Updated on 2023/01/31

写真a

 
NAGAI Tomoaki
 
Organization
School of Medicine (Life Sciences and Social Medicine) Department of Biochemistry Assistant Professor
Title
Assistant Professor

Degree

  • 博士 (生命科学) ( 2013.7   東北大学 )

Research Interests

  • Cell biology, Cytoskeleton, Centrosome, Cell polarity, Cancer

Education

  • Tohoku University

    - 2013.7

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    Country: Japan

  • Tohoku University   Faculty of Science

    - 2008.3

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    Country: Japan

Research History

  • Fukushima Medical University   School of Medicine (Life Sciences and Social Medicine) Department of Biochemistry   Assistant Professor

    2019.10 - Now

Papers

  • Tactics of cancer invasion: Solitary and collective invasion

    Nagai T., Ishikawa T., Minami Y., Nishita M.

    Journal of Biochemistry   167 ( 4 )   347 - 355   2021.1( ISSN:0021924X

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1093/JB/MVAA003

  • Roles of TOG and jelly-roll domains of centrosomal protein CEP104 in its functions in cilium elongation and Hedgehog signaling.

    Yamazoe T, Nagai T, Umeda S, Sugaya Y, Mizuno K

    The Journal of biological chemistry   295 ( 43 )   14723 - 14736   2020.10( ISSN:0021-9258

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1074/jbc.RA120.013334

    PubMed

  • Tactics of cancer invasion: solitary and collective invasion(和訳中)

    Nagai Tomoaki, Ishikawa Tomohiro, Minami Yasuhiro, Nishita Michiru

    The Journal of Biochemistry   167 ( 4 )   347 - 355   2020.4( ISSN:0021-924X

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Furry protein suppresses nuclear localization of yes-associated protein (YAP) by activating NDR kinase and binding to YAP.

    Irie K, Nagai T, Mizuno K

    The Journal of biological chemistry   2020.1( ISSN:0021-9258

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1074/jbc.RA119.010783

    PubMed

  • Tactics of cancer invasion: solitary and collective invasion.

    Nagai T, Ishikawa T, Minami Y, Nishita M

    Journal of biochemistry   2020.1( ISSN:0021-924X

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1093/jb/mvaa003

    PubMed

  • Human-specific mutations in VMAT1 confer functional changes and multi-directional evolution in the regulation of monoamine circuits.

    Sato DX, Ishii Y, Nagai T, Ohashi K, Kawata M

    BMC evolutionary biology   19 ( 1 )   220   2019.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1186/s12862-019-1543-8

    PubMed

  • Cullin-3-KCTD10-mediated CEP97 degradation promotes primary cilium formation.

    Nagai T, Mukoyama S, Kagiwada H, Goshima N, Mizuno K

    Journal of cell science   131 ( 24 )   2018.12( ISSN:0021-9533

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1242/jcs.219527

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  • First person - Tomoaki Nagai

    Nagai T.

    Journal of Cell Science   131 ( 24 )   2018.12( ISSN:00219533

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1242/JCS.227322

  • 【タンパク質・核酸の分子修飾】細胞質/オルガネラでの分子修飾 微小管 アセチル化,脱アセチル化

    永井 友朗, 水野 健作

    生体の科学   69 ( 5 )   484 - 485   2018.10( ISSN:0370-9531

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Glucose deprivation induces primary cilium formation through mTORC1 inactivation.

    Takahashi K, Nagai T, Chiba S, Nakayama K, Mizuno K

    Journal of cell science   131 ( 1 )   2018.1( ISSN:0021-9533

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1242/jcs.208769

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  • Localization of Protein Kinase NDR2 to Peroxisomes and Its Role in Ciliogenesis.

    Abe S, Nagai T, Masukawa M, Okumoto K, Homma Y, Fujiki Y, Mizuno K

    The Journal of biological chemistry   292 ( 10 )   4089 - 4098   2017.3( ISSN:0021-9258

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1074/jbc.M117.775916

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  • A pleckstrin homology-like domain is critical for F-actin binding and cofilin-phosphatase activity of Slingshot-1.

    Takahashi K, Okabe H, Kanno SI, Nagai T, Mizuno K

    Biochemical and biophysical research communications   482 ( 4 )   686 - 692   2017.1( ISSN:0006-291X

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1016/j.bbrc.2016.11.095

    PubMed

  • Jasplakinolide induces primary cilium formation through cell rounding and YAP inactivation.

    Nagai T, Mizuno K

    PloS one   12 ( 8 )   e0183030   2017

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1371/journal.pone.0183030

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  • Localization of NDR2 to peroxisomes and its role in ciliogenesis.

    Abe S., Nagai T., Masukawa M., Okumoto K., Homma Y., Fujiki Y., Mizuno K.

    J. Biol Chem.   2017

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Pharmacological Inhibition of Centrosome Clustering by Slingshot-Mediated Cofilin Activation and Actin Cortex Destabilization.

    Konotop G, Bausch E, Nagai T, Turchinovich A, Becker N, Benner A, Boutros M, Mizuno K, Krämer A, Raab MS

    Cancer research   76 ( 22 )   6690 - 6700   2016.11( ISSN:0008-5472

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1158/0008-5472.CAN-16-1144

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  • Cep164, but not EB1, is critical for centriolar localization of TTBK2 and its function in ciliogenesis

    Oda T., Chiba S., Nagai T., Mizuno K.

    Cilia   ( SUPPLEMENT 1 )   2015.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1186/2046-2530-4-S1-P66

  • Binding to Cep164, but not EB1, is essential for centriolar localization of TTBK2 and its function in ciliogenesis.

    Oda T, Chiba S, Nagai T, Mizuno K

    Genes to cells : devoted to molecular & cellular mechanisms   19 ( 12 )   927 - 40   2014.12( ISSN:1356-9597

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1111/gtc.12191

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  • 【広がるHippo pathway研究-癌から各種疾患へ】基礎編 哺乳類NDRキナーゼの細胞機能 もうひとつのHippo下流キナーゼ

    永井 友朗, 水野 健作

    医学のあゆみ   251 ( 5 )   365 - 370   2014.11( ISSN:0039-2359

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    Language:English   Publishing type:Research paper (scientific journal)  

  • 無脊椎動物及び脊椎動物におけるFurryタンパク質の多様な機能(Multifaceted roles of Furry proteins in invertebrates and vertebrates)

    Nagai Tomoaki, Mizuno Kensaku

    The Journal of Biochemistry   155 ( 3 )   137 - 146   2014.3( ISSN:0021-924X

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Multifaceted roles of Furry proteins in invertebrates and vertebrates.

    Nagai T, Mizuno K

    Journal of biochemistry   155 ( 3 )   137 - 46   2014.3( ISSN:0021-924X

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1093/jb/mvu001

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  • TTBK2はCep164と結合することで中心体に局在し,一次繊毛形成を促進する

    小田聡明, 千葉秀平, 永井友朗, 水野健作

    日本分子生物学会年会プログラム・要旨集(Web)   37th   2014

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    Language:English   Publishing type:Research paper (scientific journal)  

    J-GLOBAL

  • Furry promotes acetylation of microtubules in the mitotic spindle by inhibition of SIRT2 tubulin deacetylase.

    Tomoaki Nagai, Masanori Ikeda, Shuhei Chiba, Shin-ichiro Kanno, Kensaku Mizuno

    Journal of Cell Science   126 ( Pt 19 )   4369 - 80   2013.10( ISSN:0021-9533

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1242/jcs.127209

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  • Furryによるチューブリン脱アセチル化酵素SIRT2の活性制御と分裂期紡錘体微小管のアセチル化に対する役割

    永井友朗, 池田真教, 千葉秀平, 菅野新一郎, 水野健作

    日本分子生物学会年会プログラム・要旨集(Web)   36th   2013

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    Language:English   Publishing type:Research paper (scientific journal)  

    J-GLOBAL

  • 微小管結合蛋白質Furryによる微小管アセチル化制御機構

    永井 友朗, 千葉 秀平, 池田 真教, 菅野 新一郎, 水野 健作

    生化学   84 ( 6 )   507 - 507   2012.6( ISSN:0037-1017

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Live-cell imaging of G-actin dynamics using sequential FDAP.

    Tai Kiuchi, Tomoaki Nagai, Kazumasa Ohashi, Naoki Watanabe, Kensaku Mizuno

    BioArchitecture   1   240 - 244   2011

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Measurements of spatiotemporal changes in G-actin concentration reveal its effect on stimulus-induced actin assembly and lamellipodium extension.

    Tai Kiuchi, Tomoaki Nagai, Kazumasa Ohashi, Kensaku Mizuno

    Journal of Cell Biology   193   365 - 380   2011

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1083/jcb.201101035

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Presentations

  • マイクロパターニング技術を用いた上皮細胞の極性形成機構の解析

    日仏生物学会第193会例会  

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    Event date: 2020.12

  • マイクロパターニング技術を用いた上皮細胞の極性形成機構の解析

    日仏生物学会第193会例会  

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    Event date: 2020.12