/10.48550/arXiv.2308.14735

  • Alterations of UHRF Family Expression and UHRF1/ICBP90 Inhibits Phosphatase and Tensin Homolog Expression in Endometrial Cancer

    Masafumi Yoshimoto, Aoi Tokuda, Ayami Eguchi, Yoshihiro Nozawa,,Tsutomu Mori, Yuji Yaginuma

    Oncology   2023.6

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    Language:English  

    DOI : 10.1159/000531209

  • Influential Force: from Higgs to the novel immune checkpoint KYNU

    Tsutomu Mori, Takashi Kawamura, Daisuke D. Ikeda, Susumu Goyama, Hiroshi Haeno, Kazuhiko Ikeda, Katsue Adachi, Yoshihiko Saito, Tomoyoshi Horisawa, Junzo Suzuki, Seiichi Takenoshita

    Jxiv   2022.9

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.51094/jxiv.156

  • NIRF研究会報告「情報と確率の等価性原理」

    森 努

    福島県立医科大学看護学部紀要   25   31 - 41   2023.3

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    Language:Japanese  

  • Gene expression profile and injury sites in mice treated with Shiga toxin 2 and lipopolysaccharide as a Shiga toxin-associated hemolytic uremic syndrome model.

    Kume Y, Go H, Maeda R, Suyama K, Mori T, Kawasaki Y, Hashimoto K, Hosoya M

    Physiological genomics   54 ( 5 )   153 - 165   2022.5( ISSN:1094-8341

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1152/physiolgenomics.00124.2021

    PubMed

  • NIRF/UHRF2 occupies a central position in the cell cycle network and allows coupling with the epigenetic landscape

    Tsutomu Mori, Daisuke D. Ikeda, Yoshiki Yamaguchi, Motoko Unoki, and NIRF Project

    FEBS Letters   586 ( 11 )   1570 - 1583   2012.4

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    Language:English   Publishing type:Research paper (other academic)  

    DOI : 10.1016/j.febslet.2012.04.038

    Other Link : http://www.sciencedirect.com/science/article/pii/S0014579312003274

  • NIRF Research Group Report: Invitation to Information Biology

    Tsutomu Mori

    Bulletin of Faculty of Nursing, Fukushima Medical University   24   21 - 28   2022.3( ISSN:1344-6975

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    Language:Japanese   Publishing type:Research paper (conference, symposium, etc.)  

  • NIRF constitutes a nodal point in the cell cycle network and is a candidate tumor suppressor

    Tsutomu Mori, Daisuke D. Ikeda, Toshihiko Fukushima, Seiichi Takenoshita, Hideo Kochi

    Cell Cycle   10 ( 19 )   2011.10

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    Language:English   Publishing type:Research paper (other academic)  

    Other Link : http://www.landesbioscience.com/journals/6/article/17176/

  • Detailed Postmortem Profiling of Inflammatory Mediators Expression Revealed Post-inflammatory Alternation in the Superior Temporal Gyrus of Schizophrenia

    Ryuta Izumi,Mizuki Hino,Akira Wada,Atsuko Nagaoka,Takashi Kawamura,Tsutomu Mori,Makoto Sainouchi,Akiyoshi Kakita,Kiyoto Kasai,Yasuto Kunii, and Hirooki Yabe

    Frontiers in Psychiatry   12   2021.3( ISSN:1664-0640

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.3389/fpsyt.2021.653821

  • Antiproliferative Effects of Short-chain Fatty Acids on Human Colorectal Cancer Cells via Gene Expression Inhibition.

    Ohara Tadashi, Tsutomu Mori

    Anticancer Research   2019 ( 39 )   4659 - 4666   2019( ISSN:0250-7005

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    Language:English   Publishing type:Research paper (scientific journal)  

    Other Link : https://ar.iiarjournals.org/content/39/9/4659.short

  • ヒト大腸癌培養細胞における短鎖脂肪酸の抗腫瘍効果と作用機序

    大原 正志, 安藤 俊夫, 河村 隆, 森 努, 錫谷 達夫

    消化と吸収   39 ( 2 )   107 - 112   2017.5( ISSN:0389-3626

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Ex vivo Pretreatment of Islets with Mitomycin C: Reduction in Immunogenic Potential of Islets by Suppressing Secretion of Multiple Chemotactic Factors.

    Sato N, Haga J, Anazawa T, Kenjo A, Kimura T, Wada I, Mori T, Marubashi S, Gotoh M

    Cell transplantation   26 ( 8 )   1392 - 1404   2017.8( ISSN:0963-6897

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1177/0963689717721233

    PubMed

  • Hmga2 collaborates with JAK2V617F in the development of myeloproliferative neoplasms

    Ueda koki, Ikeda Kazuhiko, Mori Tsutomu, et al

    Blood Advances   1 ( 15 )   1001 - 1015   2017.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1182/bloodadvances.2017004457

  • NIRF is a ubiquitin ligase that is capable of ubiquitinating PCNP, a PEST-containing nuclear protein.

    FEBS Letters   557 ( 1-3 )   209 - 214   2004( ISSN:0014-5793

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    Publishing type:Research paper (other academic)  

  • Characterization of autoantibodies against the E1α subunit of branched-chain 2-oxo acid dehydrogenase in patients with primary biliary cirrhosis

    Tsutomu Mori, Hiromasa Ohira, Masahito Kuroda, Masaki Kato, Yoshiki Yamaguchi, and Hideo Kochi

    International Journal of Hepatology   2012   Article ID 369740   2012

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    Language:English   Publishing type:Research paper (other academic)  

    DOI : 10.1155/2012/369740

    Other Link : http://www.hindawi.com/journals/ijhep/2012/369740/

  • NIRF induces G1 arrest and associates with Cdk2.

    Li Y, Mori T, Hata H, Homma Y, Kochi H

    Biochem Biophys Res Commun.   319 ( 2 )   464 - 468   2004.6

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    Language:English   Publishing type:Research paper (other academic)  

  • Epitope mapping on E1α subunit of pyruvate dehydrogenase complex with autoantibodies of patients with primary biliary cirrhosis

    Liver International   23 ( 5 )   355 - 362   2003( ISSN:1478-3223

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    Publishing type:Research paper (other academic)  

  • NIRF, a novel RING finger protein, is involved in cell-cycle regulation

    Biochem Biophys Res Commun.   296 ( 3 )   530 - 536   2002( ISSN:0006-291X

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    Publishing type:Research paper (other academic)  

  • Autoantibodies of sera from patients with primary biliary cirrhosis recognize the alpha subunit of the decarboxylase component of human branched-chain 2-oxo acid dehydrogenase complex.

    J Hepatol   34 ( 6 )   799 - 804   2001( ISSN:0168-8278

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    Publishing type:Research paper (other academic)  

  • cDNA cloning of the chicken branched-chain alpha-keto acid dehydrogenase complex. Chicken-specific residues of the acyltransferase affect the overall activity and the interaction with the dehydrogenase.

    Eur J Biochem   268 ( 3 )   727 - 36   2001( ISSN:0014-2956

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    Publishing type:Research paper (other academic)  

  • Autoantigens recognized by anti-mitochondrial autoantibodies

    Jpn J Clin Chem   29 ( 4 )   162 - 168   2000( ISSN:0370-5633

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    Publishing type:Research paper (other academic)  

  • Binding properties of the components of branched-chain 2-oxo acid dehydrogenase complex on ELISA.

    Journal of Biochemistry   116 ( 5 )   1111 - 1116   1994

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    Publishing type:Research paper (other academic)  

  • Both induction and activation of the branched-chain 2-oxo acid dehydrogenase complex in primary-cultured rat hepatocytes by clofibrate.

    Journal of Biochemistry   109 ( 6 )   822 - 827   1991

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    Publishing type:Research paper (other academic)  

  • Control of the activity of branched-chain α-keto acid dehydrogenase complex in primary cultured rat hepatocytes.

    Fukushima Journal of Medical Science   35 ( 1 )   19 - 27   1989

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    Publishing type:Research paper (other academic)  

  • Linear epitope mapping on Elα of pyruvate dehydrogenase complex with autoantibodies in primary biliary cirrhosis.

    24   206   1994

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    Publishing type:Research paper (other academic)  

  • Regulation by induction of branched-chain 2-oxo acid dehydrogenase complex in clofibrate-fed rat liver

    Ono K, Shioya H, Hakozaki M, Honda K, Mori T, Kochi H

    Biochemical and Biophysical Research Communications   172 ( 1 )   243 - 248   1990

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    Language:English   Publishing type:Research paper (other academic)  

  • 遺伝子発現阻害を介したヒト大腸癌細胞に対する短鎖脂肪酸の抗増殖効果(Antiproliferative Effects of Short-chain Fatty Acids on Human Colorectal Cancer Cells via Gene Expression Inhibition)

    Ohara Tadashi, Mori Tsutomu

    Archives of Kohno Clinical Medicine Research Institute   35   61 - 68   2020.4( ISSN:0912-9413

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    Language:English   Publishing type:Research paper (scientific journal)  

  • NIRF研究会活動報告 : 一筋の光明

    森 努

    福島県立医科大学看護学部紀要   18   41 - 42   2016.3( ISSN:13446975

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Expression of activation-induced cytidine deaminase enhances the clearance of pneumococcal pneumonia: evidence of a subpopulation of protective anti-pneumococcal B1a cells.

    Yamamoto N, Kerfoot SM, Hutchinson AT, Dela Cruz CS, Nakazawa N, Szczepanik M, Majewska-Szczepanik M, Nazimek K, Ohana N, Bryniarski K, Mori T, Muramatsu M, Kanemitsu K, Askenase PW

    Immunology   147 ( 1 )   97 - 113   2016.1( ISSN:0019-2805

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1111/imm.12544

    PubMed

  • Immunohistochemical analysis-based proteomic subclassification of newly diagnosed glioblastomas

    Motomura, Kazuya; Natsume, Atsushi; Watanabe, Reiko; Ito, Ichiro; Kato, Yukinari; Momota, Hiroyuki; Nishikawa, Ryo; Mishima, Kazuhiko; Nakasu, Yoko; Abe, Tatsuya; Namba, Hiroki; Nakazato, Yoichi; Tashiro, Hiroshi; Takeuchi, Ichiro; Mori, Tsutomu; Wakabayashi, Toshihiko

    Cancer Science   103 ( 10 )   1871 - 1879   2012.10

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    Language:English   Publishing type:Research paper (other academic)  

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Presentations

  • The influential force: its formulation and applications

    2023.10  

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    Event date: 2023.10

  • 情報と確率の等価性原理

    福島医学会学術研究集会   2023.5  

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    Event date: 2023.5

  • Discovery of a novel immune checkpoint KYNU/kynureninase by the Ab initio genetic orbital method

    Fukushima Medical Society Academic Research Meeting  

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    Event date: 2022.10

  • Identification of a Novel Immune Checkpoint KYNU by the Ab Initio Genetic Orbital Method

    Annual Meeting of the Japanese Cancer Association   2023.9  

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    Event date: 2023.9

  • Discovery of a Novel Immune Checkpoint KYNU by the Ab Initio Genetic Orbital Method

    IIBMP2023   2023.9  

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    Event date: 2023.9

  • Ab initio遺伝子軌道法による新規免疫チェックポイントKYNUの同定

    第42回日本トリプトファン研究会学術集会   2023.12  

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    Event date: 2023.12

  • STAIC - An informatic tool for a comprehensive analysis of novel cancer genes

    BMB2015  

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    Event date: 2015.12

  • 戦略的がん遺伝子解析ツールSTAIC:癌関連遺伝子の新規同定のために

    第74回日本癌学会学術総会  

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    Event date: 2015.10

  • 戦略的がん遺伝子解析ツールSTAIC:癌関連遺伝子の新規同定のために

    第74回日本癌学会学術総会  

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    Event date: 2015.10

  • STAIC - An informatic tool for a comprehensive analysis of novel cancer genes

    BMB2015  

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    Event date: 2015

  • STAIC - An informatic tool for a comprehensive analysis of novel cancer genes

    第38回日本分子生物学会年会、第88回日本生化学会大会 合同大会  

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    Event date: 2015

  • 戦略的がん遺伝子解析ツールSTAIC:癌関連遺伝子の新規同定のために

    第74回日本癌学会学術総会  

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    Event date: 2015

  • STAIC - An informatic tool for a comprehensive analysis of novel cancer genes

    BMB2015  

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    Event date: 2015

  • NIRF/UHRF2 occupies a central position between the cell cycle network and the epigenetic machinery, and is a candidate tumor suppressor

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    Event date: 2012.12

  • NIRF/UHRF2 occupies a central position in the cell cycle network

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    Event date: 2012.11

  • NIRF/UHRF2 occupies a central position in the cell cycle network and allows coupling with the epigenetic landscape

    NIRF Project Symposium  

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    Event date: 2012.8

  • 動物界におけるNIRFの中心性

    NIRFプロジェクト定例第3回研究会  

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    Event date: 2011.9

  • A systems biology approach to the NIRF interaction network.

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    Event date: 2011.7

  • NIRFプロジェクトの現状と課題 〜データベースの利用について〜

    NIRFプロジェクト定例第2回研究会  

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    Event date: 2010.12

  • PBC患者抗BCOADC-E1α抗体のエピトープ解析

    第21回「The Meeting of Liver and Immunology」  

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    Event date: 2010.9

  • Cancer Outlier Profile Analysis of NIRF in Cancer Database

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    Event date: 2010.7

  • 細胞周期制御因子NIRFのCancer Outlier Profile Analysis (COPA)解析

    福島医学会学術研究集会  

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    Event date: 2010.5

  • The NIRF Ubiquitin Ligase Interacts With the Cell-Cycle Machinery and Induces Cell Cycle Arrest

    Greehey CCRI Symposium  

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    Event date: 2009.2

  • NIRF constitutes a nodal point in cell-cycle regulation

    BIochemistry and Molecular Biology 2007  

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    Event date: 2007.12

  • ユビキチンリガーゼNIRFによる細胞周期制御機構

    日本生化学会東北支部・第73例会  

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    Event date: 2007.5

  • NIRF constitutes a nodal point in cell-cycle regulation.

    The 46th Annual Meeting of the American Society for Cell Biology  

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    Event date: 2006.12

  • NIRF is a multi-functional ubiquitin ligase that induces cell-cycle arrest via ubiquitination of cyclin D1.

    20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress.  

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    Event date: 2006.6

  • NIRF induces cell-cycle arrest via ubiquitination of cyclin D1.

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    Event date: 2006.5

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Industrial property rights

  • 相互依存性の特定方法

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    Property type:Patent

    Application no:特願2019-509406  Date applied:2017.3

    Publication no:WO2018/181988  Date published:2018.10

    Patent/Registration no:特許第6820621号  Date registered:2021.1  Date issued:2021.1

  • 肺癌の予後バイオマーカー

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    Property type:Patent

    Application no:特願2020-532429  Date applied:2019.7

    Announcement no:特許第7114112  Date announced:2022.7

    Patent/Registration no:特許7114112号  Date registered:2022.7  Date issued:2022.7