セルファクトリー部門
活動内容
加工したヒト細胞などを用いて、動物実験の代替となる薬の評価方法の開発を行います。
また、様々な細胞を用いて、薬の効果や副作用を調べます。
これらの評価に他部門で解析されたデータを付加し、薬の効果や副作用の詳細な分析を行います。
スタッフ
| 家村 俊一郎 | 教授 |
| 檜山 源 | 講師 |
| 橘内 唯 | 研究員 |
| 七森 和 | 研究員 |
| 安間 千智 | 研究員 |
主な論文・学会発表等
研究員の過去の主な業績をリストアップしています
論文
- Construction of in vitro patient-derived tumor models to evaluate anticancer agents and cancer immunotherapy. Takahashi et al., Oncology Letters, 21, 406 (2021)
- An in vitro system for evaluating molecular targeted drugs usin g lung patient-derived tumor organoids. Takahashi et al., Cells, 8, 481 (2019)
- 実験医学別冊 「患者由来がんモデルを用いたがん研究実践ガイド CDX・スフェロイド・オルガノイド・PDX/PDOX を網羅 臨床検体の取り扱い指針から樹立プロトコールと入手法まで」、佐々木博巳/編、羊土社 ISBN 978-4-7581-2242-9 (2019)
- Tamura H, Higa A, Hoshi H, Hiyama G, Takahashi N, Ryufuku M, Morisawa G, Yanagisawa Y, Ito E, Imai JI, Dobashi Y, Katahira K, Soeda S, Watanabe T, Fujimori K, Watanabe S, Takagi M. Evaluation of anticancer agents using patient-derived tumor organoids characteristically similar to source tissues. Oncol Rep., 40, 635-646, (2018)
- Higa A, Hoshi H, Yanagisawa Y, Ito E, Morisawa G, Imai JI, Watanabe S, Takagi M. Evaluation system for arrhythmogenic potential of drugs using human-induced pluripotent stem cell-derived cardiomyocytes and gene expression analysis. J Toxicol Sci., 42, 755-761. (2017)
- Hoshi H, Hiyama G, Ishikawa K, Inageda K, Fujimoto J, Wakamatsu A, Togashi T, Kawamura Y, Takahashi N, Higa A, Goshima N, Semba K, Watanabe S, Takagi M. Construction of a novel cell-based assay for the evaluation of anti-EGFR drug efficacy against EGFR mutation. Oncol Rep. 37, 66-76 (2017)
- Higa A, Hoshi H, Takagi M. Differing responses of human stem cell-derived cardiomyocytes to arrhythmogenic drugs, determined using impedance measurements. Fundam. Toxicol. Sci. 3, 47-53 (2016)
- Izumikawa, M., Takagi, M., Shin-ya, K. JBIR-78 and JBIR-95: Phenylacetylated peptides isolated from Kibdelosporangium sp. AK-AA56. J Nat Prod, 75, 280-284 (2012)
- Hosoya, T., Hirokawa, T., Takagi, M., Shin-ya, K. Trichostatin Analogues JBIR-109, JBIR-110, and JBIR-111 from the marine sponge-derived Streptomyces sp. RM72. J Nat Prod, 75, 285-289 (2012)
- Takahashi, M., Takemoto, Y., Shimazu, T., Kawasaki, H., Tachibana, M., Shinkai, Y., Takagi, M., Shin-ya, K., Igarashi, Y., Ito, A., Yoshida, M. Inhibition of histone H3K9 methyltransferases by gliotoxin and related epipolythiodioxopiperazines. J Antibiot, 65, 263-265 (2012)
- Takagi, M., Ueda, JY., Hwang, JH., Hashimoto, J., Izumikawa, M., Murakami, H., Sekido, Y., Shin-ya, K. Tyrosyl-DNA phosphodiesterase 1 inhibitor from an anamorphic fungus. J Nat Prod, 75, 764-767 (2012)
- Maruyama, C., Toyoda, J., Kato, Y., Izumikawa, M., Takagi, M., Shin-Ya, K., Katano, H., Utagawa, T., Hamano, Y. A stand-alone adenylation domain forms amide bonds in streptothricin biosynthesis. Nat Chem Biol, 8, 791-797 (2012)
- Kawahara, T., Izumikawa, M., Takagi, M., Shin-ya, K. Relative configuration of JBIR-129, a cytotoxic 34-membered glycosidic polyol macrolide from Streptomyces sp. RK74. Org Lett, 14, 4434-4437 (2012)
- Kawahara, T., Hwang, JH., Izumikawa, M., Hashimoto, J., Takagi, M., Shin-ya, K. JBIR-129 and -139, Cytotoxic 34-membered polyol macrolides of microbial origin. J Nat Prod, 75, 1814−1818 (2012)