Updated on 2024/03/26

写真a

 
SASAKI Michiko
 
Organization
Integrated Center for Science and Humanities Biology and Chemistry Professor
School of Health Sciences Professor
Title
Professor

Degree

  • 博士(薬学) ( 2006   広島大学 )

Research Interests

  • 有機合成化学

Education

  • 広島大学大学院   医歯薬学総合研究科

    - 2006

  • 広島大学大学院   医歯薬学総合研究科

    - 2003

  • Hiroshima University   Faculty of Medicine

    - 2002

Research History

  • Fukushima Medical University   Fukushima Medical University Integrated Center for Science and Humanities   Professor

    2019.10 - Now

  • 広島大学   大学院医歯薬保健学研究院   准教授

    2012 - 2017

  • マサチューセッツ工科大学   化学科   研究員

    2010 - 2011

  • 広島大学   大学院医歯薬学総合研究科   助教

    2007 - 2012

  • 広島大学   大学院医歯薬学総合研究科   助手

    2004 - 2007

Papers

  • Abnormal Michael Reaction: Condition-Dependent Product Distributions in the Michael Reaction of Monoalkyl-Substituted Malonates

    Sasaki Michiko, Kasahara Akitomo, Takeda Kei

    The Journal of Organic Chemistry   ASAP   2024

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1021/acs.joc.4c00139

  • Formal Bimolecular [2+2+2] Cycloaddition Strategy for the Synthesis of Pyridines: Intramolecular Propargylic Ene Reaction/Aza Diets-Alder Reaction Cascades

    Sasaki Michiko, Hamzik Philip J., Ikemoto Hidaka, Bartko Samuel G., Danheiser Rick L.

    ORGANIC LETTERS   20 ( 19 )   6244 - 6249   2018.10( ISSN:1523-7060

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    Publishing type:Research paper (scientific journal)  

    DOI : 10.1021/acs.orglett.8b02728

  • Steric Course of Deprotonation/Substitution of Chelating/Dipole-Stabilizing-Group-Substituted -Amino- and -Oxynitriles

    Sasaki Michiko, Shimabara Rumiko, Takegawa Tomo, Kotomori Yuri, Otani Yuko, Ohwada Tomohiko

    EUROPEAN JOURNAL OF ORGANIC CHEMISTRY   ( 30 )   4128 - 4134   2018.8( ISSN:1434-193X

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    Publishing type:Research paper (scientific journal)  

    DOI : 10.1002/ejoc.201800484

  • Computation-Assisted Disconnection Approach for the Synthesis of Neoantimycins, 15-Membered Macrocyclic Depsipeptides

    Yamakoshi Shuhei, Okamoto Masako, Sawamoto Hiroaki, Arai Yuuki, Kawanishi Eiji, Sasaki Michiko, Takeda Kei

    CURRENT ORGANIC SYNTHESIS   14 ( 2 )   299 - 308   2017( ISSN:1570-1794

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    Publishing type:Research paper (scientific journal)  

    DOI : 10.2174/1570179413666160624105401

  • Carbanion-Induced [3+2] Annulation of Donor-Acceptor Cyclopropanes

    Sasaki Michiko, Kondo Yasuhiro, Nishio Takuya, Takeda Kei

    ORGANIC LETTERS   18 ( 15 )   3858 - 3861   2016.8( ISSN:1523-7060

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    Publishing type:Research paper (scientific journal)  

    DOI : 10.1021/acs.orglett.6b01865

  • Spontaneous Oxygenation of Siloxy-N-silylketenimines to alpha-Ketoamides

    Sasaki Michiko, Ando Masafumi, Kawahata Masatoshi, Yamaguchi Kentaro, Takeda Kei

    ORGANIC LETTERS   18 ( 7 )   1598 - 1601   2016.4( ISSN:1523-7060

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    Publishing type:Research paper (scientific journal)  

    DOI : 10.1021/acs.orglett.6b00455

  • Stereochemical Course of Deprotonation-Acylation of N-Boc- and N-Carbamoyl-2-cyano-6-methylpiperidines

    Kotomori Yuri, Sasaki Michiko, Kawahata Masatoshi, Yamaguchi Kentaro, Takeda Kei

    JOURNAL OF ORGANIC CHEMISTRY   80 ( 21 )   11013 - 11020   2015.11( ISSN:0022-3263

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    Publishing type:Research paper (scientific journal)  

    DOI : 10.1021/acs.joc.5b02178

  • Enantioselective Synthesis of Allenylenol Silyl Ethers via Chiral Lithium Amide Mediated Reduction of Ynenoyl Silanes and Their Diels-Alder Reactions

    Sasaki Michiko, Kondo Yasuhiro, Moto-ishi Ta-ichi, Kawahata Masatoshi, Yamaguchi Kentaro, Takeda Kei

    ORGANIC LETTERS   17 ( 5 )   1280 - 1283   2015.3( ISSN:1523-7060

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    Publishing type:Research paper (scientific journal)  

    DOI : 10.1021/acs.orglett.5b00261

  • Formation of 2-Cyano-2-siloxyvinylallenes via Cyanide-Induced Brook Rearrangement in gamma-Bromo-alpha,beta,gamma,delta-unsaturated Acylsilanes

    Ando Masafumi, Sasaki Michiko, Miyashita Izumi, Takeda Kei

    JOURNAL OF ORGANIC CHEMISTRY   80 ( 1 )   247 - 255   2015.1( ISSN:0022-3263

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    Publishing type:Research paper (scientific journal)  

    DOI : 10.1021/jo502323v

  • Enantioselective Synthesis of alpha-Silylamines by Meerwein-Ponndorf-Verley-Type Reduction of alpha-Silylimines by a Chiral Lithium Amide

    Kondo Yasuhiro, Sasaki Michiko, Kawahata Masatoshi, Yamaguchi Kentaro, Takeda Kei

    JOURNAL OF ORGANIC CHEMISTRY   79 ( 8 )   3601 - 3609   2014.4( ISSN:0022-3263

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    Publishing type:Research paper (scientific journal)  

    DOI : 10.1021/jo500441a

  • Enantiodivergent Deprotonation/Acylation of alpha-Amino Nitriles

    Sasaki Michiko, Takegawa Tomo, Sakamoto Kunihiro, Kotomori Yuri, Otani Yuko, Ohwada Tomohiko, Kawahata Masatoshi, Yamaguchi Kentaro, Takeda Kei

    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION   52 ( 49 )   12956 - 12960   2013.12( ISSN:1433-7851

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    Publishing type:Research paper (scientific journal)  

    DOI : 10.1002/anie.201306443

  • Chirality transfer in Brook rearrangement-mediated S(E)2 ' solvolytic protonation and its use in estimation of the propensity for racemization of the alpha-lithiocarbanions of the substituents

    Sasaki Michiko, Fujiwara Misato, Kotomori Yuri, Kawahata Masatoshi, Yamaguchi Kentaro, Takeda Kei

    TETRAHEDRON   69 ( 29 )   5823 - 5828   2013.7( ISSN:0040-4020

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    Publishing type:Research paper (scientific journal)  

    DOI : 10.1016/j.tet.2013.05.043

  • Synthetic Potential of Configurationally Unstable Chiral Carbanions

    Sasaki Michiko, Takeda Kei

    JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN   71 ( 2 )   136 - 148   2013.2( ISSN:0037-9980

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    Publishing type:Research paper (scientific journal)  

    DOI : 10.5059/yukigoseikyokaishi.71.136

  • Synthetic Potential of Configurationally Unstable Chiral Carbanions

    Sasaki Michiko, Takeda Kei

    SYNLETT   ( 15 )   2153 - 2164   2012.9( ISSN:0936-5214

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    Publishing type:Research paper (scientific journal)  

    DOI : 10.1055/s-0031-1290440

  • Enantioselective trapping of an alpha-chiral carbanion of acyclic nitrile by a carbon electrophile

    Sasaki Michiko, Takegawa Tomo, Ikemoto Hidaka, Kawahata Masatoshi, Yamaguchi Kentaro, Takeda Kei

    CHEMICAL COMMUNICATIONS   48 ( 23 )   2897 - 2899   2012( ISSN:1359-7345

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    Publishing type:Research paper (scientific journal)  

    DOI : 10.1039/c2cc00082b

  • Steric Course of the Electrophilic Substitution of a Lithiocarbanion Generated from (S,E)-1-Phenylbut-2-en-1-yl Diisopropylcarbamate and Solvent Effects

    Ikemoto Hidaka, Sasaki Michiko, Kawahata Masatoshi, Yamaguchi Kentaro, Takeda Kei

    EUROPEAN JOURNAL OF ORGANIC CHEMISTRY   ( 32 )   6553 - 6557   2011.11( ISSN:1434-193X

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    Publishing type:Research paper (scientific journal)  

    DOI : 10.1002/ejoc.201100970

  • Enantioselective Synthesis of Siloxyallenes from Alkynoylsilanes by Reduction and a Brook Rearrangement and Their Subsequent Trapping in a [4+2] Cycloaddition

    Sasaki Michiko, Kondo Yasuhiro, Kawahata Masatoshi, Yamaguchi Kentaro, Takeda Kei

    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION   50 ( 28 )   6375 - 6378   2011( ISSN:1433-7851

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    Publishing type:Research paper (scientific journal)  

    DOI : 10.1002/anie.201102430

  • Solvent Effects on the Steric Course of the [2,3]-Wittig Rearrangement of (S,E)-[3-(Allyloxy)prop-1-ene-1,3-diyl]dibenzene and Derivatives

    Ikemoto Hidaka, Sasaki Michiko, Takeda Kei

    EUROPEAN JOURNAL OF ORGANIC CHEMISTRY   ( 34 )   6643 - 6650   2010.12( ISSN:1434-193X

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    Publishing type:Research paper (scientific journal)  

    DOI : 10.1002/ejoc.201001061

  • Formal Total Syntheses of (+)-Prelaureatin and (+)-Laurallene by Diastereoseleetive Brook Rearrangement-Mediated [3+4] Annulation

    Sasaki Michiko, Oyamada Kazuhisa, Takeda Kei

    JOURNAL OF ORGANIC CHEMISTRY   75 ( 11 )   3941 - 3943   2010.6( ISSN:0022-3263

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    Publishing type:Research paper (scientific journal)  

    DOI : 10.1021/jo.100708n

  • DEVELOPMENT OF EPOXYSILANE REARRANGEMENT AND ITS APPLICATION TO CHIRALITY TRANSFER

    Sasaki Michiko, Ikemoto Hidaka, Takeda Kei

    HETEROCYCLES   78 ( 12 )   2919 - 2941   2009.12( ISSN:0385-5414

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    Publishing type:Research paper (scientific journal)  

    DOI : 10.3987/REV-09-657

  • [2,3]-Wittig Rearrangement of Enantiomerically Enriched 3-Substituted 1-Propenyloxy-1-phenyl-2-propen-1-yl Carbanions: Effect of Heteroatoms and Conjugating Groups on Planarization of an alpha-Oxy-Benzylcarbanion through a Double Bond

    Sasaki Michiko, Ikemoto Hidaka, Kawahata Masatoshi, Yamaguchi Kentaro, Takeda Kei

    CHEMISTRY-A EUROPEAN JOURNAL   15 ( 18 )   4663 - 4666   2009( ISSN:0947-6539

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    Publishing type:Research paper (scientific journal)  

    DOI : 10.1002/chem.200802322

  • Stereoselective S(E)2 ' Protonation of alpha-Hydroxyallylsilanes Mediated by a Brook Rearrangement

    Sasaki Michiko, Shirakawa Yuri, Kawahata Masatoshi, Yamaguchi Kentaro, Takeda Kei

    CHEMISTRY-A EUROPEAN JOURNAL   15 ( 14 )   3363 - 3366   2009( ISSN:0947-6539

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    Publishing type:Research paper (scientific journal)  

    DOI : 10.1002/chem.200802499

  • Development and synthetic application of epoxysilane rearrangement

    Sasaki Michiko

    YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN   128 ( 8 )   1169 - 1177   2008.8( ISSN:0031-6903

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    Publishing type:Research paper (scientific journal)  

    DOI : 10.1248/yakushi.128.1169

  • Chirality transfer from epoxide to carbanion: Base-induced alkylation of O-carbamoyl cyanohydrins of beta-silyl-alpha,beta-epoxy aldehyde

    Sasaki Michiko, Kawanishi Eiji, Shirakawa Yuri, Kawahata Masatoshi, Masu Hyuma, Yamaguchi Kentaro, Takeda Kei

    EUROPEAN JOURNAL OF ORGANIC CHEMISTRY   ( 18 )   3061 - 3064   2008.6( ISSN:1434-193X

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    Publishing type:Research paper (scientific journal)  

    DOI : 10.1002/ejoc.200800300

  • Diastereoselective brook rearrangement-mediated [3+4] annulation: Application to a formal synthesis of (+)-laurallene

    Sasaki Michiko, Hashimoto Azusa, Tanaka Koudal, Kawahata Masatoshi, Yamaguchi Kentaro, Takeda Kei

    ORGANIC LETTERS   10 ( 9 )   1803 - 1805   2008.5( ISSN:1523-7060

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    Publishing type:Research paper (scientific journal)  

    DOI : 10.1021/ol8003595

  • Tandem epoxysilane rearrangement/Wittig-type reactions using gamma-phosphinoyl- and gamma-phosphonio-alpha,beta-epoxysilane

    Sasaki Michiko, Horai Mal, Takeda Kei

    TETRAHEDRON LETTERS   47 ( 52 )   9271 - 9273   2006.12( ISSN:0040-4039

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    Publishing type:Research paper (scientific journal)  

    DOI : 10.1016/j.tetlet.2006.10.121

  • Epoxysilane rearrangement: Mechanistic studies and synthetic applications

    Sasaki Michiko, Takeda Kei

    JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN   64 ( 11 )   1148 - 1158   2006.11( ISSN:0037-9980

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    Publishing type:Research paper (scientific journal)  

    DOI : 10.5059/yukigoseikyokaishi.64.1148

  • Epoxysilane rearrangement induced by a carbanion generated by conjugate addition of enolates of chloroacetate and alpha-chloroacetamides: formation of functionalized cyclopropane derivatives.

    Okamoto N, Sasaki M, Kawahata M, Yamaguchi K, Takeda K

    Organic letters   8 ( 9 )   1889 - 1891   2006.4( ISSN:1523-7060

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    Publishing type:Research paper (scientific journal)  

    DOI : 10.1021/ol060469k

    PubMed

  • Asymmetric [2,3]-Wittig rearrangement induced by a chiral carbanion whose chirality was transferred from an epoxide.

    Sasaki M, Higashi M, Masu H, Yamaguchi K, Takeda K

    Organic letters   7 ( 26 )   5913 - 5915   2005.12( ISSN:1523-7060

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    Publishing type:Research paper (scientific journal)  

    DOI : 10.1021/ol052544h

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  • Gamma-p-toluenesulfonyl-alpha,beta-epoxysilane: a new and practical acrolein beta-anion equivalent.

    Sasaki M, Takeda K

    Organic letters   6 ( 26 )   4849 - 4851   2004.12( ISSN:1523-7060

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    Publishing type:Research paper (scientific journal)  

    DOI : 10.1021/ol048160t

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  • Stereoselective construction of eight-membered oxygen heterocycles by Brook rearrangement-mediated [3 + 4] annulation.

    Sawada Y, Sasaki M, Takeda K

    Organic letters   6 ( 13 )   2277 - 2279   2004.6( ISSN:1523-7060

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    Publishing type:Research paper (scientific journal)  

    DOI : 10.1021/ol0492243

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  • Tandem base-promoted ring-opening/Brook rearrangement/allylic alkylation of O-silyl cyanohydrins of beta-silyl-alpha,beta-epoxyaldehyde: scope and mechanism.

    Sasaki M, Kawanishi E, Nakai Y, Matsumoto T, Yamaguchi K, Takeda K

    The Journal of organic chemistry   68 ( 24 )   9330 - 9339   2003.11( ISSN:0022-3263

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    Publishing type:Research paper (scientific journal)  

    DOI : 10.1021/jo0352934

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  • Tandem base-promoted ring opening/brook rearrangement/allylic alkylation of O-silyl cyanohydrins of beta-silyl-alpha,beta-epoxyaldehydes.

    Takeda K, Kawanishi E, Sasaki M, Takahashi Y, Yamaguchi K

    Organic letters   4 ( 9 )   1511 - 1514   2002.5( ISSN:1523-7060

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    Publishing type:Research paper (scientific journal)  

    DOI : 10.1021/ol025738v

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Books

  • Molecular Rearrangements in Organic Synthesis

    Michiko Sasaki, Kei Takeda(Brook Rearrangement (Chapter 6))

    Wiley  2015.10 

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    Language:English   Book type:Scholarly book

Presentations

  • Abnormal Michael Reaction: Conditions-Dependent Product Distributions in the Michael Reaction of Monoalkylmalonates

    The 15th International Kyoto Conference on New Aspects of Organic Chemistry (IKCOC-15)   2023.11  

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    Event date: 2023.11

  • A New Type of Abnormal Michael Reaction: Formation of Cyclopentenecarboxylate by the Reaction of 7-Bis(alkoxycarbonyl)-2-heptenoate with a Base

    化学系学協会東北大会  

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    Event date: 2022.9

  • Reactions of Acylsilanes with Potassium Cyanide under Chiral Phase-Transfer Catalytic Conditions

    Molecular Chirality Asia 2016, 4.20-4.22, Osaka, Japan.  

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    Event date: 2016.4

  • Stereochemical Course of Deprotonation/Acylation of α-Amino Nitriles

    The 13th International Kyoto Conference on New Aspects of Organic Chemistry, Kyoto.  

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    Event date: 2015.11

  • Fitst Total Synthesis of Prunustatin A

    The 13th International Kyoto Conference on New Aspects of Organic Chemistry, Kyoto.  

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    Event date: 2015.11

  • Enantioselective Deprotonation-Substitution of α-Chelating Group-Substituted Nitriles

    44th National Organic Symposium, University of Maryland, College Park, MD, USA.  

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    Event date: 2015.6 - 2015.7

  • Formation of α-Keto Amides from α-Siloxy-N- Silylketenimines via Air Oxidation

    44th National Organic Symposium, University of Maryland, College Park, MD, USA.  

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    Event date: 2015.6 - 2015.7

  • Reactivity and Configurational Stability of α-Nitrile Carbanions

    10th International Symposium on Carbanion Chemistry, Kyoto.  

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    Event date: 2013.9

  • Tandem Reactions Induced by Enantioselective Reduction by Lithium Amide

    10th International Symposium on Carbanion Chemistry, Kyoto.  

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    Event date: 2013.9

  • Generation and Trapping of N-Silyl Ketene Imines at Low Temperature

    10th International Symposium on Carbanion Chemistry, Kyoto.  

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    Event date: 2013.9

  • Enantiodivergent Deprotonation–Benzoylation of α-Amino Nitriles

    43rd National Organic Chemistry Symposium,Seattle, Washington, USA.  

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    Event date: 2013.6

  • Synthesis of α-Silylamines by Enantioselective Reduction of α-Silylimine

    43rd National Organic Chemistry Symposium, Seattle, Washington, USA.  

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    Event date: 2013.6

  • Generation and Trapping of N-Silyl Ketenimins at Low Temperature

    43rd National Organic Chemistry Symposium, Seattle, Washington, USA.  

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    Event date: 2013.6

  • Enantioselective Trapping of Chiral α-Nitrile Carbanions

    12th International Kyoto Conference on New Aspects of Organic Chemistry (IKCOC-12), Kyoto.  

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    Event date: 2012.11

  • Mechanistic Study of Stereoselective SE2' Protonation of α-Hydroxy Allyl Silanes

    12th International Kyoto Conference on New Aspects of Organic Chemistry (IKCOC-12), Kyoto.  

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    Event date: 2012.11

  • Enantioselective trapping of an α-chiral carbanion of acyclic nitrile by a carbon electrophile

    19th International Conference on Organic Synthesis, Melbourne, Australia.  

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    Event date: 2012.7

  • Evaluation of the configurational stability of carbanions next to conjugating electron-withdrawing groups

    19th International Conference on Organic Synthesis, Melbourne, Australia.  

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    Event date: 2012.7

  • Enantioselective Synthesis of Allenes via Tandem Enantioselective Reduction/Brook Rearrangement

    10th International Symposium on Organic Reactions, Yokohama.  

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    Event date: 2011.11

  • Chiral Organolithiums Next to a Conjugative Electron-Withdrawing Group: Their Configurational Stability and Enantioselective Trapping by an Electrophile

    The 242nd National Meeting of the American Chemical Society, Denver, Colorado, USA.  

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    Event date: 2011.8

  • Chiral Organolithiums Next to a Conjugative Electron-Withdrawing Group: Their Configurational Stability and Enantioselective Trapping by an Electrophile

    The 242nd National Meeting of the American Chemical Society (Sci-Mix), Denver, Colorado, USA.  

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    Event date: 2011.8

  • Enantioselective Synthesis of Siloxyallenes from Alkynoylsilanes Via Tandem Enantioselective Reduction/Brook Rearrangement and Their Subsequent Trapping by [4 + 2] Cycloaddition

    42nd National Organic Chemistry Symposium, Princeton University, Princeton, NJ, USA  

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    Event date: 2011.6

  • Enantioselective Generation of Mesomerically-Stabilized Lithiocarbanions and Evaluation of Their Configurational Stability

    42nd National Organic Chemistry Symposium, Princeton University, Princeton, NJ, USA  

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    Event date: 2011.6

  • Enantioselective Synthesis of Siloxyallenes from Alkynylacylsilanes via Tandem Enantioselective Reduction/Brook rearrangement

    22nd International Symposium on Chirality (Chirality 2010; ISCD-22), Sapporo.  

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    Event date: 2010.7

  • Solvent Effects on the Configurational Stability of Chiral Carbanions

    22nd International Symposium on Chirality (Chirality 2010; ISCD-22), Sapporo.  

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    Event date: 2010.7

  • Effects of Solvents on the Trapping of Chiral Carbanions by [2,3]-Wittig Rearrangement

    11th International Kyoto Conference on New Aspects of Organic Chemistry (IKCOC-11), Kyoto.  

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    Event date: 2009.11

  • Use of a Brook Rearrangement-Mediated [3 + 4] Annulation Toward the Total Synthesis of (+)-Prelaureatin

    41st National Organic Chemistry Symposium, the University of Colorado, Boulder, CO, USA.  

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    Event date: 2009.6

  • Trapping of Chiral Carbanions by [2,3]-Wittig Rearrangement: Effect of Heteroatoms and Conjugating Groups

    41st National Organic Chemistry Symposium, the University of Colorado, Boulder, CO, USA.  

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    Event date: 2009.6

  • Trapping of Chiral Carbanions by [2,3]-Wittig Rearrangement

    The 236th National Meeting of the American Chemical Society (Sci-Mix), Philadelphia, PA, USA.  

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    Event date: 2008.8

  • Chirality Transfer from Epoxide to Carbanion: Base-induced Alkylation of O-Carbamoyl Cyanohydrins of β-Silyl-α,β-epoxyaldehyde

    The 236th National Meeting of the American Chemical Society, Philadelphia, PA, USA.  

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    Event date: 2008.8

  • Trapping of Chiral Carbanions by [2,3]-Wittig Rearrangement

    The 236th National Meeting of the American Chemical Society, Philadelphia, PA, USA.  

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    Event date: 2008.8

  • Chirality Transfer from Epoxide to α-Nitrile Allylic Carbanion via Epoxysilane Rearrangement

    40th National Organic Chemistry Symposium, Duke University, Durham, NC, USA.  

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    Event date: 2007.6

  • Formal Synthesis of Laurallene Using Brook Rearrangement-Mediated [3 + 4] Annulation

    40th National Organic Chemistry Symposium, Duke University, Durham, NC, USA.  

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    Event date: 2007.6

  • Enantioselective [2,3]-Wittig Rearrangement Featuring Chirality Transfer from Epoxide

    39th National Organic Chemistry Symposium, Salt Lake City, UT, USA.  

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    Event date: 2005.6

  • γ-Sulfonyl-α,β-Epoxysilane: A New Versatile Acrolein β-Anion Equivalent

    15th International Conference on Organic Synthesis (ICOS-15), Nagoya.  

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    Event date: 2004.8

  • Alkylation of Metalated O-Protected Cyanohydrins of β-Silyl-α,β-epoxyaldehydes: Scope and Mechanism

    9th International Kyoto Conference on New Aspects of Organic Chemistry (IKCOC-9), Kyoto.  

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    Event date: 2003.11

  • Chirality Transfer from Epoxide to Carbanion: Alkylation of Metalated O-Protected Cyanohydrins of β-Silyl-α,β-epoxyaldehydes

    19th International Congress of Heterocyclic Chemistry, Fort Collins, USA.  

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    Event date: 2003.8

  • Alkylation of Metalated O-Silyl Cyanohydrins of β-Silyl-α,β-epoxyaldehydes via Tandem Ring Opening-Brook Rearrangement-Allylic Rearrangement

    18th International Congress of Heterocyclic Chemistry, Yokohama.  

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    Event date: 2001.7

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Industrial property rights

  • テロメア結合タンパク質を阻害する化合物、及びそれを含むテロメア結合タンパク質阻害剤

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    Property type:Patent

    Application no:2020-508284  Date applied:2019.3

    Announcement no:WO2019/181714  Date announced:2019.9

    Patent/Registration no:7284518  Date registered:2023.5 

    Rights holder:国立大学法人広島大学    Country of applicant:Domestic , International (PCT) application   Country of acquisition:Domestic

Awards

  • 日本薬学会中国四国支部奨励賞

    2007.11  

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    Country:Japan

Research Projects

  • アニオン安定化置換基の隣接位におけるキラルカルバニオンの発生と捕捉

    2022.4 - 2027.3

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    科学研究費補助金 基盤研究 (C)

  • P–キラルホスホニウムを対カチオンとするエナンチオ選択的求核付加反応の開発

    2016.4 - 2018.3

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    科学研究費補助金 基盤研究 (C)

  • キラルカルバニオンからの不斉転写によるアレン誘導体のエナンチオ選択的合成法の開発

    2015.4 - 2017.3

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    科学研究費補助金 挑戦的萌芽研究

  • [1,n]-双極子活性種の発生法の開発と合成反応への展開

    2013.4 - 2016.3

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    科学研究費補助金 基盤研究 (C)

  • アミノ酸を不斉源とするキラルα-ニトリルカルバニオンの発生と捕捉

    2013.4

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    内藤記念科学振興財団研究助成

  • 立体化学的に不安定なキラルカルバニオンの合成化学への展開開

    2012.4 - 2016.3

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    蓬庵社研究助成

  • 新規1,n-双極子活性種発生法の開発および合成反応への展開

    2012.4 - 2015.3

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    林女性自然科学者研究女性基金・研究助成

  • 不安定活性種を利用する新規合成反応の開発

    2012.4

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    武田科学振興財団薬学系研究奨励

  • 多官能性求核的カルベンの創生と不斉反応への展開

    2010.4 - 2013.3

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    科学研究費補助金 若手研究 (B)

  • アレン類のエナンチオ選択的合成法の開発とその合成反応としての展開

    2010.4 - 2013.3

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    科学研究費補助金 基盤研究 (B)

  • 米国マサチューセッツ工科大学化学科留学

    2010.4 - 2011.3

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    日本学術振興会 優秀若手研究者海外派遣事業

  • 連続的炭素-炭素結合形成反応を機軸とする含八員環天然有機化合物の合成研究

    2008.4 - 2010.3

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    科学研究費補助金 若手研究 (B)

  • 共役性電子求引基の隣接位におけるキラルカルバニオンの発生と捕捉

    2008.4 - 2010.3

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    科学研究費補助金 挑戦的萌芽研究

  • エポキシドからの遠隔位不斉転写を利用するタンデム反応の開発

    2008.4

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    広島大学研究支援金

  • 連続反応におけるキラルカルバニオンの立体制御

    2007.4 - 2010.3

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    科学研究費補助金 基盤研究 (B)

  • エポキシシランを不斉源とする新規不斉転写反応の開発研究

    2007.4

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    上原記念生命科学財団研究奨励金

  • Chirality Transfer from Epoxide to α-Nitrile Allylic Carbanion via Epoxysilane Rearrangement

    2006.4

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    海外発表促進助成(日本科学協会)

  • エポキシドからカルバニオンへの不斉転写反応の開発

    2005.4 - 2006.3

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    笹川科学助成

  • Enantioselective [2,3]-Wittig Rearrangement Featuring Chirality Transfer from Epoxide

    2005.4

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    林女性自然科学者研究助成基金 「国際研究交流助成」

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