Organization
School of Nursing Department of Human Life Sciences Associate Professor
Title
Associate Professor
Contact information
Homepage
MORI Tsutomu
Degree
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博士(医学) ( その他の授与機関 )
Research Interests
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Development of the Ab Initio Genetic Orbital Method
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Identification of a novel immune checkpoint ＃IKYNU”IR
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Formulation of the Influential Force
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Development of infinite dimensional information theory
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Systems Biology towards the Cell Cycle Control by the NIRF Ubiquitin Ligase
Research Areas
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Manufacturing Technology (Mechanical Engineering, Electrical and Electronic Engineering, Chemical Engineering) / Biofunction and bioprocess engineering / Systems Biology
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Life Science / Molecular biology / Molecular Biology
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Life Science / Medical biochemistry / Medical Chemistry in General
Research History
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Fukushima Medical University Associate Professor
2017.2 - Now
Professional Memberships
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NIRF Project
2010.8 - Now
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日本トリプトファン研究会
2023.10 - Now
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日本バイオインフォマティクス学会
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日本分子生物学会
Committee Memberships
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NIRF Project Project Leader
2010.8 - Now
Papers
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Masafumi Yoshimoto, Aoi Tokuda, Ayami Eguchi, Yoshihiro Nozawa, Tsutomu Mori, Yuji Yaginuma
Experimental Cell Research 437 ( 2 ) 114018 2024.4（ ISSN:0014-4827 ）
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Influential Force: from Higgs to the novel immune checkpoint KYNU
Tsutomu Mori, Takashi Kawamura, Daisuke D. Ikeda, Susumu Goyama, Hiroshi Haeno, Kazuhiko Ikeda, Katsue Adachi, Yoshihiko Saito, Tomoyoshi Horisawa, Junzo Suzuki, Seiichi Takenoshita
Jxiv 2022.9
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Equivalence Principle of the P-value and Mutual Information
Tsutomu Mori, Takashi Kawamura
arXiv 2023.8
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Impaired Repopulating Ability of Uhrf2-/- Hematopoietic Progenitor Cells in Mice
Takahiro Sano, Koki Ueda, Keiji Minakawa, Tsutomu Mori, Yuko Hashimoto, Haruhiko Koseki, Yasuchika Takeishi, Kazuhiko Ikeda, and Takayuki Ikezoe
Genes 2023 ( 14 ) 1531 2023.7
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Masafumi Yoshimoto, Aoi Tokuda, Ayami Eguchi, Yoshihiro Nozawa,,Tsutomu Mori, Yuji Yaginuma
Oncology 2023.6
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NIRF研究会報告「情報と確率の等価性原理」
森 努
福島県立医科大学看護学部紀要 25 31 - 41 2023.3
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NIRF/UHRF2 occupies a central position in the cell cycle network and allows coupling with the epigenetic landscape
Tsutomu Mori, Daisuke D. Ikeda, Yoshiki Yamaguchi, Motoko Unoki, and NIRF Project
FEBS Letters 586 ( 11 ) 1570 - 1583 2012.4
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NIRF constitutes a nodal point in the cell cycle network and is a candidate tumor suppressor
Tsutomu Mori, Daisuke D. Ikeda, Toshihiko Fukushima, Seiichi Takenoshita, Hideo Kochi
Cell Cycle 10 ( 19 ) 2011.10
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Kume Y, Go H, Maeda R, Suyama K, Mori T, Kawasaki Y, Hashimoto K, Hosoya M
Physiological genomics 54 ( 5 ) 153 - 165 2022.5（ ISSN:1094-8341 ）
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NIRF Research Group Report: Invitation to Information Biology
Tsutomu Mori
Bulletin of Faculty of Nursing, Fukushima Medical University 24 21 - 28 2022.3（ ISSN:1344-6975 ）
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Characterization of autoantibodies against the E1α subunit of branched-chain 2-oxo acid dehydrogenase in patients with primary biliary cirrhosis
Tsutomu Mori, Hiromasa Ohira, Masahito Kuroda, Masaki Kato, Yoshiki Yamaguchi, and Hideo Kochi
International Journal of Hepatology 2012 Article ID 369740 2012
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NIRF induces G1 arrest and associates with Cdk2.
Li Y, Mori T, Hata H, Homma Y, Kochi H
Biochem Biophys Res Commun. 319 ( 2 ) 464 - 468 2004.6
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Ryuta Izumi,Mizuki Hino,Akira Wada,Atsuko Nagaoka,Takashi Kawamura,Tsutomu Mori,Makoto Sainouchi,Akiyoshi Kakita,Kiyoto Kasai,Yasuto Kunii, and Hirooki Yabe
Frontiers in Psychiatry 12 2021.3（ ISSN:1664-0640 ）
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Epitope mapping on E1α subunit of pyruvate dehydrogenase complex with autoantibodies of patients with primary biliary cirrhosis
Liver International 23 ( 5 ) 355 - 362 2003（ ISSN:1478-3223 ）
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NIRF, a novel RING finger protein, is involved in cell-cycle regulation
Biochem Biophys Res Commun. 296 ( 3 ) 530 - 536 2002（ ISSN:0006-291X ）
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Antiproliferative Effects of Short-chain Fatty Acids on Human Colorectal Cancer Cells via Gene Expression Inhibition.
Ohara Tadashi, Tsutomu Mori
Anticancer Research 2019 ( 39 ) 4659 - 4666 2019（ ISSN:0250-7005 ）
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Sato N, Haga J, Anazawa T, Kenjo A, Kimura T, Wada I, Mori T, Marubashi S, Gotoh M
Cell transplantation 26 ( 8 ) 1392 - 1404 2017.8（ ISSN:0963-6897 ）
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Hmga2 collaborates with JAK2V617F in the development of myeloproliferative neoplasms
Ueda koki, Ikeda Kazuhiko, Mori Tsutomu, et al
Blood Advances 1 ( 15 ) 1001 - 1015 2017.5
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NIRF is a ubiquitin ligase that is capable of ubiquitinating PCNP, a PEST-containing nuclear protein.
FEBS Letters 557 ( 1-3 ) 209 - 214 2004（ ISSN:0014-5793 ）
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Autoantibodies of sera from patients with primary biliary cirrhosis recognize the alpha subunit of the decarboxylase component of human branched-chain 2-oxo acid dehydrogenase complex.
J Hepatol 34 ( 6 ) 799 - 804 2001（ ISSN:0168-8278 ）
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ヒト大腸癌培養細胞における短鎖脂肪酸の抗腫瘍効果と作用機序
大原 正志, 安藤 俊夫, 河村 隆, 森 努, 錫谷 達夫
消化と吸収 39 ( 2 ) 107 - 112 2017.5（ ISSN:0389-3626 ）
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cDNA cloning of the chicken branched-chain alpha-keto acid dehydrogenase complex. Chicken-specific residues of the acyltransferase affect the overall activity and the interaction with the dehydrogenase.
Eur J Biochem 268 ( 3 ) 727 - 36 2001（ ISSN:0014-2956 ）
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Autoantigens recognized by anti-mitochondrial autoantibodies
Jpn J Clin Chem 29 ( 4 ) 162 - 168 2000（ ISSN:0370-5633 ）
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Binding properties of the components of branched-chain 2-oxo acid dehydrogenase complex on ELISA.
Journal of Biochemistry 116 ( 5 ) 1111 - 1116 1994
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Both induction and activation of the branched-chain 2-oxo acid dehydrogenase complex in primary-cultured rat hepatocytes by clofibrate.
Journal of Biochemistry 109 ( 6 ) 822 - 827 1991
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Control of the activity of branched-chain α-keto acid dehydrogenase complex in primary cultured rat hepatocytes.
Fukushima Journal of Medical Science 35 ( 1 ) 19 - 27 1989
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Linear epitope mapping on Elα of pyruvate dehydrogenase complex with autoantibodies in primary biliary cirrhosis.
24 206 1994
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Regulation by induction of branched-chain 2-oxo acid dehydrogenase complex in clofibrate-fed rat liver
Ono K, Shioya H, Hakozaki M, Honda K, Mori T, Kochi H
Biochemical and Biophysical Research Communications 172 ( 1 ) 243 - 248 1990
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遺伝子発現阻害を介したヒト大腸癌細胞に対する短鎖脂肪酸の抗増殖効果(Antiproliferative Effects of Short-chain Fatty Acids on Human Colorectal Cancer Cells via Gene Expression Inhibition)
Ohara Tadashi, Mori Tsutomu
Archives of Kohno Clinical Medicine Research Institute 35 61 - 68 2020.4（ ISSN:0912-9413 ）
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森 努
福島県立医科大学看護学部紀要 18 41 - 42 2016.3（ ISSN:13446975 ）
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Yamamoto N, Kerfoot SM, Hutchinson AT, Dela Cruz CS, Nakazawa N, Szczepanik M, Majewska-Szczepanik M, Nazimek K, Ohana N, Bryniarski K, Mori T, Muramatsu M, Kanemitsu K, Askenase PW
Immunology 147 ( 1 ) 97 - 113 2016.1（ ISSN:0019-2805 ）
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Immunohistochemical analysis-based proteomic subclassification of newly diagnosed glioblastomas
Motomura, Kazuya; Natsume, Atsushi; Watanabe, Reiko; Ito, Ichiro; Kato, Yukinari; Momota, Hiroyuki; Nishikawa, Ryo; Mishima, Kazuhiko; Nakasu, Yoko; Abe, Tatsuya; Namba, Hiroki; Nakazato, Yoichi; Tashiro, Hiroshi; Takeuchi, Ichiro; Mori, Tsutomu; Wakabayashi, Toshihiko
Cancer Science 103 ( 10 ) 1871 - 1879 2012.10
Presentations
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Comprehensive identification of novel immune checkpoints by the ab initio network expander
2024.5
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Discovery of immune checkpoints by the ab initio network expander: Identification and functional analysis of Tim-3
2024.5
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Identification of a Novel Immune Checkpoint KYNU by the Ab Initio Genetic Orbital Method
Annual Meeting of the Japanese Cancer Association 2023.9
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Discovery of a Novel Immune Checkpoint KYNU by the Ab Initio Genetic Orbital Method
IIBMP2023 2023.9
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Discovery of a novel immune checkpoint KYNU/kynureninase by the Ab initio genetic orbital method
Fukushima Medical Society Academic Research Meeting
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The influential force: its formulation and applications
2023.10
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情報と確率の等価性原理
福島医学会学術研究集会 2023.5
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研究実践により得られた成果
My Premiumを語る会 2023.12
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Ab initio遺伝子軌道法による新規免疫チェックポイントKYNUの同定
第42回日本トリプトファン研究会学術集会 2023.12
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STAIC - An informatic tool for a comprehensive analysis of novel cancer genes
BMB2015
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戦略的がん遺伝子解析ツールSTAIC：癌関連遺伝子の新規同定のために
第74回日本癌学会学術総会
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戦略的がん遺伝子解析ツールSTAIC：癌関連遺伝子の新規同定のために
第74回日本癌学会学術総会
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STAIC - An informatic tool for a comprehensive analysis of novel cancer genes
BMB2015
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戦略的がん遺伝子解析ツールSTAIC：癌関連遺伝子の新規同定のために
第74回日本癌学会学術総会
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STAIC - An informatic tool for a comprehensive analysis of novel cancer genes
BMB2015
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STAIC - An informatic tool for a comprehensive analysis of novel cancer genes
第38回日本分子生物学会年会、第88回日本生化学会大会 合同大会
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NIRF/UHRF2 occupies a central position between the cell cycle network and the epigenetic machinery, and is a candidate tumor suppressor
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NIRF/UHRF2 occupies a central position in the cell cycle network
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NIRF/UHRF2 occupies a central position in the cell cycle network and allows coupling with the epigenetic landscape
NIRF Project Symposium
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動物界におけるNIRFの中心性
NIRFプロジェクト定例第３回研究会
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A systems biology approach to the NIRF interaction network.
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NIRFプロジェクトの現状と課題 〜データベースの利用について〜
NIRFプロジェクト定例第２回研究会
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PBC患者抗BCOADC-E1α抗体のエピトープ解析
第２１回「The Meeting of Liver and Immunology」
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Cancer Outlier Profile Analysis of NIRF in Cancer Database
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細胞周期制御因子NIRFのCancer Outlier Profile Analysis (COPA)解析
福島医学会学術研究集会
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The NIRF Ubiquitin Ligase Interacts With the Cell-Cycle Machinery and Induces Cell Cycle Arrest
Greehey CCRI Symposium
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NIRF constitutes a nodal point in cell-cycle regulation
BIochemistry and Molecular Biology 2007
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ユビキチンリガーゼNIRFによる細胞周期制御機構
日本生化学会東北支部・第73例会
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NIRF constitutes a nodal point in cell-cycle regulation.
The 46th Annual Meeting of the American Society for Cell Biology
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NIRF is a multi-functional ubiquitin ligase that induces cell-cycle arrest via ubiquitination of cyclin D1.
20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress.
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NIRF induces cell-cycle arrest via ubiquitination of cyclin D1.
Industrial property rights
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相互依存性の特定方法
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肺癌の予後バイオマーカー