Updated on 2024/02/16
anti-tumor immunity, tumor microenvironment, tumor-associated macrophage
Oncoimmunology
molecular biology
Immunology
Life Science / Tumor biology / Oncoimmunotherapy
Fukushima Medical University Department of Multidisciplinary Treatment of Cancer and Regional Medical Support Associate Professor PhD of Life Science
2022.1 - Now
Country：Japan
Fukushima Medical University Endowed Chair Department of Obesity and Inflammation Research Associate Professor
2020.12 - 2021.12
Fukushima Medical University Dept. Medical Electrophysiology/Dept. Gastrointestinal Tract Surgery Lecturer
2020.2 - 2020.11
Country：Japan
Fukushima Medical University Dept. Progressive DOHaD Research/Dept. of Gastrointestinal Tract Surgery Lecturer
2019.6 - Now
Fukushima Medical University Endowed Chair Department of Progressive DOHaD Research Associate Professor
2019.6 - 2020.11
エルゼビアジャパン eReview コミッティメンバー 免疫学
2017.1 - Now
Japan Society for Biological Therapy
2019.8 - Now
Japanese cancer association
2019.6 - Now
The Molecular Biology Society of Japan
2008.10 - Now
Down-regulation of stimulator of interferon genes (STING) expression and CD8(+) T-cell infiltration depending on HER2 heterogeneity in HER2-positive gastric cancer.
Fukai S, Nakajima S, Saito M, Saito K, Kase K, Nakano H, Sato T, Sakuma M, Kaneta A, Okayama H, Mimura K, Sakamoto W, Saze Z, Momma T, Kono K
Gastric cancer 26 ( 6 ) 878 - 890 2023.8
A Potential Biomarker of Dynamic Change in Peripheral CD45RA(-)CD27(+)CD127(+) Central Memory T Cells for Anti-PD-1 Therapy in Patients with Esophageal Squamous Cell Carcinoma.
Sakuma M, Mimura K, Nakajima S, Kaneta A, Kikuchi T, Nirei A, Tada T, Hanayama H, Okayama H, Sakamoto W, Saito M, Momma T, Saze Z, Kono K
Cancers 15 ( 14 ) 3641 2023.7（ ISSN:2072-6694 ）
The Impact of Tumor Cell-Intrinsic Expression of Cyclic GMP-AMP Synthase (cGAS)-Stimulator of Interferon Genes (STING) on the Infiltration of CD8(+) T Cells and Clinical Outcomes in Mismatch Repair Proficient/Microsatellite Stable Colorectal Cancer.
Nakajima S, Kaneta A, Okayama H, Saito K, Kikuchi T, Endo E, Matsumoto T, Fukai S, Sakuma M, Sato T, Mimura K, Saito M, Saze Z, Sakamoto W, Onozawa H, Momma T, Kono K
Cancers 15 ( 10 ) 2826 2023.5（ ISSN:2072-6694 ）
Radiation-Induced Remodeling of the Tumor Microenvironment Through Tumor Cell-Intrinsic Expression of cGAS-STING in Esophageal Squamous Cell Carcinoma.
Nakajima S, Mimura K, Kaneta A, Saito K, Katagata M, Okayama H, Saito M, Saze Z, Watanabe Y, Hanayama H, Tada T, Sakamoto W, Momma T, Ohira H, Kono K
International journal of radiation oncology, biology, physics 115 ( 4 ) 957 - 971 2023.3（ ISSN:0360-3016 ）
M2 tumor-associated macrophages resist to oxidative stress through heme oxygenase-1 in the colorectal cancer tumor microenvironment.
Ito M, Mimura K, Nakajima S, Okayama H, Saito K, Nakajima T, Kikuchi T, Onozawa H, Fujita S, Sakamoto W, Saito M, Momma T, Saze Z, Kono K
Cancer immunology, immunotherapy : CII 72 ( 7 ) 2233 - 2244 2023.3（ ISSN:0340-7004 ）
ARID1A deficiency is targetable by AKT inhibitors in HER2-negative gastric cancer.
Sato T, Saito M, Nakajima S, Saito K, Katagata M, Fukai S, Okayama H, Sakamoto W, Saze Z, Momma T, Mimura K, Kono K
Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 26 ( 3 ) 379 - 392 2023.2（ ISSN:1436-3291 ）
Phase I/II clinical trial of nivolumab in combination with oligo-fractionated irradiation for unresectable advanced or recurrent gastric cancer.
Mimura K, Ogata T, Yoshimoto Y, Yoshida D, Nakajima S, Sato H, Machida N, Yamada T, Watanabe Y, Tamaki T, Fujikawa H, Inokuchi Y, Hayase S, Hanayama H, Saze Z, Katoh H, Takahashi F, Oshima T, Suzuki Y, Kono K
Commun Med (Lond) 3 ( 1 ) 111 2023
TIM-3 Expression and M2 Polarization of Macrophages in the TGFβ-Activated Tumor Microenvironment in Colorectal Cancer.
Katagata M, Okayama H, Nakajima S, Saito K, Sato T, Sakuma M, Fukai S, Endo E, Sakamoto W, Saito M, Saze Z, Momma T, Mimura K, Kono K.
Cancers (Basel) 15 ( 20 ) 4943 2023
Radiation-induced remodeling of the tumor-microenvironment through tumor cell-intrinsic expression of cGAS-STING in esophageal squamous cell carcinoma.
Shotaro Nakajima, Kosaku Mimura, Akinao Kaneta, Katsuharu Saito, Masanori Katagata, Hirokazu Okayama, Motonobu Saito, Zenichiro Saze, Yohei Watanabe, Hiroyuki Hanayama, Takeshi Tada, Wataru Sakamoto, Tomoyuki Momma, Hiromasa Ohira, Koji Kono
International journal of radiation oncology, biology, physics 115 ( 4 ) 957 - 971 2022.11（ ISSN:0360-3016 ）
[Expression of the cGAS-STING Pathway in dMMR/MSI-H in Colorectal Cancer].
Kaneta A, Nakajima S, Mimura K, Kono K
Gan to kagaku ryoho. Cancer & chemotherapy 49 ( 10 ) 1130 - 1132 2022.10（ ISSN:0385-0684 ）
dMMR/MSI-H大腸癌におけるcGAS-STING経路の発現
金田晃尚，中嶋正太郎，三村耕作，河野浩二
癌と化学療法 49 ( 10 ) 1130 - 1132 2022.10
Immune escape mechanism behind resistance to anti-PD-1 therapy in gastrointestinal tract metastasis in malignant melanoma patients with multiple metastases
Ito M, Mimura K, Nakajima S, Saito K, Min AKT, Okayama H, Saito M, Momma T, Saze Z, Ohtsuka M, Yamamoto T, Kono K.
Cancer Immunol Immunother. 71 ( 9 ) 2293 - 2300 2022.9
Akinao Kaneta, Shotaro Nakajima, Hirokazu Okayama, Takuro Matsumoto, Katsuharu Saito, Tomohiro Kikuchi, Eisei Endo, Misato Ito, Kosaku Mimura, Yasuyuki Kanke, Motonobu Saito, Zenichiro Saze, Shotaro Fujita, Wataru Sakamoto, Hisashi Onozawa, Tomoyuki Momma, Shinji Ohki, Koji Kono
Cancer immunology, immunotherapy : CII 71 ( 11 ) 2765 - 2776 2022.4（ ISSN:0340-7004 ）
SH2D4A downregulation due to loss of chromosome 8p is associated with poor prognosis and low T cell infiltration in colorectal cancer
Matsumoto T, Okayama H, Nakajima S, Saito K, Ito M, Kaneta A, Kanke Y, Onozawa H, Hayase S, Fujita S, Sakamoto W, Saito M, Seze Z, Momma T, Mimura K, Kono K.
Br J Cancer. 126 ( 6 ) 917 - 926 2022.4
Misato Ito, Kosaku Mimura, Shotaro Nakajima, Katsuharu Saito, Aung Kyi Thar Min, Hirokazu Okayama, Motonobu Saito, Tomoyuki Momma, Zenichiro Saze, Mikio Ohtsuka, Toshiyuki Yamamoto, Koji Kono
Cancer Immunology, Immunotherapy 71 ( 9 ) 2293 - 2300 2022.1（ ISSN:0340-7004 ）
Matsumoto T, Okayama H, Nakajima S, Saito K, Ito M, Kaneta A, Kanke Y, Onozawa H, Hayase S, Fujita S, Sakamoto W, Saito M, Seze Z, Momma T, Mimura K, Kono K
British journal of cancer 126 ( 6 ) 917 - 926 2021.12（ ISSN:0007-0920 ）
S H Petersen, L F Kua, S Nakajima, W P Yong, K Kono
Scientific reports 11 ( 1 ) 12264 - 12264 2021.12
SH2D4A downregulation due to loss of chromosome 8p is associated with poor prognosis and low T cell infiltration in colorectal cancer
Matsumoto T, Okayama H, Nakajima S, Saito K, Ito M, Kaneta A, Kanke Y, Onozawa H, Hayase S, Fujita S, Sakamoto W, Saito M, Seze Z, Momma T, Mimura K, Kono K
Br J Cancer 2021.12
SH2D4A downregulation due to loss of chromosome 8p is associated with poor prognosis and low T cell infiltration in colorectal cancer
Matsumoto T, Okayama H, Nakajima S, Saito K, Ito M, Kaneta A, Kanke Y, Onozawa H, Hayase S, Fujita S, Sakamoto W, Saito M, Seze Z, Momma T, Mimura K, Kono K
Br J Cancer 2021.12
Matsumoto T., Okayama H., Nakano H., Ito M., Nakajima S., Saito M., Saze Z., Momma T., Mimura K., Kono K.
Gan to kagaku ryoho. Cancer & chemotherapy 48 ( 10 ) 1275 - 1277 2021.10（ ISSN:03850684 ）
[Immunotherapy Targeting Tumor-Associated Carbohydrate Antigens in Deficient Mismatch Repair Colorectal Cancer].
Matsumoto T, Okayama H, Nakano H, Ito M, Nakajima S, Saito M, Saze Z, Momma T, Mimura K, Kono K
Gan to kagaku ryoho. Cancer & chemotherapy 48 ( 10 ) 1275 - 1277 2021.10（ ISSN:0385-0684 ）
ミスマッチ修復機構欠損大腸癌における糖鎖抗原を標的とした免疫療法の可能性
松本 拓朗, 岡山 洋和, 仲野 宏, 伊藤 美郷, 中嶋 正太郎, 齋藤 元伸, 佐瀬 善一郎, 門馬 智之, 三村 耕作, 河野 浩二
癌と化学療法 48 ( 10 ) 1275 - 1277 2021.10（ ISSN:0385-0684 ）
Prajwal Neupane, Kosaku Mimura, Shotaro Nakajima, Hirokazu Okayama, Misato Ito, Aung Kyi Thar Min, Katsuharu Saito, Hisashi Onozawa, Shotaro Fujita, Wataru Sakamoto, Motonobu Saito, Zenichiro Saze, Tomoyuki Momma, Koji Kono
Anticancer research 41 ( 10 ) 4895 - 4905 2021.10（ ISSN:0250-7005 ）
Shotaro Nakajima, Kosaku Mimura, Takuro Matsumoto, Aung Kyi Thar Min, Misato Ito, Hiroshi Nakano, Prajwal Neupane, Yasuyuki Kanke, Hirokazu Okayama, Motonobu Saito, Tomoyuki Momma, Yohei Watanabe, Hiroyuki Hanayama, Suguru Hayase, Zenichiro Saze, Koji Kono
Scientific reports 11 ( 1 ) 16891 - 16891 2021.8
Naoto Yamauchi, Yasuyuki Kanke, Katsuharu Saito, Hirokazu Okayama, Shoki Yamada, Shotaro Nakajima, Eisei Endo, Koji Kase, Leo Yamada, Hiroshi Nakano, Takuro Matsumoto, Hiroyuki Hanayama, Yohei Watanabe, Suguru Hayase, Motonobu Saito, Zenichiro Saze, Kosaku Mimura, Tomoyuki Momma, Shinji Oki, Yuko Hashimoto, Koji Kono
Oncology letters 21 ( 6 ) 445 - 445 2021.6（ ISSN:1792-1074 ）
Shotaro Nakajima, Kosaku Mimura, Katsuharu Saito, Aung Kyi Thar Min, Eisei Endo, Leo Yamada, Koji Kase, Naoto Yamauchi, Takuro Matsumoto, Hiroshi Nakano, Yasuyuki Kanke, Hirokazu Okayama, Motonobu Saito, Prajwal Neupane, Zenichiro Saze, Yohei Watanabe, Hiroyuki Hanayama, Suguru Hayase, Akinao Kaneta, Tomoyuki Momma, Shinji Ohki, Hiromasa Ohira, Koji Kono
Molecular cancer research : MCR 19 ( 6 ) 1085 - 1095 2021.6（ ISSN:1541-7786 ）
ARID1A deficiency in EBV-positive gastric cancer is partially regulated by EBV-encoded miRNAs, but not by DNA promotor hypermethylation.
Koji Kase, Motonobu Saito, Shotaro Nakajima, Daisuke Takayanagi, Katsuharu Saito, Leo Yamada, Mai Ashizawa, Hiroshi Nakano, Hiroyuki Hanayama, Hisashi Onozawa, Hirokazu Okayama, Hisahito Endo, Shotaro Fujita, Wataru Sakamoto, Zenichiro Saze, Tomoyuki Momma, Kosaku Mimura, Shinji Ohki, Kouya Shiraishi, Takashi Kohno, Koji Kono
Carcinogenesis 42 ( 1 ) 21 - 30 2021.2（ ISSN:0143-3334 ）
Hiroshi Nakano, Motonobu Saito, Shotaro Nakajima, Katsuharu Saito, Yuko Nakayama, Koji Kase, Leo Yamada, Yasuyuki Kanke, Hiroyuki Hanayama, Hisashi Onozawa, Hirokazu Okayama, Shotaro Fujita, Wataru Sakamoto, Zenichiro Saze, Tomoyuki Momma, Kosaku Mimura, Shinji Ohki, Akiteru Goto, Koji Kono
Scientific reports 11 ( 1 ) 1982 - 1982 2021.1
ARID1A欠損胃癌における合成致死に基づいたEZH2阻害剤の選択的感受性(Selective sensitivity of EZH2 inhibitors based on synthetic lethality in ARID1A-deficient gastric cancer)
Yamada Leo, Saito Motonobu, Aung Kyi Thar Min , Saito Katsuharu, Ashizawa Mai, Kase Koji, Nakajima Shotaro, Onozawa Hisashi, Okayama Hirokazu, Endo Hisahito, Fujita Shotaro, Sakamoto Wataru, Saze Zenichiro, Momma Tomoyuki, Mimura Kosaku, Ohki Shinji, Kono Koji
Gastric Cancer 24 ( 1 ) 60 - 71 2021.1（ ISSN:1436-3291 ）
Tn Antigen Expression Defines an Immune Cold Subset of Mismatch-Repair Deficient Colorectal Cancer.
Takuro Matsumoto, Hirokazu Okayama, Shotaro Nakajima, Katsuharu Saito, Hiroshi Nakano, Eisei Endo, Koji Kase, Misato Ito, Naoto Yamauchi, Leo Yamada, Yasuyuki Kanke, Hisashi Onozawa, Shotaro Fujita, Wataru Sakamoto, Motonobu Saito, Zenichiro Saze, Tomoyuki Momma, Kosaku Mimura, Koji Kono
International journal of molecular sciences 21 ( 23 ) 1 - 13 2020.11（ ISSN:16616596 ）
A TGFβ-dependent stromal subset underlies immune checkpoint inhibitor efficacy in DNA mismatch repair-deficient/microsatellite instability-high colorectal cancer.
Eisei Endo, Hirokazu Okayama, Katsuharu Saito, Shotaro Nakajima, Leo Yamada, Daisuke Ujiie, Koji Kase, Shotaro Fujita, Hisahito Endo, Wataru Sakamoto, Motonobu Saito, Zenichiro Saze, Tomoyuki Momma, Shinji Ohki, Kosaku Mimura, Koji Kono
Molecular cancer research : MCR 18 ( 9 ) 1402 - 1413 2020.9（ ISSN:1541-7786 ）
Aung Kyi Thar Min, Kosaku Mimura, Shotaro Nakajima, Hirokazu Okayama, Katsuharu Saito, Wataru Sakamoto, Shotaro Fujita, Hisahito Endo, Motonobu Saito, Zenichiro Saze, Tomoyuki Momma, Shinji Ohki, Koji Kono
Cancer immunology, immunotherapy : CII 70 ( 2 ) 289 - 298 2020.7（ ISSN:0340-7004 ）
Current status of immune checkpoint inhibitors for gastric cancer.
Koji Kono, Shotaro Nakajima, Kosaku Mimura
Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 23 ( 4 ) 565 - 578 2020.7（ ISSN:1436-3291 ）
Current status of immune checkpoint inhibitors for gastric cancer(和訳中)
Kono Koji, Nakajima Shotaro, Mimura Kosaku
Gastric Cancer 23 ( 4 ) 565 - 578 2020.7（ ISSN:1436-3291 ）
Activation of the reward system ameliorates passive cutaneous anaphylactic reaction in mice.
Shotaro Nakajima, Satoshi Manita, Guannan Yu, Kayoko Ishimaru, Koji Kono, Kazuo Kitamura, Atsuhito Nakao
Allergy 75 ( 12 ) 3275 - 3279 2020.6（ ISSN:0105-4538 ）
Leo Yamada, Motonobu Saito, Aung Kyi Thar Min, Katsuharu Saito, Mai Ashizawa, Koji Kase, Shotaro Nakajima, Hisashi Onozawa, Hirokazu Okayama, Hisahito Endo, Shotaro Fujita, Wataru Sakamoto, Zenichiro Saze, Tomoyuki Momma, Kosaku Mimura, Shinji Ohki, Koji Kono
Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 24 ( 1 ) 60 - 71 2020.6（ ISSN:1436-3291 ）
cutting-edge medicineがん診療の副作用マネジメント 複合がん免疫療法の発展を目指して
中嶋 正太郎, 河野 浩二
Precision Medicine 3 ( 4 ) 299 - 302 2020.4（ ISSN:2434-3625 ）
Ishimaru K, Nakajima S, Yu G, Nakamura Y, Nakao A
International journal of molecular sciences 20 ( 24 ) 2019.12（ ISSN:16616596 ）
Resveratrol inhibits IL-33-mediated mast cell activation by targeting the MK2/3-PI3K/Akt axis.
Nakajima S, Ishimaru K, Kobayashi A, Yu G, Nakamura Y, Oh-Oka K, Suzuki-Inoue K, Kono K, Nakao A
Scientific reports 9 ( 1 ) 18423 2019.12
The frequency of Th17 cells in the small intestine exhibits a day-night variation dependent on circadian clock activity.
Ha Pham Thu Le, Yuki Nakamura, Kyoko Oh-Oka, Kayoko Ishimaru, Shotaro Nakajima, Atsuhito Nakao
Biochemical and biophysical research communications 490 ( 2 ) 290 - 295 2017.8
Induction of Colonic Regulatory T Cells by Mesalamine by Activating the Aryl Hydrocarbon Receptor.
Kyoko Oh-Oka, Yuko Kojima, Koichiro Uchida, Kimiko Yoda, Kayoko Ishimaru, Shotaro Nakajima, Jun Hemmi, Hiroshi Kano, Yoshiaki Fujii-Kuriyama, Ryohei Katoh, Hiroyuki Ito, Atsuhito Nakao
Cellular and molecular gastroenterology and hepatology 4 ( 1 ) 135 - 151 2017.7
Mimura K, Kua LF, Shimasaki N, Shiraishi K, Nakajima S, Siang LK, Shabbir A, So J, Yong WP, Kono K
Cancer immunology, immunotherapy : CII 66 ( 5 ) 605 - 613 2017.5（ ISSN:0340-7004 ）
Selective deletion of adipocytes, but not preadipocytes, by TNF-α through C/EBP- and PPARγ-mediated suppression of NF-κB.
Minori Tamai, Tsuyoshi Shimada, Nobuhiko Hiramatsu, Kunihiro Hayakawa, Maro Okamura, Yasuhiro Tagawa, Shuhei Takahashi, Shotaro Nakajima, Jian Yao, Masanori Kitamura
Laboratory investigation; a journal of technical methods and pathology 97 ( 2 ) 228 - 228 2017.2
Shiraishi K, Mimura K, Kua LF, Koh V, Siang LK, Nakajima S, Fujii H, Shabbir A, Yong WP, So J, Takenoshita S, Kono K
Journal of gastroenterology 51 ( 12 ) 1101 - 1111 2016.12（ ISSN:0944-1174 ）
Nakajima S, Koh V, Kua LF, So J, Davide L, Lim KS, Petersen SH, Yong WP, Shabbir A, Kono K
Journal of immunology (Baltimore, Md. : 1950) 197 ( 9 ) 3735 - 3745 2016.11（ ISSN:0022-1767 ）
eIF2α-independent inhibition of TNF-α-Triggered NF-κB activation by salubrinal
Nakajima S., Chi Y., Gao K., Kono K., Yao J.
Biological and Pharmaceutical Bulletin 38 ( 9 ) 1368 - 1374 2015.9（ ISSN:09186158 ）
Purinergic control of AMPK activation by ATP released through connexin 43 hemichannels - pivotal roles in hemichannel-mediated cell injury.
Yuan Chi, Kun Gao, Kai Li, Shotaro Nakajima, Satoru Kira, Masayuki Takeda, Jian Yao
Journal of cell science 127 ( Pt 7 ) 1487 - 99 2014.4
Acidic stress-ER stress axis for blunted activation of NF-kappa B in mesothelial cells exposed to peritoneal dialysis fluid (vol 27, pg 4053, 2012)
Hisashi Johno, Ryouji Ogata, Shotaro Nakajima, Nobuhiko Hiramatsu, Tetsuro Kobayashi, Hideaki Hara, Masanori Kitamura
NEPHROLOGY DIALYSIS TRANSPLANTATION 29 ( 2 ) 470 - 470 2014.2（ ISSN:0931-0509 ）
Bidirectional regulation of NF-κB by reactive oxygen species: a role of unfolded protein response.
Shotaro Nakajima, Masanori Kitamura
Free radical biology & medicine 65 162 - 174 2013.12（ ISSN:0891-5849 ）
Selective, potent blockade of the IRE1 and ATF6 pathways by 4-phenylbutyric acid analogues.
Hui Zhang, Shotaro Nakajima, Hironori Kato, Liubao Gu, Tatsuya Yoshitomi, Kaoru Nagai, Hideyuki Shinmori, Susumu Kokubo, Masanori Kitamura
British journal of pharmacology 170 ( 4 ) 822 - 34 2013.10
Intervention in genotoxic stress-induced senescence by cordycepin through activation of eIF2α and suppression of Sp1.
Liubao Gu, Hisashi Johno, Shotaro Nakajima, Tatsuya Yoshitomi, Shuhei Takahashi, Masanori Kitamura
Toxicological sciences : an official journal of the Society of Toxicology 134 ( 2 ) 345 - 54 2013.8
Pleiotropic Potential of Dehydroxymethylepoxyquinomicin for NF-kappa B Suppression via Reactive Oxygen Species and Unfolded Protein Response
Shotaro Nakajima, Hironori Kato, Liubao Gu, Shuhei Takahashi, Hisashi Johno, Kazuo Umezawa, Masanori Kitamura
JOURNAL OF IMMUNOLOGY 190 ( 12 ) 6559 - 6569 2013.6（ ISSN:0022-1767 ）
Blockade of Smad signaling by 3'-deoxyadenosine: a mechanism for its anti-fibrotic potential.
Liubao Gu, Hisashi Johno, Shotaro Nakajima, Hironori Kato, Shuhei Takahashi, Ryohei Katoh, Masanori Kitamura
Laboratory investigation; a journal of technical methods and pathology 93 ( 4 ) 450 - 61 2013.4
アバス-リックマン-ピレ 分子細胞免疫学 原著第１０版
中尾篤人（用語解説）
エルゼビアジャパン株式会社 2023.1
Basic Immunology: Functions and Disorders of the immune System Sixth Edition
2020.8
Precision Medicine
Shotaro Nakajima, Kono Koji（cutting-edge medicine -The development of combination cancer immunotherapy-）
Hokuryukan 2020.3
Cellular and molecular immunology
（index）
Elsevier 2018.3
Neoadjuvant che-motherapy- induced IL34 signaling promotes chemoresistance in esophageal cancer
Fukushima-NIH National Cancer Institute Joint Symposium 2023.1
大腸癌における腫瘍細胞内 cGAS-STING経路を標的とした新規治療戦略
第35回日本バイオセラピィ学会学術集会総会 2022.12
放射線治療による腫瘍細胞内 cGAS-STING経路を介した食道扁平上皮癌微小環境リモデリング機構の解明
第35回日本バイオセラピィ学会学術集会総会 2022.12
上部消化管癌における抗PD-1療法と局所放射線療法を用いた複合がん免疫療法の開発
第35回日本バイオセラピィ学会学術集会総会 2022.12
癌間質におけるTGF-βと腫瘍浸潤免疫細胞でのTIM3の発現との関連について
第35回日本バイオセラピィ学会学術集会総会 2022.12
ARID1A欠損胃癌に対するAKT阻害薬の有効性
第35回日本バイオセラピィ学会学術集会総会 2022.12
HER2陽性胃癌におけるcGAS-STING経路の役割
第35回日本バイオセラピィ学会学術集会総会 2022.12
Targeting the tumor immune microenvironment in colorectal cancer
2022.12
大腸癌腫瘍微小環境におけるM2腫瘍関連マクロファージの浸潤頻度増加機序について
第60回日本癌治療学会学術集会 2022.10
大腸癌における免疫チェックポイントリガンドの発現状況について
第60回日本癌治療学会学術集会 2022.10
dMMR/MSI大腸癌におけるSTING高発現はCD8陽性T細胞の高浸潤に寄与する
第60回日本癌治療学会学術集会 2022.10
大腸癌の腫瘍免疫抑制機構
第60回日本癌治療学会学術集会 2022.10
大腸癌腫瘍微小環境における M2 腫瘍関連マクロファージの浸潤機序について
第77回日本消化器外科学会総会 2022.7
進行食道扁平上皮癌症例における複合がん免疫療法の開発
第77回日本消化器外科学会総会 2022.7
dMMR/MSI ⼤腸癌における cGAS-STING 経路の発現
第43回癌免疫外科研究会 2022.5
術前補助化学療法が⾷道扁平上⽪癌腫瘍微⼩環境に及ぼす影響
第43回癌免疫外科研究会 2022.5
進⾏⾷道扁平上⽪癌における抗 PD-1 療法と局所放射線療法を⽤いた複合がん 免疫療法の開発
第43回癌免疫外科研究会 2022.5
大腸癌腫瘍微小環境における免疫チェックポイントレセプターとリガンドの発現について
第122回日本外科学会定期学術集会 2022.4
術前化学療法が食道扁平上皮癌の腫瘍随伴マクロファージおよび腫瘍微小環境に及ぼす影響
第122回日本外科学会定期学術集会 2022.4
抗VEGFR2抗体を用いたM2腫瘍関連マクロファージ制御の可能性について
第122回日本外科学会定期学術集会 2022.4
EBV関連胃癌におけるPD-L1高発現は2つの異なる機序により引き起こされる
第122回日本外科学会定期学術集会 2022.4
食道扁平上皮癌における間質のCAFs関連分子発現は予後に関連する
第122回日本外科学会定期学術集会 2022.4
当科における働き方改革への対応と医学博士・内視鏡外科技術認定医「量産」への取り組み
第122回日本外科学会定期学術集会 2022.4
胃癌サブタイプにおける PD-L1 発現の比較検討
第122回日本外科学会定期学術集会 2022.4
CD163 陽性 M2 腫瘍関連マクロファージと PD-1 を標的とした複合がん免疫療法の開発
第122回日本外科学会定期学術集会 2022.4
術前補助化学療法が食道扁平上皮癌微小環境に及ぼす影響
第34回日本バイオセラピィ学会学術集会総会
食道扁平上皮癌の術前化学療法が誘導するIL-34がマクロファージのM2分極と薬剤感受性低下を促進する
第80回日本癌学会学術総会
術前補助化学療法により産生されるIL-34が食道扁平上皮癌の腫瘍随伴マクロファージ及び薬剤感受性に及ぼす影響
第42回癌免疫外科研究会
術前化学療法が食道癌微小環境に及ぼす影響の解析
第33回日本バイオセラピィ学会学術集会総会
食道扁平上皮癌における術前補助化学療法が腫瘍随伴マクロファージ に及ぼす影響
第79回日本癌学会学術総会
放射線照射が誘導する食道癌微小環境でのM2マクロファージの変化-複合がん免疫療法の発展を目指して-
第32回日本バイオセラピィ学会学術集会総会
STING経路を標的としたHER2陽性胃癌の新規治療戦略
Grant number：23K08177 2023.4 - 2026.3
基盤研究(C)
金田晃尚
Authorship：Coinvestigator(s) Grant type：Competitive
Grant amount：\4680000 （ Direct Cost: \3600000 、 Indirect Cost：\1080000 ）
低線量被曝が腫瘍随伴マクロファージの分化・機能に及ぼす影響（継続）
2023.3 - 2024.3
中嶋正太郎、神沼修
Authorship：Principal investigator
放射線とNivo併用におけるImmunogenic cell deathの検証
Grant number：22H03151 2022.4 - 2025.3
基盤研究(B)
河野 浩二, 松本 拓朗, 中嶋 正太郎, 三村 耕作
Grant amount：\13390000 （ Direct Cost: \10300000 、 Indirect Cost：\3090000 ）
T-DXdがHER2陽性胃癌における抗腫瘍免疫応答に及ぼす影響
Grant number：22K16493 2022.4 - 2025.3
若手研究
芦澤 舞
Grant amount：\4550000 （ Direct Cost: \3500000 、 Indirect Cost：\1050000 ）
食道癌の免疫放射線療法におけるcGAS-STING経路を介した腫瘍微小環境の制御
Grant number：22K08779 2022.4 - 2025.3
基盤研究(C)
中嶋 正太郎
Grant amount：\4160000 （ Direct Cost: \3200000 、 Indirect Cost：\960000 ）
低線量被曝が腫瘍随伴マクロファージの分化・機能に及ぼす影響
2022.4 - 2023.3
神沼 修、中嶋 正太郎
抗癌剤による食道扁平上皮癌微小環境におけるIL-34調節機構とTAMとの関連
Grant number：21K08758 2021.4 - 2024.3
基盤研究(C)
門馬 智之, 河野 浩二, 中嶋 正太郎
Grant amount：\4160000 （ Direct Cost: \3200000 、 Indirect Cost：\960000 ）
低線量被曝が腫瘍随伴マクロファージの分化・機能に及ぼす影響
2021.4 - 2022.3
神沼 修、中嶋 正太郎
抗癌剤による食道扁平上皮癌微小環境におけるIL-34調節機構とTAMとの関連
2021.3 - 2024.3
門馬 智之、中嶋 正太郎
食道癌における腫瘍随伴マクロファージに着目した免疫放射線療法の新規作用機序の解明
Grant number：20K17695 2020.4 - 2022.3
若手研究(B)
中嶋正太郎
Authorship：Principal investigator Grant type：Competitive
Grant amount：\4290000 （ Direct Cost: \3300000 、 Indirect Cost：\990000 ）
Effects of adipose tissue macrophages on mast cell metabolism
Grant number：18K16142 2018.4 - 2020.3
Grant-in-Aid for Early-Career Scientists
Nakajima Shotaro
Grant amount：\4160000 （ Direct Cost: \3200000 、 Indirect Cost：\960000 ）
In this study, we investigate whether and how obesity exacerbates allergic reaction.
We found that increased plasma histamine level by passive systemic anaphylaxis, a classical model of IgE/mast cell-mediated systemic allergic reaction, was significantly higher in high fat diet-induced obese mice than non-obese mice. To elucidate how obesity reinforces allergic reaction, we focus on the roles of adipose tissue macrophages because they are closely associated with obesity-related chronic diseases. In vitro experiment revealed that mRNA expression of osteopontin in macrophages was up-regulated by co-culturing with adipocytes. It has been reported that osteopontin regulates IL-12 production. Indeed, we found that IL-12 significantly enhanced degranulation of mast cell by antigen-challenge.
「病は気から」は本当か？アレルギー界の大きな謎に挑む！
2017.6
中嶋正太郎
Authorship：Principal investigator Grant type：Competitive
サイエンスカフェ
2017.10
