Updated on 2024/09/12

写真a

 
IKEZOE Takayuki
 
Organization
School of Medicine (Clinical Medicine) Department of Hematology Chairman of the Department
Title
Chairman of the Department

Degree

  • 博士(医学) ( 1997.3   高知医科大学 )

Research Interests

  • 血管内皮細胞

  • トロンボモジュリン

  • hematological malignancy

Research Areas

  • Life Science / Hematology and medical oncology  / Hematology

  • Life Science / Hematology and medical oncology

Education

  • Kochi Medical School   Faculty of Medicine

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    Country: Japan

Research History

  • Fukushima Medical University   School of Medicine (Clinical Medicine) Department of Hematology   Chairman of the Department

    2017.2 - Now

  • Fukushima Medical University

    2016.5 - Now

  • Kochi University Research and Education Faculty, Medical Sciences Cluster Clinical Medicine Unit   Lecturer

    2016.4

Papers

  • Outcomes of adult patients with early T-cell precursor (ETP) acute lymphoblastic leukemia/lymphoma (ALL) and non-ETP T-ALL

    Yasushi Onishi, Eijiro Furukawa, Mayumi Kamata, Masahiko Fukatsu, Yoshihiro Kameoka, Shunsuke Hatta, Hiroyuki Hamada, Tatsuo Oyake, Tatsuyuki Kai, Masumi Sukegawa, Shinji Nakajima, Ryo Yanagiya, Kohei Yamaguchi, Taro Takahashi, Yoriko Harazaki, Toru Izumi, Kazunori Murai, Shigeki Ito, Takayuki Ikezoe, Kenichi Ishizawa, Naoto Takahashi, Hideo Harigae

    International Journal of Hematology   117 ( 5 )   738 - 747   2023.5( ISSN:0925-5710

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1007/s12185-023-03546-6

    PubMed

  • がん関連血栓症の予防・治療のガイドライン

    池添 隆之, 林 裕美

    血液内科   86 ( 3 )   433 - 438   2023.3( ISSN:2185-582X

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    Language:Japanese  

  • 2022 Hot Topics 凝固(血栓)分野

    根木 玲子, 池添 隆之, 向井 幹夫

    日本血栓止血学会誌   34 ( 1 )   72 - 74   2023.2( ISSN:0915-7441

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    Language:Japanese  

  • 日本人発作性夜間ヘモグロビン尿症患者におけるravulizumabおよびeculizumabの選択

    石山 謙, 臼杵 憲祐, 池添 隆之, 後藤 明彦, Myren Karl-Johan, Tomazos Ioannis, 下野 明彦, 二宮 治彦, 櫻井 政寿, 中尾 眞二, 西村 純一

    臨床血液   64 ( 1 )   9 - 17   2023.1( ISSN:0485-1439

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    Language:Japanese  

  • [Japanese patient preferences between ravulizumab and eculizumab for the treatment of paroxysmal nocturnal hemoglobinuria].

    Ishiyama K, Usuki K, Ikezoe T, Gotoh A, Myren KJ, Tomazos I, Shimono A, Ninomiya H, Sakurai M, Nakao S, Nishimura JI

    [Rinsho ketsueki] The Japanese journal of clinical hematology   64 ( 1 )   9 - 17   2023( ISSN:0485-1439

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    Language:Japanese  

    DOI : 10.11406/rinketsu.64.9

    PubMed

  • Phase I study of alvocidib plus cytarabine/mitoxantrone or cytarabine/daunorubicin for acute myeloid leukemia in Japan(和訳中)

    Ikezoe Takayuki, Ando Kiyoshi, Onozawa Masahiro, Yamane Takahisa, Hosono Naoko, Morita Yasuyoshi, Kiguchi Toru, Iwasaki Hiromi, Miyamoto Toshihiro, Matsubara Keisuke, Sugimoto Saori, Miyazaki Yasushi, Kizaki Masahiro, Akashi Koichi

    Cancer Science   113 ( 12 )   4258 - 4266   2022.12( ISSN:1347-9032

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    Language:English  

  • Prognostic value of plasma high mobility group box 1 protein and histone H3 levels in patients with disseminated intravascular coagulation: a multicenter prospective cohort study.

    Hirotaka Mori, Yuki Kataoka, Kayo Harada-Shirado, Noriaki Kawano, Mineji Hayakawa, Yoshinobu Seki, Toshimasa Uchiyama, Kazuma Yamakawa, Hiroyasu Ishikura, Yuhei Irie, Kenji Nishio, Noritaka Yada, Kohji Okamoto, Shingo Yamada, Takayuki Ikezoe

    Thrombosis journal   20 ( 1 )   49   2022.8( ISSN:1477-9560

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    Language:English  

    DOI : 10.1186/s12959-022-00406-x

    PubMed

  • 【徹底ガイドDICのすべて 2022-'23】類似病態、鑑別すべき病態 SOS(類洞閉塞症候群)とTLS(腫瘍崩壊症候群)

    池添 隆之

    救急・集中治療   34 ( 2 )   942 - 950   2022.7( ISSN:1346-0935

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    Language:Japanese  

  • 【徹底ガイドDICのすべて 2022-'23】治療薬 可溶性トロンボモジュリン(内科)

    池添 隆之

    救急・集中治療   34 ( 2 )   868 - 873   2022.7( ISSN:1346-0935

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    Language:Japanese  

  • A randomized, placebo-controlled clinical trial evaluating olipudase alfa enzyme replacement therapy for chronic acid sphingomyelinase deficiency (ASMD) in adults: One-year results.

    Melissa Wasserstein, Robin Lachmann, Carla Hollak, Laila Arash-Kaps, Antonio Barbato, Renata C Gallagher, Roberto Giugliani, Norberto Bernardo Guelbert, Takayuki Ikezoe, Olivier Lidove, Paulina Mabe, Eugen Mengel, Maurizio Scarpa, Eubekir Senates, Michel Tchan, Jesus Villarrubia, Yixin Chen, Sandy Furey, Beth L Thurberg, Atef Zaher, Monica Kumar

    Genetics in medicine : official journal of the American College of Medical Genetics   24 ( 7 )   1425 - 1436   2022.7( ISSN:1098-3600

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    Language:English  

    DOI : 10.1016/j.gim.2022.03.021

    PubMed

  • DAMPs、PAMPs、RAMPs(第2回) 白血病、血液病とDAMPs、PAMPs

    池添 隆之

    Thrombosis Medicine   12 ( 2 )   135 - 140   2022.6( ISSN:2186-0327

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    Language:Japanese  

  • 【血液疾患のすべて】赤血球系疾患 発作性夜間ヘモグロビン尿症

    池添 隆之

    日本医師会雑誌   151 ( 特別1 )   S187 - S188   2022.6( ISSN:0021-4493

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    Language:Japanese  

  • 【血液疾患のすべて】治療 抗凝固因子製剤(AT、TM)

    池添 隆之

    日本医師会雑誌   151 ( 特別1 )   S142 - S143   2022.6( ISSN:0021-4493

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  • 【DIC・関連疾患・COVID-19と臨床検査】DICを理解するためのLecture (Part 2)DICの治療戦略 急性前骨髄球性白血病(APL)に合併したDICの治療戦略

    池添 隆之

    Land-Mark in Thrombosis & Haemostasis   ( 2 )   71 - 74   2022.6( ISSN:2436-0635

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    Language:Japanese  

  • CHOP療法で奏効が得られた芽球性形質細胞様樹状細胞腫瘍の1例

    佐藤 佑紀, 深津 真彦, 福地 恒一郎, 尾張 真維, 遠藤 麻美子, 高橋 裕志, 原田 佳代, 木村 哲, 小山 大輔, 池添 隆之

    臨床血液   63 ( 5 )   492 - 492   2022.5( ISSN:0485-1439

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    Language:Japanese  

  • A phase II randomized study evaluating azacitidine versus conventional care regimens in newly diagnosed elderly Japanese patients with unfavorable acute myeloid leukemia

    Iida Hiroatsu, Imada Kazunori, Ueda Yasunori, Kubo Kohmei, Yokota Akira, Ito Yoshikazu, Kiguchi Toru, Hata Tomoko, Nawa Yuichiro, Ikezoe Takayuki, Uchida Toshiki, Morita Yasuyoshi, Kawashima Ichiro, Chiba Masahiro, Morimoto Kensaku, Hirooka Shihomi, Miyazaki Yasushi, Ohno Ryuzo, Naoe Tomoki, the Study Group

    International Journal of Hematology   115 ( 5 )   694 - 703   2022.5( ISSN:0925-5710

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    Language:English  

  • 肝類洞閉塞症候群の病態と治療

    池添 隆之

    血液内科   84 ( 4 )   622 - 629   2022.4( ISSN:2185-582X

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    Language:Japanese  

  • Long-term follow-up of patients with paroxysmal nocturnal hemoglobinuria treated with eculizumab: post-marketing surveillance in Japan

    Ikezoe Takayuki, Noji Hideyoshi, Ueda Yasutaka, Kanda Yoshinobu, Okamoto Shinichiro, Usuki Kensuke, Matsuda Takahisa, Akiyama Hirozumi, Shimono Akihiko, Yonemura Yuji, Kawaguchi Tatsuya, Chiba Shigeru, Kanakura Yuzuru, Nishimura Jun-ichi, Ninomiya Haruhiko, Obara Naoshi

    International Journal of Hematology   115 ( 4 )   470 - 480   2022.4( ISSN:0925-5710

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  • Case Report: Coexistence of Multiple Myeloma and Auricular Chondritis in VEXAS Syndrome.

    Haruki Matsumoto, Yuya Fujita, Masahiko Fukatsu, Takayuki Ikezoe, Kohei Yokose, Tomoyuki Asano, Naomi Tsuchida, Ayaka Maeda, Shuhei Yoshida, Honami Hashimoto, Jumpei Temmoku, Naoki Matsuoka, Makiko Yashiro-Furuya, Shuzo Sato, Mai Murakami, Hidenori Sato, Chiharu Sakuma, Kazumasa Kawashima, Norshalena Shakespear, Yuri Uchiyama, Hiroshi Watanabe, Yohei Kirino, Naomichi Matsumoto, Kiyoshi Migita

    Frontiers in immunology   13   897722   2022

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    DOI : 10.3389/fimmu.2022.897722

    PubMed

  • An evaluation of the Japanese Society on Thrombosis and Hemostasis criteria for disseminated intravascular coagulation as a predictor of prognosis in patients with infection.

    Seiji Madoiwa, Goichi Honda, Noriaki Kawano, Toshimasa Uchiyama, Kazuo Kawasugi, Naoki Takezako, Kei Suzuki, Yoshinobu Seki, Takayuki Ikezoe, Kohji Okamoto, Hideo Wada

    International journal of laboratory hematology   43 ( 6 )   1566 - 1574   2021.12( ISSN:1751-5521

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1111/ijlh.13643

    PubMed

  • 治療法の再整理とアップデートのために 専門家による私の治療 播種性血管内凝固(DIC)

    池添 隆之

    日本医事新報   ( 5089 )   40 - 41   2021.11( ISSN:0385-9215

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    Language:Japanese  

  • SOS/TA-TMAの診断と治療

    池添 隆之

    日本造血・免疫細胞療法学会雑誌   10 ( 4 )   136 - 144   2021.10

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    Language:Japanese  

  • 治療法の再整理とアップデートのために 専門家による私の治療 自己免疫性溶血性貧血(AIHA)

    池添 隆之

    日本医事新報   ( 5088 )   48 - 49   2021.10( ISSN:0385-9215

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    Language:Japanese  

  • Study for exploring myeloma-initiating cell using normal B cell-derived iPS cells(和訳中)

    日本血液学会学術集会   83回   PS - 2   2021.9

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  • 発作性夜間ヘモグロビン尿症患者(PNH)に対するラブリズマブ特定使用成績調査の中間解析

    臼杵 憲祐, 池添 隆之, 石山 謙, 神田 善伸, 後藤 明彦, 松田 貴久, 下野 明彦, 秋山 仁泉, 小原 直, 西村 純一

    日本血液学会学術集会   83回   PS - 1   2021.9

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    Language:Japanese  

  • 血液内科医が遭遇する止血検査コンサルテーションへのアプローチ

    池添 隆之

    臨床血液   62 ( 8 )   1195 - 1204   2021.8( ISSN:0485-1439

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  • A Case of Acquired von Willebrand Syndrome Complicated by Acute Myelomonocytic Leukemia.

    Masahiko Fukatsu, Hiroshi Ohkawara, Hiroshi Takahashi, Hirotaka Mori, Mai Yaginuma, Mamiko Endo, Akiko Shichishima-Nakamura, Takahiro Sano, Kayo Harada-Shirado, Satoshi Kimura, Kazuei Ogawa, Yuko Hashimoto, Takayuki Ikezoe

    Case reports in oncology   14 ( 2 )   1152 - 1158   2021.5( ISSN:1662-6575

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    Language:English  

    DOI : 10.1159/000517439

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  • Dasatinib induces endothelial-to-mesenchymal transition in human vascular-endothelial cells: counteracted by cotreatment with bosutinib.

    Lobna Alkebsi, Xintao Wang, Hiroshi Ohkawara, Masahiko Fukatsu, Hirotaka Mori, Takayuki Ikezoe

    International journal of hematology   113 ( 3 )   441 - 455   2021.3( ISSN:0925-5710

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1007/s12185-020-03034-1

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  • Hypofibrinogenemia is associated with a high degree of risk in infectious diseases: a post-hoc analysis of post-marketing surveillance of patients with disseminated intravascular coagulation treated with thrombomodulin alfa.

    Kazuo Kawasugi, Hideo Wada, Goichi Honda, Noriaki Kawano, Toshimasa Uchiyama, Seiji Madoiwa, Naoki Takezako, Kei Suzuki, Yoshinobu Seki, Takayuki Ikezoe, Toshiaki Iba, Kohji Okamoto

    Thrombosis journal   19 ( 1 )   12 - 12   2021.2( ISSN:1477-9560

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1186/s12959-021-00264-z

    PubMed

    PubMed Central

  • 治療法の再整理とアップデートのために 専門家による私の治療 自己免疫性溶血性貧血

    池添 隆之

    日本医事新報   ( 5051 )   37 - 38   2021.2( ISSN:0385-9215

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    Language:Japanese  

  • 臨床に直結するDIC検査学 急性白血病に合併するDICの発症機序

    池添 隆之

    日本検査血液学会雑誌   22 ( 1 )   68 - 75   2021.2( ISSN:1347-2836

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  • Simultaneous silencing Aurora-A and UHRF1 inhibits colorectal cancer cell growth through regulating expression of DNMT1 and STAT1.

    Han J, Chen X, Xu J, Chu L, Li R, Sun N, Jiang Z, Liu H, Ge X, Zheng J, Yang J, Ikezoe T

    International journal of medical sciences   18 ( 15 )   3437 - 3451   2021( ISSN:14491907

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    DOI : 10.7150/ijms.61969

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  • An interim analysis of the relationships between the kinetics of PNH clone size and clinical course in bone marrow failure syndromes-Japanese Multicentre Prospective Study

    補体   58 ( 1 )   50 - 51   2021( ISSN:2188-8205

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    J-GLOBAL

  • Weight Loss Intervention before Cord Blood Transplantation in an Obese Patient with Acute Myeloid Leukemia: A Case Study.

    Ryuichi Kasahara, Takaaki Fujita, Ryohei Jinbo, Tatsuyuki Kai, Yuichi Yamamoto, Shinichiro Morishita, Miki Furukawa, Yutaka Shiga, Hideo Kimura, Masahiko Fukatsu, Kayo Harada, Satoshi Kimura, Takayuki Ikezoe

    Progress in rehabilitation medicine   6   20210018 - 20210018   2021

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  • Targeting HLA-F suppresses the proliferation of glioma cells via a reduction in hexokinase 2-dependent glycolysis.

    Xin Chen, Na Sun, Rongqin Li, Xuejia Sang, Xueqin Li, Jie Zhao, Jing Han, Jing Yang, Takayuki Ikezoe

    International journal of biological sciences   17 ( 5 )   1263 - 1276   2021( ISSN:14492288

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    DOI : 10.7150/ijbs.56357

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  • Inhibition of Aurora-A promotes CD8+ T cell infiltration by mediating IL-10 production in cancer cells

    Han Jing, Jiang Zhen, Wang Chennan, Chen Xin, Li Rongqing, Sun Na, Liu Xiangye, Wang Hui, Hong Li, Zheng Kuiyang, Yang Jing, Ikezoe Takayuki

    Molecular Cancer Research   18 ( 10 )   1589 - 1602   2020.10

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  • Results from multinational phase 3 studies of ravulizumab (ALXN1210) versus eculizumab in adults with paroxysmal nocturnal hemoglobinuria: subgroup analysis of Japanese patients.

    Ishiyama K, Nakao S, Usuki K, Yonemura Y, Ikezoe T, Uchiyama M, Mori Y, Fukuda T, Okada M, Fujiwara SI, Noji H, Rottinghaus S, Aguzzi R, Yokosawa J, Nishimura JI, Kanakura Y, Okamoto S

    International journal of hematology   112 ( 4 )   466 - 476   2020.10( ISSN:0925-5710

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    DOI : 10.1007/s12185-020-02934-6

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  • Severe Antithrombin deficiency may be associated with a high risk of pathological progression of DIC with suppressed fibrinolysis

    Wada Hideo, Honda Goichi, Kawano Noriaki, Uchiyama Toshimasa, Kawasugi Kazuo, Madoiwa Seiji, Takesako Naoki, Suzuki Kei, Seki Yoshinobu, Ikezoe Takayuki, Iba Toshiaki, Okamoto Kohji

    Clinical and Applied Thrombosis/Hemostasis   26   2020.8

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  • DICのエビデンスの再検証 日本血栓止血学会DIC診断基準2017年版の有用性の評価と新規予後予測マーカーの探索

    池添 隆之

    日本血栓止血学会誌   31 ( 2 )   169 - 169   2020.5( ISSN:0915-7441

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  • 同種末梢血造血幹細胞移植後に重篤なPassenger Lymphocyte Syndromeを起こした一例

    力丸 峻也, 高野 希美, 川畑 絹代, 小野 智, 皆川 敬治, 渡邉 万央, 佐々木 睦美, 高橋 沙樹, 奥津 美穂, 安田 広康, 木村 哲, 池添 隆之, 池田 和彦

    日本輸血細胞治療学会誌   66 ( 2 )   386 - 386   2020.5( ISSN:1881-3011

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  • 難治性結節性リンパ球優位型ホジキンリンパ腫に対してrituximab併用化学療法が奏効した1例

    矢澤 里穂, 佐野 隆浩, 高橋 裕志, 大河原 浩, 橋本 優子, 池添 隆之

    臨床血液   61 ( 4 )   419 - 420   2020.4( ISSN:0485-1439

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  • 急性白血病患者にみられる播種性血管内凝固の発症における血中核内蛋白の役割(Circulating intranuclear proteins may play a role in development of disseminated intravascular coagulation in individuals with acute leukemia)

    Harada-Shirado Kayo, Wang Xintao, Mori Hirotaka, Fukatsu Masahiko, Takahashi Hiroshi, Shichishima-Nakamura Akiko, Kimura Satoshi, Ohkawara Hiroshi, Yamada Shingo, Ito Takashi, Ikezoe Takayuki

    International Journal of Hematology   111 ( 3 )   378 - 387   2020.3( ISSN:0925-5710

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  • The link between interleukin-1β and acute myocardial infarction in chronic myeloid leukemia patients treated with nilotinib: cross-sectional study.

    Hirotaka Mori, Masumi Sukegawa, Masahiko Fukatsu, Takahiro Sano, Hiroshi Takahashi, Kayo Harada, Satoshi Kimura, Hiroshi Ohkawara, Kenichi Nakamura, Masayuki Mita, Tomiyoshi Saito, Yoichi Hamazaki, Masatsugu Ohta, Takayuki Ikezoe

    Annals of hematology   99 ( 2 )   359 - 361   2020.2( ISSN:0939-5555

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    DOI : 10.1007/s00277-019-03896-4

    PubMed

  • Analysis of the association between resolution of disseminated intravascular coagulation (DIC) and treatment outcomes in post-marketing surveillance of thrombomodulin alpha for DIC with infectious disease and with hematological malignancy by organ failure.

    Kawano N, Wada H, Uchiyama T, Kawasugi K, Madoiwa S, Takezako N, Suzuki K, Seki Y, Ikezoe T, Hattori T, Okamoto K

    Thrombosis journal   18 ( 1 )   2   2020

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    DOI : 10.1186/s12959-020-0216-6

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  • JAK2 V617F Mutation Promoted IL-6 Production and Glycolysis Mediating PKM1 Stabilization in Macrophages.

    Li R, Sun N, Chen X, Li X, Zhao J, Cheng W, Hua H, Fukatsu M, Mori H, Takahashi H, Ohkawara H, Fukami M, Okamoto M, Hamazaki Y, Zheng K, Yang J, Ikezoe T

    Frontiers in immunology   11   589048   2020

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    DOI : 10.3389/fimmu.2020.589048

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  • 出血傾向の診断と病態に基づく治療

    池添隆之

    日本内科学会雑誌   109 ( 7 )   1337 - 1339   2020

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  • 自己免疫性溶血性貧血

    張替秀郎, 西村純一, 植田康敬, 髙森弘之, 和田秀穂, 亀崎豊実, 川本晋一郎, 池添隆之, 菅野 仁, 大賀正一, 服部幸夫, 山城安啓 金倉 譲

    特発性造血障害疾患の診療の参照ガイド令和元年度改訂版   191 - 229   2020

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  • 発作性夜間ヘモグロビン尿症

    金倉 譲, 二宮治彦, 中熊秀喜, 七島 勉, 川口辰哉, 中尾眞二, 神田善伸, 池添隆之, 後藤明彦, 櫻井政寿, 髙森弘之, 植田康敬, 木下タロウ, 西村純一, 三谷絹子

    特発性造血障害疾患の診療の参照ガイド令和元年度改訂版   137 - 174   2020

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  • Severe Antithrombin Deficiency May be Associated With a High Risk of Pathological Progression of DIC With Suppressed Fibrinolysis

    Wada H., Honda G., Kawano N., Uchiyama T., Kawasugi K., Madoiwa S., Takezako N., Suzuki K., Seki Y., Ikezoe T., Iba T., Okamoto K.

    Clinical and Applied Thrombosis/Hemostasis   26   2020( ISSN:10760296

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    DOI : 10.1177/1076029620941112

  • Treatment of T-Cell Prolymphocytic Leukemia with Central Nervous System Involvement Using Intrathecal Alemtuzumab Administration.

    Jinichi Mori, Kumi Oshima, Satoshi Kimura, Takayuki Ikezoe

    Case reports in hematology   2020   8822172 - 8822172   2020( ISSN:2090-6560

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  • Bortezomib-EPOCH併用療法で奏効が得られた形質芽球性リンパ腫の1例

    森 博隆, 深津 真彦, 原田 佳代, 木村 哲, 佐野 隆浩, 高橋 裕志, 大河原 浩, 池添 隆之, 喜古 雄一郎

    臨床血液   60 ( 11 )   1594 - 1594   2019.11( ISSN:0485-1439

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  • Introduction of Chromosomal Translocation t(11;14) and a p53 Deletion into Normal B Cell-Derived iPSCs to Elucidate the Cellular Origin of Myeloma Cells

    Aki Yanagi, Naohiro Tsuyama, Misaki Sugai, Yu Abe, Yusuke Azami, Yukari Yanai, Akinobu Ota, Karnan Sivasundaram, Moe Muramatsu, Tomonari Shigemura, Megumi Sasatani, Yuko Hashimoto, Kenji Kamiya, Ichiro Hanamura, Takayuki Ikezoe, Masafumi Onodera, Akira Sakai

    BLOOD   134   2019.11( ISSN:0006-4971

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    DOI : 10.1182/blood-2019-122344

  • 2019 international clinical practice guidelines for the treatment and prophylaxis of venous thromboembolism in patients with cancer.

    Dominique Farge, Corinne Frere, Jean M Connors, Cihan Ay, Alok A Khorana, Andres Munoz, Benjamin Brenner, Ajay Kakkar, Hanadi Rafii, Susan Solymoss, Dialina Brilhante, Manuel Monreal, Henri Bounameaux, Ingrid Pabinger, James Douketis, International Initiative on Thrombosis and Cancer (ITAC)advisory panel, Walter Ageno, Fernando Ajauro, Kamal R. Al-Aboudi, Thierry Alcindor, Thierry Andre, Pantep Angchaisuksiri, Darko Antic, Juan I. Arcelus, Eric Assenat, Kenneth A. Bauer, Ali Bazarbachii, Ilham Benzidia, Jan BeyerWestendorf, Viktoria Bitsadze, Dorit Blickstein, Mark Blostein, Isabel Bogalho, Barbara Bournet, Patricia Casais, Antoine F. Carpentier, Gabriela CesarmanMaus, Joydeep Chakbrabartty, Hugo Clemente, Jérôme Connault, Ludovic Doucet, Cécile Durant, Joseph Emmerich, Anna Falanga, Clemens Feistritzer, Carme Font, Charles Francis, Enrique Gallardo, Thomas Gary, Jean-Christophe Gris, Cecilia Guillermo, Adrian Hij, Russel D. Hull, Takayuki Ikezoe, Luis Jara-Palomares, Nigel S. Key, Jamilya Khrizroeva, Maral Koolian, Florian Langer, Claire Le Hello, Ramón Lecumberri, Lai Heng Lee, Howard Liebman, Luisa Lopes Dos Santos, Duarte Henrique Machado, Isabelle Madelaine, Alexander Makatsariya, Mario Mandala, Anthony Marayevas, Zora Marjanovic, Christine Marosi, Ellis Martin, Luis Meillon, Emmanuel Messas, Antonio Moreira, Ahmet M. Demir, Arlette Ndour, Michel Nguessan, Remedios Otero-Candelera, Vanessa Pachon Olmos, Ana Pais, Florian Posch, Matthias Preusser, Hanno Riess, Marc Righini, Cynthia Rothschild, Andre Roussin, José Antonio Rueda-Camino, Pedro Ruiz-Artacho, Sanjith Saseedharan, Ali Shamseddine, Gerald Soff, Hans Stricker, Vicky Tagalakis, Ali Taher, Toutou Toussaint, Javier Trujillo-Santos, Stéphane Villiers, Raymond Wong, Norizaku Yamada

    The Lancet Oncology   20 ( 10 )   e566 - e588   2019.10

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    DOI : 10.1016/S1470-2045(19)30336-5.

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  • 211At標識抗CXCR4抗体の腫瘍移植マウスにおける体内分布

    織内 昇, 趙 松吉, 粟生木 美穂, 譚 成博, 右近 直之, 西嶋 剣一, 鷲山 幸信, 高橋 和弘, 池添 隆之, 伊藤 浩

    核医学   56 ( Suppl. )   S149 - S149   2019.10( ISSN:0022-7854

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  • ガイドライン ここがポイント! 造血細胞移植ガイドラインSOS/TA-TMA

    池添 隆之

    Thrombosis Medicine   9 ( 3 )   256 - 261   2019.9( ISSN:2186-0327

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  • 治療法の再整理とアップデートのために 専門家による私の治療 播種性血管内凝固(DIC)

    池添 隆之

    日本医事新報   ( 4966 )   49 - 49   2019.6( ISSN:0385-9215

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  • 同種末梢血造血幹細胞移植後にPassenger Lymphocyte Syndromeを起こした1例

    力丸 峻也, 高野 希美, 川畑 絹代, 小野 智, 皆川 敬治, 渡邉 万央, 鈴木 裕恵, 佐々木 睦美, 高橋 沙樹, 安田 広康, 木村 哲, 池添 隆之, 池田 和彦

    日本輸血細胞治療学会誌   65 ( 3 )   666 - 667   2019.6( ISSN:1881-3011

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  • 治療法の再整理とアップデートのために 専門家による私の治療 播種性血管内凝固(DIC)

    池添 隆之

    日本医事新報   ( 4966 )   49 - 49   2019.6( ISSN:0385-9215

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  • 新しいDIC診療ガイドライン作成への問題点 造血器腫瘍に合併したDICおける基本的な考え

    池添 隆之

    日本血栓止血学会誌   30 ( 2 )   346 - 346   2019.5( ISSN:0915-7441

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  • 腫瘍崩壊症候群にDICを合併し、核内タンパクのHMGB-1やhistone H3が高値を示した急性白血病症例についての検討

    原田 佳代, 王 新涛, 深津 真彦, 高橋 裕志, 七島 晶子, 木村 哲, 大河原 浩, 山田 晋吾, 伊藤 隆史, 池添 隆之

    日本血栓止血学会誌   30 ( 2 )   406 - 406   2019.5( ISSN:0915-7441

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  • Attempt to elucidate the mechanism of development of multiple myeloma using iPS cells derived from normal B cells

    International Journal of Myeloma   9 ( 1 )   82 - 82   2019.5

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  • プレリキサホル投与とアフェレーシス可否の決定における採取前日の末梢血中CD34陽性細胞数測定

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    日本輸血細胞治療学会誌   65 ( 2 )   349 - 349   2019.4( ISSN:1881-3011

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  • 献腎移植後に発症した治療抵抗性移植後リンパ増殖性疾患の1例

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    福島医学雑誌   69 ( 1 )   110 - 110   2019.4( ISSN:0016-2582

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  • 末梢血幹細胞移植により寛解を得られている骨髄異形成症候群とベーチェット病の1例

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    臨床血液   60 ( 4 )   337 - 337   2019.4( ISSN:0485-1439

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  • 同種骨髄移植後の再発時に多発髄外浸潤を呈した急性骨髄性白血病の1例

    深津 真彦, 金澤 晃子, 柳田 拓実, 木村 悟, 斎藤 由理恵, 松田 信, 小田島 肇, 池添 隆之, 神林 裕行

    臨床血液   60 ( 4 )   332 - 332   2019.4( ISSN:0485-1439

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  • 造血器腫瘍と免疫・凝固系 第4回 造血幹細胞移植後の免疫凝固異常

    大河原 浩, 池添 隆之

    Thrombosis Medicine   9 ( 1 )   60 - 66   2019.3( ISSN:2186-0327

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  • オーバービュー

    池添 隆之

    臨床血液   60 ( 6 )   646 - 646   2019( ISSN:0485-1439

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    DOI : 10.11406/rinketsu.60.646

  • Lenalidomide as a Beneficial Treatment Option for Renal Impairment Caused by Light Chain Deposition Disease.

    Kimura S, Ohkawara H, Ogawa K, Tanaka M, Sano T, Harada-Shirado K, Takahashi H, Ueda K, Shichishima-Nakamura A, Matsumoto H, Ikeda K, Kazama JJ, Hashimoto Y, Ikezoe T

    Internal medicine (Tokyo, Japan)   57 ( 24 )   3651 - 3657   2018.12( ISSN:0918-2918

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    DOI : 10.2169/internalmedicine.1018-18

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  • miR-217 sensitizes chronic myelogenous leukemia cells to tyrosine kinase inhibitors by targeting pro-oncogenic anterior gradient 2.

    Pan B, Yang J, Wang X, Xu K, Ikezoe T

    Experimental hematology   68   80 - 88.e2   2018.12( ISSN:0301-472X

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    DOI : 10.1016/j.exphem.2018.09.001

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  • TM由来変異ペプチドによる血管内皮細胞保護薬の開発

    池添 隆之

    上原記念生命科学財団研究報告集   32   1 - 5   2018.12

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  • 【高齢者の非腫瘍性血液疾患】高齢者の凝固異常症

    原田 佳代, 池添 隆之

    血液フロンティア   29 ( 1 )   71 - 79   2018.12( ISSN:1344-6940

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  • Lenalidomide as a Beneficial Treatment Option for Renal Impairment Caused by Light Chain Deposition Disease

    Kimura Satoshi, Ohkawara Hiroshi, Ogawa Kazuei, Tanaka Mizuko, Sano Takahiro, Harada-Shirado Kayo, Takahashi Hiroshi, Ueda Koki, Shichishima-Nakamura Akiko, Matsumoto Hayato, Ikeda Kazuhiko, Kazama Junichiro James, Hashimoto Yuko, Ikezoe Takayuki

    Internal Medicine   57 ( 24 )   3651 - 3657   2018.12( ISSN:0918-2918

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  • 【徹底ガイド DICのすべて 2019-20】(X章)類似病態、鑑別すべき病態 SOS(類洞閉塞症候群)とTLS(腫瘍崩壊症候群)

    池添 隆之

    救急・集中治療   30 ( 臨増 )   441 - 448   2018.11( ISSN:1346-0935

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  • 【徹底ガイド DICのすべて 2019-20】(IX章)治療薬 可溶性トロンボモジュリン(内科)

    池添 隆之

    救急・集中治療   30 ( 臨増 )   372 - 377   2018.11( ISSN:1346-0935

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  • Independent Paroxysmal Nocturnal Hemoglobinuria and Myelodysplastic Syndrome Clones in a Patient With Complete Bone Marrow Failure.

    Mita M, Shichishima T, Noji H, Takahashi H, Nakamura KI, Ikezoe T

    HemaSphere   2 ( 5 )   e142   2018.10

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    DOI : 10.1097/HS9.0000000000000142

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  • Cytoprotective and pro-angiogenic functions of thrombomodulin are preserved in the C loop of the fifth epidermal growth factor-like domain.

    Wang X, Pan B, Honda G, Wang X, Hashimoto Y, Ohkawara H, Xu K, Zeng L, Ikezoe T

    Haematologica   103 ( 10 )   1730 - 1740   2018.10( ISSN:0390-6078

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    DOI : 10.3324/haematol.2017.184481

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  • 【血小板減少症の病態と治療】DICと血小板減少

    原田 佳代, 池添 隆之

    Thrombosis Medicine   8 ( 3 )   185 - 193   2018.9( ISSN:2186-0327

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  • 私のこの一枚 多発髄外浸潤を伴って再発した急性骨髄性白血病

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    血液フロンティア   28 ( 10 )   1425 - 1428   2018.9( ISSN:1344-6940

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  • Attempt to make abnormal B lymphocytes as myeloma-initiating cells from B-iPSCs

    59 ( 9 )   1695 - 1695   2018.9( ISSN:0485-1439

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  • Analysis of myeloproliferative neoplasm hematopoiesis with knock-in mice with Calr mutants

    59 ( 9 )   1612 - 1612   2018.9( ISSN:0485-1439

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  • 気管に限局して発症し気管閉塞を来たした節外性NK/T細胞リンパ腫、鼻型

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    臨床血液   59 ( 8 )   1012 - 1015   2018.8( ISSN:0485-1439

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  • Correction to: Effects of eculizumab treatment on quality of life in patients with paroxysmal nocturnal hemoglobinuria in Japan.

    Ueda Y, Obara N, Yonemura Y, Noji H, Masuko M, Seki Y, Wada K, Matsuda T, Akiyama H, Ikezoe T, Chiba S, Kanda Y, Kawaguchi T, Shichishima T, Nakakuma H, Okamoto S, Nishimura JI, Kanakura Y, Ninomiya H

    International journal of hematology   108 ( 2 )   233 - 235   2018.8( ISSN:0925-5710

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    DOI : 10.1007/s12185-018-2486-3

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  • 【血液疾患を見逃さないために-プライマリ・ケアと専門医コンサルトのタイミング】さまざまな症候・画像所見の診かた・考え方と紹介のタイミング 出血傾向・血栓傾向

    原田 佳代, 池添 隆之

    Medicina   55 ( 8 )   1218 - 1221   2018.7( ISSN:0025-7699

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  • 【出血性疾患と血栓性疾患 これを読めば貴方も二刀流】治療 出血性・血栓性疾患の治療update 播種性血管内凝固症候群(DIC)の治療

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    Medical Practice   35 ( 7 )   1117 - 1121   2018.7( ISSN:0910-1551

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  • 補体を治療ターゲットにすることの意義

    二宮 治彦, 池添 隆之, 稲城 玲子, 川口 辰哉, 木下 タロウ, 西村 純一

    PNH Frontier   ( 5 )   4 - 13   2018.6( ISSN:2188-4552

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  • Effects of eculizumab treatment on quality of life in patients with paroxysmal nocturnal hemoglobinuria in Japan

    Ueda Yasutaka, Obara Naoshi, Yonemura Yuji, Noji Hideyoshi, Masuko Masayoshi, Seki Yoshinobu, Wada Katsuya, Matsuda Takahisa, Akiyama Hirozumi, Ikezoe Takayuki, Chiba Shigeru, Kanda Yoshinobu, Kawaguchi Tatsuya, Shichishima Tsutomu, Nakakuma Hideki, Okamoto Shinichiro, Nishimura Jun-ichi, Kanakura Yuzuru, Ninomiya Haruhiko

    International Journal of Hematology   107 ( 6 )   656 - 665   2018.6( ISSN:0925-5710

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  • 【血管内皮細胞機能を再考する】 血管内皮細胞機能の保護作用が期待される薬剤

    池添 隆之

    Thrombosis Medicine   8 ( 1 )   45 - 51   2018.3( ISSN:2186-0327

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  • 福島医大での造血細胞移植の実際と今後の取り組み

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    福島県農村医学会雑誌   58 ( 1 )   1 - 3   2018.3( ISSN:0911-9426

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  • Effects of eculizumab treatment on quality of life in patients with paroxysmal nocturnal hemoglobinuria in Japan.

    Ueda Y, Obara N, Yonemura Y, Noji H, Masuko M, Seki Y, Wada K, Matsuda T, Akiyama H, Ikezoe T, Chiba S, Kanda Y, Kawaguchi T, Shichishima T, Nakakuma H, Okamoto S, Nishimura JI, Kanakura Y, Ninomiya H

    International journal of hematology   1 - 10   2018.1( ISSN:0925-5710

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    DOI : 10.1007/s12185-018-2409-3

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  • Defibrotide Stimulates Angiogenesis and Protects Endothelial Cells from Calcineurin Inhibitor-Induced Apoptosis via Upregulation of AKT/Bcl-xL.

    Wang X, Pan B, Hashimoto Y, Ohkawara H, Xu K, Zeng L, Ikezoe T

    Thrombosis and haemostasis   118 ( 1 )   161 - 173   2018.1( ISSN:0340-6245

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    DOI : 10.1160/TH17-04-0275

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  • Cytoprotective and pro-angiogenic functions of thrombomodulin are preserved in the C loop of the fifth epidermal growth factor-like domain

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    Haematologica   103 ( (10) )   1730 - 1740   2018

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  • miR-217 sensitizes chronic myelogenous leukemia cells to tyrosine kinase inhibitors by targeting pro-oncogenic anterior gradient 2

    Bin Pan, Jing Yang, Xiangmin Wang, Kailin Xu, Takayuki Ikezoe

    Experimental Hematology   68   80 - 88   2018

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  • Lenalidomide as a beneficial treatment option for renal impairment caused by light chain deposition disease

    Satoshi Kimura, Hiroshi Ohkawara, Kazuei Ogawa, Mizuko Tanaka, Takahiro Sano, Kayo Harada-Shirado, Hiroshi Takahashi, Koki Ueda, Akiko Shichishima-Nakamura, Hayato Matsumoto, kazuhiko Ikeda, Junichiro James Kazama, Yuko Hashimoto, Takayuki Ikezoe

    Internal Medicine   15 ( (24) )   3651 - 3657   2018

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  • Airway obstruction due to localized tracheal lesion of extranodal NK/T-cell lymphoma, nasal type

    TAKAHASHI Hiroshi, HASHIMOTO Yuko, OGAWA Kazuei, IKEZOE Takayuki, OHKAWARA Hiroshi, SHICHISHIMA-NAKAMURA Akiko, FUKATSU Masahiko, SANO Takahiro, HARADA-SHIRADO Kayo, KIMURA Satoshi, TOGAWA Ryuichi, TASAKI Kazuhiro

    Rinsho Ketsueki   59 ( 8 )   1012 - 1015   2018( ISSN:0485-1439

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    DOI : 10.11406/rinketsu.59.1012

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  • In vitro studies on the role of recombinant human soluble thrombomodulin in the context of retinoic acid mediated APL differentiation syndrome

    Kojima S., Nishioka C., Chi S., Yokoyama A., Ikezoe T.

    Leukemia Research   63   1 - 9   2017.12( ISSN:01452126

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    DOI : 10.1016/j.leukres.2017.10.003

  • In vitro studies on the role of recombinant human soluble thrombomodulin in the context of retinoic acid mediated APL differentiation syndrome

    Shinsuke Kojima, Chie Nishioka, SungGi Chi, Akihito Yokoyama, Takayuki Ikezoe

    Leukemia Research   63   1 - 9   2017.12

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  • The BCR/ABL tyrosine kinase inhibitor, nilotinib, stimulates expression of IL-1β in vascular endothelium in association with downregulation of miR-3p

    Masumi Sukegawa, Xiangmin Wang, Chie Nishioka, Bin Pan, Kailin Xu, Hiroshi Ohkawara, Yoichi Hamasaki, Masayuki Mita, Kenichi Nakamura, Masatoshi Okamoto, Hiromi Shimura, Masatsugu Ohta, Takayuki Ikezoe

    Leukemia Research   58   83 - 90   2017.11

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  • Steroid-resistant autoimmune myelofibrosis in a patient with autoimmune hepatitis and Evans syndrome complicated with increased expression of TGF-β in the bone marrow: a case report

    Hiroshi Ohkawara, Miki Furukawa, Kazuhiko Ikeda, Akiko Shichishima-Nakamura, Masahiko Fukatsu, Takahiro Sano, Koki Ueda, Satoshi Kimura, Risa Kanai, Yuka Oka, Fumi Murakami, Osamu Suzuki, Yuko Hashimoto, Kazuei Ogawa, Takayuki Ikezoe

    International Journal of Hematology   106 ( 5 )   718 - 724   2017.11

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  • Romidepsin in Japanese patients with relapsed or refractory peripheral T-cell lymphoma: a phase Ⅰ/Ⅱ and pharmacokinetics study

    Dai Maruyama, Kensei Tobinai, Michinori Ogura, Toshiki Uchida, Kiyohiko Hatake, Masafumi Taniwaki, Kiyoshi Ando, Kunihiro Tsukasaki, Takashi Isida, Naoki Kobayashi, Kenichi Ishizawa, Yoichi Tatsumi, Koji Kato, Toru Kiguchi, Takayuki Ikezoe, Eric Laille, Tokihiro Ro, Hiromi Tamakoshi, Sanae Sakurai, Tomoko Ohtsu

    International Journal of Hematology   106 ( 5 )   655 - 665   2017.11

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  • Romidepsin in Japanese patients with relapsed or refractory peripheral T-cell lymphoma: a phase I/II and pharmacokinetics study(和訳中)

    Maruyama Dai, Tobinai Kensei, Ogura Michinori, Uchida Toshiki, Hatake Kiyohiko, Taniwaki Masafumi, Ando Kiyoshi, Tsukasaki Kunihiro, Ishida Takashi, Kobayashi Naoki, Ishizawa Kenichi, Tatsumi Yoichi, Kato Koji, Kiguchi Toru, Ikezoe Takayuki, Laille Eric, Ro Tokihiro, Tamakoshi Hiromi, Sakurai Sanae, Ohtsu Tomoko

    International Journal of Hematology   106 ( 5 )   655 - 665   2017.11( ISSN:0925-5710

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  • Steroid-resistant autoimmune myelofibrosis in a patient with autoimmune hepatitis and Evans syndrome complicated with increased expression of TGF-β in the bone marrow: a case report.

    Ohkawara H, Furukawa M, Ikeda K, Shichishima-Nakamura A, Fukatsu M, Sano T, Ueda K, Kimura S, Kanai R, Oka Y, Murakami F, Suzuki O, Hashimoto Y, Ogawa K, Ikezoe T

    International journal of hematology   106 ( 5 )   718 - 724   2017.11( ISSN:0925-5710

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    DOI : 10.1007/s12185-017-2268-3

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  • Steroid-resistant autoimmune myelofibrosis in a patient with autoimmune hepatitis and Evans syndrome complicated with increased expression of TGF-β in the bone marrow: a case report(和訳中)

    Ohkawara Hiroshi, Furukawa Miki, Ikeda Kazuhiko, Shichishima-Nakamura Akiko, Fukatsu Masahiko, Sano Takahiro, Ueda Koki, Kimura Satoshi, Kanai Risa, Oka Yuka, Murakami Fumi, Suzuki Osamu, Hashimoto Yuko, Ogawa Kazuei, Ikezoe Takayuki

    International Journal of Hematology   106 ( 5 )   718 - 724   2017.11( ISSN:0925-5710

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  • Romidepsin in Japanese patients with relapsed or refractory peripheral T-cell lymphoma: a phase I/II and pharmacokinetics study.

    Maruyama D, Tobinai K, Ogura M, Uchida T, Hatake K, Taniwaki M, Ando K, Tsukasaki K, Ishida T, Kobayashi N, Ishizawa K, Tatsumi Y, Kato K, Kiguchi T, Ikezoe T, Laille E, Ro T, Tamakoshi H, Sakurai S, Ohtsu T

    International journal of hematology   106 ( 5 )   655 - 665   2017.11( ISSN:0925-5710

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    DOI : 10.1007/s12185-017-2286-1

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  • Correction: Inhibition of IRE1α-driven pro-survival pathways is a promising therapeutic application in acute myeloid leukemia.

    Haibo Sun, De-Chen Lin, Xiao Guo, Behzad Kharabi Masouleh, Sigal Gery, Qi Cao, Serhan Alkan, Takayuki Ikezoe, Chie Akiba, Ronald Paquette, Wenwen Chien, Carsten Müller-Tidow, Yang Jing, Konstantin Agelopoulos, Markus Müschen, H Phillip Koeffler

    Oncotarget   8 ( 38 )   64651 - 64651   2017.9

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    DOI : 10.18632/oncotarget.20707

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  • The amelioration of myelofibrosis with thrombocytopenia by a JAK1/2 inhibitor, ruxolitinib, in a post-polycythemia vera myelofibrosis patient with a JAK2 Exon 12 mutation

    Ikeda Kazuhiko, Ueda Koki, Sano Takahiro, Ogawa Kazuei, Ikezoe Takayuki, Hashimoto Yuko, Morishita Soji, Komatsu Norio, Ohto Hitoshi, Takeishi Yasuchika

    Internal Medicine   56 ( 13 )   1705 - 1710   2017.7

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    DOI : 10.2169/internalmedicine.56.7871

  • The BCR/ABL tyrosine kinase inhibitor, nilotinib, stimulates expression of IL-1β in vascular endothelium in association with downregulation of miR-3p.

    Sukegawa M, Wang X, Nishioka C, Pan B, Xu K, Ohkawara H, Hamasaki Y, Mita M, Nakamura K, Okamoto M, Shimura H, Ohta M, Ikezoe T

    Leukemia research   58   83 - 90   2017.7( ISSN:0145-2126

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    DOI : 10.1016/j.leukres.2017.05.005

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  • The Amelioration of Myelofibrosis with Thrombocytopenia by a JAK1/2 Inhibitor, Ruxolitinib, in a Post-polycythemia Vera Myelofibrosis Patient with a JAK2 Exon 12 Mutation

    Ikeda Kazuhiko, Ueda Koki, Sano Takahiro, Ogawa Kazuei, Ikezoe Takayuki, Hashimoto Yuko, Morishita Soji, Komatsu Norio, Ohto Hitoshi, Takeishi Yasuchika

    Internal Medicine   56 ( 13 )   1705 - 1710   2017.7( ISSN:0918-2918

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  • Hmga2 collaborates with <i>JAK2</i>V617F in the development of myeloproliferative neoplasms.

    Ueda K, Ikeda K, Ikezoe T, Harada-Shirado K, Ogawa K, Hashimoto Y, Sano T, Ohkawara H, Kimura S, Shichishima-Nakamura A, Nakamura Y, Shikama Y, Mori T, Mason PJ, Bessler M, Morishita S, Komatsu N, Shide K, Shimoda K, Koide S, Aoyama K, Oshima M, Iwama A, Takeishi Y

    Blood advances   1 ( 15 )   1001 - 1015   2017.6( ISSN:2473-9529

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    DOI : 10.1182/bloodadvances.2017004457

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  • Hmga2 collaborates with JAK2V617F in the development of myeloproliferative neoplasms

    Koki Ueda, Kazuhiko Ikeda, Takayuki Ikezoe, Kayo Harada-Shirado, Kazuei Ogawa, Yuko Hashimoto, Takahiro Sano, Hiroshi Ohkawara, Satoshi Kimura, Akiko Shichishima-Nakamura, Yuichi Nakamura, Yayoi Shikama, Tsutomu Mori, Philip J. Mason, Monica Bessler, Soji Morishita, Norio Komatsu, Kotaro Shide, Kazuya Shimoda, Shuhei Koide, Kazumasa Aoyama, Motohiko Oshima, Atsushi Iwama, Yasuchika Takeishi

    blood advances   1 ( 15 )   1001 - 1015   2017.6

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  • A possible role of low regulatory T cells in anti-acetylcholine receptor antibody positive myasthenia gravis after bone marrow transplantation.

    Fukatsu M, Murakami T, Ohkawara H, Saito S, Ikeda K, Kadowaki S, Sasaki I, Segawa M, Soeda T, Hoshi A, Takahashi H, Shichishima-Nakamura A, Ogawa K, Sugiura Y, Ohto H, Takeishi Y, Ikezoe T, Ugawa Y

    BMC neurology   17 ( 1 )   93   2017.5

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    DOI : 10.1186/s12883-017-0881-7

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  • The Fifth Epidermal Growth Factor-like Region of Thrombomodulin Alleviates Murine Graft-versus-Host Disease in a G-Protein Coupled Receptor 15 Dependent Manner

    Bin Pan, Xiangmin Wang, Shinsuke Kojima, Akihito Yokoyama, Goichi Honda, Kaikin Xu, Takayuki Ikezoe

    Biology of Blood and Marrow Transplantation   23 ( 5 )   746 - 756   2017.5

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  • The Fifth Epidermal Growth Factor-like Region of Thrombomodulin Alleviates Murine Graft-versus-Host Disease in a G-Protein Coupled Receptor 15 Dependent Manner.

    Pan B, Wang X, Kojima S, Nishioka C, Yokoyama A, Honda G, Xu K, Ikezoe T

    Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation   23 ( 5 )   746 - 756   2017.5( ISSN:1083-8791

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    DOI : 10.1016/j.bbmt.2017.02.001

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  • G-protein coupled receptor 15 mediates angiogenesis and cytoprotective function of thrombomodulin.

    Pan B, Wang X, Nishioka C, Honda G, Yokoyama A, Zeng L, Xu K, Ikezoe T

    Scientific reports   7 ( 1 )   692   2017.4

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    DOI : 10.1038/s41598-017-00781-w

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  • MicroRNA-9 plays a role in interleukin-10-mediated expression of E-cadherin in acute myelogenous leukemia cells

    Chie Nishioka, Takayuki Ikezoe, Bin Pan, Kaikin Xu, Akihito Yokoyama

    Cancer Science   108 ( 4 )   685 - 695   2017.4

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  • G-protein coupled receptor 15 mediates angiogenesis and cytoprotective function of thrombomodulin

    Bin Pan, Xiangmin Wang, Chie Nishioka, Goichi Honda, Akihito Yokoyama, Lingyu Zeng, Kailin Xu, Takayuki Ikezoe

    Scientific Reports   7 ( 1 )   692   2017.4

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  • MicroRNA-9 plays a role in interleukin-10-mediated expression of E-cadherin in acute myelogenous leukemia cells

    Nishioka Chie, Ikezoe Takayuki, Pan Bin, Xu Kailin, Yokoyama Akihito

    Cancer Science   108 ( 4 )   685 - 695   2017.4( ISSN:1347-9032

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  • MicroRNA-9 plays a role in interleukin-10-mediated expression of E-cadherin in acute myelogenous leukemia cells.

    Nishioka C, Ikezoe T, Pan B, Xu K, Yokoyama A

    Cancer science   108 ( 4 )   685 - 695   2017.4( ISSN:1347-9032

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    DOI : 10.1111/cas.13170

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  • Autocrine and Paracrine Interactions between Multiple Myeloma Cells and Bone Marrow Stromal Cells by Growth Arrest-specific Gene 6 Cross-talk with Interleukin-6.

    Furukawa M, Ohkawara H, Ogawa K, Ikeda K, Ueda K, Shichishima-Nakamura A, Ito E, Imai JI, Yanagisawa Y, Honma R, Watanabe S, Waguri S, Ikezoe T, Takeishi Y

    The Journal of biological chemistry   292 ( 10 )   4280 - 4292   2017.3( ISSN:0021-9258

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    DOI : 10.1074/jbc.M116.733030

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  • Diagnosis and relapse: cytogenetically normal acute myelogenous leukemia without FLT3-ITD or MLL-PTD

    W Chien, QY Sun, LW Ding, A Mayakonda, S Takao, L Liu, SL Lim, KT Tan, M Garg, A De Sousa Maria Varela, J Xiao, N Jacob, K Behrens, C Stocking, M Lill, V Madan, N Hattori, S Gery, S Ogawa, S Wakita, Takayuki Ikezoe, LY Shin, T Alpermann, T Haferlach, H Yang, HP Koeffler

    Leukemia   31 ( 3 )   762 - 766   2017.3

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  • Autocrine and paracrine interactions between multiple myeloma cells and bone marrow stromal cells by growth arrest-specific gene 6 cross-talk with interleukin-6

    Miki Furukawa, Hiroshi Ohkawara, Kazuei Ogawa, Kazuhiko Ikeda, Koki Ueda, Akiko Shichishima-Nakamura, Emi Ito, Jun-ichi Imai, Yuka Yanagisawa, Reiko Honma, Shinya Watanabe, Satoshi Waguri, Takayuki Ikezoe, Yasuchika Takeishi

    Journal of Biological Chemistry   292 ( 10 )   4280 - 4292   2017.3

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  • The fifth epidermal growth factor like region of thrombomodulin alleviates LPS-induced sepsis through interacting with GPR15.

    Pan B, Wang X, Kojima S, Nishioka C, Yokoyama A, Honda G, Xu K, Ikezoe T

    Thrombosis and haemostasis   117 ( 3 )   570 - 579   2017.2( ISSN:0340-6245

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    DOI : 10.1160/TH16-10-0762

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  • Thrombomodulin blocks calcineurin inhibitor-induced vascular permeability via inhibition of Src/VE-cadherin axis

    Ikezoe T., Yang J., Nishioka C., Umezawa K., Yokoyama A.

    Bone Marrow Transplantation   52 ( 2 )   245 - 251   2017.2( ISSN:02683369

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    DOI : 10.1038/bmt.2016.241

  • The fifth epidermal growth factor like region of thrombomodulin alleviates LPS-induced sepsis through interacting with GPR15

    Bin Pan, Xiangmin Wang, Shinsuke Kojima, Chie Nishioka, Akihito Yokoyama, Goichi Honda, Kailin Xu, Takayuki Ikezoe

    Thrombosis and Haemostasis   117 ( 3 )   570 - 579   2017.2

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  • Thrombomodulin blocks calcineurin inhibitor-induced vascular permeability via inhibition of Src/VE-cadherin axis

    Takayuki Ikezoe, J Yang, C Nishioka, K Umezawa, A Yokoyama

    Bone Marrow Transplantation   52 ( 2 )   245 - 251   2017.2

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  • Mutational profiling of a MonoMAC syndrome family with GATA2 deficiency

    Ding L., Ikezoe T., Tan K., Mori M., Mayakonda A., Chien W., Lin D., Jiang Y., Lill M., Yang H., Sun Q., Koeffler H.

    Leukemia   31 ( 1 )   244 - 245   2017.1( ISSN:08876924

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    DOI : 10.1038/leu.2016.256

  • The fifth epidermal growth factor-like region of thrombomodulin exerts cytoprotective function and prevents SOS in a murine model

    Ikezoe T., Yang J., Nishioka C., Pan B., Xu K., Furihata M., Nakamura K., Yurimoto H., Sakai Y., Honda G., Yokoyama A.

    Bone Marrow Transplantation   52 ( 1 )   73 - 79   2017.1( ISSN:02683369

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    DOI : 10.1038/bmt.2016.195

  • The fifth epidermal growth factor-like region of thrombomodulin exerts cytoprotective function and prevents SOS in a murine model

    Takayuki Ikezoe, J Yang, C Nishioka, B Pan, K Xu, M Furihata, K Nakamura, H Yurimoto, Y Sakai, G Honda, A Yokoyama

    Bone Marrow Transplantation   52 ( 1 )   73 - 79   2017.1

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  • Mutational profiling of a MonoMAC syndrome family with GATA2 deficiency

    Ling-Wen Ding, Takayuki Ikezoe, Kar-Tong Tan, Masakazu Mori, Anand Mayakonda, Wenwen Chien, De-Chen Lin, Yan-Yi Jiang, Michael Lill, Henry Yang, Qiao-Yang Sun, H. Phillip Koeffler

    Leukemia   31 ( 1 )   244 - 245   2017.1

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  • A possible role of low regulatory T cells in anti-acetylcholine receptor antibody positive myasthenia gravis after bone marrow transplantation

    Masahiko Fukatsu, Takenobu Murakami, Hiroshi Ohkawara, Shunichi Saito, Kazuhiko Ikeda, Suguru Kadowaki, Itaru Sasaki, Mari Segawa, Tomoko Soeda, Akihiko Hoshi, Hiroshi Takahashi, Akiko Shichishima-Nakamura, Kazuei Ogawa, Yoshihiro Sugita, Hitoshi Ohto, Yasuchika Takeishi, Takayuki Ikezoe, Yoshikazu Ugawa

    BMC Neurology   17 ( 1 )   93   2017

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  • オーバービュー

    池添 隆之

    臨床血液   58 ( 5 )   514 - 515   2017( ISSN:0485-1439

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    DOI : 10.11406/rinketsu.58.514

  • Ⅷ.特論 白血病治療標的としてのshugoshin 1

    池添隆之

    日本臨床   74 ( 10 )   557 - 560   2016.12

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  • 【白血病学(下)-最新の基礎、臨床研究-】 白血病治療標的としてのshugoshin 1

    池添 隆之

    日本臨床   74 ( 増刊10 白血病学(下) )   557 - 560   2016.12( ISSN:0047-1852

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  • 【造血器腫瘍のゲノム/エピゲノム解析研究と免疫/分子標的療法の進歩】 MDSのゲノム/エピゲノム解析研究と治療の進歩

    植田 航希, 池添 隆之

    血液内科   73 ( 5 )   571 - 579   2016.11( ISSN:2185-582X

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  • 造血器腫瘍に合併するDICの診断・管理

    池添 隆之

    臨床血液   57 ( 10 )   2136 - 2144   2016.10( ISSN:0485-1439

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  • Digital necrosis associated with chronic cold haemagglutinin disease

    Masakazu Mori, Takayuki Ikezoe, Yu Arakawa, Akihito Yokoyama

    British Journal of Haematology   174 ( 3 )   343   2016.8

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    DOI : 10.1111/bjh.14169

  • BCR/ABL increases EZH2 levels which regulates XIAP expression via miRNA-219 in chronic myeloid leukemia cells

    NISHIOKA, Chie; IKEZOE, Takayuki*; YANG, Jing; YOKOYAMA, Akihito

    Leukemia Research   45   24 - 32   2016.6

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    DOI : 10.1016/j.leukres.2016.03.012

  • 診断に難渋した悪性腫瘍に伴う乳酸アシドーシスの1例

    田村 恵理, 谷口 義典, 西山 充, 矢田部 智昭, 井上 紘輔, 荒川 悠, 森 正和, 池添 隆之, 寺田 典生, 藤本 新平

    日本内科学会雑誌   105 ( 6 )   1041 - 1048   2016.6( ISSN:0021-5384

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  • GPR15はTMの血管内皮細胞生存シグナルを細胞内に伝達する

    池添 隆之, 西岡 千恵, Yang Jing, Pan Bin, 本田 剛一, 横山 彰仁

    日本血栓止血学会誌   27 ( 2 )   234 - 234   2016.5( ISSN:0915-7441

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  • Inhibition of IRE1α-driven pro-survival pathways is a promising therapeutic application in acute myeloid leukemia

    Haibo Sun, De-Chen Lin, Xiao Guo, Behzad Kharabi Masouleh, Sigal Gery, Qi Cao, Serhan Alkan, Takayuki Ikezoe, Chie Akiba, Ronald Paquette, Wenwen Chien, Carsten Müller-Tidow, Yang Jing, Konstantin Agelopoulos, Markus Müschen, H Phillip Koeffler

    Oncotarget   7 ( 14 )   18736 - 18749   2016.4

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    DOI : 10.18632/oncotarget.7702

  • 造血幹細胞移植後の血液凝固異常

    池添 隆之

    高知県医師会医学雑誌   21 ( 1 )   38 - 49   2016.3( ISSN:2186-9863

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  • 治療抵抗性急性骨髄性白血病におけるCD82発現の意義

    西岡 千惠, 池添 隆之

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  • Relationship between HMGB1 and PAI-1 after allogeneic hematopoietic stem cell transplantation

    NOMURA, Shosaku; MAEDA, Yoshinobu; ISHII, Kazuyoshi; KATAYAMA, Yuta; YAGI, Hideo; FUJISHIMA, Naoto; OTA, Shuichi; MORIYAMA, Masato; IKEZOE, Takayuki*; MIYAZAKI, Yasuhiko; HAYASHI, Kunio; FUJITA, Shinya; SATAKE, Atsushi; ITO, Tomoki; KYO, Taiichi; TANIMOTO, Mitsune

    Journal of Blood Medicine   7   1 - 4   2016.1

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    DOI : 10.2147/JBM.S93008

  • 造血器腫瘍に合併するDICの診断・管理

    池添隆之

    臨床血液   57 ( 10 )   2136 - 2144   2016

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  • Diagnosis and management of DIC complicated by hematological malignancies.

    Takayuki Ikezoe

    [Rinsho ketsueki] The Japanese journal of clinical hematology   57 ( 10 )   2136 - 2144   2016( ISSN:0485-1439

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  • The novel function of CD82 and its impact on BCL2L12 via AKT/STAT5 signal pathway in acute myelogenous leukemia cells

    NISHIOKA, Chie; IKEZOE, Takayuki*; TAKEUCHI, Asako; NOBUMOTO, Atsuya; TSUDA, Masayuki; YOKOYAMA, Akihito

    Leukemia   ( 12 )   2296 - 2306   2015.12

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    DOI : 10.1038/leu.2015.219

  • Disseminated intravascular coagulation in non-Hodgkin lymphoma

    CHI, SungGi; IKEZOE, Takayuki*

    International Journal of Hematology   102 ( 4 )   413 - 419   2015.10

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    DOI : 10.1007/s12185-015-1854-5

  • リンパ腫学-最新の研究動向- リンパ腫の治療 合併症の診断と対策(治療・予防) 播種性血管内凝固症候群

    池添隆之*

    日本臨牀   73 ( 8 )   470 - 475   2015.10

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  • 【リンパ腫学-最新の研究動向-】 リンパ腫の治療 合併症の診断と対策(治療・予防) 播種性血管内凝固症候群

    池添 隆之

    日本臨床   73 ( 増刊8 リンパ腫学 )   470 - 475   2015.10( ISSN:0047-1852

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  • 非Hodgkinリンパ腫における播種性血管内凝固(Disseminated intravascular coagulation in non-Hodgkin lymphoma)

    Chi SungGi, Ikezoe Takayuki

    International Journal of Hematology   102 ( 4 )   413 - 419   2015.10( ISSN:0925-5710

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  • CD82抗体は抗がん剤AraCの抗白血病効果を増強させる

    西岡 千惠, 池添 隆之, 横山 彰仁

    日本癌学会総会記事   74回   P - 2262   2015.10( ISSN:0546-0476

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  • 血管内皮細胞関連因子:トロンボモジュリン

    池添隆之*

    Thrombosis Medicine   5 ( 3 )   208 - 213   2015.9

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  • Blockade of CD82 by a monoclonal antibody potentiates anti-leukemia effects of AraC in vivo

    NISHIOKA, Chie; IKEZOE, Takayuki*; YOKOYAMA, Akihito

    Cancer Medicine   4 ( 9 )   1426 - 1431   2015.9

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    DOI : 10.1002/cam4.482

  • 【血管内皮細胞関連因子】 トロンボモジュリン

    池添 隆之

    Thrombosis Medicine   5 ( 3 )   208 - 213   2015.9( ISSN:2186-0327

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  • STAT5A regulates DNMT3A in CD34+/CD38- AML cells.

    TAKEUCHI, Asako; NISHIOKA, Chie; IKEZOE, Takayuki*; YANG, Jing; YOKOYAMA, Akihito

    Leukemia Research   39 ( 8 )   897 - 905   2015.8

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    DOI : 10.1016/j.leukres.2015.05.006

  • 悪性リンパ腫の日和見感染症予防対策(Q&A)

    伊豆津宏二, 池添隆之*

    日本医事新報   4756   56   2015.6

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  • ダイナミックに変わりつつあるDICの診断・治療:DIC臨床各論 造血幹細胞移植とDIC TAM/GVHDなどとの鑑別は?

    池添隆之*

    血栓と循環   23 ( 2 )   128 - 134   2015.6

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  • DIC治療の考え方(Q&A)

    池添隆之*, 川端 浩

    日本医事新報   4755   57 - 58   2015.6

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  • 悪性リンパ腫の日和見感染症予防対策

    伊豆津 宏二, 池添 隆之

    日本医事新報   ( 4756 )   56 - 56   2015.6( ISSN:0385-9215

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    Language:English   Publishing type:Research paper (scientific journal)  

  • 【ダイナミックに変わりつつあるDICの診断・治療】 DIC臨床各論 造血幹細胞移植とDIC TAM/GVHDなどとの鑑別は?

    池添 隆之

    血栓と循環   23 ( 2 )   128 - 134   2015.6( ISSN:0919-7036

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  • DIC治療の考え方

    池添 隆之, 川端 浩

    日本医事新報   ( 4755 )   57 - 58   2015.6( ISSN:0385-9215

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  • DIC治療の考え方

    池添 隆之, 川端 浩

    日本医事新報   ( 4755 )   57 - 58   2015.6( ISSN:0385-9215

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Epstein-Barr virus-positive pyothorax-associated lymphoma arising from a posttraumatic empyema

    TANIGUCHI, Ayuko; HASHIDA, Yumiko; NEMOTO, Yuiko; MACHIDA, Hisanori; CHI, SungGi; IKEZOE, Takayuki*; YOKOYAMA, Akihito; DAIBATA, Masanori

    Acta Haematologica   134 ( 3 )   155 - 160   2015.5

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    Language:English   Publishing type:Research paper (other academic)  

    DOI : 10.1159/000380809

  • Tetraspanin Family Member, CD82, Regulates Expression of EZH2 via Inactivation of p38 MAPK Signaling in Leukemia Cells

    NISHIOKA, Chie; IKEZOE, Takayuki*; YANG, Jing; YOKOYAMA, Akihito

    PLoS One   10 ( 5 )   e0125017   2015.5

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    DOI : 10.1371/journal.pone.0125017

  • 若年成人に発症した全身性EBV陽性Tリンパ増殖症小児型

    酒井 瑞, 砥谷 和人, 佃 月恵, 荒川 悠, 池添 隆之, 弘井 誠, 横山 彰仁

    臨床血液   56 ( 5 )   501 - 505   2015.5( ISSN:0485-1439

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  • 造血幹細胞移植と血管病変:造血幹細胞移植と肝中心静脈閉塞症

    池添隆之*

    Angiology Frontier   14 ( 1 )   33 - 39   2015.4

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  • 【造血幹細胞移植と血管病変】 造血幹細胞移植と肝中心静脈閉塞症

    池添 隆之

    Angiology Frontier   14 ( 1 )   33 - 39   2015.4( ISSN:1347-6874

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  • Ph陽性白血病のtyrosine kinase inhibitorへの耐性獲得とmiR-217

    西岡千惠, 池添隆之*

    血液内科   70 ( 1 )   87 - 91   2015.1

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  • Thrombomodulin alleviates murine GVHD in association with an increase in the proportion of regulatory T cells in the spleen

    IKEZOE, Takayuki*; YANG, Jing; NISHIOKA, Chie*; YOKOYAMA, Akihito

    Bone Marrow Transplantation   50 ( 1 )   113 - 120   2015.1

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    DOI : 10.1038/bmt.2014.208

  • Thrombomodulin/activated protein C system in septic disseminated intravascular coagulation

    IKEZOE, Takayuki*

    Journal of intensive care   3 ( 1 )   1   2015.1

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    DOI : 10.1186/s40560-014-0050-7

  • Ph陽性白血病のtyrosine kinase inhibitorへの耐性獲得とmiR-217

    西岡 千惠, 池添 隆之

    血液内科   70 ( 1 )   87 - 92   2015.1( ISSN:2185-582X

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  • Thrombomodulin/activated protein C system in septic disseminated intravascular coagulation

    Ikezoe Takayuki

    Journal of Intensive Care   3 ( January )   1 - 8   2015.1

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  • Ph陽性白血病のtyrosine kinase inhibitorへの耐性獲得とmiR-217

    西岡 千惠, 池添 隆之

    血液内科   70 ( 1 )   87 - 92   2015.1( ISSN:2185-582X

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  • 若年成人に発症した全身性EBV陽性Tリンパ増殖症小児型

    酒井 瑞, 砥谷和人, 佃 月恵, 荒川 悠, 池添隆之*, 弘井 誠, 横山彰仁

    臨床血液   56 ( 5 )   501 - 505   2015

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  • トロンボモジュリンの上皮増殖因子様構造を用いた血管内皮細胞保護薬の開発

    池添隆之*

    先進医薬研究振興財団研究成果報告集 2014年度   78 - 79   2015

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  • TM変異体による血管内皮細胞保護

    池添 隆之

    上原記念生命科学財団研究報告集   28   1 - 6   2014.12

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  • BCR/ABL regulates expression of EZH2 via STAT5 in Ph+ leukemia cells

    73回   P - 2271   2014.9( ISSN:0546-0476

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  • 多発性冠動脈内血栓症を併発しエクリズマブが著効した発作性夜間ヘモグロビン尿症

    谷口 亜裕子, 池添 隆之, 竹内 麻子, 砥谷 和人, 吉本 光広, 谷岡 克敏, 北岡 裕章, 横山 彰仁

    臨床血液   55 ( 8 )   965 - 969   2014.8( ISSN:0485-1439

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  • 【徹底ガイド DICのすべて 2014-15】 (IX章)治療薬 可溶性トロンボモジュリン(内科)

    池添 隆之

    救急・集中治療   26 ( 5-6 )   911 - 917   2014.7( ISSN:1346-0935

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  • Pathogenesis of disseminated intravascular coagulation in patients with acute promyelocytic leukemia, and its treatment using recombinant human soluble thrombomodulin

    Ikezoe Takayuki

    International Journal of Hematology   100 ( 1 )   27 - 37   2014.7( ISSN:0925-5710

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  • 【徹底ガイド DICのすべて 2014-15】 (X章)類似病態、鑑別すべき病態 SOS(類洞閉塞症候群)とTLS(腫瘍崩壊症候群)

    池添 隆之

    救急・集中治療   26 ( 5-6 )   971 - 978   2014.7( ISSN:1346-0935

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  • Pathogenesis of disseminated intravascular coagulation in patients with acute promyelocytic leukemia, and its treatment using recombinant human soluble thrombomodulin.

    Takayuki Ikezoe

    International journal of hematology   100 ( 1 )   27 - 37   2014.7

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    DOI : 10.1007/s12185-013-1463-0

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  • 造血器疾患と止血凝固(第6回) 悪性リンパ腫と凝固異常

    池添 隆之

    Thrombosis Medicine   4 ( 2 )   163 - 168   2014.6( ISSN:2186-0327

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  • Bcr-Abl activates AURKA and AURKB in chronic myeloid leukemia cells via AKT signaling.

    Jing Yang, Takayuki Ikezoe, Chie Nishioka, Keiko Udaka, Akihito Yokoyama

    International journal of cancer   134 ( 5 )   1183 - 94   2014.3

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    DOI : 10.1002/ijc.28434

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  • Downregulation of miR-217 correlates with resistance of ph+ leukemia cells to ABL tyrosine kinase inhibitors

    Nishioka Chie, Ikezoe Takayuki, Yang Jing, Nobumoto Atsuya, Tsuda Masayuki, Yokoyama Akihito

    Cancer Science   105 ( 3 )   297 - 307   2014.3( ISSN:1347-9032

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  • Downregulation of miR-217 correlates with resistance of Ph(+) leukemia cells to ABL tyrosine kinase inhibitors.

    Chie Nishioka, Takayuki Ikezoe, Jing Yang, Atsuya Nobumoto, Masayuki Tsuda, Akihito Yokoyama

    Cancer science   105 ( 3 )   297 - 307   2014.3

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    DOI : 10.1111/cas.12339

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  • 【血液凝固の制御機構と臨床応用への展望】 トロンボモジュリンの臨床応用

    池添 隆之

    日本血栓止血学会誌   25 ( 1 )   61 - 69   2014.2( ISSN:0915-7441

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  • CD82 regulates STAT5/IL-10 and supports survival of acute myelogenous leukemia cells.

    Chie Nishioka, Takayuki Ikezoe, Jing Yang, Atsuya Nobumoto, Sayo Kataoka, Masayuki Tsuda, Keiko Udaka, Akihito Yokoyama

    International journal of cancer   134 ( 1 )   55 - 64   2014.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1002/ijc.28348

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  • CD34⁺/CD38⁻ acute myelogenous leukemia cells aberrantly express Aurora kinase A.

    Jing Yang, Takayuki Ikezoe, Chie Nishioka, Atsuya Nobumoto, Keiko Udaka, Akihito Yokoyama

    International journal of cancer   133 ( 11 )   2706 - 19   2013.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1002/ijc.28277

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  • Recombinant human soluble thrombomodulin is active against hemophagocytic lymphohistiocytosis associated with acquired immunodeficiency syndrome

    Chi SungGi, Ikezoe Takayuki, Takeuchi Asako, Takaoka Masato, Yokoyama Akihito

    International Journal of Hematology   98 ( 5 )   615 - 619   2013.11( ISSN:0925-5710

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  • Effect of recombinant human soluble thrombomodulin on clinical outcomes of patients with coagulopathy after hematopoietic stem cell transplantation.

    Takayuki Ikezoe, Asako Takeuchi, SungGi Chi, Masato Takaoka, Kazuki Anabuki, Tsukie Kim, Mizu Sakai, Ayuko Taniguchi, Kazuto Togitani, Akihito Yokoyama

    European journal of haematology   91 ( 5 )   442 - 7   2013.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1111/ejh.12188

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  • Over-expression of Mcl-1 impairs the ability of ATRA to induce growth arrest and differentiation in acute promyelocytic leukemia cells.

    Jing Yang, Takayuki Ikezoe, Chie Nishioka, Akihito Yokoyama

    Apoptosis : an international journal on programmed cell death   18 ( 11 )   1403 - 1415   2013.11

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    DOI : 10.1007/s10495-013-0872-0

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  • IL-1β inhibits self-renewal capacity of dormant CD34⁺/CD38⁻ acute myelogenous leukemia cells in vitro and in vivo.

    Jing Yang, Takayuki Ikezoe, Chie Nishioka, Atsuya Nobumoto, Akihito Yokoyama

    International journal of cancer   133 ( 8 )   1967 - 81   2013.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1002/ijc.28198

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  • CD34⁺/CD38⁻ acute myelogenous leukemia cells aberrantly express CD82 which regulates adhesion and survival of leukemia stem cells.

    Chie Nishioka, Takayuki Ikezoe, Mutsuo Furihata, Jing Yang, Satoshi Serada, Tetsuji Naka, Atsuya Nobumoto, Sayo Kataoka, Masayuki Tsuda, Keiko Udaka, Akihito Yokoyama

    International journal of cancer   132 ( 9 )   2006 - 19   2013.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1002/ijc.27904

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  • A novel treatment strategy targeting shugoshin 1 in hematological malignancies.

    Jing Yang, Takayuki Ikezoe, Chie Nishioka, Akihito Yokoyama

    Leukemia research   37 ( 1 )   76 - 82   2013.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1016/j.leukres.2012.10.002

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Books

  • 今日の治療指針 2017年版

    福井次矢,高木 誠,小室一成(10 血液疾患 播種性血管内凝固症候群)

    医学書院  2017.1  ( ISBN:978-4-260-02393-1

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    Responsible for pages:675-676   Language:Japanese  

    Authors name of the chapter and paper which it took charge of:池添隆之   Publication place:東京  

  • 高知大学医学部付属病院の最新治療がわかる本

    高知大学医学部附属病院(骨髄移植って、大手術ですか?)

    バリュ-メディカル  2015.2  ( ISBN:978-4864890304

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    Responsible for pages:118-119   Language:Japanese  

    Authors name of the chapter and paper which it took charge of:池添隆之*   Publication place:東京  

Presentations

  • Subcutaneous daratumumab(DARA SC) + bortezomib, cyclophosphamide, and dexamethasone(VCd) in Asian patients with newly diagnosed light chain(AL) amyloidosis: subgroup analysis from the phase 3 andromeda study

    62th American Society of Hematology(ASH) Annual Meeting and Exposition  

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    Event date: 2020.12

  • Chromosomal translocation t(11:14) induced by the Cre-loxP system in normal B cell-derived iPS cells for the study of myeloma-initiating cells

    62th American Society of Hematology(ASH) Annual Meeting and Exposition  

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    Event date: 2020.12

  • Phase1 study of alvocidib(DSP-2033) in combination with cytarabine/mitoxantrone(ACM) or cytarabine/daunorubicin(A+7+3) in Japanese patients(Pts) with acute myeloid leukemia(AML)

    62th American Society of Hematology(ASH) Annual Meeting and Exposition  

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    Event date: 2020.12

  • One-year results of the randomized ASCEND trial of olipudase alfa enzyme replacement therapy in adults with chronic acid sphingomyelinase deficiency shows significant visceral, pulmonary, and hematologic improvements in olipudase-alfa-treated but not placebo-treated patients

    American Society of Human Genetics(ASHG) Virtual Meeting 2020  

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    Event date: 2020.10

  • PNH患者を対象としたラブリズマブ(ALXN1210)対エクリズマブのALXN1210第Ⅲ相試験における日本人集団の結果

    第82回 日本血液学会学術集会  

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    Event date: 2020.10 - 2020.11

  • 急性白血病のDIC診断における核内蛋白の有用性について

    第82回 日本血液学会学術集会  

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    Event date: 2020.10 - 2020.11

  • 中枢神経浸潤を伴うT細胞性前リンパ球性白血病に対するアレムツズマブ髄注療法

    第82回 日本血液学会学術集会  

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    Event date: 2020.10 - 2020.11

  • HIV感染に合併した赤芽球癆の1例

    第82回 日本血液学会学術集会  

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    Event date: 2020.10 - 2020.11

  • Cre/LoxPシステムを用いた正常Bリンパ球由来iPS細胞への染色体転座t(11;14)誘導

    第82回 日本血液学会学術集会  

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    Event date: 2020.10 - 2020.11

  • ヒト線維芽細胞由来iPS細胞からの血球分化誘導

    第82回 日本血液学会学術集会  

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    Event date: 2020.10 - 2020.11

  • 深層学習モデルを用いた骨髄スメアの異形成判定

    第82回 日本血液学会学術集会  

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    Event date: 2020.10 - 2020.11

  • 腹腔鏡下小腸切除術に続き化学療法を施行したmonomorphic epitheliotropic intestinal T-cell lymphoma

    第82回 日本血液学会学術集会  

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    Event date: 2020.10 - 2020.11

  • ラブリズマブ治療を受けたPNH患者における感染症に関連したブレイクスルー溶血の一症例

    第82回 日本血液学会学術集会  

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    Event date: 2020.10 - 2020.11

  • 血栓止血学会DIC診断基準2017を用いた凝固分子マーカーの評価

    第21回 日本検査血液学会学術集会  

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    Event date: 2020.7

  • 血液腫瘍に合併するDICの診断における核内蛋白の有用性について

    第21回 日本検査血液学会学術集会  

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    Event date: 2020.7

  • 日本血栓止血学会DIC診断基準2017年版の有用性の評価と新規予後予測マーカーの検索

    第42回 日本血栓止血学会学術集会  

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    Event date: 2020.6

  • 感染症型DICにおける低フィブリノゲン血症は予後不良である

    第42回 日本血栓止血学会学術集会  

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    Event date: 2020.6

  • Single arm of bendamustine in combination with rituximab for relapsed or refractory diffuse large B-cell lymphoma in Japan

    The 25th International Congress of the European Hematology Association in Frankfurt  

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    Event date: 2020.6

  • 同種末梢血幹細胞移植後に重篤なPassenger Lymphocyte Syndromeを起こした一例

    第68回 日本輸血・細胞治療学会学術総会  

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    Event date: 2020.5

  • 発症後4日で突然の心停止に至った血栓性血小板減少性紫斑病の1剖検例

    第219回 日本内科学会 東北地方会  

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    Event date: 2020.2

  • 造血器腫瘍や造血細胞移植後に合併するDICの病態と診断・治療~SFの有用性について

    第11回 日本血栓止血学会学術標準化委員会シンポジウム  

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    Event date: 2017.1

  • DIC診断基準(旧厚生省)には満たさないものの抗凝固療法が必要であった凝固異常合併症悪性リンパ腫症例の臨床的特徴

    第11回 日本血栓止血学会学術標準化委員会シンポジウム  

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    Event date: 2017.1

  • HMGA2 orchestrates the tumorgenesis of myeloproliferative neoplasms (MPN) in corporation with JAK2V617F

    58th American Society of Hematology (ASH) Annual Meeting and Exposition  

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    Event date: 2016.12

  • Phase I/II multicenter study of romidepsin in Japanese patients with relapsed or refractory peripheral T-Cell lymphoma

    58th American Society of Hematology (ASH) Annual Meeting and Exposition  

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    Event date: 2016.12

  • 血液凝固検査値は何かを語る −血液疾患における凝固線溶検査結果の読み方と治療−

    第49回 日本臨床衛生検査技師会中四国支部医学検査学会  

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    Event date: 2016.11

  • トロンボモジュリンが持つ新規な作用機序

    Shizuoka Hematology Forum  

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    Event date: 2016.11

  • 同種造血幹細胞移植におけるボリコナゾールおよびキャンディン系抗真菌薬予防投与の有効性に関する後方視的解析

    第8回 県北感染症診断・治療研究会  

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    Event date: 2016.11

  • 造血細胞移植後の内皮症候群に対する取り組み

    岩手血液疾患研究会  

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    Event date: 2016.11

  • MDSを取り巻く最近の話題

    三重MDS治療学術講演会  

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    Event date: 2016.11

  • 末梢神経障害で発症した原発性マクログロブリン血症の一例

    第32回 悪性リンパ腫(M.L.)研究会  

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    Event date: 2016.11

  • 末梢神経障害で発症した原発性マクログロブリン血症の一例

    第32回 悪性リンパ腫(M.L.)研究会  

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    Event date: 2016.11

  • 移植後の内皮細胞障害に起因する合併症の診断と管理

    第22回 小児血液・SCT研究会  

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    Event date: 2016.10

  • トロンボモジュリンが持つ新規な作用機序

    DCI講演会  

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    Event date: 2016.10

  • Early initiation of defibrotide or thrombomodulin treatment for sinusoidal obstruction syndrome

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    Event date: 2016.10

  • 造血器腫瘍に合併するDICの診断・管理

    第78回 日本血液学会学術集会  

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    Event date: 2016.10

  • トロンボモジュリン変異体を用いた創薬の取り組み

    北日本後天性血友病診療ネットワーク学術集会・東北止血血栓研究会 合同学術集会  

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    Event date: 2016.10

  • miR-9 plays a role in IL-10-mediated expression of E-cadherin in acute myelogenous leukemia cells

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    Event date: 2016.10

  • トロンボモジュリンが持つ新規な作用機序

    徳島DICフォーラム  

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    Event date: 2016.9

  • ここまで進歩した血液がん治療

    福島薬剤師会・福島病院薬剤師会福島支部 合同研修会  

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    Event date: 2016.9

  • ここまで進歩した血液がん治療

    S.T.R. Medical Conference  

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    Event date: 2016.9

  • 同種造血幹細胞移植後の肝障害の診断に肝生検が有用であった二次性ヘモクロマトリーシスの一例

    第122回 日本血液学会東北地方会  

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    Event date: 2016.9

  • トロンボモジュリンが持つ新規な作用機序

    京滋 血液DIC治療セミナー  

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    Event date: 2016.9

  • 手術と薬物療法の追加で、新鮮凍結血漿輸血を大幅に削減できた大動脈解離による慢性DIC症例

    第109回 日本輸血・細胞治療学会 東北支部例会  

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    Event date: 2016.9

  • TMのオーバービューと移植後合併症に対する創薬の取り組み

    第7回 Stem Cell Transplantation Complication Conference (SCTCC)  

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    Event date: 2016.9

  • トロンボモジュリンが持つ新規な作用機序

    Akita Thrombomodulin Seminar  

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    Event date: 2016.8

  • 同種造血幹細胞移植後の肝障害の診断に肝生検が有用であった二次性ヘモクロマトリーシスの一例

    第63回 福島血液研究会  

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    Event date: 2016.7

  • 手術、薬物療法の追加で、新鮮凍結血漿輸血を、大幅に削減できた大動脈解離による慢性DIC症例

    第63回 福島血液研究会  

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    Event date: 2016.7

  • 造血器腫瘍に合併したDICに対するリコモジュリンの使用経験

    静岡県東部地区血液内科DICフォーラム  

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    Event date: 2016.7

  • ここまで進化した血液がん治療

    平成28年度 第2回 臨床腫瘍セミナー  

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    Event date: 2016.6

  • GPR15はTMの血管内皮細胞生存シグナルを細胞内に伝達する

    第38回 日本血栓止血学会学術集会  

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    Event date: 2016.6

  • トロンボモジュリンが持つ新規な作用機序

    第5回 久留米・佐賀血液凝固を学ぶ会  

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    Event date: 2016.5

  • 頭蓋内多発腫瘤を契機に診断へと至った血管内大細胞型B細胞リンパ腫の1例

    第113回 日本内科学会四国地方会  

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    Event date: 2015.12

  • 造血器腫瘍に合併したDICに対するリコモジュリンの使用経験

    第4回 新潟トロンボモジュリン血液フォーラム  

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    Event date: 2015.11

  • 超高齢者に対するダサチニブ少量投与の安全性と有効性

    Shikoku CML EXPERT Seminar  

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    Event date: 2015.10

  • 多発性骨髄腫を取り巻く最近の話題

    Orthopedics Collaboration Conference  

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    Event date: 2015.10

  • Incidence and prophylais of herpes zoster in patients with myeloma in the era of novel agents

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    Event date: 2015.10

  • 家族性骨髄異形成症候群の1例

    第77回 日本血液学会学術集会  

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    Event date: 2015.10

  • Re-administration of lenalidomide after alveolar hemorrhage in a patient with refractory myeloma

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    Event date: 2015.10

  • Filgrastim biosimilars are comparable to filgrastims and lenogratims in peripheral stem cell harvest

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    Event date: 2015.10

  • Blockade of CD82 by a monoclonal antibody potentiates antileukemia effects of AraC in vivo

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    Event date: 2015.10

  • トロンボモジュリン製剤の新規作用機序の解明と移植後DICに対する効果

    福岡血液免疫セミナー  

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    Event date: 2015.7

  • 急激な経過で両手指の虚血性壊死をきたしたリンパ形質細胞性リンパ腫

    第55回 日本リンパ網内系学会総会  

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    Event date: 2015.7

  • モノクロタリン誘発マウスSOSに対するトロンボモジュリン変異体の予防効果の検証

    第37回 日本血栓止血学会学術集会  

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    Event date: 2015.5

  • SFによるDIC早期診断とrTMによる先制治療

    第37回 日本血栓止血学会学術集会  

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    Event date: 2015.5

  • SFによるDIC早期診断とrTMによる先制治療の提唱

    第32回 有明セミナー  

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    Event date: 2015.5

  • The extracellular domain of thrombomodulin induces erythroid differentiation and hampers proliferation of human leukemia cells in vitro and in vivo

    American Association for Cancer Research (AACR) Annual Meeting 2015  

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    Event date: 2015.4

  • トロンボモジュリン製剤の新規作用機序の解明と敗血症性DICに対する効果

    救急集中治療セミナー  

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    Event date: 2015.3

  • 造血器腫瘍に合併したDICに対するリコモジュリンの使用経験

    第2回 Hematology DIC Seminar  

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    Event date: 2015.3

  • 骨髄増殖性腫瘍:up-to-date

    MPNカンファレンスShikoku  

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    Event date: 2015.2

  • DIC 診断基準暫定案と旧厚生省診断基準の診断率の比較検討 -単施設での後方視的研究-

    第9 回日本血栓止血学会学術標準化委員会(SSC)シンポジウム  

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    Event date: 2015.2

  • 造血器腫瘍に合併したDICに対するリコモジュリンの使用経験

    第3回 富山県血液内科DIC講演会  

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    Event date: 2015.2

  • 造血細胞移植後の凝固異常症に対するrTMの効果

    Thrombomodulin Forum  

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    Event date: 2015.1

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Research Projects

  • トロンボモジュリン由来ペプチドによる特発性肺線維症の新規治療法の開発

    Grant number:19K08844  2019.4 - 2022.3

    基盤研究(C)

    王 新涛, 池添 隆之

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    Grant amount:\4160000 ( Direct Cost: \3200000 、 Indirect Cost:\960000 )

  • 骨髄異形成症候群における無効造血環境形成の血球動態に基づく基礎的検討

    Grant number:19K08820  2019.4 - 2022.3

    基盤研究(C)

    色摩 弥生, 橋本 優子, 池添 隆之

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    Grant amount:\4290000 ( Direct Cost: \3300000 、 Indirect Cost:\990000 )

  • ヒストンを標的とする移植後合併症の早期診断マーカーと治療法の開発

    Grant number:18K07419  2018.4 - 2021.3

    基盤研究(C)

    原田 佳代, 池添 隆之

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    Grant amount:\3380000 ( Direct Cost: \2600000 、 Indirect Cost:\780000 )

    播種性血管内凝固症候群(DIC)では、基礎疾患を背景に過凝固状態が惹起され、全身の細小血管内に微小血栓が形成される結果、循環不全による多臓器障害が出現する。これまでの研究で、核内蛋白のヒストンやHMGB1がDICの出現に関与していることが判っている。
    造血器腫瘍を基礎疾患とする場合でも、寛解導入療法として抗がん剤による化学療法が施行されると、腫瘍崩壊が出現し、腫瘍崩壊症候群を引き起こしたり、DICの増悪が認められることは日常臨床で経験する。
    そこでまず我々は、造血器腫瘍における化学療法時にDICが出現した際、血清中のヒストンやHMGB1が病態の惹起と完成に重要な役割を果たしていると考え、凝固マーカー(PT-INR, FBG, FDP, TAT, AT, SFなど)とヒストン並びにHMGB1の値を測定し、相関を検討することにした。対象は、当科に入院し化学療法を施行された白血病や悪性リンパ腫、それに多発性骨髄腫などの造血器腫瘍患者で、化学療法の前後、および入院治療経過中、適宜、末梢血採決で検体を採取した。
    また、移植治療における重篤な合併症である肝中心静脈閉塞症(SOS/VOD)は、内皮障害よりか凝固状態となり、多臓器不全から死の転帰をとることも稀ではないが、こうした凝固異常の病態においていもヒストンやHMGB1が診断早期のマーカーと成り得る可能性について研究を進める。

  • TM変異体による新規血管内皮保護薬の開発

    Grant number:18H02844  2018.4 - 2021.3

    基盤研究(B)

    池添 隆之

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    Grant amount:\10660000 ( Direct Cost: \8200000 、 Indirect Cost:\2460000 )

    トロンボモジュリンの5番目の上皮細胞増殖因子様領域(TME5)は40アミノ酸から構成され、2つのS-S結合で3つのループ構造をもつ。われわれは、TME5が発揮する血管内皮保護作用や血管新生作用がどのループに存在するのかを検証するためそれぞれのループを形成するアミノ酸を化学合成した(TME5A, TME5B, TME5C)。臍帯静脈内皮細胞(HUVEC)の培養液中にそれぞれの合成アミノ酸を添加すると、興味深いことにTME5Cの存在下でHUVECの細胞増殖活性が増した。一方で、TME5AとBにはそのような活性は認められなかった。免疫抑制剤による細胞障害からHUVECを保護する作用もTME5Cのみに認められた。この19アミノ酸からなるTME5Cは血液凝固系に作用しないことも、正常人の血漿にTME5Cを添加後血液凝固時間が延長しないことから確認できた。マトリゲルにTME5Cを混じてマウスの皮下に移植すると、3日後に血管増生が確認できた。さらに、マウスに抗がん剤と放射線照射を行い、肝類洞閉塞症候群(SOS)を作製した。このモデルにTME5Cを投与することでSOSを予防することに成功した。出血に関する副作用は確認されなかった。

  • A critical role of Gas6-TAM signaling pathway in the pathology of HSCT-associated TMA

    Grant number:18K08366  2018.4 - 2021.3

    Grant-in-Aid for Scientific Research (C)

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    Grant amount:\2600000 ( Direct Cost: \2000000 、 Indirect Cost:\600000 )

  • 造血幹細胞移植後の免疫システムにおけるGas6の役割

    Grant number:17K09959  2017.4 - 2020.3

    基盤研究(C)

    大河原 浩, 小川 一英, 池添 隆之, 池田 和彦

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    Grant amount:\2990000 ( Direct Cost: \2300000 、 Indirect Cost:\690000 )

    同種造血幹細胞移植に関連する移植片対宿主病(GVHD)の分子機構の詳細は不明な点が多い.これまでの我々の予備実験では, 急性GVHDの好発時期に血清Gas6は有意に増加していた。しかも, gradeII以上のGVHD症例に有意に高値である興味深い結果を得た. さらに,我々は血清Gas6はFCMによってドナーTリンパ球及び単球から分泌される可能性を見出した. また, 血清Gas6は凝固/線溶関連マーカーや各種ケモカインと相関関係を示す興味深い結果を得た. また, 病理組織学的検討では、腸管GVHD病変組織にGas6及びTAM受容体Merが高発現することを明らかにした. 培養血管内皮細胞を用いたin vitro実験では, rGas6及びgradeⅢのGVHD患者血清が血管内皮障害(ICAM-1及びICAM-1発現増加)を誘導し、Mer阻害剤はそれらの蛋白発現変化を抑えた. さらに, rGas6及びGVHD患者血清は内皮細胞のアポトーシスを誘導したが, Mer阻害剤はそのアポトーシス誘導を抑えた。これらの結果は, GVHDの重要な病態である血管内皮障害の分子機序に, Gas6-Merシグナルが重要な役割を担うことを示す. さらに, GVHDを誘導させた同種移植マウスを用いたin vivo実験で, GVHD誘導マウスの血清Gas6は有意に増加した. 病理組織学的検討では肝GVHDの病変組織でGas6とMer発現増加を認めた. さらに, GVHD誘導マウスにMer阻害剤を静脈内投与すると, GVHD病変が著明に改善した. 本研究はGVHDの病態解明に寄与するとともに, Gas6-Merシグナルが新たな治療標的候補や新規バイオマーカーとなることを証明した.

  • トロンボモジュリン変異体による新規血管内皮保護薬の開発

    2014 - 2016

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