Updated on 2023/11/16

写真a

 
SEKIMATA Masayuki
 
Organization
Research Facility Attached to the School of Medicine Radioisotope Center Associate Professor
Title
Associate Professor
Contact information
メールアドレス

Degree

  • 博士(医学) ( 東京大学 )

Research Interests

  • Molecular Cell Biology

Research Areas

  • Life Science / Functional biochemistry  / Functional Biochemistry

Research History

  • Fukushima Medical University   Associate Professor

    2017.2 - Now

Qualification acquired

  • 第1種放射線取扱主任者

Papers

  • Involvement of a novel zinc finger protein, MIZF, in transcriptional repression by interacting with a methyl-CpG-binding protein, MBD2

    J. of Biological Chemistry   276 ( 46 )   42632 - 42638   2001

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    Publishing type:Research paper (other academic)  

  • Morphological Changes and Detachment of Adherent cells Induced by P122, a GTPase-activating Protein for Rho

    The Journal of Biological Chemistry   274 ( 25 )   17757   1999

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    Publishing type:Research paper (other academic)  

  • Detection of Protein Kinase Activity Specifically Activated at Metaphase-Anaphase Transition

    Journal of cell Biology   132 ( 4 )   635   1996

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    Publishing type:Research paper (other academic)  

  • Essential Role of Phospholipase C-(]G6777[)2 in B Cell Development and Function

    The Journal of Immunology   165 ( 4 )   1738 - 1742   2000

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    Publishing type:Research paper (other academic)  

  • Isolation of human minor histocompatibility peptiteds

    International Immunology   4 ( 2 )   301   1992

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    Publishing type:Research paper (other academic)  

  • Different effects of Substitutions at Residues 224 and 228 of MHC class Ⅰ on the Recognition of CD8

    The Journal of Immunology   150 ( 10 )   4416   1993

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    Publishing type:Research paper (other academic)  

  • The complex formation of MASP-3 with pattern recognition molecules of the lectin complement pathway retains MASP-3 in the circulation.

    Kusakari K, Machida T, Ishida Y, Omori T, Suzuki T, Sekimata M, Wada I, Fujita T, Sekine H

    Frontiers in immunology   13   907023   2022

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    Language:English  

    DOI : 10.3389/fimmu.2022.907023

    PubMed

  • Deletion of PIN4 Suppresses the Protein Transport Defects Caused by sec12-4 Mutation in Saccharomyces cerevisiae.

    Murakami-Sekimata A, Sekimata M, Sato N, Hayasaka Y, Nakano A

    Microbial physiology   30 ( 1-6 )   25 - 35   2020( ISSN:2673-1665

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1159/000509633

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  • Cutting edge: Role of MASP-3 in the physiological activation of factor D of the alternative complement pathway

    Hayashi M., Machida T., Ishida Y., Ogata Y., Omori T., Takasumi M., Endo Y., Suzuki T., Sekimata M., Homma Y., Ikawa M., Ohira H., Fujita T., Sekine H.

    Journal of Immunology   203 ( 6 )   1411 - 1416   2019.9( ISSN:00221767

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.4049/jimmunol.1900605

  • Runx1 and ROrgt cooperate to upregulate IL-22 expression in Th cells through its distal enhancer

    Sekimata M., Yoshida D., Araki A., Asao H., Iseki K., Murakami-Sekimata A.

    Journal of Immunology   202 ( 11 )   3198 - 3210   2019.6( ISSN:00221767

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.4049/jimmunol.1800672

  • マウス胎児顎下腺上皮細胞の初代培養におけるSerum ReplacementとRho-associated protein kinase阻害剤Y-27632の効果

    推名 祐美, 本間 千明, 阿蘓 裕子, 柳橋 志帆, 関亦 正幸, 関亦 明子

    山形医学   36 ( 2 )   98 - 105   2018.8( ISSN:0288-030X

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    Language:English   Publishing type:Research paper (scientific journal)  

  • The effects of neuregulin 1 and/or fibroblast growth fctor 1 on the differentiation of mouse embryonic submandibular gland ex vivo culture cells

    Hayasaka Yuto, Nogawa Hiroyuki, Sekimata Masayuki, Murakami-Sekimata Akiko

    Bulletin of Yamagata University (Medical Science)   34 ( 2 )   42 - 49   2016.9

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    Language:Japanese   Publishing type:Research paper (bulletin of university, research institution)  

  • The effects of neuregulin 1 and/or fibroblast growth fctor 1 on the differentiation of mouse embryonic submandibular gland ex vivo culture cells

    Hayasaka Yuto, Nogawa Hiroyuki, Sekimata Masayuki, Murakami-Sekimata Akiko

    Bulletin of Yamagata University (Medical Science)   34 ( 2 )   42 - 49   2016.9

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    Language:English   Publishing type:Research paper (scientific journal)  

  • The effects of neuregulin 1 and/or fibroblast growth fctor 1 on the differentiation of mouse embryonic submandibular gland ex vivo culture cells

    Hayasaka Yuto, Nogawa Hiroyuki, Sekimata Masayuki, Murakami-Sekimata Akiko

    Bulletin of Yamagata University (Medical Science)   34 ( 2 )   42 - 49   2016.9

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    Language:English   Publishing type:Research paper (scientific journal)  

  • The effects of neuregulin 1 and/or fibroblast growth fctor 1 on the differentiation of mouse embryonic submandibular gland ex vivo culture cells

    Hayasaka Yuto, Nogawa Hiroyuki, Sekimata Masayuki, Murakami-Sekimata Akiko

    Bulletin of Yamagata University (Medical Science)   34 ( 2 )   42 - 49   2016.9

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    Language:English   Publishing type:Research paper (scientific journal)  

  • マウス胎児唾液腺上皮組織の体外培養におけるneuregulin 1とfibroblast growth factor 1の細胞分化への作用

    早坂 勇人, 野川 宏幸, 関亦 正幸, 関亦 明子

    山形医学   34 ( 2 )   42 - 49   2016.8( ISSN:0288-030X

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    Language:English   Publishing type:Research paper (scientific journal)  

  • CpG methylation prevents YY1-mediated transcriptional activation of the vimentin promoter

    Sekimata M, Murakami-Sekimata A, Homma Y

    Biochem Biophys Res Commun   414 ( 4 )   767 - 772   2011.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1016/j.bbrc.2011.09.155

  • CCCTC-binding factor and the transcription factor T-bet orchestrate T helper 1 cell-specific structure and function at the interferon-gamma locus

    Sekimata M, Pérez-Melgosa M, Miller SA, Weinmann AS, Sabo PJ, Sandstrom R, Dorschner MO, Stamatoyannopoulos JA, Wilson CB

    Immunity   31 ( 4 )   551 - 564   2009.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1016/j.immuni.2009.08.021

  • Epigenetic control of T-helper-cell differentiation

    Wilson CB, Rowell E, Sekimata M

    Nat Rev Immunol   9 ( 2 )   91 - 105   2009.2

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Epigenetic control of T-helper-cell differentiation.

    Wilson CB, Rowell E, Sekimata M

    Nature reviews. Immunology   9 ( 2 )   91 - 105   2009.2( ISSN:1474-1733

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1038/nri2487

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  • Comprehensive epigenetic profiling identifies multiple distal regulatory elements directing transcription of the gene encoding interferon-gamma

    Schoenborn JR, Dorschner MO, Sekimata M, Santer DM, Shnyreva M, Fitzpatrick DR, Stamatoyannopoulos JA, Wilson CB

    Nat Immunol   8 ( 7 )   732 - 742   2007.7

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Comprehensive epigenetic profiling identifies multiple distal regulatory elements directing transcription of the gene encoding interferon-gamma.

    Schoenborn JR, Dorschner MO, Sekimata M, Santer DM, Shnyreva M, Fitzpatrick DR, Stamatoyannopoulos JA, Wilson CB

    Nature immunology   8 ( 7 )   732 - 42   2007.7( ISSN:1529-2908

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1038/ni1474

    PubMed

  • Negative regulation of CD8 expression via Cd8 enhancer-mediated recruitment of the zinc finger protein MAZR.

    Bilic I, Koesters C, Unger B, Sekimata M, Hertweck A, Maschek R, Wilson CB, Ellmeier W

    Nature immunology   7 ( 4 )   392 - 400   2006.4( ISSN:1529-2908

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1038/ni1311

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  • Involvement of poly(ADP-ribose) polymerase 1 in ERBB2 expression in rheumatoid synovial cells.

    Kitamura T, Sekimata M, Kikuchi S, Homma Y

    American journal of physiology. Cell physiology   289 ( 1 )   C82 - 8   2005.7( ISSN:0363-6143

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1152/ajpcell.00486.2004

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  • Regulation of Rb gene expression by an MBD2-interacting zinc finger protein MIZF during myogenic differentiation.

    Sekimata M, Homma Y

    Biochemical and biophysical research communications   325 ( 3 )   653 - 9   2004.12( ISSN:0006-291X

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1016/j.bbrc.2004.10.090

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  • A PLCdelta1-binding protein, p122/RhoGAP, is localized in caveolin-enriched membrane domains and regulates caveolin internalization.

    Yamaga M, Sekimata M, Fujii M, Kawai K, Kamata H, Hirata H, Homma Y, Yagisawa H

    Genes to cells : devoted to molecular & cellular mechanisms   9 ( 1 )   25 - 37   2004.1( ISSN:1356-9597

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1111/j.1356-9597.2004.00698.x

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  • Sequence-specific transcriptional repression by an MBD2-interacting zinc finger protein MIZF.

    Sekimata M, Homma Y

    Nucleic acids research   32 ( 2 )   590 - 7   2004( ISSN:0305-1048

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1093/nar/gkh249

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  • An invasion-independent pathway of blood-borne metastasis: a new murine mammary tumor model.

    Sugino T, Kusakabe T, Hoshi N, Yamaguchi T, Kawaguchi T, Goodison S, Sekimata M, Homma Y, Suzuki T

    The American journal of pathology   160 ( 6 )   1973 - 80   2002.6( ISSN:0002-9440

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1016/S0002-9440(10)61147-9

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  • Enhanced activity of variant phospholipase C-delta1 protein (R257H) detected in patients with coronary artery spasm.

    Nakano T, Osanai T, Tomita H, Sekimata M, Homma Y, Okumura K

    Circulation   105 ( 17 )   2024 - 9   2002.4( ISSN:0009-7322

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1161/01.cir.0000014613.36469.3f

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Presentations

  • IFN-gamma 遺伝子座のクロマチン構造形成と転写制御におけるCTCF-コヒーシン結合 領域の機能

    第41回日本分子生物学会年会  

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    Event date: 2018.11

  • 唾液腺保護ケア開発を目指したマウス唾液腺上皮細胞の培養における低分子化合物の効果について

    第 6 回看護理工学会学術集会  

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    Event date: 2018.10

  • Serum Replacement and Rho kinase (ROCK) inhibitor, Y-27632 were essential for the monolayer culture of mouse embryonic submandibular gland epithelial cells in serum-free medium.

    第70回日本細胞生物学会年会  

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    Event date: 2018.6

  • インターロイキン9(IL9)遺伝子サイレンサーと転写因子Runx1によるエピジェネティックなIL9転写調節機構の解明

    第40回日本分子生物学会年会  

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    Event date: 2017.12

  • インターロイキン9(IL9)遺伝子サイレンサーと転写因子Runx1によるエピジェネティックなIL9転写調節機構の解明

    第40回日本分子生物学会年会  

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    Event date: 2017.12

  • 唾液腺保護ケア開発を目指したマウス唾液腺培養モデル構築の試みにおけるSerum Replacementの効果について

    第5回看護理工学会学術集会  

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    Event date: 2017.10

  • 唾液腺保護ケア開発を目指したマウス唾液腺培養モデル構築の試みにおけるSerum Replacementの効果について

    第5回看護理工学会学術集会  

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    Event date: 2017.10

  • マウス胎児顎下腺原基上皮細胞の無血清培地による単層化培養の試み

    第90回日本組織培養学会  

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    Event date: 2017.6 - 2017.7

  • マウス胎児顎下腺原基上皮細胞の無血清培地による単層化培養の試み

    第90回日本組織培養学会  

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    Event date: 2017.6

  • STARR-seq法で同定したエンハンサーと転写因子Runx1によるエピジェネティクなIL-22遺伝子発現調節機構

    第39回日本分子生物学会年会  

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    Event date: 2016.11 - 2016.12

  • STARR-seq法で同定したエンハンサーと転写因子Runx1によるエピジェネティクなIL-22遺伝子発現調節機構

    第39回日本分子生物学会年会  

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    Event date: 2016.11

  • STARR-seq法で同定したエンハンサーと転写因子Runx1によるエピジェネティクなIL-22遺伝子発現調節機構

    第39回日本分子生物学会年会  

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    Event date: 2016.11

  • 唾液腺保護ケアの開発を目指したマウス胎児唾液腺単層化培養の試み

    第4回看護理工学会学術集会  

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    Event date: 2016.10

  • 唾液腺保護ケアの開発を目指したマウス胎児唾液腺単層化培養の試み

    第4回看護理工学会学術集会  

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    Event date: 2016.10

  • 唾液腺保護ケアの開発を目指したマウス胎児唾液腺単層化培養の試み

    第4回看護理工学会学術集会  

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    Event date: 2016.10

  • マウス胎児顎下腺上皮組織の体外培養におけるneuregulin 1とfibroblast growth factor 1の細胞分化への作用

    第89回日本組織培養学会学術集会  

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    Event date: 2016.5

  • マウス胎児顎下腺上皮組織の体外培養におけるneuregulin 1とfibroblast growth factor 1の細胞分化への作用

    第89回日本組織培養学会学術集会  

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    Event date: 2016.5

  • マウス胎児顎下腺上皮組織の体外培養におけるneuregulin 1とfibroblast growth factor 1の細胞分化への作用

    第89回日本組織培養学会学術集会  

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    Event date: 2016.5

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