Updated on 2025/04/28
修士（保健学）、博士（医学）
がん
内部障害
運動生理学
理学療法
リハビリテーション
Life Science / Rehabilitation science
Life Science / Medical technology assessment
Life Science / Nutrition science and health science
Life Science / Physical education, and physical and health education
Life Science / Biomedical engineering
Life Science / Nutrition science and health science
Life Science / Physical education, and physical and health education
Life Science / Rehabilitation science
Hyogo College of Medicine Graduate School, Division of Medical Sciences
- 2012.3
Kobe University Graduate School, Division of Medical Sciences
- 2008.3
Fukushima Medical University Professor
2021.4 - Now
Fukushima Medical University School of Medicine (Clinical Medicine) Department of Rehabilitation Medicine Professor
2021.4 - Now
新潟大学大学院医歯学総合研究科 客員研究員
2017.4 - Now
Hyogo College of Medicine Part-time Lecturer
2016.4 - 2024.3
国立がん研究センター中央病院 外来研究員 外来研究員
2016.4 - 2022.3
Niigata University of Health and Welfare Associate Professor
2016.4 - 2021.3
Hyogo College of Medicine
2014.4 - 2016.3
Hyogo College of Medicine
2003.10 - 2016.3
大阪厚生年金病院 リハビリテーション科 理学療法士
1997.4 - 2003.9
THE JAPANESE ASSOCIATION OF REHABILITATION MEDICINE
International Society of Physical and Rehabilitation Medicine
American College of Sports Medicine
日本理学療法士協会「理学療法学」「Physical Therapy Research」
日本がんサポーティブケア学会
日本心臓リハビリテーション学会
JAPANESE PHYSICAL THERAPY ASSOCIATION
日本癌治療学会
Frontiers in Medicine Associate Editor
2021.7 - Now
Cochrane Rehabilitation Review Committee member
2020.9 - 2021.3
日本理学療法士協会「理学療法学」「Physical Therapy Research」 編集委員
2019.6 - Now
World Cancer Research Fund International (UK) grant programme
2019.3 - 2020.3
Committee type：Academic society
専門理学療法士（神経系）
201004
専門理学療法士（内部障害）
201004
Physiotherapist
199704
Relationship between quality of life before treatment and survival in patients with hematological malignancies: A meta-analysis.
Keiichi Osaki, Shinichiro Morishita, Jiro Nakano, Junichiro Inoue, Taro Okayama, Katsuyoshi Suzuki, Takashi Tanaka, Takuya Fukushima
Fukushima journal of medical science 2025.2
Impact of online support of physical activity management using a wearable device on renal function in patients with acute coronary syndrome: a randomized controlled trial protocol.
Toshimi Sato, Daisuke Suzuki, Yuichiro Sasamoto, Masahiro Ono, Namiko Shishito, Kohko Kanazawa, Akihito Watanabe, Koichi Naito, Shinichiro Morishita, Masahiro Kohzuki
PeerJ 13 e19067 2025
Effect of increased fear of falling on falls in patients undergoing HD: A narrative review.
Nobuyuki Shirai, Shinichiro Morishita, Yutaka Osawa, Suguru Yamamoto
Fukushima journal of medical science 2024.12
Relationship between patient-reported health-related quality of life as measured with the SF-36 or SF-12 and their mortality risk in patients with diverse cancer type: a meta-analysis.
Takashi Tanaka, Shinichiro Morishita, Jiro Nakano, Junichiro Inoue, Taro Okayama, Katsuyoshi Suzuki, Keiichi Osaki, Takuya Fukushima
International journal of clinical oncology 2024.11
Rehabilitation practices during hematopoietic stem cell transplantation: An international survey.
Victor F Leite, Sonal Oza, Sara C Parke, Toure Barksdale, Aliea Herber, Vishal Bansal, Jae Yong Jeon, Orla McCour, Shinichiro Morishita, Mahmoud D Aljurf
Hematology/oncology and stem cell therapy 17 ( 3 ) 176 - 183 2024.10
Effect of Combined Exercise and Nutrition Interventions During Inpatient Chemotherapy in Acute Leukemia and Malignant Lymphoma Patients: A Randomized Controlled Trial.
Ryuichi Kasahara, Shinichiro Morishita, Takaaki Fujita, Ryohei Jinbo, Junko Kubota, Aya Takano, Shoko Takahashi, Sayaka Kisara, Kazumi Jinbo, Yuichi Yamamoto, Masae Kakuta, Tatsuyuki Kai, Yutaka Shiga, Hideo Kimura, Miki Furukawa, Shigehira Saji
Nutrition and cancer 1 - 9 2024.9
Current status of research on sarcopenia in post-treatment cancer survivors in Japan:A narrative review.
Keiichi Osaki, Takuya Fukushima, Katsuyoshi Suzuki, Akiho Kamimura, Saki Yanai, Shinichiro Morishita
Fukushima journal of medical science 2024.6
Global quality of life and mortality risk in patients with cancer: a systematic review and meta-analysis.
Takuya Fukushima, Katsuyoshi Suzuki, Takashi Tanaka, Taro Okayama, Junichiro Inoue, Shinichiro Morishita, Jiro Nakano
Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation 2024.5
Impact of quality of life on mortality risk in patients with esophageal cancer: a systematic review and meta-analysis.
Junichiro Inoue, Shinichiro Morishita, Taro Okayama, Katsuyoshi Suzuki, Takashi Tanaka, Jiro Nakano, Takuya Fukushima
Esophagus : official journal of the Japan Esophageal Society 2024.5
Pretreatment quality of life and survival in patients with lung cancer: a systematic review and meta-analysis.
Taro Okayama, Katsuyoshi Suzuki, Shinichiro Morishita, Junichiro Inoue, Takashi Tanaka, Jiro Nakano, Takuya Fukushima
BMC cancer 24 ( 1 ) 495 - 495 2024.4
Association between quality of life and mortality risk in patients with breast cancer: a systematic review and meta-analysis.
Katsuyoshi Suzuki, Shinichiro Morishita, Jiro Nakano, Taro Okayama, Junichiro Inoue, Takashi Tanaka, Takuya Fukushima
Breast cancer (Tokyo, Japan) 2024.4（ ISSN:1340-6868 ）
Inpatient Rehabilitation of Hematopoietic Stem Cell Transplant Patients: Managing Challenging Impairments and Medical Fragility.
Jack B Fu, Shinichiro Morishita
American journal of physical medicine & rehabilitation 103 ( 3S Suppl 1 ) S46 - S51 2024.3（ ISSN:0894-9115 ）
Protein intake and its relationship with frailty in chronic kidney disease.
Nobuyuki Shirai, Suguru Yamamoto, Yutaka Osawa, Atsuhiro Tsubaki, Shinichiro Morishita, Toshiko Murayama, Ichiei Narita
Clinical and experimental nephrology 28 ( 5 ) 447 - 453 2024.2（ ISSN:1342-1751 ）
Impact of moderate to vigorous intensity physical activity on change in renal function in patients after acute myocardial infarction.
Toshimi Sato, Masahiro Ono, Keiichi Kawamura, Wakako Naganuma, Namiko Shishito, Shinichiro Morishita, Yuichiro Sasamoto, Masahiro Kohzuki
Heart and vessels 39 ( 5 ) 393 - 403 2024.1（ ISSN:0910-8327 ）
Low muscle strength and physical function contribute to falls in hemodialysis patients, but not muscle mass.
Nobuyuki Shirai, Suguru Yamamoto, Yutaka Osawa, Atsuhiro Tsubaki, Shinichiro Morishita, Tsubasa Sugahara, Ichiei Narita
Clinical and experimental nephrology 28 ( 1 ) 67 - 74 2024.1（ ISSN:1342-1751 ）
The effect of massage on the plantar flexor muscles during the fixation period in postoperative patients with an ankle fracture.
Masanobu Yokochi, Masatoshi Nakamura, Ayaka Iwata, Ryota Kaneko, Shinichiro Morishita, Naoyuki Oi
Journal of bodywork and movement therapies 37 183 - 187 2024.1（ ISSN:1360-8592 ）
Is Phase Angle Useful in Screening for Sarcopenia in Patients with Hematologic Malignancies?
Ryuichi Kasahara, Takaaki Fujita, Ryohei Jinbo, Junko Kubota, Aya Takano, Shoko Takahashi, Yuka Ohashi, Kazumi Jinbo, Yuichi Yamamoto, Tatsuyuki Kai, Yutaka Shiga, Hideo Kimura, Miki Furukawa, Mai Owari, Shinichiro Morishita
Nutrition and cancer 76 ( 1 ) 121 - 127 2024（ ISSN:0163-5581 ）
Prediction of Walking Independence in Older Women with Vertebral Compression Fracture Using Phase Angle: A Preliminary Study Using Propensity Score.
Megumi Kurita, Takaaki Fujita, Ryuichi Kasahara, Yuichi Yamamoto, Yoko Ohira, Koji Otsuki, Shinichiro Morishita
Progress in rehabilitation medicine 9 20240004 - 20240004 2024
Relationship of Cognitive Function with Oxygenated Haemoglobin Concentration Difference Between the Left and Right Prefrontal Cortex During 40-Min Moderate-Intensity Exercise.
W Qin, S Kojima, S Morishita, D Qu, L Huang, A Tsubaki
Advances in experimental medicine and biology 1463 119 - 125 2024
Near-Infrared Spectroscopy Analysis of Triceps Brachii Muscle Oxygenation During Sprinting in Wheelchair Basketball Players: A Pilot Study.
Yasuhiro Endo, Hideto Kanzaki, Kazuhiro Endo, Shinichiro Morishita
Advances in experimental medicine and biology 1463 353 - 358 2024
Mental Workload and Prefrontal Brain Activity During Silent Reading Task in University Students with Problematic Smartphone Use.
Akihiko Asao, Daiki Yamaguchi, Shinichiro Morishita
Advances in experimental medicine and biology 1463 103 - 107 2024
Neurological Outcomes of Chemotherapy-Induced Peripheral Neuropathy in Patients With Cancer: A Systematic Review and Meta-Analysis.
Katsuyoshi Suzuki, Shinichiro Morishita, Jiro Nakano, Taro Okayama, Junichiro Inoue, Takashi Tanaka, Takuya Fukushima
Integrative cancer therapies 22 ( 22 ) 1 - 12 2023.11
Impact of Sarcopenia on Outcome of Exercise Therapy in Older Non-Hodgkin Lymphoma Patients.
Ryuichi Kasahara, Takaaki Fujita, Ryohei Jinbo, Junko Kubota, Aya Takano, Shoko Takahashi, Yuka Ohashi, Kazumi Jinbo, Yuichi Yamamoto, Tatsuyuki Kai, Yutaka Shiga, Hideo Kimura, Miki Furukawa, Mai Owari, Shinichiro Morishita
Integrative cancer therapies 22 ( 22 ) 1 - 9 2023.11
Verification of quality assurance for blood culture surveillance using 6 years of data from the Japan Infection Prevention and Control Conference for National and Public University Hospitals.
Kiyosuke M, Morishita S, Nakaie K, Kondo S, Sonobe K, Goto M, Ohashi K, Kashiyama S, Japan Infection Prevention and Control Conference for National and Public University Hospitals
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 29 ( 6 ) 565 - 570 2023.6（ ISSN:1341-321X ）
Effect of rehabilitation in patients undergoing hematopoietic stem cell transplantation.
Takahiro Takekiyo, Shinichiro Morishita
Fukushima journal of medical science 69 ( 2 ) 73 - 83 2023.5（ ISSN:0016-2590 ）
Ryohei Jinbo, Ryuichi Kasahara, Shinichiro Morishita, Junko Kubota, Aya Takano, Shoko Takahashi, Sayaka Kisara, Kazumi Jinbo, Yuichi Yamamoto, Tatsuyuki Kai, Yutaka Shiga, Hideo Kimura, Miki Furukawa, Takaaki Fujita
Medicine 102 ( 6 ) e32901 - e32901 2023.2（ ISSN:0025-7974 ）
Frequency and reasons for unplanned transfer to the primary acute care service of inpatient rehabilitation glioblastoma multiforme patients.
Jack B Fu, Ekta Gupta, Shinichiro Morishita, Clark R Andersen, An T Ngo-Huang, Jessica P Engle, Ying Guo
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 31 ( 2 ) 122 - 122 2023.1
Physical Therapy for a Multiple Myeloma Patient with COVID-19: A Case Report.
Keiichi Osaki, Shinichiro Morishita, Tetsuhiro Shimokawa, Akiho Kamimura, Takashi Sekiyama, Chisaki Kanehiro, Atsushi Shindo, Kensuke Shiga, Eri Kawata
Progress in rehabilitation medicine 8 20230007 - 20230007 2023
Recent Findings in Physical Exercise for Cancer Survivors.
Shinichiro Morishita, Katsuyoshi Suzuki, Taro Okayama, Junichiro Inoue, Takashi Tanaka, Jiro Nakano, Takuya Fukushima
Physical therapy research 26 ( 1 ) 10 - 16 2023（ ISSN:2189-8448 ）
Peak exercise oxygen uptake and changes in renal function in patients after acute myocardial infarction.
Toshimi Sato, Shinichiro Morishita, Masahiro Ono, Yoshinari Funami, Keishi Hayao, Daichi Kusano, Masahiro Kohzuki
Heart & lung : the journal of critical care 57 277 - 282 2022.10
Dynamic and static balance functions in hemodialysis patients and non-dialysis dependent CKD patients.
Nobuyuki Shirai, Suguru Yamamoto, Yutaka Osawa, Atsuhiro Tsubaki, Shinichiro Morishita, Ichiei Narita
Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy 2022.9
Relationship between Nutrition-Related Problems and Falls in Hemodialysis Patients: A Narrative Review.
Nobuyuki Shirai, Tatsuro Inoue, Masato Ogawa, Masatsugu Okamura, Shinichiro Morishita, Yamamoto Suguru, Atsuhiro Tsubaki
Nutrients 14 ( 15 ) 2022.8
Dysfunction in dynamic, but not static balance is associated with risk of accidental falls in hemodialysis patients: a prospective cohort study.
Nobuyuki Shirai, Suguru Yamamoto, Yutaka Osawa, Atsuhiro Tsubaki, Shinichiro Morishita, Ichiei Narita
BMC nephrology 23 ( 1 ) 237 - 237 2022.7
Quality of life of patients with hematological malignancies and factors affecting health state utility values.
Keiichi Osaki, Shinichiro Morishita, Suzuho Takami, Yuki Sakai, Akiho Kamimura, Atsushi Shindo, Eri Kawata
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 30 ( 6 ) 5319 - 5327 2022.3（ ISSN:0941-4355 ）
Differences in the Relationships Between Muscle Strength, Muscle Mass, Balance Function, and Quality of Life for Middle-Aged and Older Breast Cancer Survivors.
Shinichiro Morishita, Ryuichi Kasahara, Yuichi Yamamoto, Ryohei Jinbo, Aya Takano, Mitsuhiko Yasuda, Atsuhiro Tsubaki, Osamu Aoki, Jack B Fu, Tetsuya Tsuji
Integrative cancer therapies 21 15347354221138574 - 15347354221138574 2022
Temporal changes in cortical oxygenation in the motor-related areas and bilateral prefrontal cortex based on exercise intensity and respiratory metabolism during incremental exercise in male subjects: A near-Infrared spectroscopy study.
Sho Kojima, Shinichiro Morishita, Kazuki Hotta, Weixiang Qin, Naoto Usui, Atsuhiro Tsubaki
Frontiers in physiology 13 794473 - 794473 2022
Perceived Exertion Correlates with Multiple Physiological Parameters During Cardiopulmonary Exercise Testing.
Shinichiro Morishita, Atsuhiro Tsubaki, Kazuki Hotta, Tatsuro Inoue, Sho Kojima, Weixiang Qin, Daichi Sato, Akihito Shirayama, Yuki Ito, Hideaki Onishi
Advances in experimental medicine and biology 1395 423 - 427 2022（ ISSN:0065-2598 ）
Fear of falling and physical activity in hemodialysis patients: a pilot study
Nobuyuki Shirai, Suguru Yamamoto, Yutaka Osawa, Atsuhiro Tsubaki, Shinichiro Morishita, Sumiyo Nitami, Ichiei Narita
Renal Replacement Therapy 7 ( 1 ) 2021.12
Relationship between balance function and QOL in cancer survivors and healthy subjects.
Shinichiro Morishita, Ryo Hirabayashi, Atsuhiro Tsubaki, Osamu Aoki, Jack B Fu, Hideaki Onishi, Tetsuya Tsuji
Medicine 100 ( 46 ) e27822 2021.11（ ISSN:0025-7974 ）
Comparison of muscle strength between hemodialysis patients and non-dialysis patients with chronic kidney disease.
Nobuyuki Shirai, Suguru Yamamoto, Yutaka Osawa, Atsuhiro Tsubaki, Shinichiro Morishita, Kanami Igarashi, Ichiei Narita
Journal of physical therapy science 33 ( 10 ) 742 - 747 2021.10（ ISSN:0915-5287 ）
Correction to: Muscle oxygen extraction and lung function are related to exercise tolerance after allogeneic hematopoietic stem cell transplantation.
Tatsushi Wakasugi, Shinichiro Morishita, Katsuji Kaida, Kazuhiro Ikegame, Yuki Uchiyama, Kazuhisa Domen
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 29 ( 10 ) 6049 - 6049 2021.10
Physical therapy for multiple myeloma patients with severely hindered daily living activities due to bone lesions: a report of two cases.
Ryohei Jinbo, Takaaki Fujita, Ryuichi Kasahara, Shinichiro Morishita, Yuichi Yamamoto, Kazumi Jinbo, Aya Takano, Junko Kubota, Shoko Takahashi, Yutaka Shiga, Hideo Kimura, Miki Furukawa, Tatsuyuki Kai
Journal of physical therapy science 33 ( 10 ) 795 - 800 2021.10（ ISSN:0915-5287 ）
Relationship Between Physical Function and Health Utility in Patients Undergoing Surgical Treatment for Malignant Pleural Mesothelioma
Takashi Tanaka, Shinichiro Morishita, Masaki Hashimoto, Toru Nakamichi, Yuki Uchiyama, Seiki Hasegawa, Kazuhisa Domen
INTEGRATIVE CANCER THERAPIES 20 ( 20 ) 1 - 8 2021.9（ ISSN:1534-7354 ）
Sex Differences in the Oxygenation of the Left and Right Prefrontal Cortex during Moderate-Intensity Exercise.
Yuta Inagaki, Reo Sato, Takashi Uchiyama, Sho Kojima, Shinichiro Morishita, Weixiang Qin, Atsuhiro Tsubaki
International journal of environmental research and public health 18 ( 10 ) 2021.5
Effects of 20-Minute Intensive Exercise on Subjects with Different Working Memory Bases.
Weixiang Qin, S Kojima, S Morishita, K Hotta, K Oyama, A Tsubaki
Advances in experimental medicine and biology 1269 289 - 294 2021.5
Relationship Between the Borg Scale Rating of Perceived Exertion and Leg-Muscle Deoxygenation During Incremental Exercise in Healthy Adults.
Shinichiro Morishita, Atsuhiro Tsubaki, Kazuki Hotta, Sho Kojima, Daichi Sato, Akihito Shirayama, Yuki Ito, Hideaki Onishi
Advances in experimental medicine and biology 1269 95 - 99 2021.5
Relationship Between Corticosteroid Dose and Muscle Oxygen Consumption in Recipients of Hematopoietic Stem-Cell Transplantation.
Shinichiro Morishita, Tatsushi Wakasugi, Katsuji Kaida, Yusuke Itani, Kazuhiro Ikegame, Hiroyasu Ogawa, Yoshihiro Fujimori, Kazuhisa Domen
Advances in experimental medicine and biology 1269 87 - 93 2021.5
Relationship Between Decrease of Oxygenation During Incremental Exercise and Partial Pressure End-Tidal Carbon Dioxide: Near-Infrared Spectroscopy Vector Analysis.
Sho Kojima, Shinichiro Morishita, Kazuki Hotta, Weixiang Qin, Toshinori Kato, Katsunori Oyama, Atsuhiro Tsubaki
Advances in experimental medicine and biology 1269 119 - 124 2021.5
Changes in the Laterality of Oxygenation in the Prefrontal Cortex and Premotor Area During a 20-Min Moderate-Intensity Cycling Exercise.
Atsuhiro Tsubaki, Shinichiro Morishita, Kazuki Hotta, Yuta Tokunaga, Weixiang Qin, Sho Kojima, Hideaki Onishi
Advances in experimental medicine and biology 1269 113 - 117 2021.5
Supine Cycling Exercise Enhances Cerebral Oxygenation of Motor-Related Areas in Healthy Male Volunteers.
D Sato, S Morishita, K Hotta, Y Ito, A Shirayama, S Kojima, W Qin, A Tsubaki
Advances in experimental medicine and biology 1269 295 - 300 2021.5
Cerebral Oxygenation Dynamics During Incremental Exercise: Comparison of Arm Cranking and Leg Cycling.
K Hashimoto, K Hotta, S Morishita, R Kanai, H Takahashi, A Tsubaki
Advances in experimental medicine and biology 1269 125 - 130 2021.5
Muscle oxygen extraction and lung function are related to exercise tolerance after allogeneic hematopoietic stem cell transplantation.
Tatsushi Wakasugi, Shinichiro Morishita, Katsuji Kaida, Kazuhiro Ikegame, Yuki Uchiyama, Kazuhisa Domen
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 29 ( 10 ) 6039 - 6048 2021.3
Physical function predicts mortality in patients with cancer: a systematic review and meta-analysis of observational studies.
Jiro Nakano, Takuya Fukushima, Takashi Tanaka, Jack B Fu, Shinichiro Morishita
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 29 ( 10 ) 5623 - 5634 2021.3
Relationship between the face scale for rating of perceived exertion and physiological parameters in older adults and patients with atrial fibrillation.
Satoshi Nashimoto, Shinichiro Morishita, Susumu Iida, Kazuki Hotta, Atsuhiro Tsubaki
Physiological reports 9 ( 5 ) e14759 2021.3
Weixiang Qin, Sho Kojima, Yudai Yamazaki, Shinichiro Morishita, Kazuki Hotta, Tatsuro Inoue, Atsuhiro Tsubaki
Applied Sciences 11 ( 4 ) 1643 - 1643 2021.2
Related Factors and Clinical Outcomes of Osteosarcopenia: A Narrative Review.
Tatsuro Inoue, Keisuke Maeda, Ayano Nagano, Akio Shimizu, Junko Ueshima, Kenta Murotani, Keisuke Sato, Kazuki Hotta, Shinichiro Morishita, Atsuhiro Tsubaki
Nutrients 13 ( 2 ) 2021.1
Rehabilitation Utilization by Cancer Patients with Pathology-Confirmed Leptomeningeal Disease Receiving Intrathecal Chemotherapy.
Jack B Fu, Amy H Ng, Diana M Molinares, Edward A Pingenot, Shinichiro Morishita, Julie K Silver, Eduardo Bruera
American journal of physical medicine & rehabilitation 100 ( 1 ) 100 - 104 2021.1
Weight Loss Intervention before Cord Blood Transplantation in an Obese Patient with Acute Myeloid Leukemia: A Case Study.
Ryuichi Kasahara, Takaaki Fujita, Ryohei Jinbo, Tatsuyuki Kai, Yuichi Yamamoto, Shinichiro Morishita, Miki Furukawa, Yutaka Shiga, Hideo Kimura, Masahiko Fukatsu, Kayo Harada, Satoshi Kimura, Takayuki Ikezoe
Progress in rehabilitation medicine 6 20210018 - 20210018 2021
Face Pain scale and Borg scale compared to physiological parameters during cardiopulmonary exercise testing.
Shinichiro Morishita, Atsuhiro Tsubaki, Kazuki Hotta, Tatsuro Inoue, Weixiang Qin, Sho Kojima, Jack B Fu, Hideaki Onishi
The Journal of sports medicine and physical fitness 61 ( 11 ) 1464 - 1468 2020.12
Physical exercise is safe and feasible in thrombocytopenic patients with hematologic malignancies: a narrative review.
Shinichiro Morishita, Jiro Nakano, Jack B Fu, Tetsuya Tsuji
Hematology (Amsterdam, Netherlands) 25 ( 1 ) 95 - 100 2020.12
The Association between time spent in performing physical activity and physical function in outpatients with type 2 diabetes who may have diabetic neuropathy: Physical Activity in Type 2 Diabetes
Nobuyuki Shirai, Atsuhiro Tsubaki, Shinichiro Morishita, Daisuke Honma, Sumiyo Isobe, Kanami Ikarashi, Akiko Suzuki, Satoru Murayama
Diabetes and Metabolic Syndrome: Clinical Research and Reviews 14 ( 6 ) 2111 - 2116 2020.11（ ISSN:1871-4021 ）
Immediate changes in anticipatory muscle activity after unexpected muscle contraction training
Osamu Aoki, Yoshitaka Otani, Shinichiro Morishita
Translational Sports Medicine 3 ( 6 ) 574 - 580 2020.11（ ISSN:2573-8488 ）
One-repetition maximum can be estimated with a handheld dynamometer and circumference in community-dwelling older adults.
Masatoshi Nakamura, Ryosuke Kiyono, Shigeru Sato, Kaoru Yahata, Shinichiro Morishita
Journal of physical therapy science 32 ( 10 ) 669 - 673 2020.10
Retrospective Analysis of Acute Rehabilitation Outcomes of Cancer Inpatients with Leptomeningeal Disease
Jack B. Fu, Diana M. Molinares, Shinichiro Morishita, Julie K. Silver, Seyedeh S. Dibaj, Ying Guo, Eduardo Bruera
PM and R 12 ( 3 ) 263 - 270 2020.3（ ISSN:1934-1482 ）
Acute moderate-intensity exercise improves 24-h sleep deprivation-induced cognitive decline and cerebral oxygenation: A near-infrared spectroscopy study
Sho Kojima, Tomoya Abe, Shinichiro Morishita, Yuta Inagaki, Weixiang Qin, Kazuki Hotta, Atsuhiro Tsubaki
Respiratory Physiology and Neurobiology 274 103354 2020.3（ ISSN:1569-9048 ）
Comparison of the Effects of Continuous and Intermittent Exercise on Cerebral Oxygenation and Cognitive Function.
Ichinose Y, Morishita S, Suzuki R, Endo G, Tsubaki A
Advances in experimental medicine and biology 1232 209 - 214 2020（ ISSN:0065-2598 ）
Relationship Between Exercise Capacity and Muscle O2Hb Saturation in Patients Before Hematopoietic Stem-Cell Transplantation.
Shinichiro Morishita, Tatsushi Wakasugi, Katsuji Kaida, Yusuke Itani, Kazuhiro Ikegame, Hiroyasu Ogawa, Yoshihiro Fujimori, Kazuhisa Domen
Advances in experimental medicine and biology 1232 215 - 221 2020（ ISSN:0065-2598 ）
Relationship Between Muscle Oxygen Saturation and Exercise Load in Patients with Malignant Hematopoietic Disease.
Tatsushi Wakasugi, Shinichiro Morishita, Katsuji Kaida, Yusuke Itani, Kazuhiro Ikegame, Norihiko Kodama, Hiroyasu Ogawa, Yoshihiro Fujimori, Kazuhisa Domen
Advances in experimental medicine and biology 1232 201 - 207 2020（ ISSN:0065-2598 ）
Effect of Exercise Duration on Post-Exercise Persistence of Oxyhemoglobin Changes in the Premotor Cortex: A Near-Infrared Spectroscopy Study in Moderate-Intensity Cycling Exercise.
Atsuhiro Tsubaki, Shinichiro Morishita, Yuta Tokunaga, Daisuke Sato, Weixiang Qin, Sho Kojima, Hideaki Onishi
Advances in experimental medicine and biology 1232 193 - 199 2020（ ISSN:0065-2598 ）
Effect of Exercise on Mortality and Recurrence in Patients With Cancer: A Systematic Review and Meta-Analysis
Shinichiro Morishita, Yohei Hamaue, Takuya Fukushima, Takashi Tanaka, Jack B. Fu, Jiro Nakano
Integrative Cancer Therapies 19 2020（ ISSN:1534-7354 ）
Cerebral Oxygenation Dynamics of the Prefrontal Cortex and Motor-Related Area During Cardiopulmonary Exercise Test: A Near-Infrared Spectroscopy Study.
Kojima S, Morishita S, Qin W, Tsubaki A
Advances in experimental medicine and biology 1232 231 - 237 2020（ ISSN:0065-2598 ）
Skeletal Muscle Index at Intensive Care Unit Admission Is a Predictor of Intensive Care Unit-Acquired Weakness in Patients With Sepsis.
Yuta Mitobe, Shinichiro Morishita, Kazuki Ohashi, Sayuri Sakai, Mieko Uchiyama, Hansani Abeywickrama, Etsuko Yamada, Yuko Kikuchi, Masakazu Nitta, Tadayuki Honda, Hiroshi Endoh, Shinji Kimura, Shuhei Sakano, Yu Koyama
Journal of clinical medicine research 11 ( 12 ) 834 - 841 2019.12（ ISSN:1918-3003 ）
Physical function and health-related quality of life in the convalescent phase in surgically treated patients with malignant pleural mesothelioma.
Takashi Tanaka, Shinichiro Morishita, Masaki Hashimoto, Toru Nakamichi, Yuki Uchiyama, Seiki Hasegawa, Kazuhisa Domen
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 27 ( 11 ) 4107 - 4113 2019.11（ ISSN:0941-4355 ）
Assessment of the Mini-Balance Evaluation Systems Test, Timed Up and Go test, and body sway test between cancer survivors and healthy participants.
Morishita S, Hirabayashi R, Tsubaki A, Aoki O, Fu JB, Onishi H, Tsuji T
Clinical biomechanics (Bristol, Avon) 69 28 - 33 2019.10（ ISSN:0268-0033 ）
Efficacies of ultrasound and a handheld dynamometer to predict one-repetition maximum.
Nakamura M, Sutoh S, Kiyono R, Sato S, Yahata K, Hiraizumi K, Morishita S
Journal of physical therapy science 31 ( 10 ) 790 - 794 2019.10（ ISSN:0915-5287 ）
Rating of perceived exertion on resistance training in elderly subjects.
Morishita S, Tsubaki A, Nakamura M, Nashimoto S, Fu JB, Onishi H
Expert review of cardiovascular therapy 17 ( 2 ) 135 - 142 2019.2（ ISSN:1477-9072 ）
The benefit of exercise in patients who undergo allogeneic hematopoietic stem cell transplantation.
Morishita S, Tsubaki A, Hotta K, Fu JB, Fuji S
The journal of the International Society of Physical and Rehabilitation Medicine 2 ( 1 ) 54 - 61 2019.1
Differences in Balance Function Between Cancer Survivors and Healthy Subjects: A Pilot Study.
Morishita S, Mitobe Y, Tsubaki A, Aoki O, Fu JB, Onishi H, Tsuji T
Integrative cancer therapies 17 ( 4 ) 1144 - 1149 2018.12（ ISSN:1534-7354 ）
Effect of Eye-Object Distance on Body Sway during Galvanic Vestibular Stimulation.
Aoki O, Otani Y, Morishita S
Brain sciences 8 ( 11 ) 2018.10
Changes in Borg scale for resistance training and test of exercise tolerance in patients undergoing allogeneic hematopoietic stem cell transplantation.
Shinichiro Morishita, Tatsushi Wakasugi, Takashi Tanaka, Tetsuya Harada, Katsuji Kaida, Kazuhiro Ikegame, Hiroyasu Ogawa, Kazuhisa Domen
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 26 ( 9 ) 3217 - 3223 2018.9（ ISSN:0941-4355 ）
Cancer survivors exhibit a different relationship between muscle strength and health-related quality of life/fatigue compared to healthy subjects
S. Morishita, A. Tsubaki, J. B. Fu, Y. Mitobe, H. Onishi, T. Tsuji
European Journal of Cancer Care 27 2018.7（ ISSN:0961-5423 ）
Impaired skeletal muscle oxygenation following allogeneic hematopoietic stem cell transplantation is associated with exercise capacity.
Tatsushi Wakasugi, Shinichiro Morishita, Katsuji Kaida, Yusuke Itani, Norihiko Kodama, Kazuhiro Ikegame, Hiroyasu Ogawa, Kazuhisa Domen
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 26 ( 7 ) 2149 - 2160 2018.7（ ISSN:0941-4355 ）
Changing Paradigms in the Rehabilitation of Inpatients with Brain Tumors.
Fu JB, Morishita S, Yadav R
Current physical medicine and rehabilitation reports 6 ( 2 ) 115 - 120 2018.6
Relationship between the rating of perceived exertion scale and the load intensity of resistance training.
Morishita S, Tsubaki A, Takabayashi T, Fu JB
Strength and conditioning journal 40 ( 2 ) 94 - 109 2018.4（ ISSN:1524-1602 ）
Bleeding frequency and characteristics among hematologic malignancy inpatient rehabilitation patients with severe thrombocytopenia
Jack B. Fu, Jegy M. Tennison, Isabel M. Rutzen-Lopez, Julie K. Silver, Shinichiro Morishita, Seyedeh S. Dibaj, Eduardo Bruera
Supportive Care in Cancer 26 ( 9 ) 1 - 7 2018.3（ ISSN:1433-7339 ）
Changes in Cerebral Oxyhaemoglobin Levels During and After a Single 20-Minute Bout of Moderate-Intensity Cycling.
Tsubaki A, Morishita S, Tokunaga Y, Sato D, Tamaki H, Yamazaki Y, Qin W, Onishi H
Advances in experimental medicine and biology 1072 127 - 131 2018（ ISSN:0065-2598 ）
Fatigue, Muscle Oxygen Consumption and Blood Flow to the Skeletal Muscle After Allogeneic Hematopoietic Stem Cell Transplantation.
Shinichiro Morishita, Tatsushi Wakasugi, Katsuji Kaida, Yusuke Itani, Kazuhiro Ikegame, Hiroyasu Ogawa, Kazuhisa Domen
Advances in experimental medicine and biology 1072 293 - 298 2018（ ISSN:0065-2598 ）
Hemoglobin Dynamics in the Skeletal Muscle of Patients with Malignant Hematopoietic Disease.
Tatsushi Wakasugi, Shinichiro Morishita, Katsuji Kaida, Yusuke Itani, Norihiko Kodama, Kazuhiro Ikegame, Hiroyasu Ogawa, Kazuhisa Domen
Advances in experimental medicine and biology 1072 287 - 291 2018（ ISSN:0065-2598 ）
Examination of the Relationship between Straight Leg Raising Repetition Count and both Knee Extension Strength and Walking Independence in Patients with Collagen Disease.
Shinya Yamauchi, Shinichiro Morishita, Yuki Uchiyama, Norihiko Kodama, Kazuhisa Domen
Progress in rehabilitation medicine 3 20180007 - 20180007 2018
Face scale rating of perceived exertion during cardiopulmonary exercise test.
Morishita S, Tsubaki A, Nashimoto S, Fu JB, Onishi H
BMJ open sport & exercise medicine 4 ( 1 ) e000474 2018
Changes in the Prefrontal Cortex Oxygenation Levels During Cycling in the Supine and Upright Positions.
Ohyanagi H, Tsubaki A, Morishita S, Obata H, Qin W, Onishi H
Advances in experimental medicine and biology 1072 133 - 137 2018（ ISSN:0065-2598 ）
Physical function was related to mortality in patients with chronic kidney disease and dialysis
Shinichiro Morishita, Atsuhiro Tsubaki, Nobuyuki Shirai
HEMODIALYSIS INTERNATIONAL 21 ( 4 ) 483 - 489 2017.10（ ISSN:1492-7535 ）
Physical function and health-related quality of life in patients undergoing surgical treatment for malignant pleural mesothelioma
Takashi Tanaka, Shinichiro Morishita, Masaki Hashimoto, Yusuke Itani, Satoshi Mabuchi, Norihiko Kodama, Seiki Hasegawa, Kazuhisa Domen
SUPPORTIVE CARE IN CANCER 25 ( 8 ) 2569 - 2575 2017.8（ ISSN:0941-4355 ）
Relationship of physical activity with physical function and health-related quality of life in patients having undergone allogeneic haematopoietic stem-cell transplantation
S. Morishita, K. Kaida, S. Yamauchi, T. Wakasugi, K. Ikegame, H. Ogawa, K. Domen
EUROPEAN JOURNAL OF CANCER CARE 26 ( 4 ) 2017.7（ ISSN:0961-5423 ）
Does physical activity improve survival and mortality among patients with different types of cancer?
Shinichiro Morishita, Atsuhiro Tsubaki, Jack B. Fu
FUTURE ONCOLOGY 13 ( 12 ) 1053 - 1055 2017.5（ ISSN:1479-6694 ）
The future of rehabilitation in oncology
Jack B. Fu, Shinichiro Morishita
FUTURE ONCOLOGY 13 ( 7 ) 585 - 587 2017.3（ ISSN:1479-6694 ）
The effects of various visual conditions on trunk control during ambulation in chronic post stroke patients
Osamu Aoki, Yoshitaka Otani, Shinichiro Morishita, Kazuhisa Domen
GAIT & POSTURE 52 301 - 307 2017.2（ ISSN:0966-6362 ）
Examination of Simple Outcome Measures and Cut-off Values Related to Walking Independence of Inpatients with Medical Diseases in Acute Care Hospitals.
Shinya Yamauchi, Shinichiro Morishita, Satoshi Mabuchi, Norihiko Kodama, Kazuhisa Domen
Progress in rehabilitation medicine 2 20170007 - 20170007 2017
Changes in oxyhemoglobin concentration in the prefrontal cortex and primary motor cortex during low- and moderate-intensity exercise on a cycle ergometer
Nana Takehara, Atsuhiro Tsubaki, Yudai Yamazaki, Chiaki Kanaya, Daisuke Sato, Shinichiro Morishita, Hideaki Onishi
Advances in Experimental Medicine and Biology 977 241 - 247 2017（ ISSN:2214-8019 ）
Cortical oxyhemoglobin elevation persists after moderate-intensity cycling exercise: A near-infrared spectroscopy study
Atsuhiro Tsubaki, Nana Takehara, Daisuke Sato, Shinichiro Morishita, Yuta Tokunaga, Kazuhiro Sugawara, Sho Kojima, Hiroyuki Tamaki, Yudai Yamazaki, Hideaki Onishi
Advances in Experimental Medicine and Biology 977 261 - 268 2017（ ISSN:2214-8019 ）
Effects of viewing distance and head flexion on postural control during one and two-legged stance
Aoki O, Otani Y, Morishita S, Domen K
Int J Physiother Res 3 ( 5 ) 1215 - 1220 2015.10（ ISSN:2321-1822 ）
Early-phase differences in health-related quality of life, psychological status, and physical function between human leucocyte antigen-haploidentical and other allogeneic haematopoietic stem cell transplantation recipients
Shinichiro Morishita, Katsuji Kaida, Shinya Yamauchi, Tatsushi Wakasugi, Kazuhiro Ikegame, Norihiko Kodama, Hiroyasu Ogawa, Kazuhisa Domen
EUROPEAN JOURNAL OF ONCOLOGY NURSING 19 ( 5 ) 443 - 450 2015.10（ ISSN:1462-3889 ）
Balance function in patients who had undergone allogeneic hematopoietic stem cell transplantation
Shinichiro Morishita, Katsuji Kaida, Osamu Aoki, Shinya Yamauchi, Tatsushi Wakasugi, Kazuhiro Ikegame, Hiroyasu Ogawa, Kazuhisa Domen
GAIT & POSTURE 42 ( 3 ) 406 - 408 2015.9（ ISSN:0966-6362 ）
Influence of gaze distance and downward gazing on postural sway in hemiplegic stroke patients
Osamu Aoki, Yoshitaka Otani, Shinichiro Morishita, Kazuhisa Domen
EXPERIMENTAL BRAIN RESEARCH 232 ( 2 ) 535 - 543 2014.2（ ISSN:0014-4819 ）
Relationship between corticosteroid dose and declines in physical function among allogeneic hematopoietic stem cell transplantation patients
Shinichiro Morishita, Katsuji Kaida, Shinya Yamauchi, Koichiro Sota, Shinichi Ishii, Kazuhiro Ikegame, Norihiko Kodama, Hiroyasu Ogawa, Kazuhisa Domen
SUPPORTIVE CARE IN CANCER 21 ( 8 ) 2161 - 2169 2013.8（ ISSN:0941-4355 ）
Gender differences in health-related quality of life, physical function and psychological status among patients in the early phase following allogeneic haematopoietic stem cell transplantation
Shinichiro Morishita, Katsuji Kaida, Shinya Yamauchi, Tatsushi Wakasugi, Satoshi Yoshihara, Kyoko Taniguchi, Shinichi Ishii, Kazuhiro Ikegame, Norihiko Kodama, Hiroyasu Ogawa, Kazuhisa Domen
PSYCHO-ONCOLOGY 22 ( 5 ) 1159 - 1166 2013.5（ ISSN:1057-9249 ）
Safety and feasibility of physical therapy in cytopenic patients during allogeneic haematopoietic stem cell transplantation
S. Morishita, K. Kaida, K. Setogawa, K. Kajihara, S. Ishii, K. Ikegame, N. Kodama, H. Ogawa, K. Domen
EUROPEAN JOURNAL OF CANCER CARE 22 ( 3 ) 289 - 299 2013.5（ ISSN:0961-5423 ）
Prevalence of sarcopenia and relevance of body composition, physiological function, fatigue, and health-related quality of life in patients before allogeneic hematopoietic stem cell transplantation
Shinichiro Morishita, Katsuji Kaida, Takashi Tanaka, Yusuke Itani, Kazuhiro Ikegame, Masaya Okada, Shinichi Ishii, Norihiko Kodama, Hiroyasu Ogawa, Kazuhisa Domen
SUPPORTIVE CARE IN CANCER 20 ( 12 ) 3161 - 3168 2012.12（ ISSN:0941-4355 ）
Impaired physiological function and health-related QOL in patients before hematopoietic stem-cell transplantation
Shinichiro Morishita, Katsuji Kaida, Kazuhiro Ikegame, Satoshi Yoshihara, Kyoko Taniguchi, Masaya Okada, Norihiko Kodama, Hiroyasu Ogawa, Kazuhisa Domen
SUPPORTIVE CARE IN CANCER 20 ( 4 ) 821 - 829 2012.4（ ISSN:0941-4355 ）
Effects of ultrasound therapy on calcificated tendinitis of the shoulder.
Koji Shomoto, Katsuhiko Takatori, Shinichiro Morishita, Koji Nagino, Waka Yamamoto, Takahiro Shimohira, Tomoaki Shimada
Journal of the Japanese Physical Therapy Association = Rigaku ryoho 5 ( 1 ) 7 - 11 2002（ ISSN:1344-1272 ）
Neuropsychological and Psychosocial Foundations of Neuro-Oncology
Jack B. Fu, Shinichiro Morishita, Katherine Connelly（Physical rehabilitation in neuro-oncology）
Elsevier 2024.8 （ ISBN:9780443156632 ）
Palliative Care in Hematologic Malignancies and Serious Blood Disorders
Jack B. Fu, George J. Francis, Shinichiro Morishita, Julie K. Silver（Rehabilitation Medicine）
Springer 2023.11 （ ISBN:9783031380570 ）
Pulmonary and Critical Care Considerations of Hematopoietic Stem Cell Transplantation
Shinichiro Morishita, Ryohei Jinbo, Ryuichi Kasahara（Pulmonary Rehabilitation in Hematopoietic Stem Cell Transplantation Patients）
Springer 2023.7 （ ISBN:9783031287961 ）
Physical Therapy and Research in Patients With Cancer
Shinichiro Morishita, Junichiro Inoue, Jiro Nakano（Physical Function and Health-Related QOL in Cancer Survivors）
Springer 2023.1
Handbook of Cancer and Immunology International journal
（Cancer Rehabilitation or Physical Exercise Effect on Immune Function）
Springer 2023.1 （ ISBN:9783030809621 ）
Frontiers in Clinical Drug Research - Anti-Cancer Agents
（Physical Exercise for Cancer Patients Treated with Chemotherapy）
Bentham 2019.6 （ ISBN:978-981-14-0514-3 ）
（Understanding cachexia, sarcopenia, and physical exercise in patients with cancer）
Intech 2017.8 （ ISBN:978-953-51-3483-1 ）
（Physical therapy in patients with cancer）
Intech 2017.5 （ ISBN:978-953-51-3112-0 ）
Most cited article of 2022
2023.6
公益財団法人 小笠原科学技術振興財団 国際研究集会出張助成 受贈（渡航先 アメリカ）
2019.6
公益財団法人 小笠原科学技術振興財団 国際研究集会出張助成 受贈（渡航先 アメリカ）
2019.6
金原一郎記念医学医療振興財団 第32回研究交流助成 受贈 (渡航先 フランス)
2018.7
公益財団法人政策医療振興財団 国際会議出席支援助成金 受贈 (渡航先 オーストリア)
2018.6
公益財団法人がん研究振興財団 看護師・薬剤師・技師等海外研修助成 受贈 (渡航先 オーストラリア)
2016.6
公益財団法人がん研究振興財団 看護師・薬剤師・技師等海外研修助成 受贈 (渡航先 アメリカ)
2015.10
公益財団法人がん研究振興財団 看護師・薬剤師・技師等海外研修助成 受贈 (渡航先 アメリカ)
2014.6
公益財団法人がん研究振興財団 看護師・薬剤師・技師等海外研修助成 受贈 (渡航先 ドイツ)
2013.6
公益財団法人がん研究振興財団 看護師・薬剤師・技師等海外研修助成 受贈 (渡航先 デンマーク)
2012.9
患者のフィジビリティを高める遠隔看護システム併用型「膵がんリハプログラム」の開発
Grant number：24K02735 2024.4 - 2029.3
基盤研究(B)
佐藤 菜保子, 霜山 真, 佐藤 大介, 元井 冬彦, 岸和田 昌之, 中谷 直樹, 森下 慎一郎, 海野 倫明, 奥坂 拓志
Grant amount：\18590000 （ Direct Cost: \14300000 、 Indirect Cost：\4290000 ）
重複障害における心腎機能改善を目指すリハビリテーションの確立
Grant number：24K14350 2024.4 - 2029.3
基盤研究(C)
上月 正博, 森下 慎一郎, 佐藤 聡見
Grant amount：\4420000 （ Direct Cost: \3400000 、 Indirect Cost：\1020000 ）
Exercise and Nutrition Program to Improve Sarcopenia and Immune Activation in Hematologic Cancer Survivors
Grant number：24K02767 2024.4 - 2028.3
Grant-in-Aid for Scientific Research (B)
Grant amount：\17940000 （ Direct Cost: \13800000 、 Indirect Cost：\4140000 ）
低酸素に対する大脳皮質微小血管機能の脆弱性イメージングと細胞組織学的な基盤の解明
Grant number：24K02802 2024.4 - 2028.3
基盤研究(B)
椿 淳裕, 田宮 創, 森下 慎一郎, 長坂 和明, 大西 秀明, 越智 元太
Grant amount：\18460000 （ Direct Cost: \14200000 、 Indirect Cost：\4260000 ）
車いすスポーツ選手における上肢筋疲労の客観的評価法の確立と障害発生リスクの解明
Grant number：24K14425 2024.4 - 2028.3
基盤研究(C)
遠藤 康裕, 神先 秀人, 森下 慎一郎
Grant amount：\4550000 （ Direct Cost: \3500000 、 Indirect Cost：\1050000 ）
血液がん患者に対し運動療法と栄養療法を加えた包括的リハビリテーションが健康効用値に及ぼす影響
2023.6 - 2024.3
森下慎一郎
化学療法を施行した血液がん患者の筋力・全身持久力と免疫機能に関する研究
2021.6 - 2022.3
森下慎一郎
Physical exercise program on immune activity in patients with hematological malignancy
Grant number：21K11176 2021.4 - 2024.3
Grant-in-Aid for Scientific Research (C)
Grant amount：\4160000 （ Direct Cost: \3200000 、 Indirect Cost：\960000 ）
地域在住乳がんサバイバーのリンパ浮腫軽減と健康関連QOLの調査
2021.3 - 2023.3
森下慎一郎
Authorship：Principal investigator Grant type：Competitive
公益財団法人 在宅医療助成勇美記念財団
化学療法を施行した血液がん患者に対する運動と栄養をあわせたリハビリテーションの研究
2020.6 - 2021.3
森下慎一郎
Authorship：Principal investigator Grant type：Competitive
公益財団法人日本政策医療財団 2020年度研究助成金
ノイズ電気刺激を用いた感覚入力変調による歩行能力の改善
Grant number：20H04095 2020.4 - 2024.3
基盤研究(B)
青木 修, 大谷 啓尊, 森下 慎一郎
Grant amount：\16640000 （ Direct Cost: \12800000 、 Indirect Cost：\3840000 ）
脳卒中片麻痺患者では運動、感覚、高次機能障害に起因するバランス低下がみられる。感覚入力信号に外部からノイズ波形を付加することで、確率論的に入力信号が感覚閾値を超えて知覚しやすくなることが示唆されている。前庭系に対してこのような感覚入力を変調するノイズ前庭電気刺激を用いることで、脳卒中患者の静的立位バランスにおける視覚代償は改善したが、歩行などの動的バランスに対する影響は明らかではない。このため、ノイズ電気刺激が動的バランスに与える影響を明らかにする目的で研究を実施した。
COVID-19の影響により脳卒中患者を対象とした介入が困難であったため、健常若年者15名(19.9±0.5歳)を対象とした。各被験者の感覚閾値の1％(偽刺激)、70％の電流強度でノイズ前庭電気刺激を適用した。立位で電気刺激適用中に能動的に前後への最大重心移動を行わせ、その際の移動距離を比較した。
結果、1％と比較して70％の電気刺激では前後方向への最大重心移動距離は約12％増大したが、統計学的有意性は認められなかった。この結果から、前庭電気刺激のみでは動的バランスへの改善効果は明らかとならなかった。
今年度の当初予定では前庭および体性感覚へのノイズ電気刺激を併用することでの効果を検証することを計画していたが、機器の不具合により前庭電気刺激単独での検証となった。このため今後は、当初予定の複数感覚への電気刺激を併用することでの動的バランスへの影響を継続検証していきたい。
酸素ダイナミクスに基づく大脳皮質微小循環の評価法の開発と検証
Grant number：20H04042 2020.4 - 2024.3
基盤研究(B)
椿 淳裕, 渡邊 博昭, 堀田 一樹, 森下 慎一郎, 池上 諒, 大西 秀明
Grant amount：\17940000 （ Direct Cost: \13800000 、 Indirect Cost：\4140000 ）
本研究は，大脳皮質の神経活動を捉える指標として酸素化ヘモグロビンを測定し，急激な血圧変化を生じさせた時の変動から循環調節に関与する領域を同定すること，導管動脈と毛細血管との差異を明らかにすることを目的に，ヒトを対象とした基礎的研究および実験動物を対象とした基礎的研究の両面からアプローチしている．
2021年度はヒトを対象とした基礎的研究として，2020年度よりも被検者を増やして実施することに加え，動物実験においてヒトでは検証できない現象の生理学的背景の解明に着手した．12週齢のWister系ラットを対象に，イソフルラン吸入麻酔下のラットの腹部大動脈を5分間駆血し，一気に開放することで急激に血圧を低下させた．この時の大脳皮質の微小循環の変化を，麻酔下，開頭下で共焦点レーザー走査顕微鏡により蛍光試薬（Fluorescein isothiocyanate）により標識した赤血球をレーザー光により検出し，高速度撮影することで，毛細血管レベルで捉えた．
ヒトを対象とした研究では，前年度と同様の結果に加え，駆血解放後の血圧最低値までの時間に比べ，酸素化ヘモグロビンの最低値までの時間が有意に遅いことが明らかとなった．この時間には領域間に差はないことを確認した．動物実験においては，血圧低下モデルの作成に時間がかかった．血圧の低下によって大脳皮質レベルの赤血球移動速度は著しく低下することがわかった．一方毛細血管径の変化は，移動速度の変化に比べ小さくかった．
同種造血細胞移植の再発率低下を目指したリハビリテーション法の確立
Grant number：20K11153 2020.4 - 2023.3
基盤研究(C)
柴崎 康彦, 森下 慎一郎, 増子 正義
Grant amount：\4290000 （ Direct Cost: \3300000 、 Indirect Cost：\990000 ）
昨年度に引き続き、同種造血細胞移植後の腫瘍免疫動態を評価を行った。昨年度はHLA半合致移植を中心に解析を行ったが、本年度は同種造血細胞移植を行った造血器腫瘍患者全例を対象として、マルチカラーフローサイトメトリー法を併用し、同種造血細胞移植後30日前後の免疫動態について評価を行った。
その結果、移植後30日時点でのCD8陽性ナイーブT細胞の比率が低く、T-EMRA細胞比率が多い症例で重症急性GVHD発症症例が有意に多いことが判明した。この傾向はドナー種類（末梢血・骨髄・臍帯血）によらず同様であった。このことは、重症急性GVHDを発症する症例は発症前から細胞障害活性を持つT細胞比率が高いことを示している。今回の結果は、aGVHDの発症を予測し、より適切なタイミングでの治療介入を行うことへ向けた重要な所見であると考えられた。
また、本年度は新たに内皮活性化およびストレス指数（EASIX）が予後に与える影響についても解析を行った。適切なリハビリテーションにより、血管内皮機能や血小板活性化の改善が認められるとの報告があることから、EASIXとリハビリテーション、筋肉量との関連性を調べることが重要と考えられる。特に移植前のEASIXのみならず、移植後のEASIXが予後に与える影響について研究を進めており、移植後1年時点でのEASIX(EASIX-1year)がその後の非再発死亡に対する有意な予後予測因子であることを発見した。本研究成果は今後、国際学会での発表も視野に研究を進めているところである。
移植成績には様々な要因があるため、適切な予後予測因子を同定することがリハビリテーション介入において重要である。そのため、同種造血細胞移植全般の予後予測についても並行して研究を進めている。
地域のがんサバイバーのための運動プログラム啓発活動
2020.4 - 2021.3
森下慎一郎
Authorship：Principal investigator Grant type：Competitive
笹川保健財団 2020年度地域啓発活動助成
乳がんサバイバーの続発性リンパ浮腫を予防し、QOLを向上させるための予防的リハビリテーション方法の検討
2019.8 - 2020.8
森下慎一郎
Authorship：Principal investigator Grant type：Competitive
公益財団法人がん研究振興財団 がんサバイバーシップ研究助成
化学療法を施行した血液がん患者の身体機能、身体活動量と健康関連QOLについて
2018.5 - 2019.3
森下慎一郎
Authorship：Principal investigator Grant type：Competitive
公益財団法人日本政策医療財団 2018年度研究助成金
Combining exercise and nutrition program for cancer patients International coauthorship
Grant number：18K10725 2018.4 - 2021.3
Grant-in-Aid for Scientific Research (C)
Morishita Shinichiro
Authorship：Principal investigator Grant type：Competitive
Grant amount：\4550000 （ Direct Cost: \3500000 、 Indirect Cost：\1050000 ）
We examined the effects of exercise and nutritional intervention in patients with hematological malignancies. The 15 subjects were devided into 7 patients with the exercise intervention only and 8 patiens with the exercise + nutrition intervention. Muscle strength (grip strength, knee extension strength), endurance, muscle mass, simple nutritional status, malaise, and QOL were measured at the admission and 3 months after admission. Exercise consisted of endurance and muscle strengthening training for 20 minutes a day, 6 days a week. Nutrition intervention used two supplements a day. In the exercise + nutrition intervention group, knee extension strength was maintained 3 months after admission compared to the admission. However, there were no significant differences between the two groups in terms of grip strength, endurance, muscle mass, MNA, and QOL.
造血幹細胞移植患者の筋力低下パターンと身体活動量の関連性を解明する
2017.10 - 2018.10
公益財団法人大和証券ヘルス財団 （第44回）調査研究助成金
造血幹細胞移植患者の移植前後における筋肉量や栄養状態と身体活動量の変化について
2017.5 - 2018.3
公益財団法人日本政策医療財団 2017年度研究助成金
２型糖尿病患者の身体活動量と身体機能低下との関連性について
2017.4 - 2018.3
古川医療福祉設備振興財団 第4回研究助成金
造血幹細胞移植患者の活動量と身体機能低下の関連性について
2016.5 - 2017.3
公益財団法人日本政策医療財団 2016年度研究助成金
Using Borg scale during self-exercise while staying in a clean room in patients undergoing allogeneic hematopoietic stem cell transplantation
2015.4 - 2017.3
Assessment of physical activity and development of a self-exercise program in patients who had undergone allogeneic hematopoietic transplantation and staying in a clean room.
2013.4 - 2015.3
造血幹細胞移植患者の身体活動量低下が健康関連QOLに及ぼす影響について
2013.3 - 2014.3
公益財団法人がん研究振興財団 がん研究助成金
造血幹細胞移植患者の身体機能及びQOL低下要因の調査と性差に基づいた新しいリハビリテーションプログラムの開発
2011.4 - 2012.3
公益財団法人がん研究振興財団 がん研究助成金
造血幹細胞移植患者に対する無菌室・準無菌室での運動療法の効果及び安全性の検討
2009.11 - 2010.3
日本理学療法士協会 日本理学療法士協会助成研究金
