北海道医療大学薬学部（助教）

2007.4 - 2008.1

北海道医療大学薬学部　（助手）

2003.4 - 2007.3

Development of pre-targeting system using low immunogenic streptavidin mutants and 211-At-labeled bis-iminobiotin

巽俊文, 山次健三, 杉山暁, ZHAO S., 粟生木美穂, 西嶋剣一, 右近直之, 下山彩希, GAO F., 城寶大輝, 織内昇, 高橋和弘, 清水洋平, 高橋和希, 安藝翔, 児玉龍彦, 鷲山幸信, 金井求

日本放射化学会討論会(Web)   66th   2022

放射線療法後の11C-メチオニンPETを用いた脳腫瘍再発の判定(Determination of brain tumor recurrence using 11C-methionine positron emission tomography after radiotherapy)

Yamaguchi Shigeru, Hirata Kenji, Okamoto Michinari, Shimosegawa Eku, Hatazawa Jun, Hirayama Ryuichi, Kagawa Naoki, Kishima Haruhiko, Oriuchi Noboru, Fujii Masazumi, Kobayashi Kentaro, Kobayashi Hiroyuki, Terasaka Shunsuke, Nishijima Ken-ichi, Kuge Yuji, Ito Yoichi M., Nishihara Hiroshi, Tamaki Nagara, Shiga Tohru

Cancer Science   112 ( 10 )   4246 - 4256   2021.10（ ISSN:1347-9032 ）

Evaluation of acute radiotoxicity profile of alpha-particle-emitting meta-211At-astato-benzylguanidine (211At-MABG) in normal BALB/c mice

Songji Zhao, Komei Washino, Miho Aoki, Naoyuki Ukon, Saki Shimoyama, Ken-ichi Nishijima, Kohshin Washiyama, Natsue Ito, Naho Yoshioka, Naomi Tamura, Kazuhiro Takahashi, Tatsuya Higashi, Hiroshi Ito

JOURNAL OF NUCLEAR MEDICINE   62   2021.5（ ISSN:0161-5505 ）

脳血流量、脳血液量、脳酸素摂取率、脳酸素消費量の定量に酸素-15標識ガスを用いた統合型PET/MRIスキャナ(Integrated PET/MRI scanner with oxygen-15 labeled gases for quantification of cerebral blood flow, cerebral blood volume, cerebral oxygen extraction fraction and cerebral metabolic rate of oxygen)

Ito Hiroshi, Kubo Hitoshi, Takahashi Kazuhiro, Nishijima Ken-Ichi, Ukon Naoyuki, Nemoto Ayaka, Sugawara Shigeyasu, Yamakuni Ryo, Ibaraki Masanobu, Ishii Shiro

Annals of Nuclear Medicine   35 ( 4 )   421 - 428   2021.4（ ISSN:0914-7187 ）

Integrated PET/MRI scanner with oxygen-15 labeled gases for quantification of cerebral blood flow, cerebral blood volume, cerebral oxygen extraction fraction and cerebral metabolic rate of oxygen.

Hiroshi Ito, Hitoshi Kubo, Kazuhiro Takahashi, Ken-Ichi Nishijima, Naoyuki Ukon, Ayaka Nemoto, Shigeyasu Sugawara, Ryo Yamakuni, Masanobu Ibaraki, Shiro Ishii

Annals of nuclear medicine   35 ( 4 )   421 - 428   2021.4（ ISSN:0914-7187 ）

Biodistribution and internal radiation dosimetry of a novel probe for thymidine phosphorylase imaging, [123I]IIMU, in healthy volunteers.

Shiro Watanabe, Ken-Ichi Nishijima, Shozo Okamoto, Keiichi Magota, Kenji Hirata, Takuya Toyonaga, Tohru Shiga, Yuji Kuge, Nagara Tamaki

Annals of nuclear medicine   34 ( 8 )   595 - 599   2020.8（ ISSN:0914-7187 ）

健常ボランティアにおけるチミジンホスホリラーゼイメージングの新規プローブである[123I]IIMUの生体内分布と内部照射線量測定(Biodistribution and internal radiation dosimetry of a novel probe for thymidine phosphorylase imaging, [123I]IIMU, in healthy volunteers)

Watanabe Shiro, Nishijima Ken-ichi, Okamoto Shozo, Magota Keiichi, Hirata Kenji, Toyonaga Takuya, Shiga Tohru, Kuge Yuji, Tamaki Nagara

Annals of Nuclear Medicine   34 ( 8 )   595 - 599   2020.8（ ISSN:0914-7187 ）

標的α線治療のためのアスタチン-211標識ボンベシン誘導体の予備的評価(Preliminary Evaluation of Astatine-211-Labeled Bombesin Derivatives for Targeted Alpha Therapy)

Aoki Miho, Zhao Songji, Takahashi Kazuhiro, Washiyama Kohshin, Ukon Naoyuki, Tan Chengbo, Shimoyama Saki, Nishijima Ken-ichi, Ogawa Kazuma

Chemical & Pharmaceutical Bulletin   68 ( 6 )   538 - 545   2020.6（ ISSN:0009-2363 ）

Development of a pre-targeting strategy of low-immunogenic mutated streptavidin with At-211 labeled modified biotin for advanced cancer treatment

Kohshin Washiyama, Akira Sugiyama, Songji Zhao, Toshifumi Tatsumi, Miho Aoki, Kenzo Yamatsugu, Ken-ichi Nishijima, Naoyuki Ukon, Saki Shimoyama, Chengbo Tan, Taiki Joho, Noboru Oriuchi, Motomu Kanai, Kazuhiro Takahashi, Tatsuhiko Kodama

JOURNAL OF NUCLEAR MEDICINE   61   2020.5（ ISSN:0161-5505 ）

Possibility of cancer-stem-cell-targeted radioimmunotherapy for acute myelogenous leukemia using 211At-CXCR4 monoclonal antibody.

Noboru Oriuchi, Miho Aoki, Naoyuki Ukon, Kohshin Washiyama, Chengbo Tan, Saki Shimoyama, Ken-Ichi Nishijima, Kazuhiro Takahashi, Hiroshi Ito, Takayuki Ikezoe, Songji Zhao

Scientific reports   10 ( 1 )   6810 - 6810   2020.4

Preliminary Evaluation of Astatine-211-Labeled Bombesin Derivatives for Targeted Alpha Therapy

Miho Aoki, Songji Zhao, Kazuhiro Takahashi, Kohshin Washiyama, Naoyuki Ukon, Chengbo Tan, Saki Shimoyama, Ken-ichi Nishijima, Kazuma Ogawa

Chemical and Pharmaceutical Bulletin   68 ( 6 )   538 - 545   2020（ ISSN:0009-2363 ）

Biodistribution and radiation dosimetry of the novel hypoxia PET probe [¹⁸F]DiFA and comparison with [¹⁸F]FMISO.

Watanabe S, Shiga T, Hirata K, Magota K, Okamoto S, Toyonaga T, Higashikawa K, Yasui H, Kobayashi J, Nishijima KI, Iseki K, Matsumoto H, Kuge Y, Tamaki N

EJNMMI research   9 ( 1 )   60 - 60   2019.7（ ISSN:2191-219X ）

Elimination of tumor hypoxia by eribulin demonstrated by 18F-FMISO hypoxia imaging in human tumor xenograft models.

Songji Zhao, Wenwen Yu, Naoyuki Ukon, Chengbo Tan, Ken-Ichi Nishijima, Yoichi Shimizu, Kei Higashikawa, Tohru Shiga, Hiroko Yamashita, Nagara Tamaki, Yuji Kuge

EJNMMI research   9 ( 1 )   51 - 51   2019.6（ ISSN:2191-219X ）

Comparative evaluation of [18F]DiFA and its analogs as novel hypoxia positron emission tomography and [18F]FMISO as the standard.

Norihito Nakata, Masato Kiriu, Yuki Okumura, Songji Zhao, Ken-Ichi Nishijima, Tohru Shiga, Nagara Tamaki, Yuji Kuge, Hiroki Matsumoto

Nuclear medicine and biology   70   39 - 45   2019.2（ ISSN:0969-8051 ）

A Novel PET Probe "[¹⁸F]DiFA" Accumulates in Hypoxic Region via Glutathione Conjugation Following Reductive Metabolism.

Shimizu Y, Zhao S, Yasui H, Nishijima KI, Matsumoto H, Shiga T, Tamaki N, Ogawa M, Kuge Y

Molecular imaging and biology   21 ( 1 )   122 - 129   2019.2（ ISSN:1536-1632 ）

L-[11C]メチオニン注射液中に混入するヨウ素由来不純物の測定法に関する検討(Measurement of Iodine-Derived Contamination in L-[11C]Methionine Injection)

小松 由紀子, 西嶋 剣一, 大曲 茂生, 金井 泰和, 仲 定宏, 東川 桂, 海老田 陽子, 志賀 哲, 畑澤 順, 玉木 長良, 久下 裕司

Radioisotopes   67 ( 3 )   75 - 83   2018.3（ ISSN:0033-8303 ）

Measurement of Iodine-Derived Contamination in L-[¹¹C]Methionine Injection

Komatsu Yukiko, Tamaki Nagara, Kuge Yuji, Nishijima Ken-ichi, Oomagari Shigeo, Kanai Yasukazu, Naka Sadahiro, Higashikawa Kei, Ebita Yoko, Shiga Tohru, Hatazawa Jun

RADIOISOTOPES   67 ( 3 )   75 - 83   2018（ ISSN:0033-8303 ）

¹¹¹In-DTPA-d-Phe^-1-Asp⁰-d-Phe¹-octreotide exhibits higher tumor accumulation and lower renal radioactivity than ¹¹¹In-DTPA-d-Phe¹-octreotide.

Oshima N, Akizawa H, Kitaura H, Kawashima H, Zhao S, Zhao Y, Nishijima KI, Kitamura Y, Arano Y, Kuge Y, Ohkura K

Nuclear medicine and biology   54   18 - 26   2017.11（ ISSN:0969-8051 ）

FMISO accumulation in tumor is dependent on glutathione conjugation capacity in addition to hypoxic state.

Masaki Y, Shimizu Y, Yoshioka T, Nishijima KI, Zhao S, Higashino K, Numata Y, Tamaki N, Kuge Y

Annals of nuclear medicine   31 ( 8 )   596 - 604   2017.10（ ISSN:0914-7187 ）

Immunoglobulin G (IgG)-Based Imaging Probe Accumulates in M1 Macrophage-Infiltrated Atherosclerotic Plaques Independent of IgG Target Molecule Expression.

Shimizu Y, Hanzawa H, Zhao Y, Fukura S, Nishijima KI, Sakamoto T, Zhao S, Tamaki N, Ogawa M, Kuge Y

Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging   19 ( 4 )   531 - 539   2017.8（ ISSN:1536-1632 ）

Changes in tumor oxygen state after sorafenib therapy evaluated by ¹⁸F-fluoromisonidazole hypoxia imaging of renal cell carcinoma xenografts.

Yu W, Zhao S, Zhao Y, Fatema CN, Murakami M, Nishijima KI, Kitagawa Y, Tamaki N, Kuge Y

Oncology letters   14 ( 2 )   2341 - 2346   2017.8（ ISSN:1792-1074 ）

Redesign of negatively charged ¹¹¹In-DTPA-octreotide derivative to reduce renal radioactivity.

Oshima N, Akizawa H, Kawashima H, Zhao S, Zhao Y, Nishijima KI, Kitamura Y, Arano Y, Kuge Y, Ohkura K

Nuclear medicine and biology   48   16 - 25   2017.5（ ISSN:0969-8051 ）

Dynamic PET evaluation of elevated FLT level after sorafenib treatment in mice bearing human renal cell carcinoma xenograft.

Ukon N, Zhao S, Yu W, Shimizu Y, Nishijima KI, Kubo N, Kitagawa Y, Tamaki N, Higashikawa K, Yasui H, Kuge Y

EJNMMI research   6 ( 1 )   90   2016.12

The reoxygenation of hypoxia and the reduction of glucose metabolism in head and neck cancer by fractionated radiotherapy with intensity-modulated radiation therapy.

Okamoto S, Shiga T, Yasuda K, Watanabe S, Hirata K, Nishijima KI, Magota K, Kasai K, Onimaru R, Tuchiya K, Kuge Y, Shirato H, Tamaki N

European journal of nuclear medicine and molecular imaging   43 ( 12 )   2147 - 2154   2016.11（ ISSN:1619-7070 ）

The Thymidine Phosphorylase Imaging Agent 123I-IIMU Predicts the Efficacy of Capecitabine.

Kobashi N, Matsumoto H, Zhao S, Meike S, Okumura Y, Abe T, Akizawa H, Ohkura K, Nishijima K, Tamaki N, Kuge Y

Journal of nuclear medicine : official publication, Society of Nuclear Medicine   57 ( 8 )   1276 - 1281   2016.8（ ISSN:0161-5505 ）

Characterization of the role of sphingomyelin synthase 2 in glucose metabolism in whole-body and peripheral tissues in mice.

Sugimoto M, Shimizu Y, Zhao S, Ukon N, Nishijima K, Wakabayashi M, Yoshioka T, Higashino K, Numata Y, Okuda T, Tamaki N, Hanamatsu H, Igarashi Y, Kuge Y

Biochimica et biophysica acta   1861 ( 8 Pt A )   688 - 702   2016.8（ ISSN:0006-3002 ）

The accumulation mechanism of the hypoxia imaging probe "FMISO" by imaging mass spectrometry: possible involvement of low-molecular metabolites.

Masaki Y, Shimizu Y, Yoshioka T, Tanaka Y, Nishijima K, Zhao S, Higashino K, Sakamoto S, Numata Y, Yamaguchi Y, Tamaki N, Kuge Y

Scientific reports   5   16802   2015.11

Relationship between biodistribution of a novel thymidine phosphorylase (TP) imaging probe and TP expression levels in normal mice.

Zhao S, Li H, Nishijima K, Zhao Y, Akizawa H, Shimizu Y, Ohkura K, Tamaki N, Kuge Y

Annals of nuclear medicine   29 ( 7 )   582 - 587   2015.8（ ISSN:0914-7187 ）

Oligodendroglial component complicates the prediction of tumour grading with metabolic imaging.

Manabe O, Hattori N, Yamaguchi S, Hirata K, Kobayashi K, Terasaka S, Kobayashi H, Motegi H, Shiga T, Magota K, Oyama-Manabe N, Nishijima K, Kuge Y, Tamaki N

European journal of nuclear medicine and molecular imaging   42 ( 6 )   896 - 904   2015.5（ ISSN:1619-7070 ）

Radiolabeled BMIPP for imaging hepatic fatty acid metabolism: evaluation of hepatic distribution and metabolism in mice at various metabolic statuses induced by fasting in comparison with palmitic acid.

Yamasaki K, Zhao S, Nishimura M, Zhao Y, Yu W, Shimizu Y, Nishijima K, Tamaki N, Takeda H, Kuge Y

Molecular imaging   14   2015（ ISSN:1535-3508 ）

[Assessment of validity of the archived standard curve in endotoxin assay, produced in other facilities].

Waki A, Mori T, Nishijima K, Honjyo K, Kayano Y, Yano R, Shiraishi H, Takaoka A, Kiyono Y, Fujibayashi Y

Kaku igaku. The Japanese journal of nuclear medicine   51 ( 4 )   383 - 386   2014.11（ ISSN:0022-7854 ）

エンドトキシン保存検量線の他施設での利用の可能性の検討

脇 厚生, 森 哲也, 西嶋 剣一, 本城 和義, 萱野 勇一郎, 矢野 良一, 白石 浩巳, 高岡 文, 清野 泰, 藤林 靖久

核医学   51 ( 4 )   383 - 386   2014.11（ ISSN:0022-7854 ）

Dual tracer evaluation of dynamic changes in intratumoral hypoxic and proliferative states after radiotherapy of human head and neck cancer xenografts using radiolabeled FMISO and FLT.

Fatema CN, Zhao S, Zhao Y, Yu W, Nishijima K, Yasuda K, Kitagawa Y, Tamaki N, Kuge Y

BMC cancer   14   692   2014.9

Prone-position acquisition of myocardial ¹²³I-metaiodobenzylguanidine (MIBG) SPECT reveals regional uptake similar to that found using ¹¹C-hydroxyephedrine PET/CT.

Yoshinaga K, Tomiyama Y, Manabe O, Kasai K, Katoh C, Magota K, Suzuki E, Nishijima KI, Kuge Y, Ito YM, Tamaki N

Annals of nuclear medicine   28 ( 8 )   761 - 769   2014.6（ ISSN:1864-6433|0914-7187 ）

【Molecular Imaging 2014　分子イメージングはどこまで進んだか】 分子イメージングの最新動向　核医学における分子イメージングの最新動向　製造標準化の現状と展望

脇 厚生, 久下 裕司, 西嶋 剣一, 藤林 靖久

INNERVISION   29 ( 7 )   23 - 26   2014.6（ ISSN:0913-8919 ）

Design, synthesis and biological evaluation of negatively charged ¹¹¹In-DTPA-octreotide derivatives.

Oshima N, Akizawa H, Zhao S, Zhao Y, Nishijima K, Kitamura Y, Arano Y, Kuge Y, Ohkura K

Bioorganic & medicinal chemistry   22 ( 4 )   1377 - 1382   2014.2（ ISSN:0968-0896|1464-3391 ）

[Assessment of validity of the archived standard curve in endotoxin assay].

Waki A, Mori T, Nishijima K, Honjyo K, Kayano Y, Yano R, Shiraishi H, Takaoka A, Kiyono Y, Fujibayashi Y, Waki A, Mori T, Nishijima K, Honjyo K, Kayano Y, Yano R, Shiraishi H, Takaoka A, Kiyono Y, Fujibayashi Y

Kaku igaku. The Japanese journal of nuclear medicine   50   289 - 296   2013.11（ ISSN:0022-7854 ）

エンドトキシン測定法における検量線の保存利用の妥当性　測定値の真値からの乖離と分散の検証

脇 厚生, 森 哲也, 西嶋 剣一, 本城 和義, 萱野 勇一郎, 矢野 良一, 白石 浩巳, 高岡 文, 清野 泰, 藤林 靖久

核医学   50 ( 4 )   289 - 296   2013.11（ ISSN:0022-7854 ）

Increased intratumoral fluorothymidine uptake levels following multikinase inhibitor sorafenib treatment in a human renal cell carcinoma xenograft model.

Murakami M, Zhao S, Zhao Y, Yu W, Fatema CN, Nishijima KI, Yamasaki M, Takiguchi M, Tamaki N, Kuge Y

Oncology letters   6 ( 3 )   667 - 672   2013.9（ ISSN:1792-1074|1792-1082 ）

Monitoring tumor proliferative response to radiotherapy using (18)F-fluorothymidine in human head and neck cancer xenograft in comparison with Ki-67.

Fatema CN, Zhao S, Zhao Y, Murakami M, Yu W, Nishijima K, Tamaki N, Kitagawa Y, Kuge Y

Annals of nuclear medicine   27 ( 4 )   355 - 362   2013.5（ ISSN:1864-6433|0914-7187 ）

Ki-67と比較したヒト頭頸部癌異種移植における18F-フルオロチミジンを用いた放射線療法への腫瘍増殖反応のモニタリング(Monitoring tumor proliferative response to radiotherapy using 18F-fluorothymidine in human head and neck cancer xenograft in comparison with Ki-67)

Fatema Chowdhury Nusrat, Zhao Songji, Zhao Yan, Murakami Masahiro, Yu Wenwen, Nishijima Ken-ichi, Tamaki Nagara, Kitagawa Yoshimasa, Kuge Yuji

Annals of Nuclear Medicine   27 ( 4 )   355 - 362   2013.5（ ISSN:0914-7187 ）

Biological characteristics of intratumoral [F-18]‑fluoromisonidazole distribution in a rodent model of glioma.

Hatano T, Zhao S, Zhao Y, Nishijima K, Kuno N, Hanzawa H, Sakamoto T, Tamaki N, Kuge Y

International journal of oncology   42 ( 3 )   823 - 30   2013.3（ ISSN:1019-6439 ）

Evaluation of changes in the tumor microenvironment after sorafenib therapy by sequential histology and 18F-fluoromisonidazole hypoxia imaging in renal cell carcinoma.

Murakami M, Zhao S, Zhao Y, Chowdhury NF, Yu W, Nishijima K, Takiguchi M, Tamaki N, Kuge Y

International journal of oncology   41 ( 5 )   1593 - 1600   2012.11（ ISSN:1019-6439|1791-2423 ）

Quantitative determination of apoptosis of pancreatic β-cells in a murine model of type 1 diabetes mellitus.

Watanabe A, Nishijima K, Zhao S, Zhao Y, Tanaka Y, Takemoto H, Strauss HW, Blankenberg FG, Tamaki N, Kuge Y

Journal of nuclear medicine : official publication, Society of Nuclear Medicine   53 ( 10 )   1585 - 1591   2012.10（ ISSN:0161-5505 ）

Effect of glycosylation on biodistribution of radiolabeled glucagon-like peptide 1.

Watanabe A, Nishijima K, Zhao S, Tanaka Y, Itoh T, Takemoto H, Tamaki N, Kuge Y

Annals of nuclear medicine   26 ( 2 )   184 - 191   2012.2（ ISSN:0914-7187 ）

Radiolabeled uracil derivative as a novel SPECT probe for thymidine phosphorylase: suppressed accumulation into tumor cells by target gene knockdown.

Li H, Zhao S, Jin Y, Nishijima K, Akizawa H, Ohkura K, Tamaki N, Kuge Y

Nuclear medicine communications   32 ( 12 )   1211 - 1215   2011.12（ ISSN:0143-3636|1473-5628 ）

Dynamic 11C-methionine PET analysis has an additional value for differentiating malignant tumors from granulomas: an experimental study using small animal PET.

Zhao S, Kuge Y, Yi M, Zhao Y, Hatano T, Magota K, Nishijima K, Kohanawa M, Tamaki N

European journal of nuclear medicine and molecular imaging   38 ( 10 )   1876 - 1886   2011.10（ ISSN:1619-7089|1619-7070 ）

治療戦略に役立つ放射性薬剤の開発 (特集 核医学検査の新しい展開--治療戦略への応用)

久下 裕司, 西嶋 剣一, 趙 松吉

映像情報medical   43 ( 11 )   842 - 849,830   2011.10（ ISSN:13461354 ）

18F-fluorothymidine PET/CT as an early predictor of tumor response to treatment with cetuximab in human lung cancer xenografts.

Takeuchi S, Zhao S, Kuge Y, Zhao Y, Nishijima K, Hatano T, Shimizu Y, Kinoshita I, Tamaki N, Dosaka-Akita H

Oncology reports   26 ( 3 )   725 - 730   2011.9（ ISSN:1791-2431|1021-335X ）

Performance characterization of the Inveon preclinical small-animal PET/SPECT/CT system for multimodality imaging.

Magota K, Kubo N, Kuge Y, Nishijima K, Zhao S, Tamaki N

European journal of nuclear medicine and molecular imaging   38 ( 4 )   742 - 752   2011.4（ ISSN:1619-7070 ）

In vitro and in vivo evaluations of a radioiodinated thymidine phosphorylase inhibitor as a tumor diagnostic agent for angiogenic enzyme imaging.

Akizawa H, Zhao S, Takahashi M, Nishijima K, Kuge Y, Tamaki N, Seki K, Ohkura K

Nuclear medicine and biology   37 ( 4 )   427 - 432   2010.5（ ISSN:0969-8051|1872-9614 ）

Clinical value and limitations of [11C]-methionine PET for detection and localization of suspected parathyroid adenomas.

Herrmann K, Takei T, Kanegae K, Shiga T, Buck AK, Altomonte J, Schwaiger M, Schuster T, Nishijima K, Kuge Y, Tamaki N

Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging   11 ( 5 )   356 - 363   2009.9（ ISSN:1536-1632|1860-2002 ）

チミジンホスホリラーゼ標的イメージング剤の開発

大倉 一枝, 高橋 正幸, 西嶋 剣一

放射線生物研究   44 ( 1 )   37 - 50   2009.3（ ISSN:0441747X ）

Myocardial beta-adrenergic receptor density assessed by 11C-CGP12177 PET predicts improvement of cardiac function after carvedilol treatment in patients with idiopathic dilated cardiomyopathy.

Naya M, Tsukamoto T, Morita K, Katoh C, Nishijima K, Komatsu H, Yamada S, Kuge Y, Tamaki N, Tsutsui H

Journal of nuclear medicine : official publication, Society of Nuclear Medicine   50 ( 2 )   220 - 225   2009.2（ ISSN:0161-5505 ）

SYNTHESIS OF C-11-LABELED URACIL DERIVATIVE FOR A PET TRACER TARGETING THYMIDINE PHOSPHORYLASE

Takahashi Masayuki, Seki Koh-ichi, Nishijima Ken-ichi, Kuge Yuji, Tamaki Nagara, Ohkura Kazue

HETEROCYCLES   76 ( 1 )   237 - 241   2008.9（ ISSN:0385-5414 ）

Decreased myocardial beta-adrenergic receptor density in relation to increased sympathetic tone in patients with nonischemic cardiomyopathy.

Tsukamoto T, Morita K, Naya M, Inubushi M, Katoh C, Nishijima K, Kuge Y, Okamoto H, Tsutsui H, Tamaki N

Journal of nuclear medicine : official publication, Society of Nuclear Medicine   48 ( 11 )   1777 - 1782   2007.11（ ISSN:0161-5505 ）

A novel and efficient synthesis of [2-11C]5-fluorouracil for prognosis of cancer chemotherapy.

Seki K, Nishijima K, Kuge Y, Tamaki N, Wiebe LI, Ohkura K

Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques   10 ( 2 )   212 - 216   2007

Photochemical synthesis of polycyclic pyrimidines through the acid catalyzed cycloaddition of 6-chloro-1-methyluracil to methyl substituted benzenes

Ohkura Kazue, Yamaguchi Takeshi, Nishijima Ken-ichi, Kuge Yuji, Seki Koh-ichi

HETEROCYCLES   70   501 - +   2006.12（ ISSN:0385-5414 ）

Synthesis of N1, N3-free pyrimidine bridged polycyclic compounds via photo-Diels-Alder reaction of N,N-diacetyl-5-fluorouracil with naphthalenes

Ohkura Kazue, Ishihara Tetsuya, Nishijima Ken-ichi, Diakur James M., Seki Koh-ichi

HETEROCYCLES   69 ( 1 )   515 - +   2006.12（ ISSN:0385-5414 ）

[11C]ホスゲンを用いた核酸系PET薬剤の合成法の開発

関 興一, 西嶋 剣一, 大倉 一枝

放射線生物研究   41 ( 4 )   387 - 398   2006.12（ ISSN:0441747X ）

[Study on the highly efficient synthesis and pharmaceutical evaluation of PET radiopharmaceuticals for the clinical application].

Nishijima K

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan   126 ( 9 )   737 - 745   2006.9（ ISSN:0031-6903|1347-5231 ）

A new convenient method for the synthesis of [2-C-11]thymine utilizing [C-11]phosgene

Ohkura Kazue, Nishijima Ken-ichi, Sanoki Kimihito, Kuge Yuji, Tamaki Nagara, Seki Koh-ichi

TETRAHEDRON LETTERS   47 ( 30 )   5321 - 5323   2006.7（ ISSN:0040-4039 ）

Stereoselective synthesis of tetrahydronaphthocyclobuta[1,2-d]pyrimidinediones from 5-fluoro-1,3-dimethyluracil and naphthalenes.

Ohkura K, Ishihara T, Nishijima K, Diakur JM, Seki K

Chemical & pharmaceutical bulletin   53 ( 2 )   258 - 259   2005.2（ ISSN:1347-5223|0009-2363 ）

Characteristic Brain distribution of 1-¹⁴C-Octanoate in a rat model of focalcerebral ischemia in comparison with those of ¹²³I-IMP and ¹²³I-Iomazenil

西嶋　剣一

J. Nud. Med   44   1168 - 1175   2003

Characteristic Brain distribution of 1-¹⁴C-Octanoate in a rat model of focalcerebral ischemia in comparison with those of ¹²³I-IMP and ¹²³I-Iomazenil

J. Nud. Med   44   1168 - 1175   2003

心臓移植後の機能回復をPETで診る

西嶋 剣一

ファルマシア   38 ( 9 )   886 - 887   2002.9（ ISSN:00148601 ）

Increased [18F]2-fluoro-2-deoxy-D-glucose ([18F]FDG) yield with recycled target [18O]water: factors affecting the [18F]FDG yield.

Nishijima K, Kuge Y, Tsukamoto E, Seki K, Ohkura K, Magata Y, Tanaka A, Nagatsu K, Tamaki N

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine   57 ( 1 )   43 - 9   2002.7（ ISSN:0969-8043 ）

心筋β受容体診断薬[11C]CGP-12177:臨床応用のための基礎的検討

元木 典子, 久下 裕司, 西嶋 剣一, 関 興一, 大倉 一枝, 馬渕 恵, 藤本 江利子, 玉木 長良

核医学   39 ( 2 )   182 - 182   2002.5（ ISSN:0022-7854 ）

A simplified and improved synthesis of [11C]phosgene with iron and iron (III) oxide.

Nishijima K, Kuge Y, Seki K, Ohkura K, Motoki N, Nagatsu K, Tanaka A, Tsukamoto E, Tamaki N

Nuclear medicine and biology   29 ( 3 )   345 - 50   2002.4（ ISSN:0969-8051 ）

使い捨てFDG合成キット　MicroLab

久下 裕司, 西嶋 剣一, 玉木 長良

Radioisotopes   51 ( 4 )   191 - 194   2002.4（ ISSN:0033-8303 ）

In vitro uptake of [1-14C]Octanoate in brain slices of rats: basic studies for assessing [1-11C]Octanoate as a PET tracer of glial functions.

Kuge Y, Hikosaka K, Seki K, Ohkura K, Nishijima K, Tsukamoto E, Tamaki N

Nuclear medicine and biology   29 ( 3 )   303 - 6   2002.4（ ISSN:0969-8051 ）

Chemical impurities in [18F]FDG preparations produced by solid-phase 18F-fluorination.

Kuge Y, Nishijima K, Nagatsu K, Seki K, Ohkura K, Tanaka A, Sasaki M, Tsukamoto E, Tamaki N

Nuclear medicine and biology   29 ( 2 )   275 - 9   2002.2（ ISSN:0969-8051 ）

使い捨てＦＤＧ合成キット　　ＭｉｃｒｏＬａｂ

久下 裕司, 西嶋 剣一, 玉木 長良

RADIOISOTOPES   51 ( 4 )   191 - 194   2002（ ISSN:0033-8303 ）

Synthesis 9, 11-diazapentacyclo-[6, 4, 0, 0^{1, 3} 0^{2, 5} 0^{4, 8}] dodecane-2, 4-diones

Heterocycles   56 ( 1-2 )   235 - 244   2002

Chemical impurities in [¹⁸F]FDG preparations produced by soild-phase ¹⁸F fluorination

Nuclear Medicine and Biology   29   275 - 279   2002

In vitro uptake of [1-¹⁴C] Octanoate in brain slices of rats : basic studies for assessing [1-¹¹C] Octaoate as a PET tracer of glial functions

Nuclear Medicine and Biology   29   303 - 306   2002

Photochemical synthesis of naphthocyclobuta-pyrimidines via 1, 2-cycloaddition of 6-chloro-1, 3-dimethyluracil with napthalenes.

Heterocycles   57 ( 8 )   1403 - 1408   2002

Thermodynamically controlled photocycloaddition of 5-fluoro-1, 3 dimethyluracil to naphthalenes

Heterocycles   58   595 - 600   2002

Increased [¹⁸F]2-fluoro-2-deoxy-d-glucose([¹⁸F]FDG) yield with recycled target [¹⁸O] water : factors affecting the [¹⁸F]FDG yield.

Applied Radiation and Isotopes   57   143 - 149   2002

In vitro uptake of [1-¹⁴C] Octanoate in brain slices of rats : basic studies for assessing [1-¹¹C] Octaoate as a PET tracer of glial functions

NISHIJIMA Ken-ichi

Nuclear Medicine and Biology   29   303 - 306   2002

Chemical impurities in [¹⁸F]FDG preparations produced by soild-phase ¹⁸F fluorination

NISHIJIMA Ken-ichi

Nuclear Medicine and Biology   29   275 - 279   2002

Synthesis 9, 11-diazapentacyclo-[6, 4, 0, 0^{1, 3} 0^{2, 5} 0^{4, 8}] dodecane-2, 4-diones

NISHIJIMA Ken-ichi

Heterocycles   56 ( 1-2 )   235 - 244   2002

Stereoselective synthesis of 4α-fluoro-5, 10-ethenobenzo[f] quinazolines via photo-Diels-Alder reaction of 5-fluoro-1, 3-dimethyluracil with naphthalenes

OHKURA K, SUGAOI T, NISHIJIMA K, KUGE Y, SEKI K

Tetrahedron Letters   43 ( 17 )   3113 - 3115   2002（ ISSN:0040-4039 ）

A simplified and improved synthesis of [^MC] phosgene with iron and iron(Ⅲ) oxide

NISHIJIMA Ki, KUGE Y, SEKI K, OHKURA K, MOTOKI N, NAGATSU K, TANAKA A, TSUKAMOTO E, TAMAKI N

Nuclear Medicine and Biology （2002）   29 ( 3 )   345 - 350   2002（ ISSN:0969-8051 ）

In vitro uptake of [1-¹⁴C] Octanoate in brain slices of rats : basic studies for assessing [1-¹¹C] Octaoate as a PET tracer of glial functions

西嶋　剣一

Nuclear Medicine and Biology   29   303 - 306   2002

Chemical impurities in [¹⁸F]FDG preparations produced by soild-phase ¹⁸F fluorination

西嶋　剣一

Nuclear Medicine and Biology   29   275 - 279   2002

Synthesis 9, 11-diazapentacyclo-[6, 4, 0, 0^{1, 3} 0^{2, 5} 0^{4, 8}] dodecane-2, 4-diones

西嶋　剣一

Heterocycles   56 ( 1-2 )   235 - 244   2002

心臓移植後の機能回復をPETで診る

西嶋　剣一

ファルマシア   38 ( 9 )   886 - 887   2002

[1-11C]オクタン酸の脳虚血病態診断薬としての可能性　局所脳虚血ラットにおけるARGによる検討

彦坂 憲司, 久下 裕司, 西嶋 剣一, 関 興一, 大倉 一枝, 塚本 江利子, 玉木 長良

核医学   38 ( 5 )   595 - 595   2001.9（ ISSN:0022-7854 ）

新規[11C]ホスゲン合成法を用いた[11C]S(-)CGP-12177の合成とラット体内動態

西嶋 剣一, 久下 裕司, 塚本 江利子, 関 興一, 大倉 一枝, 馬渕 恵, 永津 弘太郎, 田中 明, 玉木 長良

核医学   38 ( 5 )   579 - 580   2001.9（ ISSN:0022-7854 ）

[1-11C]オクタン酸の脳機能診断薬としての可能性　ラット脳スライスを用いるin vitro実験

彦坂 憲司, 久下 裕司, 西嶋 剣一, 関 興一, 大倉 一枝, 塚本 江利子, 玉木 長良

核医学   38 ( 5 )   595 - 595   2001.9（ ISSN:0022-7854 ）

オンカラム法(FDG MicroLabTM)を用いる18F-FDGの合成　エンドトキシン試験及び無菌試験に関する検討

久下 裕司, 西嶋 剣一, 永津 弘太郎, 田中 明, 塚本 江利子, 玉木 長良

核医学   38 ( 2 )   125 - 130   2001.3（ ISSN:0022-7854 ）

オニカラム法（FDG-MicroLab^TM）を用いる¹⁸F-FDGの合成：エンドトキシン試験および無菌試験に関する検討

西嶋　剣一

核医学   38 ( 2 )   125 - 130   2001

Acid-catalyzed photorearrangement of the bond-switching isomer of a pentamethylcylooctaprimidine-2, 4-dione

Heterocycles   55 ( 6 )   1015 - 1018   2001

Electrocyclic rearrangement of pentamethylcyclooctapyrimidine-2, 4diones : reaction pathway into a 9, 11-diazapentacyclo-[6, 4, 0, 0^{1, 3} 0^{2, 5} 0^{4, 8}] dodecane system

Photochemistry and Photobiology   74 ( 3 )   385 - 390   2001

Photochemical synthesis and characterization of the tautomers of 1, 3, 5, 7, 9-and 1, 3, 6, 8, 10 pentamethylcyclooctapyrimidine-2, 4-dione

NISHIJIMA Ken-ichi

Heterocycles   54 ( 1 )   65 - 68   2001

Acid-catalyzed photoreaction of 6-chloro-1, 3-dimethyluracil and mesitylene formation of photocycloadducts and characterization

OHKURA K, NISHIJIMA K, SEKI K

Chemical&Pharmaceutical Bulletin   49 ( 4 )   384 - 390   2001（ ISSN:1347-5223|0009-2363 ）

Photochemical synthesis and characterization of the tautomers of 1, 3, 5, 7, 9-and 1, 3, 6, 8, 10 pentamethylcyclooctapyrimidine-2, 4-dione

西嶋　剣一

Heterocycles   54 ( 1 )   65 - 68   2001

[1-11C]オクタン酸の局所脳虚血ラットにおける脳内分布　イオマゼニルとの対比

彦坂 憲司, 久下 裕司, 西嶋 剣一, 関 興一, 大倉 一枝, 玉木 長良

核医学   37 ( 5 )   571 - 571   2000.9（ ISSN:0022-7854 ）

18O-ターゲット水によるFDG収量の変化　要因の検討

西嶋 剣一, 久下 裕司, 塚本 江利子, 玉木 長良, 関 興一, 大倉 一枝, 永津 弘太郎, 田中 明, 間賀田 泰寛

核医学   37 ( 5 )   578 - 578   2000.9（ ISSN:0022-7854 ）

オンカラム法を用いる18F-FDGの合成　エンドトキシン試験及び無菌試験に関する検討

久下 裕司, 西嶋 剣一, 塚本 江利子, 玉木 長良, 関 興一, 大倉 一枝, 田中 明, 永津 弘太郎

核医学   37 ( 5 )   578 - 578   2000.9（ ISSN:0022-7854 ）

Photochemistry 9, 10-dihydro-1, 3, 5, 7-tetramethyl-9-methylenecylooctapyrimidine-2, 4-dione ; synthesis of through electrocyclic reactions

NISHIJIMA Ken-ichi

Heterocycles   53 ( 6 )   1247 - 1250   2000

FDG MicroLab TMシステムを用いる18F-FDGの合成　臨床応用のための基礎的検討

久下 裕司, 塚本 江利子, 加藤 千恵次, 関 興一, 大倉 一枝, 大宮 康明, 西嶋 剣一, 田中 明, 佐々木 基仁, 玉木 長良

核医学   36 ( 8 )   873 - 878   1999.10（ ISSN:0022-7854 ）

FDG MicroLab^TMシステムを用いる¹⁸F-FDGの合成：臨床応用のための基礎的検討

西嶋　剣一

核医学   36 ( 8 )   873 - 878   1999

Measurement of Iodine-Derived Contamination in L-[¹¹C]Methionine Injection

RADIOISOTOPES  

放射性フッ素標識化合物

放射性フッ素標識化合物

増殖性疾患の内用放射線治療剤

ウラシル化合物又はその塩、これらを有効成分として含有するイメージング剤、およびこれらを有効成分として含有する腫瘍診断をするためのイメージング剤

ウラシル化合物又はその塩、これらを有効成分として含有するイメージング剤、およびこれらを有効成分として含有する腫瘍診断をするためのイメージング剤

PD-ECGF targeted tumor treatment with new At-211 radiolabeled uracil derivatives

Grant number：19K08180  2019.4 - 2022.3

Grant-in-Aid for Scientific Research (C)

NISHIJIMA Ken-ichi

PD-ECGFを標的とした腫瘍イメージング：I-123標識体の製造システムの開発

2014 - 2016

血管新生因子ＰＤ－ＥＣＧＦを標的としたＦ－１８標識イメージング剤の開発

2011 - 2013

西嶋 剣一、大倉 一枝

PD-ECGF-targeted tumor imaging with new radiolabeled uracil derivatives

2008 - 2010

PD-ECGFを標的とした分子イメージング剤の開発

2006 - 2007