Organization
School of Medicine (Life Sciences and Social Medicine) Department of Systems Neuroscience Associate Professor
Title
Associate Professor
Contact information
TAKAHASHI Kazumi
Degree
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博士(情報科学) ( 東北大学 )
Research Interests
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neuronal mechanisms of sleep-waking cycles, single unit recording
Research Areas
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Life Science / Physiology / Environmental Physiology(includes Sports Medicine/Nutritional Physiology)
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Life Science / Clinical pharmacy / hypnology
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Life Science / Clinical pharmacy / Neuro and Musculer Physiology
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Life Science / Neuroscience-general / Neuro Science in General
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Life Science / Physiology / hypnology
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Life Science / Physiology / Neuro and Musculer Physiology
Research History
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Fukushima Medical University Associate Professor
2017.2 - Now
Professional Memberships
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Japanese Society of Sleep Research
Committee Memberships
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日本睡眠学会 評議員
2007.11 - Now
Papers
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Chemogenetic activation of mammalian brain neurons expressing insect Ionotropic Receptors by systemic ligand precursor administration
Yoshio Iguchi, Ryoji Fukabori, Shigeki Kato, Kazumi Takahashi, Satoshi Eifuku, Yuko Maejima, Kenju Shimomura, Hiroshi Mizuma, Aya Mawatari, Hisashi Doi, Yilong Cui, Hirotaka Onoe, Keigo Hikishima, Makoto Osanai, Takuma Nishijo, Toshihiko Momiyama, Richard Benton, Kazuto Kobayashi
Communications biology 7 ( 547 ) 1 - 13 2024.5
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Enhanced Retrieval of Taste Associative Memory by Chemogenetic Activation of Locus Coeruleus Norepinephrine Neurons
Fukabori Ryoj, Iguchi Yoshio, Kato Shigeki, Takahashii Kazumi, Eifuku Satoshi, Tsuji Shingo, Hazama Akihiro, Uchigashima Motokazu, Watanabe Masahiko, Mizuma Hiroshi, Cui Yilong,Onoe Hirotaka,Hikishima Keigo,Yasoshima Yasunobu, Osanai Makoto,Inagaki Ryo,Fukunaga Kohji, Nishijo Takuma, Momiyama Toshihiko, Benton Richard, Kobayashi Kazuto
Journal of Neuroscience 40 ( 43 ) 8367 - 8385 2020.10（ ISSN:0270-6474 ）
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Sleep-waking discharge of ventral tuberomammillary neurons in wild-type and histidine decarboxylase knock-out mice
Kazuya Sakai, Kazumi Takahashi, Christelle Anaclet and Jian-Sheng Lin
Frontiers in behavioral neuroscience 4 1 - 10 2010.10
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Locus coeruleus neuronal activity during the sleep-waking cycle in mice
K.Takahashi, Y. KAYAMA, J.-S.Lin, K.Sakai
Neuroscience 169 1115 - 1126 2010.6
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Characterization and mapping of sleep-waking specific neurons in the basal forebrain and preoptic hypothalamus in mice
K.Takahashi, J.-S.Lin, K.Sakai
Neuroscience 161 269 - 292 2009.3
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Neuronal activity of orexin and non-orexin waking-active neurons during wake–sleep states in the mouse
K. Takahashi, J.-S. Lin and K. Sakai
Neuroscience 153 ( 3 ) 860 - 870 2008.5
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脳幹網様体賦活系の各種神経細胞と覚醒機構
小山純正、高橋和巳
Clinical Neuroscience 25 ( 4 ) 388 - 390 2007.4
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Neuronal activity of histaminergic tuberomammillary neurons during wake-sleep states in the mouse
K Takahashi, J-S Lin, K Sakai
The Journal of Neuroscience 26 ( 40 ) 10292 - 10298 2006.10
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Requirement of tryptophan hydroxylase during development for maturation of sensorimotor gating
K Nakamura, Y Koyama, K Takahashi, H Tsurui, Y Xiu, M Ohtsuji, Q-S Lin, Y Sugawara, K Sawabe, A Ohashi, T Ohnuma, H Arai, H Nishimura, H Hasegawa, S Hirose
The Journal of Molecular Biology 363 345 - 354 2006.8
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Orexinergic projections to the cat midbrain mediate alternation of emotional behavioural states from locomotion to cataplexy
Takakusaki K, Takahashi K, Saitoh K, Harada H, Okumura T, Kayama Y, Koyama Y.
The Journal of Physiology 568 ( 3 ) 1003 - 1020 2005.11
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State-dependent effects of orexins on the serotonergic dorsal raphe neurons in the rat
Takahashi K, Wang QP, Guan JL, Kayama Y, Shioda S, Koyama Y.
Regulatory Peptides 126 ( 1-2 ) 43 - 47 2005.3
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The orexinergic synaptic innervation of serotonin- and orexin 1-receptor-containing neurons in the dorsal raphe nucleus
Wang QP, Koyama Y, Guan JL, Takahashi K, Kayama Y, Shioda S.
Regulatory Peptides 126 ( 1-2 ) 35 - 42 2005.3
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Is state-dependent alternation of slow dynamics in central single neurons during sleep present in the rat ventroposterior thalamic nucleus?
Takahashi K, Koyama Y, Kayama Y, Nakamura K, Yamamoto M.
Neurosci Research 48 ( 2 ) 203 - 210 2004.2
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睡眠・覚醒の神経機構
香山雪彦、小山純正、高橋和巳
最新医学 59 ( 3 ) 31 - 36 2004.3
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State-dependent activity of neurons in the perifornical hypothalamic area during sleep and waking
Koyama Y, Takahashi K, Kodama T, Kayama Y.
Neuroscience 119 ( 4 ) 1209 - 1219 2003
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Effects of orexin on the laterodorsal tegmental neurons
Psychiatry and Clinical Neurosciences 56 335 - 336 2002
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Firing properties of neurones in the laterodorsal hypothalamic area during sleep and wakefulness
Koyama Y, Kodama T, Takahashi K, Okai K, Kayama Y.
Psychiatry and Clinical Neurosciences 56 ( 3 ) 339 - 340 2002.1
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脳幹の覚醒機構
小山純正、高橋和巳、香山雪彦
Clinical Neuroscience 20 ( 4 ) 390 - 393 2002.4
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The effects of prolactin on the mesopontine tegmental neurons
Psychiatry and Clinical Neurosciences 54 ( 3 ) 257 - 258 2000
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State-dependency of neuronal slow dynamics during sleep observed in cat lateral geniculate nucleus
Sleep Research Online 3 ( 4 ) 147 - 154 2000
Books
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睡眠学第２版
日本睡眠学会「睡眠学第２版」編集委員会（第３章 睡眠・覚醒調節の神経機構）
朝倉書店 2020.11
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Histamine research in the millennium
T Watanabe, H Timmerman, K Yanai（Histamine is a transmitter to maintain tonic firing of mesopontine tegmental cholinergic neurons during wakefulness）
2001.1
Presentations
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Subpopulations of the dorsomedial hypothalamic neurons show anticipating activity to sleep/wake states and cardiovascular fluctuation
The 46th annual meeting of the Japan neuroscience society 2023.8
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睡眠・覚醒時のラット視床下部背内側核における単一ニューロン活動
日本睡眠学会第４７回定期学術集会
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Single neuronal activity in the dorsomedial hypothalamic nucleus of rats across sleep-wake cycles
第９９回日本生理学会大会
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睡眠・覚醒サイクルにおけるラット視床下部背内側ニューロンの活動記録
第１６回環境生理学プレコングレス
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睡眠・覚醒サイクルにおけるラット分界条床核の単一ニューロン活動
日本睡眠学会第４６回定期学術集会
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ラット視床背内側核ニューロンの睡眠・覚醒時の活動記録
第52回東北生理談話会
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Spontaneous neuronal activity in the bed nucleus of the stria terminalis across sleep-waking cycles in rat
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覚醒・睡眠時のラット視床背内側核ニューロン活動記録と覚醒刺激に対する応答
日本睡眠学会第４４回定期学術集会
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Short response latency of hypothalamic waking-specific neurons to auditory arousal stimulus
The 95th annual meeting of the physiological society of Japan
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視床下部脳弓周囲領域覚醒系ニューロンの聴覚性覚醒刺激に対する応答
第４９回東北生理談話会
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聴覚性覚醒刺激に対する視床下部脳弓周囲領域ニューロンの活動応答
日本睡眠学会第４２回定期学術集会
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Neural system regulating start and end of REM sleep
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イソフルラン麻酔下におけるラット下丘の電気刺激による覚醒反応
日本睡眠学会第４１回定期学術集会
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Mesopontine-amygdala mechanisms inducing blood pressure fluctuation during REM sleep
The 4th Annual IIIS Symposium
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多点電極によるセロトニン作動性ニューロン活動の記録
日本睡眠学会第40回定期学術集会
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Interaction of brainstem neurons at the state transition investigated through Si neural probe
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Neuronal mechanisms of cortical desynchronization during wakefulness and paradoxical sleep
The 8th Asian Sleep Research Society Congress
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リヨンの思い出とニューロン活動を見る楽しさ
日本睡眠学会第３９回定期学術集会
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Changes in the state of wakefulness in the locus coeruleus noradrenergic neurons-ablated mice
The 91st annual meeting of the physiological society of Japan
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Effects of specific immunotoxic lesion of the noradrenergic neurons in the locus coeruleus on the state of wakefulness in mice
Annual Meeting of Society for Neuroscience
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睡眠・覚醒調節における青斑核ノルアドレナリンニューロンの役割
第45回東北生理談話会
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イムノトキシンによる青斑核ノルアドレナリンニューロンの選択的破壊マウスにおける睡眠・覚醒調節
包括脳ワークショップ
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青斑核ノルアドレナリンニューロンの特異的破壊による覚醒反応の解析
第38回日本睡眠学会定期学術集会
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Roles of noradrenergic and histaminegic neurons in arousal mechnisms
The 90th annual meeting of the physiological society of japan
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イムノトキシンによる青斑核ノルアドレナリンニューロンの選択的破壊がマウスの睡眠・覚醒サイクルに与える影響について
第35回日本神経科学大会
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青斑核のノルアドレナリンニューロンの選択的破壊がマウスの睡眠・覚醒サイクルに与える影響について
第37回日本睡眠学会定期学術集会
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睡眠・覚醒調節ニューロン群それぞれの違い
日本睡眠学会第37回定期学術集会
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Burstic eye movements during paladoxical sleep were not under the control of superior colliculus
Worldsleep 2011
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青斑核ノルアドレナリンニューロンの睡眠覚醒移行期の活動変化は視索前野/前脳基底部の睡眠ニューロンの活動変化に先行する
第４３回東北生理談話会
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脳幹のアセチルコリン作動性ニューロンと非アセチルコリン作動性ニューロンのレム睡眠における活動様式について
第４３回東北生理談話会
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Change in activity of noradrenergic locus coeruleus neurons precedes that of sleep-promoting neurons in the basal forebrain and preoptic hypothalamus during sleep-wake state transitions
20th congress of the european sleep research society
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マウスの青斑核ノルアドレナリンニューロンは睡眠/覚醒の移行期において視索前野/前脳基底部の睡眠ニューロンに先行して活動を変化させる
日本睡眠学会第３５回定期学術集会
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単一ユニット記録からわかる覚醒ニューロンの睡眠・覚醒機構における役割
日本睡眠学会第３５回定期学術集会
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Sleep-waking discharge of preoptic and basal forebrain neurons is not consistent with the current active hypothesis of sleep
The 87 th annual meeting of the physiological society of Japan
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Orexinergic regulation of GABA release in the pedunculopontine tegmental nucleus
The 87th annual meeting of the physiological society of Japan
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Tonic and phasic regulations of muscular tonus through the hypothalamus
the 3rd International Symposium on Mobiligence
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GABA release from the sunstantia nigra pars reticulata and the pedunculopontine tegmental nucleus is facilitated by orexin
The 6th Congress of Asian Sleep Research Society
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The sleep process does not start with the activation of sleep-promoting neurons in the basal forebrain and preoptic hypothalamus
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Inhibition of burstic eye movements during paradoxical sleep after superior colliculus lesion
The 6th Congress of Asian Sleep Research Society
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Effects of the superior colliculus lesions upon rapid eye movements during paradoxical sleep in the rat
The 39th Annual Meeting of Society for Neuroscience
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Orexin facilitates GABA release from the sunstantia nigra pars reticulata and the pedunculopontine tegmental nucleus that regulate muscular tonus
The 39th Annual Meeting of Society for Neuroscience
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上丘破壊によるラット逆説睡眠中の急速眼球運動の抑制
第32回日本神経科学大会
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Hypothalamic regulation of muscular tonus through the orexinergic and non-orexinergic systems
the 36th International Congress of Physiological Sciences
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覚醒機構としてのヒスタミン
第３３回日本睡眠学会定期学術集会
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マウスオレキシンユーロンの睡眠・覚醒時の活動
第３３回日本睡眠学会定期学術集会
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Neuronal activity of identified orexin and non-orexin neuronneurons across sleep-waking cycles in mice
the 85th Annual Meeting of the Physiological society of Japn
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結節乳頭核ヒスタミンニューロン活動が覚醒状態の発現に果たす役割
第11回日本ヒスタミン学会
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Neuronal activity of histaminergic tuberomammillary neurons during sleep-wake states in the mouse
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視床下部及び脳幹の睡眠・覚醒調節ニューロン群が示す活動変化の時間順序
日本睡眠学会第32回定期学術集会
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睡眠・覚醒の移行期において脳幹及び視床下部のニューロンが示す活動変化の順序
第40回東北生理談話会
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A temporal sequence of changes in firing among the wake- and sleep-promoting neurons at the transition between aleep and wakefulness in mice
Neuro 2007
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A temporal sequence of activity changes among wake- and sleep-promoting neurons in the brainstem and posterior hypothalamus in mice
5th congress of the world federation of sleep research and sleep medicine societies
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Hypothalamic regulation of muscular tonus -involvement of orexinergic and GABAergic neurons
The 2nd international symposium on Mobiligence
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歩行及び筋緊張調節機構に対するオレキシン入力の役割
第1回Motor Control研究会
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Is the cessation of histaminergic tuberomamillary neurons during sleep caused by the activation of preoptic sleep-promoting neurons?
The 84rd Annual Meeting of the Physiological Society of Japan
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Waking-specific discharge of histaminergic tuberomamillary neurons in the mouse
18th Congress of the European Sleep Research Society
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Neurotransmitters that maintain and supress the tonic firing of the serotonergic neurons in the dorsal raphe during sleep waking cycles
The 29th Annual Meeting of the Japan Neuroscience Society
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マウスにおけるヒスタミンニューロンの睡眠・覚醒時の活動記録と同定
日本睡眠学会第31回定期学術集会
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Penile erection during REM sleep regulated by the laterodorsal tegmental nucleus
The 83rd Annual Meeting of the Physiological Society of Japan
Awards
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日本睡眠学会研究奨励賞
2007.11
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日本ヒスタミン学会第4回和田記念賞
2008.1
Research Projects
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覚醒状態及び覚醒系ニューロンに対して睡眠中枢が果たす生理的役割の解明
2009.4 - 2012.3
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睡眠覚醒時のヒスタミンニューロンが示す活動変化の制御メカニズムの解明
2008.4 - 2011.3
高橋和巳、小山純正 福島大学共生システム理工学類 辛島彰洋 東北大学大学院情報科学研究科
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視床下部睡眠覚醒調節ニューロンの同定と活動記録及び制御機構のの解明
2006.4 - 2008.3
高橋和巳、小山純正
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適応的行動発現を可能にする自律神経系と意識（覚醒）調節系の統合メカニズム
2006.4 - 2007.3
小山純正、児玉亨