Anaphylatoxin concentration in aqueous and vitreous humor in the eyes with vitreoretinal interface abnormalities

Oguchi Y, Sekiryu T, Omori T, Kato Y, Ogasawara M, Sugano Y, Itagaki K, Ojima A, Machida T, Sekine H

Exp Eye Res   195   2020年6月

Evidence for activation of lectin and classical pathway complement components in aqueous humor of neovascular age-related macular degeneration

Tomoko Omori, Yasuharu Oguchi, Takeshi Machida, Yutaka Kato, Yumi Ishida, Akira Ojima, Kanako Itagaki, Hiroaki Shintake, Ryutaro Tomita, Akihito Kasai, Yukinori Sugano, Masashi Ogasawara, Hideharu Sekine, and Tetsuju Sekiryu

Ophthalmic Research   63 ( 3 )   252 - 258   2020年5月

A novel complement inhibitor sMAP-FH targeting both the lectin and alternative complement pathways

Takasumi M, Omori T, Machida T, Ishida Y, Hayashi M, Suzuki T, Homma Y, Endo Y, Takahashi M, Ohira H, Fujita T, Sekine H

The FASEB Journal   34 ( 5 )   6598 - 6612   2020年3月

感染症と補体・凝固線溶系

関根英治

Thrombosis Medicine   10   274 - 280   2020年

Post-Traumatic Growth and Resilience Among Medical Students After the March 2011 Disaster in Fukushima, Japan.

Kaye-Kauderer HP, Levine J, Takeguchi Y, Machida M, Sekine H, Taku K, Yanagisawa R, Katz C

The Psychiatric quarterly   90 ( 3 )   507 - 518   2019年9月（ ISSN:0033-2720 ）

Complement activation by autoantigen recognition in the growth process of benign prostatic hyperplasia

Junya Hata, Takeshi Machida, Kanako Matsuoka, Seiji Hoshi, Hidenori Akaihata, Hiroyuki Hiraki, Toshiyuki Suzuki, Soichiro Ogawa, Masao Kataoka, Nobuhiro Haga, Kei Ishibashi, Yoshimi Homma, Hideharu Sekine, Yoshiyuki Kojima

Scientific Reports   9   20357   2019年

Cutting Edge: Role of MASP-3 in the Physiological Activation of Factor D of the Alternative Complement Pathway

Manabu Hayashi, Takeshi Machida, Yumi Ishida, Yusuke Ogata, Tomoko Omori, Mika Takasumi, Yuichi Endo, Toshiyuki Suzuki, Masayuki Sekimata, Yoshimi Homma, Masahito Ikawa, Hiromasa Ohira, Teizo Fujita, and Hideharu Sekine

The Journal of Immunology   203 ( 6 )   1411 - 1416   2019年（ ISSN:0022-1767 ）

Response to Comment on “Cutting Edge: Role of MASP-3 in the Physiological Activation of Factor D of the Alternative Complement Pathway”

Takeshi Machida, Manabu Hayashi, Teizo Fujita, and Hideharu Sekine

The Journal of Immunology   203 ( 12 )   3091 - 3092   2019年

Tofacitinib inhibits granulocyte-macrophage colony-stimulating factor-induced NLRP3 inflammasome activation in human neutrophils.

Furuya MY, Asano T, Sumichika Y, Sato S, Kobayashi H, Watanabe H, Suzuki E, Kozuru H, Yatsuhashi H, Koga T, Ohira H, Sekine H, Kawakami A, Migita K

Arthritis research & therapy   20 ( 1 )   196   2018年8月（ ISSN:1478-6354 ）

Medical Student Reactions to Disaster after the 2011 Great East Japan Earthquake: Motivation and Posttraumatic Growth.

Taku K, Prioleau PG, Anderson DS, Takeguchi Y, Sekine H, Maeda M, Yabe H, Yanagisawa RT, Katz CL

The Psychiatric quarterly   2018年8月（ ISSN:0033-2720 ）

Essential Roles for Mannose-Binding Lectin-Associated Serine Protease-1/3 in the Development of Lupus-Like Glomerulonephritis in MRL/lpr Mice

Machida T, Sakamoto N, Ishida Y, Takahashi M, Fujita T, Sekine H

Frontiers in Immunology   9   1191   2018年5月

「補体」シリーズ<第6回>　補体と全身性エリテマトーデス(SLE)

関根 英治

Schneller   ( 106 )   13 - 17   2018年4月

Fukushima Triple Disaster and the Road to Recovery: a Qualitative Exploration of Resilience in Internally Displaced Residents.

Mann CL, Gillezeau CN, Massazza A, Lyons DJ, Tanaka K, Yonekura K, Sekine H, Yanagisawa R, Katz CL

The Psychiatric quarterly   89 ( 2 )   383 - 397   2018年1月（ ISSN:0033-2720 ）

全身性エリテマトーデスの病態理解の進歩　SLEにおける補体活性化経路の役割

関根 英治, 大森 智子, 坂本 夏美, 町田 豪

福島医学雑誌   67 ( 3 )   113 - 122   2017年12月（ ISSN:0016-2582 ）

Deconstructing the Lectin Pathway in the Pathogenesis of Experimental Inflammatory Arthritis: Essential Role of the Lectin Ficolin B and Mannose-Binding Protein-Associated Serine Protease 2.

Banda NK, Acharya S, Scheinman RI, Mehta G, Takahashi M, Endo Y, Zhou W, Farrar CA, Sacks SH, Fujita T, Sekine H, Holers VM

Journal of immunology (Baltimore, Md. : 1950)   199 ( 5 )   1835 - 1845   2017年9月（ ISSN:0022-1767 ）

Evaluation of blood-brain barrier function by quotient alpha2macroglobulin and its relationship with interleukin-6 and complement component 3 levels in neuropsychiatric systemic lupus erythematosus

Tomoyuki Asano, Hiromi Ito, Yoshinobu Kariya, Kyoka Hoshi, Akioh Yoshihara, Yoshikazu Ugawa, Hideharu Sekine, Shunsei Hirohata, Yoshiki Yamaguchi, Shuzo Sato, Hiroko Kobayashi, Kiyoshi Migita, Hiromasa Ohira, Yasuhiro Hashimoto, Hiroshi Watanabe

PlosOne   12 ( 10 )   e0186414   2017年

Autoimmune disease mouse model exhibits pulmonary arterial hypertension.

Sugimoto K, Nakazato K, Sato A, Suzuki S, Yoshihisa A, Machida T, Saitoh SI, Sekine H, Takeishi Y

PloS one   12 ( 9 )   e0184990   2017年

Evaluation of blood-brain barrier function by quotient alpha2 macroglobulin and its relationship with interleukin-6 and complement component 3 levels in neuropsychiatric systemic lupus erythematosus.

Asano T, Ito H, Kariya Y, Hoshi K, Yoshihara A, Ugawa Y, Sekine H, Hirohata S, Yamaguchi Y, Sato S, Kobayashi H, Migita K, Ohira H, Hashimoto Y, Watanabe H

PloS one   12 ( 10 )   e0186414   2017年

Mannan-Binding Lectin-Associated Serine Protease 1/3 Cleavage of Pro-Factor D into Factor D In Vivo and Attenuation of Collagen Antibody-Induced Arthritis through Their Targeted Inhibition by RNA Interference-Mediated Gene Silencing.

Banda NK, Acharya S, Scheinman RI, Mehta G, Coulombe M, Takahashi M, Sekine H, Thiel S, Fujita T, Holers VM

Journal of immunology (Baltimore, Md. : 1950)   197 ( 9 )   3680 - 3694   2016年11月（ ISSN:0022-1767 ）

Granular C3 dermatosis

Hashimoto T., Tsuruta D., Yasukochi A., Imanishi H., Sekine H., Fujita T., Wanibuchi H., Gi M., Kárpáti S., Sitaru C., Zone J., Endo D., Abe S., Nishino T., Koji T., Ishii N.

Acta Dermato-Venereologica   96 ( 6 )   748 - 753   2016年9月（ ISSN:00015555 ）

【補体関連疾患の新局面】 膠原病への補体の関与と抗補体療法の可能性

関根 英治

医学のあゆみ   257 ( 8 )   854 - 860   2016年5月（ ISSN:0039-2359 ）

Post-traumatic stress and growth among medical student volunteers after the March 2011 disaster in Fukushima, Japan: Implications for student involvement with future disasters

David Anderson, Phoebe Prioleau, Kanako Taku, Yu Naruse, Hideharu Sekine, Masaharu Maeda, Hirooki Yabe, Craig Katz, Robert Yanagisawa

Psychia Quart   87 ( 2 )   241 - 251   2016年

補体異常値を示す疾患とそのメカニズム

関根英治、大森智子、町田豪

補体   52 ( 2 )   14 - 26   2015年12月

補体異常値を示す疾患とそのメカニズム

関根 英治, 大森 智子, 町田 豪

補体   52 ( 2 )   14 - 26   2015年12月（ ISSN:2188-8205 ）

補体異常値を示す疾患とそのメカニズム

関根英治、大森智子、町田豪

補体   52 ( 2 )   14 - 26   2015年12月

補体異常値を示す疾患とそのメカニズム

関根英治、大森智子、町田豪

補体   52 ( 2 )   14 - 26   2015年

遺伝性血管性浮腫(HAE)ガイドライン　改訂2014年版

堀内 孝彦, 大澤 勲, 岡田 秀親, 塚本 浩, 中尾 実樹, 木下 タロウ, 高橋 実, 野中 勝, 松下 操, 関根 英治, 山本 哲郎, 若宮 伸隆, 藤田 禎三, 瀬谷 司, 井上 徳光, 大井 洋之, 一般社団法人日本補体学会HAEガイドライン作成委員会

補体   51 ( 2 )   24 - 30   2014年12月（ ISSN:2188-8205 ）

Lessons learned from mice deficient in lectin complement pathway molecules.

Genster N, Takahashi M, Sekine H, Endo Y, Garred P, Fujita T

Molecular immunology   61 ( 2 )   59 - 68   2014年10月（ ISSN:0161-5890 ）

Comment on "the pro-factor D cleaving activity of MASP-1/-3 is not required for alternative pathway function".

Takahashi M, Sekine H, Fujita T

Journal of immunology (Baltimore, Md. : 1950)   192 ( 12 )   5448 - 9   2014年6月（ ISSN:0022-1767 ）

Comment on "the pro-factor D cleaving activity of MASP-1/-3 is not required for alternative pathway function"

Takahashi M., Sekine H., Fujita T.

Journal of Immunology   192 ( 12 )   5448 - 5449   2014年6月（ ISSN:00221767 ）

Comment on "the pro-factor D cleaving activity of MASP-1/-3 is not required for alternative pathway function".

Minoru Takahashi, Hideharu Sekine, Teizo Fujita

J Immunol   192 ( 12 )   5448 - 5449   2014年

Lessons learned from mice deficient in lectin complement pathway molecules.

Ninette Genster, Minoru Takahashi, Hideharu Sekine, Yuichi Endo, Peter Garred, Teizo Fujita

Mol Immunol   61 ( 2 )   59 - 68   2014年

Comment on "the pro-factor D cleaving activity of MASP-1/-3 is not required for alternative pathway function".

Minoru Takahashi, Hideharu Sekine, Teizo Fujita

J Immunol   192 ( 12 )   5448 - 5449   2014年

Comment on "the pro-factor D cleaving activity of MASP-1/-3 is not required for alternative pathway function".

Minoru Takahashi, Hideharu Sekine, Teizo Fujita

J Immunol   192 ( 12 )   5448 - 5449   2014年

Lessons learned from mice deficient in lectin complement pathway molecules.

Ninette Genster, Minoru Takahashi, Hideharu Sekine, Yuichi Endo, Peter Garred, Teizo Fujita

Mol Immunol   61 ( 2 )   59 - 68   2014年

Lessons learned from mice deficient in lectin complement pathway molecules.

Ninette Genster, Minoru Takahashi, Hideharu Sekine, Yuichi Endo, Peter Garred, Teizo Fujita

Mol Immunol   61 ( 2 )   59 - 68   2014年

Comment on "the pro-factor D cleaving activity of MASP-1/-3 is not required for alternative pathway function".

Minoru Takahashi, Hideharu Sekine, Teizo Fujita

J Immunol   192 ( 12 )   5448 - 5449   2014年

Lessons learned from mice deficient in lectin complement pathway molecules.

Ninette Genster, Minoru Takahashi, Hideharu Sekine, Yuichi Endo, Peter Garred, Teizo Fujita

Mol Immunol   61 ( 2 )   59 - 68   2014年

Comment on "Mannan-binding lectin-associated serine protease (MASP)-1 is crucial for lectin pathway activation in human serum, whereas neither MASP-1 nor MASP-3 is required for alternative pathway function".

Minoru Takahashi, Hideharu Sekine, Yuichi Endo, Teizo Fujita

J Immunol   190   2477   2013年6月

補体の異常値と疾患

関根 英治, 町田 豪, 坂本 夏美, 高橋 実

福島医学雑誌   63 ( 2 )   93 - 107   2013年6月（ ISSN:0016-2582 ）

Role of complement in a murine model of peanut-induced anaphylaxis.

Kodama T, Sekine H, Takahashi M, Iwaki D, Machida T, Kanno K, Ishida Y, Endo Y, Fujita T

Immunobiology   218 ( 6 )   844 - 50   2013年6月（ ISSN:0171-2985 ）

Comment on "Mannan-binding lectin-associated serine protease (MASP)-1 is crucial for lectin pathway activation in human serum, whereas neither MASP-1 nor MASP-3 is required for alternative pathway function".

Minoru Takahashi, Hideharu Sekine, Yuichi Endo, Teizo Fujita

J Immunol   190   2477   2013年6月

The role of MASP-1/3 in complement activation

Sekine H, Takahashi M, Iwaki D, Fujita T

Adv Exp Med Biol   735   41 - 53   2013年

補体の異常値と疾患

関根英治、町田豪、坂本夏美、高橋実

福島医学雑誌   63 ( 2 )   93 - 107   2013年

補体の異常値と疾患

関根英治、町田豪、坂本夏美、高橋実

福島医学雑誌   63 ( 2 )   93 - 107   2013年

Comment on "Mannan-binding lectin-associated serine protease (MASP)-1 is crucial for lectin pathway activation in human serum, whereas neither MASP-1 nor MASP-3 is required for alternative pathway function".

Minoru Takahashi, Hideharu Sekine, Yuichi Endo, Teizo Fujita

J Immunol   190   2477   2013年

Comment on "Mannan-binding lectin-associated serine protease (MASP)-1 is crucial for lectin pathway activation in human serum, whereas neither MASP-1 nor MASP-3 is required for alternative pathway function".

Minoru Takahashi, Hideharu Sekine, Yuichi Endo, Teizo Fujita

J Immunol   190   2477   2013年

The role of MASP-1/3 in complement activation.

Sekine H, Takahashi M, Iwaki D, Fujita T

Advances in experimental medicine and biology   735   41 - 53   2013年（ ISSN:0065-2598 ）

補体の異常値と疾患

関根英治、町田豪、坂本夏美、高橋実

福島医学雑誌   63 ( 2 )   93 - 107   2013年

The dual role of complement in the progression of renal disease in NZB/W F1 mice and alternative pathway inhibition

Sekine H, Ruiz P, Gilkeson GS, Tomlinson S

Mol Immunol   49   317 - 323   2011年10月

The benefit of targeted and selective inhibition of the alternative complement pathway for modulating autoimmunity and renal disease in MRL/lpr mice

Sekine H, Kinser TT, Qiao F, Martinez E, Paulling E, Ruiz P, Gilkeson GS, Tomlinson S

Arthritis Rheum   63   1076 - 1085   2011年4月

Comment on "Reassessment of the role of mut S homolog 5 in Ig class switch recombination shows lack of involvement in cis- and trans-switching"

Sekine H, Ferreira RC, Pan-Hammarstr&#246;m Q, Hammarstr&#246;m L, Gilkeson GS, Behrens TW

J Immunol   182   4495 - 4496   2009年4月

Role for Msh5 in the regulation of Ig class switch recombination

Sekine H, Ferreira RC, Pan-Hammarstrom Q, Graham RR, Ziemba B, de Vries SS, Liu J, Hippen K, Koeuth T, Ortmann W, Iwahori A, Elliott MK, Offer S, Skon C, Du L, Novitzke J, Lee AT, Zhao N, Tompkins JD, Altshuler D, Gregersen PK, Cunningham-Rundles C, Harris RS, Her C, Nelson DL, Hammarstrom L, Gilkeson GS, Behrens TW

Proc Natl Acad Sci USA   104   7193 - 7198   2007年4月

Role of MHC-linked genes in autoantigen selection and renal disease in a murine model of systemic lupus erythematosus

Sekine H, Graham KL, Zhao S, Elliott MK, Ruiz P, Utz PJ, Gilkeson GS

J Immunol   177   7423 - 7434   2006年11月

Enrichment of Anti-Glomerular Antigen Antibody-Producing Cells in the Kidneys of MRL/MpJ-Faslpr Mice

Sekine H, Watanabe H, Gilkeson GS

J Immunol   172   3913 - 3921   2004年3月

An ancient lectin-dependent complement system in an ascidian: novel lectin isolated from the plasma of the solitary ascidian, Halocynthia roretzi

Sekine H, Kenjo A, Azumi K, Ohi G, Takahashi M, Kasukawa R, Ichikawa N, Nakata M, Mizuochi T, Matsushita M, Endo Y, Fujita T

J Immunol   167   4504 - 4510   2001年10月

Complement component C3 is not required for full expression of immune complex glomerulonephritis in MRL/lpr mice

Sekine H, Reilly CM, Molano ID, Garnier G, Circolo A, Ruiz P, Holers VM, Boackle SA, Gilkeson GS

J Immunol   166   6444 - 6451   2001年5月

補体レクチン経路と第二経路を標的としたMAp44-fHの開発

研究連携セミナーポスター発表会2017  

Significant role for splenic marginal zone B cells in anti-dsDNA autoantibody production in lupus-prone mice with an MRL background

第46回日本免疫学会学術集会  

トワイライトセミナー：補体の基礎

第47回日本腎臟学会東部学術大会  

トワイライトセミナー：補体の基礎

第47回日本腎臟学会東部学術大会  

補体レクチン経路と第二経路を標的とする新規抗補体薬sMAP-fHの開発

第54回日本補体学会学術集会  

CRISPR/Cas9システムによるスプライシングバリアントの機能解析

研究連携セミナーポスター発表会2016  

Essential role of mannose-binding lectin-associated serine proteases-1/3 (MASP-1/3) in the development of lupus-like glomerulonephritis in MRL/lpr mice

XXVIth International Complement Workshop  

IFN-γ-receptor is required for intrafollicular localization of marginal zone B cells in the spleens of lupus-prone MRL+/+ mice

16th International Congress of Immunology  

補体制御因子sMAPとH因子を応用した新規抗補体薬の開発

平成28年サマーポスターセッション  

炎症性疾患に自然免疫はどう関与するのか〜補体の役割を中心に〜

第23回日本集中治療医学会東北地方会  

炎症性疾患に自然免疫はどう関与するのか〜補体の役割を中心に〜

第23回日本集中治療医学会東北地方会  

IFN-γ-receptorはMRL+/+マウスの脾臓における自己反応性辺縁帯B細胞の濾胞内局在を促進する

Rheumatology Conference 2016  

Upregulation of C3 and alpha-2-Macroglobulin in cerebrospinal fluid of neuropsychiatric systemic lupus erythematosus

18th Annual Meeting of American College of Rheumatology  

Upregulation of C3 and alpha-2-Macroglobulin in cerebrospinal fluid of neuropsychiatric systemic lupus erythematosus

18th Annual Meeting of American College of Rheumatology  

Altered localization of CD19+ B cells in the splenic germinal centers of IFN-γ-receptor-1 deficient lupus-prone MRL+/+ mice

11th International Congress on Systemic Lupus Erythematosus  

Altered localization of CD19+ B cells in the splenic germinal centers of IFN-γ-receptor-1 deficient lupus-prone MRL+/+ mice

11th International Congress on Systemic Lupus Erythematosus  

マウス型リコンビナントタンパクrmMAp44-PA, rmMAp44-Igの作成と補体レクチン経路の阻害作用

第52回日本補体学会学術集会  

マウス型リコンビナントタンパクrmMAp44-PA, rmMAp44-Igの作成と補体レクチン経路の阻害作用

第52回日本補体学会学術集会  

マウス型リコンビナントタンパクrmMAp44-PA, rmMAp44-Igの作成と補体レクチン経路の阻害作用

第52回日本補体学会学術集会  

Altered localization of CD19+ B cells in the splenic germinal centers of IFN-γ-receptor-1 deficient lupus-prone MRL+/+ mice

11th International Congress on Systemic Lupus Erythematosus  

Altered localization of CD19+ B cells in the splenic germinal centers of IFN-γ-receptor-1 deficient lupus-prone MRL+/+ mice

11th International Congress on Systemic Lupus Erythematosus  

Altered localization of CD19+ B cells in the splenic germinal centers of IFN-γ-receptor-1 deficient lupus-prone MRL+/+ mice

11th International Congress on Systemic Lupus Erythematosus  

Autoantibody-secreting marginal zone B cells develop significantly in lupus-prone MRL/lpr mice but not associated with expression of IFN-γ-receptor-1 on their surfaces

第43回日本免疫学会学術集会  

A dual role for IFN-γ in development of peripheral B cells in lupus-prone MRL/lpr mice

2014-Annual Scientific Meeting of the American College of Rheumatology  

A dual role for IFN-γ in development of peripheral B cells in lupus-prone MRL/lpr mice

2014-Annual Scientific Meeting of the American College of Rheumatology  

腹膜炎ー敗血症モデルにおける補体因子MASP-1/3の役割

第51回補体シンポジウム  

腹膜炎ー敗血症モデルにおける補体因子MASP-1/3の役割

第51回補体シンポジウム  

Role of MASP-1/3 in activation of the alternative complement pathway and development of renal disease in a murine model of systemic lupus erythematosus

9th International Congress of Autoimmunity  

Role of MASP-1/3 in activation of the alternative complement pathway and development of renal disease in a murine model of systemic lupus erythematosus

9th International Congress of Autoimmunity  

腹膜炎ー敗血症モデルにおける補体因子MASP-1/3の役割

第51回補体シンポジウム  

Autoantibody-secreting marginal zone B cells develop significantly in lupus-prone MRL/lpr mice but not associated with expression of IFN-γ-receptor-1 on their surfaces

Autoantibody-secreting marginal zone B cells develop significantly in lupus-prone MRL/lpr mice but not associated with expression of IFN-γ-receptor-1 on their surfaces  

Autoantibody-secreting marginal zone B cells develop significantly in lupus-prone MRL/lpr mice but not associated with expression of IFN-γ-receptor-1 on their surfaces

第43回日本免疫学会学術集会  

A dual role for IFN-γ in development of peripheral B cells in lupus-prone MRL/lpr mice

2014-Annual Scientific Meeting of the American College of Rheumatology  

A dual role for IFN-γ in development of peripheral B cells in lupus-prone MRL/lpr mice

2014-Annual Scientific Meeting of the American College of Rheumatology  

Role of MASP-1/3 in activation of the alternative complement pathway and development of renal disease in a murine model of systemic lupus erythematosus

9th International Congress of Autoimmunity  

Role of MASP-1/3 in activation of the alternative complement pathway and development of renal disease in a murine model of systemic lupus erythematosus

9th International Congress of Autoimmunity  

Role of MASP-1/3 in activation of the alternative complement pathway and development of renal disease in a murine model of systemic lupus erythematosus

9th International Congress of Autoimmunity  

Autoantibody-secreting marginal zone B cells develop significantly in lupus-prone MRL/lpr mice but not associated with expression of IFN-γ-receptor-1 on their surfaces

Autoantibody-secreting marginal zone B cells develop significantly in lupus-prone MRL/lpr mice but not associated with expression of IFN-γ-receptor-1 on their surfaces  

A dual role for IFN-γ in development of peripheral B cells in lupus-prone MRL/lpr mice

2014-Annual Scientific Meeting of the American College of Rheumatology  

IFN-γ-receptor-1 is expressed abundantly on splenic B cells of MRL/lpr mice and is involved in peripheral B-cell survival/maintenance and autoantibody production

第42回日本免疫学会学術集会  

Masp-1/3 deficient MRL/lpr mice lack the alternative complement pathway activation and are protected from development of lupus-like glomerulonephritis

The 77th Annual Meeting of the American College of Rheumatology  

Masp-1/3 deficient MRL/lpr mice lack the alternative complement pathway activation and are protected from development of lupus-like glomerulonephritis

The 77th Annual Meeting of the American College of Rheumatology  

Lack of IRF-1 accelerates development of tubulointerstitial nephritis and pulmonary granulomas with predominant Th2 polarity in lupus-prone MRL/lpr mice

15th International Congress of Immunology  

Aged IRF-4-deficient lupus-prone MRL/lpr mice show peripheral B-cell deficiency with elevated serum IFN-γ levels and increased expression of IFN-γ-receptor-1 on B cells

15th International Congress of Immunology  

Lupus-prone MRL/lpr mice express IFN-γ-receptor-1 abundantly on peripheral B cells that is responsible for peripheral B-cell survival/maintenance and autoantibody production

5th International Conference on “B cells and Autoimmunity”  

Lack of IRF-1 accelerates development of tubulointerstitial nephritis and pulmonary granulomas with predominant Th2 polarity in lupus-prone MRL/lpr mice

15th International Congress of Immunology  

Aged IRF-4-deficient lupus-prone MRL/lpr mice show peripheral B-cell deficiency with elevated serum IFN-γ levels and increased expression of IFN-γ-receptor-1 on B cells

15th International Congress of Immunology  

Aged IRF-4-deficient lupus-prone MRL/lpr mice show peripheral B-cell deficiency with elevated serum IFN-γ levels and increased expression of IFN-γ-receptor-1 on B cells

15th International Congress of Immunology  

Aged IRF-4-deficient lupus-prone MRL/lpr mice show peripheral B-cell deficiency with elevated serum IFN-γ levels and increased expression of IFN-γ-receptor-1 on B cells

15th International Congress of Immunology  

IFN-γ-receptor-1 is expressed abundantly on splenic B cells of MRL/lpr mice and is involved in peripheral B-cell survival/maintenance and autoantibody production

第42回日本免疫学会学術集会  

IFN-γ-receptor-1 is expressed abundantly on splenic B cells of MRL/lpr mice and is involved in peripheral B-cell survival/maintenance and autoantibody production

IFN-γ-receptor-1 is expressed abundantly on splenic B cells of MRL/lpr mice and is involved in peripheral B-cell survival/maintenance and autoantibody production  

Lack of IRF-1 accelerates development of tubulointerstitial nephritis and pulmonary granulomas with predominant Th2 polarity in lupus-prone MRL/lpr mice

15th International Congress of Immunology  

Lack of IRF-1 accelerates development of tubulointerstitial nephritis and pulmonary granulomas with predominant Th2 polarity in lupus-prone MRL/lpr mice

15th International Congress of Immunology  

Lupus-prone MRL/lpr mice express IFN-γ-receptor-1 abundantly on peripheral B cells that is responsible for peripheral B-cell survival/maintenance and autoantibody production

5th International Conference on “B cells and Autoimmunity”  

Lupus-prone MRL/lpr mice express IFN-γ-receptor-1 abundantly on peripheral B cells that is responsible for peripheral B-cell survival/maintenance and autoantibody production

5th International Conference on “B cells and Autoimmunity”  

Masp-1/3 deficient MRL/lpr mice lack the alternative complement pathway activation and are protected from development of lupus-like glomerulonephritis

The 77th Annual Meeting of the American College of Rheumatology  

Masp-1/3 deficient MRL/lpr mice lack the alternative complement pathway activation and are protected from development of lupus-like glomerulonephritis

The 77th Annual Meeting of the American College of Rheumatology  

Aged IRF-4-deficient lupus-prone MRL/lpr mice show peripheral B-cell deficiency with elevated serum IFN-γ levels and increased expression of IFN-γ-receptor-1 on B cells

15th International Congress of Immunology  

Masp-1/3 deficient MRL/lpr mice lack the alternative complement pathway activation and are protected from development of lupus-like glomerulonephritis

The 77th Annual Meeting of the American College of Rheumatology  

Lack of IRF-1 accelerates development of tubulointerstitial nephritis and pulmonary granulomas with predominant Th2 polarity in lupus-prone MRL/lpr mice

15th International Congress of Immunology  

IFN-γ-receptor-1 is expressed abundantly on splenic B cells of MRL/lpr mice and is involved in peripheral B-cell survival/maintenance and autoantibody production

IFN-γ-receptor-1 is expressed abundantly on splenic B cells of MRL/lpr mice and is involved in peripheral B-cell survival/maintenance and autoantibody production  

Lack of interferon regulatory factor-1 accelerates development of interstitial nephritis, renal vasculitis, and pulmonary granulomas with predominant Th2 polarity in lupus-prone MRL/lpr mice

第41回日本免疫学会学術集会  

IRF-1 deficient lupus-prone MRL/lpr mice show reduced glomerulonephritis but develop severe interstitial nephritis, renal vasculitis and pulmonary granulomas with propensity for Th2 polarity

The 76th Annual Meeting of the American College of Rheumatology  

MBL-associated serine protease (MASP)-1/3 promotes the inhibition of the alternative pathway activation

XXIV International Complement Workshop  

Role of complement in a murine model of peanut-induced anaphylaxis

XXIV International Complement Workshop  

IRF-4欠損MRL/lprマウスはTh1過剰応答を起こし複数の組織に肉芽腫生病変を発症する

第40回日本免疫学会総会・学術集会  

Interferon regulatory factor-4 deficient lupus-prone MRL/lpr mice show strong propensity for Th1 polarity and develop granulomatous lesions in multiple organs

The 75th Annual Meeting of the American College of Rheumatology  

The benefit of targeted and selective inhibition of the alternative complement pathway for modulating autoimmunity and renal disease in murine models of systemic lupus erythematosus

The 5th Complement Workshop  

IRF4-deficient lupus-prone MRL/lpr mice lack serum Ig/auto-Abs and Th17 cells but develop non-immune complex-mediated diffuse proliferative glomerulonephritis and dermatitis/ear necrosis

The 74th Annual Meeting of the American College of Rheumatology  

ループス腎炎と補体・補体第2経路を特異的に標的とする治療戦略

第47回補体シンポジウム  

IRF4-deficient lupus-prone MRL/lpr mice lack serum immunoglobulin and glomerular immune complex/C3 deposits but develop proliferative glomerulonephritis and dermatitis/ear necrosis

14th International Congress of Immunology  

転写因子IRF4欠損SLEモデルマウスが示唆するループス腎炎の新たなメカニズム

Rheumatology Conference 2010  

第２経路を標的とした補体経路の抑制はSLEモデルMRL/lprマウスの腎炎を改善する

第39回日本免疫学会総会・学術集会  

IRF4-deficient lupus-prone MRL/lpr mice lack serum immunoglobulin and glomerular immune complex/C3 deposits but develop diffuse proliferative glomerulonephritis and dermatitis/ear necrosis

Immunodeficiencies and Autoimmune Diseases Scientific Colloquium  

Targeted Inhibition of the Alternative Pathway Ameliorates Progression of Renal Disease in Murine Models of Systemic Lupus Erythematosus

The 73nd Annual Meeting of the American College of Rheumatology  

補体第2経路特異的阻害剤CR2-fH融合蛋白を用いたループス様腎炎の抑制効果

第18回　日本リウマチ学会　北海道・東北支部学術集会  

インターフェロン調節因子-4(IRF4)遺伝子欠損 MRL/lpr マウスを用いたループス様腎炎の検討

第18回　日本リウマチ学会　北海道・東北支部学術集会  

Targeted Inhibition of the Alternative Pathway by CR2-fH Fusion Protein Ameliorates Progression of Renal Disease in MRL/lpr Mice

The 72nd Annual Meeting of the American College of Rheumatology  

Interferon-Regulatory Factor 4 Is Required for Full Expression of Lupus Nephritis in MRL/lpr Mice

The 72nd annual meeting of the American College of Rheumatology  

補体因子ＭＡＳＰ－１／３を標的とする新規製剤の開発とＳＬＥモデル動物への治療効果

2014年4月 - 2016年3月

転写因子IRF4は自己免疫疾患における肉芽腫の形成に関与する

2011年4月 - 2014年3月

ループス腎炎発症にCD4陽性T細胞が直接関与する

2009年4月 - 2011年3月