Cutting Edge: Role of MASP-3 in the Physiological Activation of Factor D of the Alternative Complement Pathway

Manabu Hayashi, Takeshi Machida, Yumi Ishida, Yusuke Ogata, Tomoko Omori, Mika Takasumi, Yuichi Endo, Toshiyuki Suzuki, Masayuki Sekimata, Yoshimi Homma, Masahito Ikawa, Hiromasa Ohira, Teizo Fujita, and Hideharu Sekine

The Journal of Immunology   203 ( 6 )   1411 - 1416   2019（ ISSN:0022-1767 ）

Response to Comment on “Cutting Edge: Role of MASP-3 in the Physiological Activation of Factor D of the Alternative Complement Pathway”

Takeshi Machida, Manabu Hayashi, Teizo Fujita, and Hideharu Sekine

The Journal of Immunology   203 ( 12 )   3091 - 3092   2019

Essential Roles for Mannose-Binding Lectin-Associated Serine Protease-1/3 in the Development of Lupus-Like Glomerulonephritis in MRL/lpr Mice

Takeshi Machida, Natsumi Sakamoto, Yumi Ishida, Minoru Takahashi, Teizo Fujita, and Hideharu Sekine

Frontiers in Immunology   9   1191   2018

Chloroplastic NADPH-dependent thioredoxin reductase from Chlorella vulgaris alleviates environmental stresses in yeast with 2-Cys peroxiredoxin

Takeshi Machida, Akiko Ishibashi, Ai Kirino, Jun-ichi Sato, Shinji Kawasaki, Youichi Niimura, Ken-ichi Honjoh, Takahisa Miyamoto

PLoS ONE   7 ( 9 )   e45988   2012

Expression pattern of a chloroplast NADPH-dependent thioredoxin reductase in Chlorella vulgaris and its interaction with 2-Cys peroxiredoxin.

Takeshi Machida, Eri Kato, Akiko Ishibashi, Jun-ichi Sato, Shinji Kawasaki, Youichi Niimura, Ken-ichi Honjoh, Takahisa Miyamoto

Bioscience, Biotechnology, and Biochemistry   73   695 - 701   2009

Isolation of cDNAs for hardening-induced genes from Chlorella vulgaris by suppression subtractive hybridization.

Takeshi Machida, Hisako Murase, Eri Kato, Ken-ichi Honjoh, Kiyoshi Matsumoto, Takahisa Miyamoto, Masayoshi Iio

Plant Science   175   238 - 246   2008

C5a stimulation induces caspase-1 activation and mature IL-1β production in human peripheral blood mononuclear cells

Yuya Fujita, Haruki Matsumoto, Kenji Inada, Michio Onizawa, Kenji Saito, Yuya Sumichika, Shuhei Yoshida, Jumpei Temmoku, Naoki Matsuoka, Tomoyuki Asano, Shuzo Sato, Takeshi Machida, Kiyoshi Migita

Immunological Medicine   47   68 - 75   2024.6

Complement activation products in tears of dry eye and meibomian gland dysfunction

Hiroki Maehara, Koki Norikawa, Keiichiro Tanaka, Yutaka Kato, Akihito Kasai, Ryo Mukai, Tomoko Omori, Takeshi Machida, Hideharu Sekine, Tetsuju Sekiryu

Scientific Reports   14   43   2024.1

Tear fluid and complement activation products in tears after ocular surgery.

Hiroki Maehara, Koki Norikawa, Keiichiro Tanaka, Yutaka Kato, Akihito Kasai, Tomoko Omori, Takeshi Machida, Hideharu Sekine, Tetsuju Sekiryu

BMC Ophthalmology   23   329   2023.7

Age-Related Maculopathy Susceptibility 2 and Complement Factor H Polymorphism and Intraocular Complement Activation in Neovascular Age-Related Macular Degeneration

Yutaka Kato, Yasuharu Oguchi, Tomoko Omori, Akihito Kasai, Masashi Ogasawara, Yukinori Sugano, Kanako Itagaki, Akira Ojima, Yumi Ishida, Takeshi Machida, Hideharu Sekine, Tetsuju Sekiryu

Ophthalmology Science   2   100167   2022

Increased CEACAM1 expression on peripheral blood neutrophils in patients with rheumatoid arthritis

Haruki Matsumoto, Yuya Fujita, Michio Onizawa, Kenji Saitoh, Yuya Sumichika, Shuhei Yoshida, Jumpei Temmoku, Naoki Matsuoka, Makiko Yashiro-Furuya, Tomoyuki Asano, Shuzo Sato, Eiji Suzuki, Takeshi Machida, Hiroshi Watanabe, Kiyoshi Migita

Frontiers in Immunology   13   978435   2022

Changes in complement activation products after anti-VEGF injection for choroidal neovascularization in age-related macular degeneration and pachychoroid disease

Keiichiro Tanaka, Yasuharu Oguchi, Tomoko Omori, Yumi Ishida, Hiroaki Shintake, Ryutaro Tomita, Akihito Kasai, Masashi Ogasawara, Yukinori Sugano, Kanako Itagaki, Akira Ojima, Takeshi Machida, Hideharu Sekine and Tetsuju Sekiryu

Scientific Reports   11 ( 1 )   8464   2021

Evidence for activation of lectin and classical pathway complement components in aqueous humor of neovascular age-related macular degeneration

Tomoko Omori, Yasuharu Oguchi, Takeshi Machida, Yutaka Kato, Yumi Ishida, Akira Ojima, Kanako Itagaki, Hiroaki Shintake, Ryutaro Tomita, Akihito Kasai, Yukinori Sugano, Masashi Ogasawara, Hideharu Sekine, and Tetsuju Sekiryu

Ophthalmic Research   63   252 - 258   2020

Anaphylatoxin concentration in aqueous and vitreous humor in the eyes with vitreoretinal interface abnormalities

Yasuharu Oguchi, Tetsuju Sekiryu, Tomoko Omori, Yutaka Kato, Masashi Ogasawara, Yukinori Sugano, Kanako Itagaki, Akira Ojima, Takeshi Machida, Hideharu Sekine

Experimental Eye Research   195   108025   2020

Complement activation products and cytokines in pachychoroid neovasculopathy and neovascular age-related macular degeneration

Yutaka Kato, Yasuharu Oguchi, Tomoko Omori, Hiroaki Shintake, Ryutaro Tomita, Akihito Kasai, Masashi Ogasawara, Yukinori Sugano, Kanako Itagaki, Akira Ojima, Takeshi Machida, Hideharu Sekine, and Tetsuju Sekiryu

Investigative Ophthalmology & Visual Science   61   39   2020

Complement activation by autoantigen recognition in the growth process of benign prostatic hyperplasia

Junya Hata, Takeshi Machida, Kanako Matsuoka, Seiji Hoshi, Hidenori Akaihata, Hiroyuki Hiraki, Toshiyuki Suzuki, Soichiro Ogawa, Masao Kataoka, Nobuhiro Haga, Kei Ishibashi, Yoshimi Homma, Hideharu Sekine, Yoshiyuki Kojima

Scientific Reports   9   20357   2019

Freezing tolerance of Lactuca sativa and induction of CBF and GolS genes during cold treatment

Ken-ichi Honjoh, Hitomi Okano, Aya Kawabata, Masaru Kurosawa, Taiki Kimura, Takeshi Machida, Yoshimitsu Masuda and Takahisa Miyamoto

Journal of Faculty of Agriculture, Kyushu University   63   249 - 257   2018

Autoimmune disease mouse model exhibits pulmonary arterial hypertension

Koichi Sugimoto, Kazuhiko Nakazato, Akihiko Sato, Satoshi Suzuki, Akiomi Yoshihisa, Takeshi Machida, Shu-ichi Saito, Hideharu Sekine, Yasuchika Takeishi

PLoS ONE   12   e0184990   2017

Recent progress in understanding pathophysiology of systemic lupus erythematosus: Role of the complement activation pathways in the development of systemic lupus erythematosus

Hideharu Sekine, Tomoko Omori, Natsumi Sakamoto, Takeshi Machida

67 ( 3 )   113 - 122   2017

IL-13-dependent biomarkers with liver inflammatory differentiation after pneumococcal sepsis during rapid inflammatory phase International coauthorship

Natsuo Yamamoto, Kiwamu Nakamura, Kazuaki Arai, Charles Dela Cruz, Takeshi Machida, Yuhko Suzuki, Yasunori Ogura, Yoshinobu Abe, Hideharu Sekine, Ken Iseki, Philip Askenase, and Keiji Kanemitsu

European Journal of Immunology   46 ( Supple 1 )   321   2016

IFN-γ-receptor-1 is required for intrafollicular localization of marginal zone B cells in the spleens of lupus-prone MRL+/+ mice International coauthorship

Takeshi Machida, Tomoko Omori, Natsumi Sakamoto, Xian Zhang, Gary S. Gilkeson, and Hideharu Sekine

European Journal of Immunology   46 ( Supple 1 )   935   2016

Essential role of mannose-binding lectin-associated serine proteases-1/3 (MASP-1/3) in the development of lupus-like glomerulonephritis in MRL/lpr mice

Natsumi Sakamoto, Takeshi Machida, Minoru Takahashi, Teizo Fujita, and Hideharu Sekine

Immunobiology   221   1166   2016

補体異常値を示す疾患とそのメカニズム

関根英治、大森智子、町田豪

補体   52 ( 2 )   14 - 26   2015

酵母の凍結ストレス耐性改善へのアプローチ

本城賢一, 町田豪, 菅向志郎, 宮本敬久

低温生物工学会誌   61   13 - 17   2015

A dual role for IFN-γ in development of peripheral B cells in lupus-prone MRL/lpr mice International coauthorship

Takeshi Machida, Natsumi Sakamoto, Gary S. Gilkeson, Hideharu Sekine

Arthritis & Rheumatology   66   S857 - S858   2014

Role of complement in a murine model of peanut-induced anaphylaxis

Toshihisa Kodama, Hideharu Sekine, Yuichi Endo, Minoru Takahashi, Daisuke Iwaki, Takeshi Machida, Kazuko Kanno, Yumi Ishida, and Teizo Fujita

Immunobiology   218 ( 6 )   844 - 850   2013

Aged IRF-4-deficient lupus-prone MRL/lpr mice show peripheral B-cell deficiency with elevated serum IFN-γ levels and increased expression of IFN-γ-receptor-1 on B cells

Takeshi Machida, Natsumi Sakamoto, Kiri Honma, Toshifumi Matsuyama, Katsuyuki Yui, and Hideharu Sekine

Frontiers in Immunology   2013

Lack of IRF-1 accelerates development of tubulointerstitial nephritis and pulmonary granulomas with predominant Th2 polarity in lupus-prone MRL/lpr mice International coauthorship

Takeshi Machida, Natsumi Sakamoto, Eiji Suzuki, Xian Zhang, Christopher M. Reilly, Gary S. Gilkeson, and Hideharu Sekine

Frontiers in Immunology   2013

IRF-1 deficient lupus-prone MRL/lpr mice show reduced glomerulonephritis but develop severe interstitial nephritis, renal vasculitis and pulmonary granulomas with propensity for Th2 polarity International coauthorship

Hideharu Sekine, Takeshi Machida, Natsumi Sakamoto, Eiji Suzuki, Xiang Zhang, Christopher M. Reily, Gary S. Gilkeson

Arthritis & Rheumatology   64   S619-620   2012

Circulating myeloid-derived suppressor cells are increased and correlate to immune suppression, inflammation, and hypoproteinemia in patients with cancer

Shinji Ohki, Masahiko Shibata, Kenji Gonda, Takeshi Machida, Tatsuo Shimura, Izumi Nakamura, Toru Ohtake, Yoshihisa Koyama, Shinichi Suzuki, Hitoshi Ohto, and Seiichi Takenoshita

Oncology Reports   28   453 - 458   2012

Interferon regulatory factor-4 deficient lupus-prone MRL/lpr mice show strong propensity for Th1 polarity and develop granulomatous lesions in multiple organs International coauthorship

Hideharu Sekine, Takeshi Machida, Eiji Suzuki, Ting Ting Hsieh Kinser, Efrain Martinez Avila, Phil Ruiz, Christopher M. Reily, Gary Gilkeson

Arthritis & Rheumatology   63   S213   2011

Enhancement of menadione stress tolerance in yeast by accumulation of hypotaurine and taurine.

Ken-ichi Honjoh, Kanae Matsuura, Takeshi Machida, Koutarou Nishi, Miki Nakao, Tomoki Yano, Takahisa, Miyamoto, Masayoshi Iio

Amino Acids   38   1173 - 1183   2010

Chloroplastic glucose 6-phosphate dehydrogenase from Chlorella vulgaris alleviates freezing and menadione-induced oxidative stresses in Saccharomyces cerevisiae.

Takeshi Machida, Naoto Ohashi, Ayano Mimura, Ken-ichi Honjoh, Masayoshi Iio, Takahisa Miyamoto

Journal of Faculty of Agriculture, Kyushu University   55   29 - 38   2010

Trehalose 6-phosphate synthase and trehalose 6-phosphate phosphatase from Nicotiana tabacum function in trehalose biosynthesis and environmental stress tolerance of yeast

Takeshi Machida, Ken-ichi Honjoh, Ayuko Aso, Maiko Yamamoto, Masayoshi Iio, Takahisa Miyamoto

Journal of Faculty of Agriculture, Kyushu University   55   261 - 268   2010

IRF-4-deficient lupus-prone MRL/lpr mice lack serum Ig/auto-Abs and Th17 cells but develop non-immune complex-mediated diffuse proliferative glomerulonephritis and dermatitis/ear necrosis International coauthorship

Hideharu Sekine, Takeshi Machida, Eiji Suzuki, Efrain Martinez Avila, Phil Ruiz, Christopher M. Reily, Gary S. Gilkeson

Arthritis & Rheumatism   62   S435   2010

Expression of a gene encoding a functional glycosyl hydrolase, trehalase, from Nicotiana tabacum in Saccharomyces cerevisiae.

Takeshi Machida, Ken-ichi Honjoh, Hideyuki Shimizu, Maiko Yamamoto, Masayoshi Iio, Takahisa Miyamoto

Journal of Faculty of Agriculture, Kyushu University   54   297 - 303   2009

Influence of cold hardening on chlorophyll and carotenoid in Chlorella vulgaris.

Yuta Watanabe, Naotaka Yamada, Takeshi Machida, Ken-ichi Honjoh, Eiichi Kuwano

Journal of Faculty of Agriculture, Kyushu University   54   195 - 200   2009

タウリン蓄積による耐凍性付与の試み

本城賢一、西孝太郎、町田豪、宮本敬久、飯尾雅嘉

低温生物工学会誌   53   47 - 51   2007

Molecular characterization of low-temperature-inducible NTR-C in Chlorella vulgaris.

Takeshi Machida, Eri Kato, Akiko Ishibashi, Naoto Ohashi, Ken-ichi Honjoh, Takahisa Miyamoto

Oxford University Press Nucleic Acids Symposium Series   51   463 - 464   2007

Improvement of Freezing and Oxidative-Stress Tolerance in Saccharomyces cerevisiae by Taurine

Ken-ichi Honjoh, Takeshi Machida, Koutarou Nishi, Kanae Matsuura, Kevin Webby Soli, Takatoshi Sakai, Hiroya Ishikawa, Kiyoshi Matsumoto, Takahisa Miyamoto, Masayoshi Iio

Food Science and Technology Research   13   145 - 154   2007

Molecular cloning and characterization of a cDNA for low-temperature-inducible cytosolic glucose 6-phosphate dehydrogenase gene from Chlorella vulgaris and expression of the gene in Saccharomyces cerevisiae

Ken-ichi Honjoh, Takeshi Machida, Takahiro Hagisako, Koushirou Suga, Madoka Yonekura, Hideyuki Shimizu, Naoto Ohashi, Takahisa Miyamoto, Masayoshi Iio, Shoji Hatano

Plant Science   172   649 - 658   2007

The significance of complex formation of MASP-3 with pattern recognition molecules of the lectin complement pathway in the long-term retention of MASP-3 in the circulation

28th International Complement Virtual Workshop  

肝臓虚血再灌流障害におけるcollectin-10とcollectin-11の役割

第60回日本補体学会学術集会   2024.9  

Collectin-10 plays a pivotal role in the development of hepatic ischemia/reperfusion injury in mice

19th European Meeting on Complement in Human Diseases   2024.9  

Role of the lectin complement pathway in the development of lupus nephritis

2023.7  

ヨウ素酸ナトリウム誘発網膜障害モデルマウスにおけるMASP-1の役割

第58回日本補体学会学術集会   2022.8  

The significance of the complex formation of mannose-binding lectin-associated serine protease-3 (MASP-3) with pattern recognition molecules of the lectin complement pathway in the activation of MASP-3 and the long-term retention of proenzyme MASP-3 in the circulation

MASP-3の活性化に対するレクチン経路の認識分子の役割

第57回日本補体学会学術集会  

加齢黄斑変性の病態におけるレクチン経路の関与の可能性

第56回日本補体学会学術集会  

MASP-1 and MASP-3 play independent roles in activation of the lectin and alternative complement pathways

27th International Complement Workshop  

MASP-1、MASP-3はレクチン経路、第二経路の活性化に独立して寄与する

第55回日本補体学会学術集会  

MRL/lprマウスのループス様糸球体腎炎におけるMASP-1/3の役割

第55回日本補体学会学術集会  

SLEモデルMRL/lprマウスの抗dsDNA抗体産生における脾臓辺縁帯B細胞の役割

Rheumatology Conference 2018  

補体レクチン経路と第二経路を標的としたMAp44-fHの開発

研究連携セミナーポスター発表会2017  

Significant role for splenic marginal zone B cells in anti-dsDNA autoantibody production in lupus-prone mice with an MRL background

第46回日本免疫学会学術集会  

Anti-inflammatory effects on liver cells with flavonoids during rapid phase in a severe sepsis

第46回日本免疫学会学術集会  

補体レクチン経路と第二経路を標的とする新規抗補体薬sMAP-fHの開発

第54回日本補体学会学術集会  

CRISPR/Cas9システムによるスプライシングバリアントの機能解析

研究連携セミナーポスター発表会2016  

Possible anti-inflammatory treatment with flavonoids during a severe sepsis

Essential role of mannose-binding lectin-associated serine proteases-1/3 (MASP-1/3) in the development of lupus-like glomerulonephritis in MRL/lpr mice

XXVIth International Complement Workshop  

IFN-γ-receptor is required for intrafollicular localization of marginal zone B cells in the spleens of lupus-prone MRL+/+ mice

16th International Congress of Immunology  

IL-13-dependent biomarkers with liver inflammatory differentiation after pneumococcal sepsis during rapid inflammatory phase

16th International Congress of Immunology  

補体制御因子sMAPとH因子を応用した新規抗補体薬の開発

平成28年サマーポスターセッション  

IFN-γ-receptorはMRL+/+マウスの脾臓における自己反応性辺縁帯B細胞の濾胞内局在を促進する

Rheumatology Conference 2016  

SLEの自己抗体産生における辺縁帯B細胞の役割

研究連携セミナーポスター発表会2015  

IFN-γ-receptor-1 is required for recruitment of CD19+CD1dhi marginal zone-B cells into the splenic germinal centers in lupus-prone MRL+/+ mice

Altered localization of CD19+ B cells in the splenic germinal centers of IFN-γ-receptor-1 deficient lupus-prone MRL+/+ mice

11th International Congress on Systemic Lupus Erythematosus  

MASP-1/3欠損MRL/lprマウスでは補体第二経路活性化が抑制され糸球体腎炎が改善する

Rheumatology Conference 2015  

SLEモデルマウスの自己抗体産生におけるIFN-γの役割

研究連携セミナー2015  

A pivotal role for enhanced IFN-γ stimulation to marginal zone B cells in autoantibody production in murine lupus.

Elevated splenic Blimp-1 and CD14 of blood leukocytes within hours in IL-13 deficient mice sepsis

Autoantibody-secreting marginal zone B cells develop significantly in lupus-prone MRL/lpr mice but not associated with expression of IFN-γ-receptor-1 on their surfaces

肺癌患者のTregにおける、転写因子Heliosに関する臨床的検討

第27回日本バイオセラピィ学会学術集会総会  

A dual role for IFN-γ in development of peripheral B cells in lupus-prone MRL/lpr mice

2014-Annual Scientific Meeting of the American College of Rheumatology  

腹膜炎ー敗血症モデルにおける補体因子MASP-1/3の役割

第51回補体シンポジウム  

Role of MASP-1/3 in activation of the alternative complement pathway and development of renal disease in a murine model of systemic lupus erythematosus

9th International Congress of Autoimmunity  

IFN-γ-receptor-1 is expressed abundantly on splenic B cells of MRL/lpr mice and is involved in peripheral B-cell survival/maintenance and autoantibody production

Masp-1/3 deficient MRL/lpr mice lack the alternative complement pathway activation and are protected from development of lupus-like glomerulonephritis

The 77th Annual Meeting of the American College of Rheumatology  

凍結貯蔵性付与を目的としたレタスの低温応答遺伝子解析

第60回日本食品科学工学会全国大会  

クロレラNTRCおよびPrx遺伝子導入による高等植物の凍結貯蔵性向上に関する研究

第60回日本食品科学工学会全国大会  

Lack of IRF-1 accelerates development of tubulointerstitial nephritis and pulmonary granulomas with predominant Th2 polarity in lupus-prone MRL/lpr mice

15th International Congress of Immunology  

Aged IRF-4-deficient lupus-prone MRL/lpr mice show peripheral B-cell deficiency with elevated serum IFN-γ levels and increased expression of IFN-γ-receptor-1 on B cells

15th International Congress of Immunology  

Lupus-prone MRL/lpr mice express IFN-γ-receptor-1 abundantly on peripheral B cells that is responsible for peripheral B-cell survival/maintenance and autoantibody production

5th International Conference on B cells and Autoimmunity  

クロレラ由来葉緑体局在型NADPH依存型チオレドキシン還元酵素ならびに2-Cysペルオキシレドキシン遺伝子導入シロイヌナズナのストレス耐性

第50回化学関連支部合同九州大会  

Lack of interferon regulatory factor-1 accelerates development of interstitial nephritis, renal vasculitis, and pulmonary granulomas with predominant Th2 polarity in lupus-prone MRL/lpr mice

IRF-1 deficient lupus-prone MRL/lpr mice show reduced glomerulonephritis but develop severe interstitial nephritis, renal vasculitis and pulmonary granulomas with propensity for Th2 polarity

2012 ACR/ARHP Annual Meeting  

癌の進行の伴う炎症と免疫抑制におけるMDSCの検討

第71回日本癌学会学術集会総会  

胃・大腸癌患者における血中可溶性IL-2受容体濃度の検討とMDSCの関連

第71回日本癌学会学術集会総会  

乳癌患者におけるMDSCとTh2優位状態の検討

第10回日本臨床腫瘍学会学術集会  

CBF遺伝子の解析に基づくレタス (Lactuca sativa L.) の低温応答性に関する研究

第49回化学関連支部合同九州大会  

乳癌患者におけるMDSCの検討

第24回日本バイオセラピィ学会学術集会総会  

Interferon regulatory factor4-deficient lupus-prone MRL/lpr mice show strong propensity for Th1 polarity and develop granulomatous lesions in multiple organs

IRF-4はMRL/lprマウスのB細胞分化・成熟に必須である

基礎合同セミナーポスター発表会2011  

IRF-4 deficient lupus-prone MRL/lpr mice develop granulomatous lesions in multiple organs with strong propensity for Th1 polarity

Myeloid Suppressor Cells in patients with breast cancer

乳癌患者における骨髄由来免疫抑制細胞（MDSC：myeloid derived suppressor cells）の検討

第49回日本癌治療学会学術集会  

Th17 and MDSC (myeloid-derived suppressor cells) influence an immune reaction in patients with cancer

レタス (Lactuca sativa) からのCBF様遺伝子のクローニング

第29回日本植物細胞分子生物学会大会シンポジウム  

クロレラNTRC/2-Cys Prx抗酸化系遺伝子導入による酵母のストレス耐性向上に関する研究

第29回日本植物細胞分子生物学会大会シンポジウム  

癌患者における骨髄由来免疫抑制細胞MDSCの検討

第21回日本樹状細胞研究会  

IRF-4欠損MRL/lprマウスはCD4陽性Th1細胞が異常増殖し肉芽腫を形成する

基礎合同セミナーポスター発表会2011  

IRF4-Deficient Lupus-Prone MRL/lpr Mice Lack Serum Ig/Auto-Abs and Th17 Cells but Develop Non-Immune Complex-Mediated Diffuse Proliferative Glomerulonephritis and Dermatitis/Ear Necrosis

The 74th annual meeting of the American College of Rheumatology  

クロレラ形質転換法の確立に基づく低温誘導性NTRC遺伝子の破壊に関する研究

平成22年度日本農芸化学会西日本支部大会  

レタスの定温および凍結耐性を評価する遺伝子マーカーの検討

第47回化学関連支部合同九州大会  

クロレラNTRC/2-Cys Prx抗酸化系過酸化物分解活性および本抗酸化系遺伝子導入による酵母の耐凍性に関する研究

第47回化学関連支部合同九州大会  

クロレラ耐凍性誘導物質ルヌラリンの構造活性相関

日本農芸化学会2010年度大会  

クロレラ耐凍性誘導物質ルヌラリンにより発現誘導される遺伝子の同定

2009年度日本農芸化学会関西・中四国・西日本支部、日本栄養・食糧学会九州・沖縄支部および日本食品科学工学会西日本支部合同沖縄大会  

クロレラの耐凍性に及ぼすルヌラリンの影響

2009年度日本農芸化学会関西・中四国・西日本支部、日本栄養・食糧学会九州・沖縄支部および日本食品科学工学会西日本支部合同沖縄大会  

クロレラ葉緑体局在NADPHチオレドキシン還元酵素と2-Cys型ペルオキシレドキシン間の相互作用解析

2009年度日本農芸化学会関西・中四国・西日本支部、日本栄養・食糧学会九州・沖縄支部および日本食品科学工学会西日本支部合同沖縄大会  

タバコ由来トレハロース合成系酵素群の酵母での発現

日本農芸化学会2009年度大会  

Chlorella vulgaris C-27株のカロテノイドに対する低温馴化の影響

日本農芸化学会2009年度大会  

クロレラ葉緑体局在NADPH依存型チオレドキシン還元酵素が関わる抗酸化系酵素群の酵母における発現とストレス耐性

日本農芸化学会2009年度大会  

Chloroplastic NADPH-dependent thioredoxin reductase from Chlorella vulgaris functions as an antioxidant system with 2-Cys peroxiredoxin

The 5th International Joint Symposium between Japan and Korea. The Recent Status and Perspective of Food System, Agricultural Environment and Biology  

クロレラ葉緑体局在NADPH依存型チオレドキシン還元酵素は2-Cys Prxと共同して過酸化物分解に機能する

日本農芸化学会西日本支部大会  

Stress tolerance of yeast expressing genes for taurine synthetic enzymes

XVI Congress of the Federation of European Societies of Plant Biology  

Chloroplastic NADPH-dependent thioredoxin reductase from Chlorella vulgaris functions as an antioxidant with 2-Cys peroxiredoxin

XVI Congress of the Federation of European Societies of Plant Biology  

クロレラ葉緑体局在NADPH依存型チオレドキシン還元酵素が関与する抗酸化システム

第45回化学関連支部合同九州大会  

ルヌラリン酸処理によるクロレラの耐凍性獲得誘導

第45回化学関連支部合同九州大会  

クロレラの耐凍性獲得に及ぼすルヌラリン酸の効果

日本農薬学会第33回大会  

クロレラ低温誘導性NTR-Cは2-Cys Prxの電子供与体として機能し過酸化物分解を促進する

日本農芸化学会2008年度大会  

Molecular characterization of low-temperature-inducible NTR-C in Chlorella vulgaris

5th International Symposium on Nucleic Acids Chemistry  

単細胞緑藻Chlorella vulgaris C-27株の耐凍性獲得に及ぼすルヌラリン酸の効果

植物化学調節学会第42回大会  

タウリン合成酵素遺伝子導入による酵母へのストレス耐性付与

第54回日本食品科学工学会  

Molecular characterization of low-temperature-inducible NTR-C from Chlorella vulgaris

Multi-functionality and Sustainability of land use in SE and E Asia: Japan-Germany International Cooperative Project on Education and Research  

Chlorella vulgaris C-27株の耐凍性獲得に及ぼすルヌラリン酸の効果

日本農芸化学会 中四国・西日本支部合同大会  

クロレラ葉緑体局在型G6PDHアイソザイムの低温下における発現挙動と機能解析

日本農芸化学会 中四国・西日本支部合同大会  

クロレラ由来低温誘導性NADPH依存型チオレドキシン還元酵素の低温での発現挙動と機能解析

第44回化学関連支部合同九州大会  

クロレラにおけるペルオキシレドキシン (Prx) 関与の過酸化物分解酵素系

日本農芸化学会2007年度大会  

クロレラ由来グルコース6-リン酸脱水素酵素アイソザイムのcDNAクローニングと低温下における発現挙動

日本農芸化学会2007年度大会  

クロレラ由来低温誘導性NADPH依存型チオレドキシン還元酵素のcDNAクローニングとその機能解析

日本農芸化学会2007年度大会  

Isolation of cDNAs for hardening specific genes from Chlorella vulgaris by using suppression subtractive hybridization

Iwate Plant Science Symposium  

クロレラ葉緑体局在型g6pdh遺伝子のcDNAクローニングとその発現挙動

第43回化学関連支部合同九州大会  

クロレラg6pdh遺伝子の酵母での発現とその耐凍性への関与

第43回化学関連支部合同九州大会  

クロレラ由来葉緑体局在型グルコース6-リン酸脱水素酵素 (ch-G6PDH) のcDNAクローニングおよび大腸菌での発現

日本農芸化学会 関西・中四国・西日本支部合同大会  

SLEの自己抗体産生には辺縁帯B細胞に対するIFN-γ刺激の増強が重要である

2015.6 - 2016.3

SLEの自己反応性B細胞の出現・活性化におけるIFN-γシグナルの役割

2014.6 - 2015.3

補体因子MASP-1/3を標的とする新規製剤の開発とSLEモデル動物への治療効果

2014.4 - 2016.3

関根 英治、町田 豪

自己反応性Th2細胞による間質性腎炎の新規モデルマウス確立と発症メカニズム解明

2013.5 - 2014.3

補体セリンプロテアーゼMASP-1はループス腎炎の病態に関与するか

2010.11 - 2011.8

低温誘導性NTR-Cの機能解明に基づく耐凍性植物の作出

2008.4 - 2010.3

平成26年度ふくしま地域医療の担い手育成事業 「メディカルサポートセミナー」

2014.7

平成25年度ふくしま地域医療の担い手育成事業 「メディカルサポートセミナー」

2013.7