肝静脈閉塞症が初発症状であったPNH症例

野地秀義, 七島　勉

PNH Frontier   3   68 - 72   2016

PNHの治療

七島　勉*

NPO法人PNH倶楽部だより   8   2 - 5   2015

A new method for maturity-dependent fractionation of neutrophil progenitors applicable for the study of myelodysplastic syndromes

HU, Huiyuan*; SHIKAMA, Yayoi*; SHICHISHIMA, Tsutomu*; IKEDA, Kazuhiko*; AKUTSU, Kazuko; ONO, Tomoyuki*; KIMURA, Hideo; OGAWA, Kazuei*; NOJI, Hideyoshi*; TAKEISHI, Yasuchika*; KIMURA, Junko*

Biomarker Research   2 ( 1 )   2   2014

Genetic variants in C5 and poor response to eculizumab

NISHIMURA, Jun-ichi; YAMAMOTO, Masaki; HAYASHI, Shin; OHYASHIKI, Kazuma; ANDO, Kiyoshi; BRODSKY, Andres; NOJI, Hideyoshi*; KITAMURA, Kunio; ETO, Tetsuya; TAKAHASHI, Toru; MASUKO, Masayoshi; MATSUMOTO, Takuro; WANO, Yuji; SHICHISHIMA, Tsutomu*; SHIBAYAMA, Hirohiko; HASE, Masakazu; LI, Lan; JOHNSON, Krista; LAZAROWSKI, Alberto; TAMBURINI, Paul; INAZAWA, Johji; KINOSHITA, Taroh; KANAKURA, Yuzuru

New England Journal of Medicine   370 ( 7 )   632 - 639   2014

PNHの集い in 旭川

七島　勉*

NPO法人PNH倶楽部だより   5   6   2014

PNH講演会・ Q & A

七島　勉*

NPO法人PNH倶楽部だより   5   3 - 5   2014

第4回造血器腫瘍免疫療法研究会に参加して

七島　勉*

造血器腫瘍免疫療法研究会 Newsletter   4   8 - 9   2013

Impairment of FOS mRNA stabilization following translation arrest in granulocytes from myelodysplastic syndrome patients

FENG, Xiaomin*; SHIKAMA, Yayoi*; SHICHISHIMA, Tsutomu*; NOJI, Hideyoshi*; IKEDA, Kazuhiko*; OGAWA, Kazuei*; KIMURA, Hideo; TAKEISHI, Yasuchika*; KIMURA, Junko*

PLoS One   8 ( 4 )   e61107   2013

Long-term efficacy and safety of eculizumab in Japanese patients with PNH: AEGIS trial

KANAKURA, Yuzuru; OHYASHIKI, Kazuma; SHICHISHIMA, Tsutomu*; OKAMOTO, Shinichiro; ANDO, Kiyoshi; NINOMIYA, Haruhiko; KAWAGUCHI, Tatsuya; NAKAO, Shinji; NAKAKUMA, Hideki; NISHIMURA, Jun-ichi; KINOSHITA, Taroh; BEDROSIAN, Camille; OZAWA, Keiya; OMINE, Mitsuhiro

International Journal of Hematology   98 ( 4 )   406 - 416   2013

PNHの治療戦略とエクリズマブ

七島　勉*

NPO法人PNH倶楽部だより   3   5 - 6   2013

PNH Q & A

七島　勉*

NPO法人PNH倶楽部だより   3   11 - 12   2013

PNHの集い in 仙台

七島　勉*

NPO法人PNH倶楽部だより   4   11 - 12   2013

Deregulated expression of HMGA2 is implicated in clonal expansion of PIGA deficient cells in paroxysmal nocturnal haemoglobinuria

MURAKAMI, Yoshiko; INOUE, Norimitsu; SHICHISHIMA, Tsutomu*; OHTA, Rieko; NOJI, Hideyoshi*; MAEDA, Yusuke; NISHIMURA, Junichi; KANAKURA, Yuzuru; KINOSHITA, Taroh

British Journal of Haematology   156 ( 3 )   383 - 387   2012

T-cell prolymphocytic leukemia in Japan: is it a variant?

KAMEOKA, Junichi; TAKAHASHI, Naoto; NOJI, Hideyoshi*; MURAI, Kazunori; TAJIMA, Katsushi; KAMEOKA, Yoshihiro; SATO, Shinji; SHICHISHIMA, Tsutomu*; ISHIDA, Yoji; HARIGAE, Hideo; SAWADA, Kenichi

International Journal of Hematology   95 ( 6 )   660 - 667   2012

Maturity-dependent fractionation of neutrophil progenitors: A new method to examine in vivo expression profiles of differentiation-regulating genes

HU, Huiyuan*; SHIKAMA, Yayoi*; SHICHISHIMA, Tsutomu*; IKEDA, Kazuhiko*; AKUTSU, Kazuko; ONO, Tomoyuki*; KIMURA, Hideo; OGAWA, Kazuei*; NOJI, Hideyoshi*; TAKEISHI, Yasuchika*; KIMURA, Junko*

Experimental Hematology   40 ( 8 )   675 - 681   2012

Safety and feasibility of high-dose ranimustine (MCNU), carboplatin, etoposide, and cyclophosphamide (MCVC) therapy followed by autologous stem cell transplantation for malignant lymphoma

KAMEOKA, Yoshihiro; TAKAHASHI, Naoto; ISHIZAWA, Kenichi; KATO, Yuichi; ITO, Jugo; SASAKI, Osamu; MURAI, Kazunori; NOJI, Hideyoshi*; HIROKAWA, Makoto; TAJIMA, Katsusi; SHICHISHIMA, Tsutomu*; ISHIDA, Yoji; HARIGAE, Hideo; SAWADA, Kenichi

International Journal of Hematology   96 ( 5 )   624 - 630   2012

溶血が引き起こすPNHの病態～NO枯渇と関連症状を中心に～

七島　勉*

溶血とNOの関係（DVD）   2012

Safety and efficacy of the terminal complement inhibitor eculizumab in Japanese patients with paroxysmal nocturnal hemoglobinuria: the AEGIS Clinical Trial

Yuzuru Kanakura, Kazuma Ohyashiki, Tsutomu Shichishima*, Okamoto Shinichiro, Kiyoshi Ando, Haruhiko Ninomiya, Tatsuya Kawaguchi, Shinji Nakao, Hideki Nakakuma, Jun-ichi Nishimura, Troh Kinoshita , Camill L Bedrosian, Marye Ellen Valentine, Gus Khursigara, Keiya Ozawa, Mitsuhiro Omine

International Journal of Hematology   93 ( 1 )   36 - 46   2011

発作性夜間ヘモグロビン尿症　診療の参照ガイド（平成22年度改訂版）

金倉　譲, 西村純一, 木下タロウ, 中尾眞二, 岡本真一郎, 中熊秀喜, 千葉　滋, 七島　勉*, 川口辰哉, 二宮治彦, 金丸昭久

厚生労働省科学研究費補助金　難治性疾患克服研究事業　特発性造血障害に関する調査研究班（平成20〜22年度）特発性造血障害疾患の「診療の参照ガイド」平成22年度改訂版   99 - 139   2011

ダサチニブが奏効した慢性腎不全を合併したイマチニブ抵抗性慢性骨髄性白血病の一例

野地秀義*, 眞下由美子*, 池田和彦*, 高橋裕志*, 原田佳代*, 古川未希*, 七島　勉*, 小川一英*, 竹石恭知*

ダサチニブ症例集   1   6 - 7   2011

Comparison of long-term clinical outcomes of CHOP chemotherapy between Japanese patients with nodal peripheral T-cell lymphomas and those with diffuse large B-cell lymphoma in the study group of the Tohoku Hematology Forum

AKAGI, Tomoaki; TAKAHASHI, Naoto; YAMAGUCHI, Kouhei; ISHIZAWA, Kenichi; MURAI, Kazunori; TAJIMA, Katsushi; IKEDA, Kazuhiko*; KAMEOKA, Yoshihiro; KAMEOKA, Junichi; ITO, Shigeki; KATO, Yuichi; NOJI, Hideyoshi*; SHICHISHIMA, Tsutomu*; ITOH, Jugoh; ICHINOHASAMA, Ryo; HARIGAE, Hideo; ISHIDA, Yoji; SAWADA, Kenichi

Journal of Clinical and Experimental Hematopathology   51 ( 1 )   29 - 35   2011

Impairment of FOS mRNA induction by a translation inhibitor puromycin in granulocytes from myelodysplastic syndrome patients

SHIKAMA, Yayoi; XIAOMIN, Feng; SHICHISHIMA, Tsutomu*; ONO, Tomoyuki; NOJI, Hideyoshi*; IKEDA, Kazuhiko*; OGAWA, Kazuei*; TAKEISHI, Yasuchika*; KIMURA, Junko

British Journal of Haematology   154 ( 4 )   525 - 527   2011

A patient with acute lymphoblastic leukaemia presenting with an extremely high level (21.0%) of HbA_1c

SUZUKI, Yuhko; SHICHISHIMA, Tsutomu*; YAMASHIRO, Yasuhiro; KIMURA, Hirokazu; ISHII, Ryuuji; MIYAZAKI, Koji; HORIE, Ryouichi; MORIYA, Tatsumi; HATTORI, Yukio

Annals of Clinical Biochemistry   48 ( 5 )   474 - 477   2011

特集　骨髄不全症診療の新しい展開　PNHの病態解析と治療の進歩

七島　勉*

血液内科   63 ( 2 )   208 - 215   2011

Low concentration of serum haptoglobin has impact on understanding complex pathophysiology in patients with acquired bone marrow failure syndromes

SHICHISHIMA, Tsutomu*; IKEDA, Kazuhiko*; TAKAHASHI, Naoto; KAMEOKA, Junichi; TAJIMA, Katsushi; MURAI, Kazunori; TAMAI, Yoshiko; SHICHISHIMA-NAKAMURA, Akiko*; AKUTSU, Kazuko*; NOJI, Hideyoshi*; OKAMOTO, Masatoshi; KIMURA, Hideo; HARIGAE, Hideo; OYAMADA, Takashi; KAMESAKI, Toyomi; TAKEISHI, Yasuchika*; SAWADA, Kenichi

International Journal of Hematology   91 ( 4 )   602 - 610   2010

解説：発作性夜間ヘモグロビン尿症の診断・治療の実際

七島　勉*

血液・腫瘍科   60 ( 6 )   777 - 786   2010

Transcripts expressed using a bicistronic vector pIREShyg2 are sensitized to nonsense-mediated mRNA decay

SHIKAMA, Yayoi; HU, Huiyuan; OHNO, Makiko; MATSUOKA, Isao; SHICHISHIMA, Tsutomu*; KIMURA, Junko

BMC Molecular Biology   11   42   2010

発作性夜間ヘモグロビン尿症の病態と治療ー最近の知見ー

七島晶子*, 七島　勉*

臨床血液   50 ( 12 )   1679 - 1686   2009

臨床的検査データのとらえ方　症例編 -51歳 男性-

七島　勉*

Medical Technology   36 ( 6 )   601 - 604   2008.6

PNHという病気

七島　勉*

再生つばさの会   60   1 - 2   2008.1

Microvascular thrombosis in the hepatic vein of a patient with paroxysmal nocturnal hemoglobinuria

NOJI, Hideyoshi*; SHICHISHIMA, Tsutomu*; OKAMOTO, Masatoshi; SHICHISHIMA-NAKAMURA, Akiko*; MATSUMOTO, Hayato*; TAJIMA, Hiroko*; OGAWA, Kazuei*; MARUYAMA, Yukio*

International Journal of Hematology   86 ( 3 )   216 - 221   2007.10

Splenic infarction after Epstein-Barr virus infection in a patient with hereditary spherocytosis

SUZUKI, Yuhko; SHICHISHIMA, Tsutomu*; MUKAE, Miyuki; OHSAKA, Manabu; HAYAMA, Miyuki; HORIE, Ryouichi; TOGANO, Tomiteru; MIYAZAKI, Koji; ICHINOE, Masaaki; IWABUCHI, Keiichi; FUJII, Hisaichi; HIGASHIHARA, Masaaki

International Journal of Hematology   85 ( 5 )   380 - 383   2007.6

The role of Wilms' tumor gene peptide-specific cytotoxic T lymphocytes in immunologic selection of a paroxysmal nocturnal hemoglobinuria clone

IIKEDA, Kazuhiko*; SHICHISHIMA, Tsutomu*; YASUKAWA, Masaki; NAKAMURA-SHICHISHIMA, Akiko*; NOJI, Hideyoshi*; AKUTSU, Kazuko*; OSUMI, Kazuoki; MARUYAMA, Yukio*

Experimental Hematology   35 ( 43 )   618 - 626   2007.4

特集：貧血ー病態の理解と最新の治療ー：発作性夜間血色素尿症の治療

七島　勉 *

Current Therapy   25 ( 3 )   210 - 213   2007.3

骨髄不全疾患としての発作性夜間血色素尿症 (PNH)

中熊秀喜 , 大屋敷一馬 , 小松則夫 , 七島　勉 *

若手臨床血液学セミナー　総説集   42 - 45   2007

鉄欠乏性貧血患者のお茶

七島　勉*

Medical Practice   23 ( 10 )   1806   2006.10

Heterogeneity in the molecular pathogenesis of paroxysmal nocturnal hemoglobinuria (PNH) syndromes and expansion mechanism of a PNH clone

SHICHISHIMA,Tsutomu*;NOJI,Hideyoshi*

International Journal of Hematology   84 ( 2 )   97 - 103   2006.8

Neutropenia due to parvovirus B19 infections in patients with paroxysmal nocturnal hemoglobinuria

ABE,Rokuo*;SHICHISHIMA,Tsutomu*;OGAWA,Kazuei*;SAITOH,Yurie*;MARUYAMA,Yukio*

Acta Haematologica   116 ( 4 )   245 - 248   2006

Neutropenia due to parvovirus B19 infections in patients with paroxysmal nocturnal hemoglobinuria

ABE,Rokuo*;SHICHISHIMA,Tsutomu*;OGAWA,Kazuei*;SAITOH,Yurie*;MARUYAMA,Yukio*

Acta Haematologica   116 ( 4 )   245 - 248   2006

Collection of MNCs and progenitor cells by two separators for PBPC transplantation: a randomized crossover trial

Kazuhiko Ikeda, Hitoshi Ohto, Kenji Nemoto, Go Yamamoto, Katsuhiko Kato , et al

Transfusion   43 ( 6 )   814 - 819   2003

Bernard-Soulier syndrome with a homozygous 13 base pair deletion in the signal peptide-coding region of the platelet glycoprotein lbβgene

Reiko Watanabe, Toshiyuki Ishibashi, Yurie Saitoh, Tsutomu Shichishima, Yukio Maruyama, et al

Blood Coagulation and Fibrinolysis   14 ( 4 )   387 - 394   2003

Phenotypes and phosphatidylinositol glycan-class A gene abnormalities during cell differentiation and maturation from precursor cells to mature granulocytes in patients with paroxysmal nocturnal hemoglobinuria

Tatsuyuki Kai, Tsutomu Shichishima, Hideyoshi Noji, Tetsuo Yamamoto, Masatoshi Okamoto, et al

Blood   100 ( 10 )   3812 - 3818   2002

A new aspect of the molecular pathogenesis of paroxysmal nocturnal hemoglobinuria

Tsutomu Shichishima, Hideyoshi Noji

Hematology   7 ( 4211-227 )   2002

B-cell chronic lymphocytic leukemia is complicated by autoimmune hemolytic anemia and anti-phospholipid syndrome

Kazuhiko Ikeda, Tsutomu Shichishima, Tokuo Yui, Atsushi Otake, Kazuyoshi Sakai, et al

Journal of Clinical and Experimental Hematopathology   42 ( 2 )   75 - 79   2002

Granulocytes from patients with paroxysmal nocturnal hemoglobinuria and normal individuals have the same sensitivity to spontaneous apoptosis

Tetsuo Yamamoto, Tsutomu Shichishima, Yayoi Shikama, Yurie Saitoh, Kazuei Ogawa, Yukio Maruyama

Experimental Hematology   130   187 - 194   2002

HLA class II haplotype and quantitation of WT1 RNA in Japanese patients with paroxysmal nocturnal hemoglobinuria

Tsutomu Shichishima, Masatoshi Okamoto, Kazuhiko Ikeda, Toshihiko Kaneshige, Haruo Sugiyama, et al

Blood   100 ( 1 )   22 - 28   2002

Truncated mutant B subunit for factor XIII causes its deficiency due to impaired intracellular transportation

Shiori Koseki, Masayoshi Souri, Shinichiro Koga, Mitsunori Yamakawa, Tsutomu Shichishima, Yukio Maruyama, Fumio Yanai, Akitada Ichinose

Blood   97 ( 9 )   2667 - 2672   2001

Complement and polymorphonuclear leukocyte activation each play a role in determining myocardial ishemia-reperfusion injury

Atsuumi T, Yaoita H, Shichishima T, Maehara K, Fujita T et al

Jpn Circ J   65 ( 7 )   659 - 666   2001

Immune thrombocytopenia in an elderly patient treated successfully by pulse therapy with cyclophosphamide

Kazuhiko Ikeda, Tsutomu Shichishima, Tokuo Yui, Kazuyoshi Sakai, Atsushi Ohtake, et al

Fukushima Journal of Medical Science   47 ( 1 )   33 - 38   2001

Ten-year survivor with multiple myeloma in first complete remission following treatment with conventional chemotherapy

Rokuo Abe, Toshiyuki Ishibashi, Tsutomu Shichishima, Yukio Maruyama

Acute Haematologica   105   241 - 243   2001

The distribution of PIG-A gene abnormalities in paroxysmal nocturnal hemoglobinuria granulocytes and cultured erythroblasts

Hideyoshi Noji, Tsutomu Shichishima, Yurie Saitoh, Tatsuyuki Kai, Tetsuo Yamamoto, et l

Experimental Hematology   29 ( 4 )   391 - 400   2001

T-prolymphocytic leukaemia with spontaneous remission

T Shichishima 1, M Kawaguchi, T MacHii, R Matsuoka, K Ogawa, Y Maruyama

British Journal of Haematology   108   397   2000

Complement sensitivity of erythrocytes in a patient with inherited complete deficiency of CD59 or with the Inab phenotype.

Tsutomu Shichishima, Yurie Saitoh, Takashi Terasawa, Hideyoshi Noji, Tatsuyuki Kai, Yukio Maruyama

British Journal of Haematology   104   303   1999

Surface expression of complement regulatory proteins, decay-accelerating factor(DAF)and CD59, on cultured human endothelial cells.

H Kunii 1, T Shichishima, Y Saitoh, H Noji, Y Maruyama

Fukushima Journal of Medical Science   44 ( 2 )   69   1998

Report on a patient with paroxysmal cold hemoglobinuria

P R Subbarayan 1, T Shichishima, H Yoshida, Y Maruyama, M Naiki

International Journal of Hematology   65   165   1997

Relationship between the phenotypes of circulating erythrocytes and cultured erythroblasts in paroxysmal nocturnal hemoglobinuria

T Shichishima 1, Y Saitoh, T Terasawa, K Ogawa, Y Maruyama

Blood   90 ( 1 )   435   1997

Chronic myelogenous leukemia with a hypooctoploid cell population

T Shichishima 1, Y Hamazaki, R Abe, Y Shiga, T Abe, Y Maruyama

Cancer Genetics and Cytogenetics   94   144   1997

In vivo effects of various therapies on complement-sensitive erythrocytes in paroxysmal nocturnal hemoglobinuria

T Shichishima 1, Y Saitoh, H Noji, T Terasawa, Y Maruyama

International Journal of Hematology   63   291   1996

Glycosyphosphatidylinositol(GPI)-anchored Membrane Proteins in Clinical pathophysiology of Paroxysmal Nocturnal Hemoglobinuria(PNH)

Fukushima Journal of Medical Science   41 ( 1 )   1   1995

"""Case of a child with paroxysmal nocturnal hemoglobinuria diaghosed by flow cytometry"""

N Kinugawa 1, T Shichishima, J Nishimura, T Kitani

Pediatric Hematology and Oncology   10   347   1993

Discordant and heterogeneous expression of GPI-anchored membrane proteins on 1eukemic cells in a patient with paroxysmal nocturnal hemoglobinuria (共著)

T Shichishima 1, T Terasawa, C Hashimoto, H Ohto, M Takahashi, A Shibata, Y Maruyama

Blood   81 ( 7 )   1855   1993

Diagnosis of paroxysmal nocturnal haemoglobinuria by phenotypic analysis of erythrocytes using two-colour flow cytometry with monoclonal antibodies to DAF and CD59/MACIF (共著)

T Shichishima 1, T Terasawa, Y Saitoh, C Hashimoto, H Ohto, Y Maruyama

British Journal of Haematology   85   378   1993

Platelct transfusion refractoriness associated with plasma proteins (共著)

H Ohto, H Yasuda, R Abe, T Ishibashi, T Shichishima, Y Maruyama, I Watanabe

British Journal of Haematology   83 ( 4 )   680   1993

"""Relationship between the proportion of paroxysmal nocturnal hemoglobinuria (PNH) Ⅲ-erythrocytes and the frequency of exacerbated hemoglobinuria in PNH"""

T Shichishima, T Terasawa, T Uchida, Y Maruyama

European Journal of Haematology   47   235   1991

Heterogeneous expression of decay accelerating factor and CD59/membrane attack complex inhibition factor on paroxysmal nocturnal haemoglobinuria (共著)

T Shichishima 1, T Terasawa, C Hashimoto, H Ohto, T Uchida, Y Maruyama

British Journal of Haematology   78   545   1991

Decay-accelerating Factor and Complement Senseitivity of Erythrocytes in Paroxysmal Nocturnal Hemoglobinuria

NINOMIYA H (Univ. Tsukuba, Ibaraki) , SHICHISHIMA T (Fukushima Medical Coll. Fukushima) , TERASAWA T (Ohu Univ., Fukushima) , ADACHI Y (Tokyo Metropolitan Bokuto Hospital, Tokyo) , AMANO M (National Medical Center, Tokyo) , KAWADA K (Tsuchiura Kyodo Hospital, Ibaraki) , KURIYA S (Nippon Medical School, Tokyo) , MIWA S (Okinaka Memorial Inst. Medical Research, Tokyo) , FUJITA T (Univ. Tsukuba, Ibaraki)

Acta Haematological Japonica   53 ( 7 )   1083   1990

Characterization of the erythropoietic progenitor cells (BFU-E) in paroxysmal nocturnal haemoglobinuria (PNH) (共著)

T Terasawa 1, T Shichishima, M Matsuda, T Uchida, S Kariyone

British Journal of Haematology   75   428   1990

Acetylcholinesterase and lymphocyte function-associated antigen 3 found on decay-accelerating factor-negative erythrocytes from some patients with paroxysmal nocturnal hemoglobinuria are lost during erythrocyte aging (共著)

E Ueda 1, T Kinoshita, T Terasawa, T Shichishima, Y Yawata, K Inoue, T Kitani

Blood   75 ( 3 )   762   1990

Paroxysmal nocturnal haemoglobinuria with coexisting deficiency of the ninth component of complement : 1ack of massive haemolytic attack (共著)

Y Yonemura 1, M Kawakita, A Koito, T Kawaguchi, H Nakakuma, T Kagimoto, T Schichishima, T Terasawa, Y Akagaki, S Inai

British Journal of Haematology   74   108   1990

Signet Cell Carcinoma of the Stomach in a Patient with Acquired Immunodeficiency Syndrome : A Case Report

T Uchida 1, J Midorikawa, H Takeda, T Shichishima, T Higuchi, T Yui, H Kimura, S Matsuda, S Kariyone

Japanese Journal of Clinical Oncology   19   75   1989

Complement sensitivity of erythroblasts and erythropoietic precursors in paroxysmal nocturnal haemoglobinuria (PNH) (共著)

T Shichishima 1, T Terasawa, T Uchida, S Kariyone

British Journal of Haematology   72   578   1989

"""Erythropoiesis of complement-sensitive cells in a PNH patient with iron deficiency anemia during iron therapy"""

T Schichishima, M Yoshida, A Yokoyama, T Terasawa, T Uchida, S Kariyone, M Sanpei

European Journal of Haematology   42   310   1989

"""Elevated Haemoglobin F in Juvenilc and adult chronic myelogenous leukaemia"""

K Shimizu 1, H Keino, T Terasawa, T Shichishima, K Ikuta, Y Hayashi

Acta Haematologica   80   28   1988

Decay-accelcrating factor (DAF) on the blood cell membranes in patients with paroxysmal nocturnal haemglobinuria (PNH) : measurement by enzyme-linked immunosorbent assay (ELISA) (共著)

H Ninomiya 1, T Abe, T Shichishima, T Terasawa, T Fujita

British Journal of Haematology   69   81   1988

Promyelocytic crisis of chronic myelocytic leukemia : Case report and review of the literature.

Tsutomu Shichishima

Acta Heamatologica Japonica   50 ( 6 )   72   1987

"""Immunocytochemical dctection of normal and abnormal megakaryocytes using monoclonal antibody to glycoprotein IIb-Ⅲa(TP80) : The guantitative assay in normal and in leukaemic patieuts"""

Tadashi Sato M.D., Tsutomu Shichishima, Hideo Kimura, Tatsumi Uchida, Shigeo Kariyone, Hitoshi Ohto, Hiroo Maeda

Scandinavian Journal of Haematology   36   415   1986

Promyelocytic crisis of chronic myelogenous 1eukemia without t (15 ; 17) (共著)

R Abe, T Shichishima, M Kawaguchi, T Uchida, S Kariyone

Cancer Genetics and Cytogenetics   21   175   1986

Usefulness of ⁶⁷Ga scintiscan for splenic hematopoiesis in chronic myelocytic leukemia.

Tsutomu Shichishima

Japanese Archives of Internal Medicine   32 ( 1 )   7   1985

Erythroid Precursor Cells in Patients with Paroxysmal Nocturnal Hemoglobinuria

T Shichishima, T Ishibashi, H Kimura, S Matsuda, T Uchida, S Kariyone

Acta Haematological Japonica   47 ( 6 )   1242   1984

臨床の手引きと臨床データ集　血液疾患診療ハンドブック 改訂3版

吉田彌太郎（発作性夜間ヘモグロビン尿症）

医薬ジャーナル社  2015.12  （ ISBN:978-4-7532-2767-9 ）

難病事典

尾崎承一（血液　溶血性貧血：発作性夜間ヘモグロビン尿症（PNH））

学研メディカル秀潤社  2015.12  （ ISBN:978-4-7809-1167-1 ）

ブラッシュアップ骨髄不全症

松田　晃（6 発作性夜間ヘモグロビン尿症（PNH）の診断と治療：6-1　病態と診断）

中外医学社  2015.10  （ ISBN:978-4-498-12594-0 ）

今日の治療と看護 (改訂第3版）

永井良三, 大田　健（血液・造血器疾患　溶血性貧血）

南江堂  2013 

病気と薬パーフェクトブック2011

古川晶彦（発作性夜間ヘモグロビン尿症）

南山堂  2011 

病気と薬パーフェクトブック2010

古川晶彦（発作性夜間ヘモグロビン尿症）

南山堂  2010 

今日の治療指針 2009年版

山口徹，北原光夫，福井次矢（発作性夜間ヘモグロビン尿症）

医学書院  2009.1 

臨床に直結する血液疾患診療のエビデンス　ベッドサイドですぐに役立つリファレンス

神田善伸（発作性夜間ヘモグロビン尿症 (PNH) に対する治療は？）

文光堂  2009 

医学書院　医学大辞典（第2版）

伊藤正男, 井村裕夫, 高久史麿（異好抗体;ウィントローブ;寒冷凝集素;寒冷凝集反応;寒冷溶血素;後天性溶血性貧血;発作性夜間ヘモグロビン尿症;慢性寒冷凝集素症;慢性溶血性貧血;網状赤血球減少;網状赤血球算定;網状赤血球増加;夜間ヘモグロビン尿症）

医学書院  2009 

病気と薬パーフェクトBOOK 2009

横田千津子，池田宇一，大越教夫（発作性夜間ヘモグロビン尿症）

南山堂  2009 

血液疾患診療ハンドブック　ー診療の手引きと臨床データ集ー　改訂版

吉田彌太郎（発作性夜間ヘモグロビン尿症）

医薬ジャーナル社  2009 

ロス先生のPNHってどんな病気？　第2版　日本語版　患者さんのためのガイド

編集：デューク大学&ユタ大学　PNH外来チーム，日本PNH専門家会議　日本語翻訳ワーキンググループ（PNHの予後（これから自分に起こることは何？））

J-PIG(日本PNH専門家会議)  2008.4 

病気と薬パーフェクトBOOK 2008

山田勝士，櫛田賢次，大井一弥，丸山　徹，高村徳人，伊藤由紀（発作性夜間ヘモグロビン尿症）

南山堂  2008.4 

ロス先生のPNHってどんな病気？　第2版　日本語版　患者さんのためのガイド

編集：デューク大学&ユタ大学　PNH外来チーム，日本PNH専門家会議　日本語翻訳ワーキンググループ（赤血球の過剰な破壊（溶血））

J-PIG(日本PNH専門家会議)  2008.4 

ロス先生のPNHってどんな病気？　第2版　日本語版　患者さんのためのガイド

編集：デューク大学&ユタ大学　PNH外来チーム，日本PNH専門家会議　日本語翻訳ワーキンググループ（非定型部位に起こる凝血（血栓））

J-PIG(日本PNH専門家会議)  2008.4 

今日の治療指針 2008年版

山口徹，北原光夫，福井次矢（悪性貧血）

医学書院  2008.1 

今日の治療指針 2007年版

山口徹，北原光夫，福井次矢（遺伝性溶血性貧血）

医学書院  2007.1 

今日の治療指針 2006年版

山口徹，北原光夫，福井次矢（自己免疫性溶血性貧血）

医学書院  2006.1 

Proposals for classification of the clinical stages, grading of severity and the molecular pathogenesis of paroxysmal nocturnal hemoglobinuria

Paroxysmal Nocturnal Hemoglobinuria and Related Disorders. Molecular Aspects of Pathogenesis  2002 

Serial analysis of clonal expansion in PNH by flow cytometry

Paroxysmal Nocturnal Hemoglobinuria and Related Disorders. Molecular Aspects of Pathogenesis  2002 

Telomeres in myelodysplastic syndrome and its related disorders: Does telomere length reflect stem cell turnover in clonal hematopoietic disorders?

Paroxysmal Nocturnal Hemoglobinuria and Related Disorders. Molecular Aspects of Pathogenesis  2002 

The clinical course of PNH in the USA and in Japan

Paroxysmal Nocturnal Hemoglobinuria and Related Disorders. Molecular Aspects of Pathogenesis  2002 

Relationship between thrombosis and coagulation markers in patients with PNH

PNHの治療 -ソリリスの適応-

川崎・横浜PNH連携の会  

High sensitivity flow cytometry to detect small population of PNH clone in bone marrow failure syndrome in Japan

26th International Complement Workshop  

PNHの多様な臨床病態とその対策

骨髄不全/PNHを考える会 -北九州/山口　Expert Meeting-  

A clinical significance and time-dependent change of PHN clone size in patients with bone marrow failure syndrome: Japanese Mmulti-centre prospective study

21st Congress of European Hematology Association  

PNHの患者管理

四国PNH講演会  

Improvement of coagulation markers, but not hemolytic markers, in a PNH case treated with eculizumab

Analysis of the data from the 4th year post marketing surveillance (PMS) of eculizumab

Morphological and cytogenetic analyses of bone marrow hematopoietic cells in patients with PNH

The PNH-type cells assessed by a standard flow cytometry using mAbs to GPI proteins or FLAER

Clinical features and QOL evaluation of Japanese PNH patients in the International PNH Registry

OPTIMA試験：高精度フローサイトメトリー法によるGPIアンカー膜蛋白欠損血球の測定の臨床的意義 -2015年中間報告（続報）-

第52回　補体シンポジウム  

The interim study of prospective observational study with PNH-type cells in Japanese patients with bone marrow failure (The OPTIMA Study: Observation of PNH-type cells in Japanese patients with bone marrow failure syndrome and in those suspected of having PNH)

20th Congress of European Hematology Association  

PNHの治療

PNH倶楽部2015  

The interim analysis of the OPTIMA (Observation of GPI-anchored protein-deficient [PNH-type] cells in Japanese patients with bone marrow failure syndrome and in those suspected of having PNH)

6th JSH International Symposium 2015  

PNHの病態・診断・治療戦略

第2回　北関東PNH研究会  

The interim analysis of the optima observation of GPI-anchored protein-deficient (PNH-type) cells in Japanese patients with bone marrow failure syndrome and in those suspected of having PNH study

2014 American Society of Hematology (ASH) Annual Meeting and Exposition  

A study on telomere lengths of granulocytes and lymphocytes from PNH patients

Relationship between thrombosis and coagulation markers in patients with PNH

Analysis of the data for the 3rd year post marketing surveillance (PMS) of eculizumab

Baseline characteristics of Japanese cohort in the international PNH registry

Improvement of coagulation markers, but not hemolytic markers, in a PNH case treated with eculizumab

Factors which might affect improvement of anemia by eculizumab in PNH patients

OPTIMA試験：高精度フローサイトメトリー法によるGPIアンカー膜蛋白欠損血球の測定法の臨床的意義 -中間報告-

第51回　補体シンポジウム  

PNH：診断と治療

第5回　東海PNH研究会　補体関連疾患セミナー  

Interim report of the optima observation of GPI-anchored protein deficient (PNH-type) cells in Japanese patients with bone marrow failure syndrome and in those suspected of having PNH study

The 19th Congress of European Hematology Association  

PNHの臨床：最近の話題

第5回　南関東PNH研究会　学術講演会  

A rare genetic polymorphism in C5 confers poor response to the anti-C5 monoclonal antibody eculizumab in 11 Japanese patients with PNH

2013 American Society of Hematology (ASH) Annual Meeting and Exposition  

Management of pregnancy in paroxysmal nocturnal hemoglobinuria (PNH): a report of 10 cases from the working group on pregnancy of the Japan PNH study group

2013 American Society of Hematology (ASH) Annual Meeting and Exposition  

Baseline assessment of GPI-anchored protein deficient blood cells in patients with bone marrow failure (The OPTIMA study)

2013 American Society of Hematology (ASH) Annual Meeting and Exposition  

発作性夜間ヘモグロビン尿症（PNH）の病態と最新治療

再生つばさの会・仙台医療講演会  

Management of pregnancy in paroxysmal nocturnal hemoglobinuria (PNH): A review of 10 cases

Inherent resistance to eculizumab in PNH

A study on IgG and C3 bound to erythrocytes in paroxysmal nocturnal hemoglobinuria (PNH) patients

The OPTIMA update: Baseline assessment of PNH-type cells in patients with bone marrow failure

Acquired von Willebrand disease (vWD) in a patient with paroxysmal nocturnal hemoglobinuria (PNH)

Efficacy of eculizumab for thrombosis resistant to anticoagulant therapy alone in a case of PNH

A study on telomere lengths of granulocytes and lymphocytes from PNH patients

Impaired stabilization of FOS mRNA in myelodysplastic syndrome-derived neutrophils

Myelodysplastic syndromes with del(13) in a patient with paroxysmal nocturnal hemoglobinuria (PNH)

PNHの病態と治療

和歌山血液疾患面白セミナー  

エクリズマブ治療の実際と問題点

和歌山PNHセミナー  

OPTIMA試験：高精度フローサイトメトリー法によるGPI アンカー膜蛋白欠損血球の検出

第50回　補体シンポジウム  

PNHの多様な臨床像とその治療戦略

宮城PNH学術講演会  

Impairment of FOS mRNA stabilization following translation arrest in granulocytes from myelodysplastic syndrome patients

Impairment of HuR-mediated FOS mRNA stabilization in granulocytes from myelodysplastic syndrome patients

2012 American Society of Hematology (ASH) Annual Meeting and Exposition  

PNHの治療戦略とエクリズマブ

NPO法人　PNH倶楽部設立1周年記念　医療講演会  

Impaired FOS mRNA stabilization via AU-rich element-binding Protein HuR in granulocytes from myelodysplastic syndrome patients

Mechanism of impaired FOS mRNA induction by emetine in myelodysplastic syndrome granulocytes

第74回 日本血液学会学術集会  

Del(13q) myelodysplastic syndromes in a patient with paroxysmal nocturnal hemoglobinuria (PNH)

第74回 日本血液学会学術集会  

Morphologic and cytogenetic examinations with bone marrow cells in PNH patients

第74回 日本血液学会学術集会  

Detection of PNH-type cells using high-resolution flow cytometry: Interim analysis of OPTIMA study

第74回 日本血液学会学術集会  

A preliminary study on telomere length of granulocytes and mononuclear cells in PNH patients

第74回 日本血液学会学術集会  

Erythema annulare centrifugum in a patient with paroxysmal nocturnal hemoglobinuria

第74回 日本血液学会学術集会  

Paroxysmal nocturnal hemoglobinuria in a patient with del(5q)(q23q32) myelodysplastic syndromes

第74回 日本血液学会学術集会  

最新のPNH治療

山形PNH講演会  

鉄キレート療法が有効であった再生不良性貧血の2症例

第197回　日本内科学会東北地方会  

PNH治療の最新治験

秋田PNH講演会  

OPTIMA試験：高精度フローサイトメトリー法によるGPIアンカー膜蛋白欠損血球の検出

第49回　補体シンポジウム  

Paroxysmal nocturnal hemoglobinuria (PNH)症例におけるEculizumab治療の赤血球結合IgGおよびC3に対する影響

第4回　造血器腫瘍免疫療法研究会  

イマチニブ切替によるニロチニブ使用経験

南東北CMLセミナー  

デフェラシロクスを用いた鉄キレート療法が有効であった再生不良性貧血の2症例

第59回　福島血液研究会  

OPTIMA試験：高精度フローサイトメトリー法によるGPIアンカー型蛋白欠損血球の検出

第22回　サイトメトリー学会  

T-PIG研究の中間報告

第3回　東北PNH研究会  

PNH患者におけるエクリズマブ投与の実際　-自験例からの知見-

北海道PNH講演会  

PNHの多様性と治療戦略

NPO法人PNH倶楽部　設立報告会・記念講演会  

溶血を伴う骨髄不全型PNHに対するアプローチ：骨髄不全型PNHの自験例

第2回　北陸PNH研究会  

Safety and feasibility of MEAM therapy followed by auto-HSCT for malignant lymphoma

Efficacy of Eculizumab for nontransfused Japanese patients with PNH: case report from AEGIS study

PNH-type cells by flow cytometric methods with a monoclonal antibody and FLAER in BMFS patients

Long-term efficacy of Eculizumab in Japanese patients with PNH: AEGIS Trial

補体研究：基礎から臨床へ：発作性夜間血色素尿症をはじめとするGPI欠損症について

第48回　補体シンポジウム  

Paroxysmal nocturnal hemoglobinuria (PNH) 8症例におけるEculizumabの効果および安全性

第3回　造血器腫瘍免疫療法研究会学術集会  

種々のPNH症例とその治療経験

Japan PNH Masters Program  

寛解中に濾胞性リンパ腫を発症した急性骨髄性白血病（Ｍ２）の症例

第193回　日本内科学会東北地方会  

Expression of HMGA2 in blood cells from patients with paroxysmal nocturnal hemoglobinuria

52nd American Society of Hematology (ASH) Annual Meeting and Exposition  

心不全徴候で再発したDLBCLの1例

第26回　悪性リンパ腫（M.L.）研究会  

急性骨髄性白血病の完全寛解中に濾胞性リンパ腫を発症した1症例

第26回　悪性リンパ腫（M.L.）研究会  

PNH診断と治療について（パネルディスカッション）

日本PNH研究会・関西キックオフミーティング  

Safety, feasibility and efficacy of MCVC therapy followed by auto-PBSCT for malignant lymphoma

A PNH patient complained of MDS and developed AML

Effect of long term eculizumab treatment on chronic kidney disease in Japanese patients with PNH

Clinical and biological features of T-cell prolymphocytic leukemia in Japan

Analysis of autologous PBSCT in four patients with cardiac amyloidosis

Two paroxysmal nocturnal hemoglobinuria patients reached hematological and clonal remission

Appearance of CD59-negative leukemic cells in patients with acute myeloid leukemia

Studies on GPI-anchor expressions by flow cytometry using FLAER in patients with acquired BMFS

Impaired c-fos induction by emetin in granulocytes from myelodysplastic syndrome patients

PNHにおける補体溶血と関連した病態

第47回　補体シンポジウム  

発作性夜間ヘモグロビン尿症4症例におけるヒト化モノクローナル抗C5抗体 (Eculizumab) の効果および安全性の検討

第47回　補体シンポジウム  

PNHと生きる

ソリリス^Ⓡ発売記念講演会  

発作性夜間ヘモグロビン尿症（PNH）4症例におけるEculizumabの効果および安全性

第2回　造血器腫瘍免疫療法研究会学術集会  

Wnt pathway is upregulated in blood cells from patients with paroxysmal nocturnal hemoglobinuria

51st Annual Meeting of the American Society of Hematology  

Chronic renal insufficiency in Japanese patients with paroxysmal nocturnal hemoglobinuria (PNH): improvement with eculizumab treatment in the long-term follow-up of the AEGIS study

51st Annual Meeting of the American Society of Hematology  

Effectiveness of iron chelation therapy with deferasirox for two bone marrow failure syndromes cases

Incidences of malignant lymphoma with hepatitis B or C virus in Tohoku district

A morphologic study of bone marrow blood cells in paroxysmal nocturnal hemoglobinuria patients

Clinico-pathological analysis for primary CNS lymphoma treated with HD-MTX (THF PCNSL study)

Autologous peripheral blood stem cell transplantation for AL amyloidosis

Effects of nonsense-mediated mRNA decay on gene expression in myelodysplastic syndromes

Expression of HMGA2 in blood cells from patients with paroxysmal nocturnal hemoglobinuria

免疫抑制療法後、長期観察により完全寛解に至った骨髄不全型発作性夜間血色素尿症（PNH）の一例

第1回　造血器腫瘍免疫療法研究会  

本邦PNH症例における補体阻害剤 (Eculizumab) の安全性と有効性：AEGIS第2相臨床試験

第46回　補体シンポジウム  

後天性骨髄不全症候群の病態と治療 -AA・PNHを中心に-

第56回　福島血液研究会  

後天性骨髄不全症候群症例における血清ハプトグロビン (Hpl) 値の診断的意義の検討

第106回　日本内科学会講演会  

骨髄不全症候群症例における血清ハプトグロビン濃度の検討

第16回　造血器腫瘍研究会  

巨大平滑筋腫に発生したびまん性大細胞性B細胞性リンパ腫 (DLBCL) の1例

第187回　日本内科学会東北地方会  

発作性夜間血色素尿症患者におけるHMGA2の発現について

厚生労働科学研究費補助金　難治性疾患克服研究事業　「特発性造血障害に関する調査研究」および「重点研究:骨髄異形成症候群に対する病態解明・治療法の開発に関する研究」平成20年度　第2回合同班会議総会  

本邦PNH患者におけるヒト化抗マウスC5抗体（Eculizumab）の有効性ならびに安全性評価試験：AEGIS第2相臨床試験

厚生労働科学研究費補助金　難治性疾患克服研究事業　「特発性造血障害に関する調査研究」および「重点研究:骨髄異形成症候群に対する病態解明・治療法の開発に関する研究」平成20年度　第2回合同班会議総会  

Safety and efficacy of the terminal complement inhibitor eculizumab in Japanese patients with Paroxysmal nocturnal hemoglobinuria: AEGIS phase II clinical study results

50th Annual Meeting of the American Society of Hematology  

Expression of HMGA2 in Blood Cells from Patients with Paroxysmal Nocturnal Hemoglobinuria

50th Annual Meeting of the American Society of Hematology  

巨大平滑筋腫に発生したび慢性大細胞性B細胞性リンパ腫の1例

第24回　悪性リンパ腫（M.L.）研究会  

骨髄異形成症候群患者の好中球分化に伴う遺伝子発現調節異常の解析 Defective gene expression during myeloid differentiation in patients with myelodysplastic syndromes

Application of new classification of PNH subcategory to Japanese patients with PNH

Factors determining cyclosporine dependence agter immunosuppressive therapy for alastic anemia

Chronic myeloid leukemia developing concurrently in a patient with follicular lymphoma

Brain thrombosis in a patient with PNH without GPI-negative erythrocytes

腹部腫瘤で発症し、組織学的な確定診断が困難であった悪性リンパ腫の1例

第7回　福島・新潟・山形血液スライドカンファランス  

腹部腫瘤で発症し、組織学的な確定診断が困難であった悪性リンパ腫の1例

第7回　福島・新潟・山形　血液スライドカンファレンス  

特発性血小板減少性紫斑病と間違われたMay-Hegglin異常の一例

第46回　東北止血・血栓研究会  

臨床経過中にびまん性大細胞型B細胞リンパ腫を発症した寒冷凝集素症症例

第106回　日本血液学会東北地方会  

凝固異常・消化器症状を呈したsystemic mastocytosis

第24回　血小板・血栓研究会  

ICD植え込み後、自己末梢血幹細胞移植を施行した心アミロイドーシスの一例

第21回　東北BMT研究会  

臨床経過中にびまん性大細胞型B細胞リンパ腫を発症した寒冷凝集素症の1例

第55回　福島血液研究会  

GPIアンカー膜蛋白欠損赤血球を認めない時期に脳血管の血栓症を合併した発作性夜間ヘモグロビン尿症 (PNH) 症例

第185回　日本内科学会東北地方会  

臨床経過中に慢性骨髄性白血病（CML）を併発した濾胞性リンパ腫症例

第15回　造血器腫瘍研究会  

ICD植え込み後、自己末梢血幹細胞移植を施行した心アミロイドーシスの一例

第30回　日本造血細胞移植学会総会  

凝固異常・消化器症状を呈したsystemic mastocytosis

凝第184回　日本内科学会東北地方会  

Changes of clonality of paroxysmal nocturnal hemoglobinuria (PNH) clones during clinical courses in patients with PNH

49th Annual Meeting of the American Society of Hematology  

The roles of Wilms' tumor gene peptide-specific cytotoxic T lymphocytes in immunologic pathophysiology of paroxysmal nocturnal hemoglobinuria

49th Annual Meeting of the American Society of Hematology  

PNHの病態と治療

再生つばさの会　仙台医療講演会・相談会  

凝固異常、消化器症状を呈したsystemic mastocytosis

第23回　悪性リンパ腫（M.L.)研究会  

Studies on serum haptoglobin level in patients with bone marrow failure syndromes (BMFS)

The role of WT1 peptide-specific CTLs in selection of a PNH clone and bone marrow failure

Clinical features of mature T-cell lymphoma

Changes of clonality of PNH clones during clinical courese in patients with PNH

Abnormalities of natural and adaptive regulatory T cells in bone Marrow failure syndromes patients

GPIアンカー膜蛋白欠損赤血球を認めない時期に脳動脈血栓症を認めた発作性夜間血色素尿症 (PNH) の一症例

第23回　血小板・血栓研究会  

骨髄不全 (BMF) 症候群症例における発作性夜間血色素尿症 (PNH) クローンのクローナリティーに関する研究

第104回　日本内科学会総会・講演会  

メシル酸イマチニブが奏功した4つの染色体に関連した複雑な染色体異常を有した慢性骨髄性白血病 (CML) 症例の1例

第14回　造血器腫瘍研究会  

骨髄不全 (MDS/PNH) の診断と治療

若手臨床血液学セミナー  

発作性夜間へもグロビン尿症（PNH）クローンの選択におけるWilms' Tumor gene (WT1) ペプチド特異的細胞傷害性Tリンパ球 (CTL) の意義

第48回　日本臨床血液学会、第103回　日本血液学会　合同地方会  

骨髄不全症候群の各種血液細胞におけるGPIアンカー膜蛋白質の発現割合とハプトグロビン濃度との関連性

第1回　THF研究会  

約1年にわたり好中球減少のみを呈した骨髄異形成症候群 (MDS) 症例

第181回　日本内科学会東北地方会