日本分子生物学会

2002 - Now

福島県立医科大学　研究連携セミナー   会計  

2012.8 - 2013.3   

Reinstating olfactory bulb-derived limbic gamma oscillations alleviates depression-like behavioral deficits in rodents.

Li Q, Takeuchi Y, Wang J, Gellért L, Barcsai L, Pedraza LK, Nagy AJ, Kozák G, Nakai S, Kato S, Kobayashi K, Ohsawa M, Horváth G, Kékesi G, Lőrincz ML, Devinsky O, Buzsáki G, Berényi A

Neuron   111 ( 13 )   2065 - 2075.e5   2023.4（ ISSN:0896-6273 ）

Highly selective transgene expression through the flip-excision switch system by using a unilateral spacer sequence

Natsuki Matsushita, Shigeki Kato, Kayo Nishizawa, Masateru Sugawara, Kosei Takeuchi, Yoshiki Miyasaka, Tomoji Mashimo, Kazuto Kobayashi

Cell Reports Methods   3 ( 2 )   100393   2023.2（ ISSN:2667-2375 ）

Leakage-repressed vectors in recombinase-dependent gene expression switch system

加藤成樹, 松下夏樹, 小林和人

日本分子生物学会年会プログラム・要旨集(Web)   46th   2023

Anatomical identification of a corticocortical top-down recipient inhibitory circuitry by enhancer-restricted transsynaptic tracing.

Atsumi Y, Oisi Y, Odagawa M, Matsubara C, Saito Y, Uwamori H, Kobayashi K, Kato S, Kobayashi K, Murayama M

Frontiers in neural circuits   17   1245097   2023（ ISSN:16625110 ）

Catecholaminergic cell type-specific expression of Cre recombinase in knock-in transgenic rats generated by the Combi-CRISPR technology

Natsuki Matsushita, Kayo Nishizawa, Shigeki Kato, Yoshio Iguchi, Ryoji Fukabori, Kosei Takeuchi, Yoshiki Miyasaka, Tomoji Mashimo, Kazuto Kobayashi

Journal of Neuroscience Methods   381   109707 - 109707   2022.11（ ISSN:0165-0270 ）

Recording and manipulation of the maternal oxytocin neural activities in mice

Hiroko Yukinaga, Mitsue Hagihara, Kazuko Tsujimoto, Hsiao-Ling Chiang, Shigeki Kato, Kazuto Kobayashi, Kazunari Miyamichi

Current Biology   32 ( 17 )   3821 - 3829.e6   2022.9（ ISSN:0960-9822 ）

Dissection of insular cortex layer 5 reveals sublayers with opposing modulatory roles in appetitive behavior

Makoto Takemoto, Shigeki Kato, Kazuto Kobayashi, Wen-Jie Song

bioRxiv   2022.6

条件付け誘発性のプラセボ鎮痛はmedial prefrontal cortex-ventrolateral periaqueductal gray回路の活性化を介する

根山広行, 武玉萍, 井上美智子, 清水朋子, 加藤成樹, 渡辺恭良, 小林和人, 崔翼龍

日本神経化学会大会抄録集(Web)   65th   2022

Thalamostriatal system controls the acquisition, performance, and flexibility of learning behavior.

Kato, S., Nishizawa, K. and Kobayashi, K.

Front. Syst Neurosci.   15   729389   2021.10

Chemogenetic inactivation reveals the inhibitory control function of the prefronto-striatal pathway in the macaque brain

Mineki Oguchi, Shingo Tanaka, Xiaochuan Pan, Takefumi Kikusui, Keiko Moriya-Ito, Shigeki Kato, Kazuto Kobayashi, Masamichi Sakagami

Communications Biology   4 ( 1 )   1088   2021.9

Ras-like Gem GTPase induced by Npas4 promotes activity-dependent neuronal tolerance for ischemic stroke.

Hiroo Takahashi, Ryo Asahina, Masayuki Fujioka, Takeshi K Matsui, Shigeki Kato, Eiichiro Mori, Hiroyuki Hioki, Tohru Yamamoto, Kazuto Kobayashi, Akio Tsuboi

Proceedings of the National Academy of Sciences of the United States of America   118 ( 32 )   2021.8（ ISSN:0027-8424 ）

Retrograde transgene expression via neuron-specific lentiviral vector depends on both species and input projections.

Otsuka, Y., Tsuge, H., Uezono, S., Tanabe, S., Fujiwara, M., Miwa, M., Kato, S., Nakamura, K., Kobayashi, K., Inoue, K. and Takada, M.

Viruses   13 ( 7 )   1387   2021.7

Retrograde Transgene Expression via Neuron-Specific Lentiviral Vector Depends on Both Species and Input Projections

Yukiko Otsuka, Hitomi Tsuge, Shiori Uezono, Soshi Tanabe, Maki Fujiwara, Miki Miwa, Shigeki Kato, Katsuki Nakamura, Kazuto Kobayashi, Ken-ichi Inoue, Masahiko Takada

Viruses   13 ( 7 )   1387 - 1387   2021.7

青斑核ノルアドレナリン神経細胞の活動亢進による情動記憶の想起の促進 新規神経活動活性化ツールによる検討

井口 善生, 深堀 良二, 加藤 成樹, 高橋 和巳, 永福 智志, 辻 真伍, 挾間 章博, 内ヶ島 基政, 渡辺 雅彦, 水間 広, 崔 翼龍, 尾上 浩隆, 疋島 啓吾, 八十島 安伸, 小山内 実, 稲垣 良, 福永 浩司, 西條 琢真, 籾山 俊彦, リチャード・ベントン, 小林 和人

日本生理学雑誌   83 ( 2 )   39 - 39   2021.5（ ISSN:0031-9341 ）

Thalamostriatal System Controls the Acquisition, Performance, and Flexibility of Learning Behavior.

Shigeki Kato, Kayo Nishizawa, Kazuto Kobayashi

Frontiers in systems neuroscience   15   729389 - 729389   2021（ ISSN:1662-5137 ）

Enhanced retrieval of taste associative memory by chemogenetic activation of locus coeruleus norepinephrine neurons.

Fukabori, R., Iguchi, Y., Kato, S., Takahashi, K., Eifuku, S., Tsuji, S., Hazama, A., Uchigashima, M., Watanabe, M., Mizuma, H., Cui, Y., Onoe, H., Hikishima, K., Yasoshima, Y., Osanai, M., Inagaki, R., Fukunaga, K., Nishijo, T., Momiyama, T., Benton, R. and Kobayashi, K.

J. Neurosci.   40 ( 43 )   8367 - 8385   2020.10

Enhanced Retrieval of Taste Associative Memory by Chemogenetic Activation of Locus Coeruleus Norepinephrine Neurons.

Fukabori R, Iguchi Y, Kato S, Takahashi K, Eifuku S, Tsuji S, Hazama A, Uchigashima M, Watanabe M, Mizuma H, Cui Y, Onoe H, Hikishima K, Yasoshima Y, Osanai M, Inagaki R, Fukunaga K, Nishijo T, Momiyama T, Benton R, Kobayashi K

The Journal of neuroscience : the official journal of the Society for Neuroscience   40 ( 43 )   8367 - 8385   2020.10（ ISSN:0270-6474 ）

Pseudotyped lentiviral vectors for tract-targeting and application for the functional control of selective neural circuits.

Kato, S. and Kobayashi, K.

J. Neurosci. Methods   344   108854   2020.10

Pseudotyped lentiviral vectors for tract-targeting and application for the functional control of selective neural circuits

Shigeki Kato, Kazuto Kobayashi

Journal of Neuroscience Methods   344   108854 - 108854   2020.10（ ISSN:0165-0270 ）

Enhanced retrieval of taste associative memory by chemogenetic activation of locus coeruleus norepinephrine neurons

Fukabori, R, Iguchi, Y, Kato, S, Takahashi, K, Eifuku, S, Tsuji, S, Hazama, A, Uchigashima, M, Watanabe, M, Mizuma, H, Cui, Y, Onoe, H, Hikishima, K, Yasoshima, Y, Osanai, M, Inagaki, R, Fukunaga, K, Nishijo, T, Momiyama, T, Benton, R, Kobayashi, K

J Neurosci.   40 ( 43 )   8367 - 8385   2020.10（ ISSN:0270-6474 ）

Dopaminergic signaling in the nucleus accumbens modulates stress-coping strategies during inescapable stress.

Cui, W., Aida, T., Ito, H., Kobayashi, K., Wada, Y., Kato, S., Nakano, T., Zhu, M., Isa, K., Kobayashi, K., Isa, T., Tanaka, K. and Aizawa, H.

J. Neurosci.   40 ( 38 )   7241 - 7254   2020.9

Dopaminergic Signaling in the Nucleus Accumbens Modulates Stress-Coping Strategies during Inescapable Stress

Wanpeng Cui, Tomomi Aida, Hikaru Ito, Kenta Kobayashi, Yusaku Wada, Shigeki Kato, Takashi Nakano, Meina Zhu, Kaoru Isa, Kazuto Kobayashi, Tadashi Isa, Kohichi Tanaka, Hidenori Aizawa

The Journal of Neuroscience   40 ( 38 )   7241 - 7254   2020.9（ ISSN:0270-6474 ）

ウイルスベクターによる遺伝子導入実験ガイド

加藤 成樹, 小林 和人

実験医学別冊   239 - 249   2020.9

Macaques Exhibit Implicit Gaze Bias Anticipating Others’ False-Belief-Driven Actions via Medial Prefrontal Cortex

Taketsugu Hayashi, Ryota Akikawa, Keisuke Kawasaki, Jun Egawa, Takafumi Minamimoto, Kazuto Kobayashi, Shigeki Kato, Yukiko Hori, Yuji Nagai, Atsuhiko Iijima, Toshiyuki Someya, Isao Hasegawa

Cell Reports   30 ( 13 )   4433 - 4444.e5   2020.3（ ISSN:2211-1247 ）

マカクザルにおける他者の誤信念理解に内側前頭前野が因果的役割を果たす

秋川 諒太, 林 剛丞, 川嵜 圭祐, 江川 純, 南本 敬史, 小林 和人, 加藤 成樹, 堀 由紀子, 永井 裕司, 飯島 淳彦, 染矢 俊幸, 長谷川 功

日本生理学雑誌   82 ( 1 )   10 - 10   2020.2（ ISSN:0031-9341 ）

The Emergence of a Stable Neuronal Ensemble from a Wider Pool of Activated Neurons in the Dorsal Medial Prefrontal Cortex during Appetitive Learning in Mic

Leonie S. Brebner, Joseph J. Ziminski, Gabriella Margetts-Smith, Meike C. Sieburg, Hayley M. Reeve, Thomas Nowotny, Johannes Hirrlinger, Tristan G. Heintz, Leon Lagnado, Shigeki Kato, Kazuto Kobayashi, Leslie A. Ramsey, Catherine N. Hall, Hans S. Crombag, Eisuke Koya

The Journal of Neuroscience   40 ( 2 )   395 - 410   2020.1（ ISSN:0270-6474 ）

The hypothalamus to brainstem circuit suppresses late-onset body weight gain

Yuko Maejima, Shigeki Kato, Shoichiro Horita, Yoichi Ueta, Seiichi Takenoshita, Kazuto Kobayashi, Kenju Shimomura

Scientific reports   9 ( 1 )   18360 - 18360   2019.12

A Novel Birthdate-Labeling Method Reveals Segregated Parallel Projections of Mitral and External Tufted Cells in the Main Olfactory System.

Hirata T, Shioi G, Abe T, Kiyonari H, Kato S, Kobayashi K, Mori K, Kawasaki T

eNeuro   6 ( 6 )   2019.11

Enhanced emotional memory retrieval by chemogenetic activation of locus coeruleus norepinephrine neurons

Fukabori, R, Iguchi, Y, Kato, S, Takahashi, K, Eifuku, S, Tsuji, S, Hazama, A, Uchigashima, M, Watanabe, M, Mizuma, H, Cui, Y, Onoe, H, Hikishima, K, Yasoshima, Y, Osanai, M, Inagaki, R, Fukunaga, K, Nishijo, T, Momiyama, T, Benton, R, Kobayashi, K

Mendeley Data   2019.11

Genetic manipulation of autonomic nerve fiber innervation and activity and its effect on breast cancer progression

Kamiya, A, Hayama, Y, Kato, S, Shimomura, A, Yamagishi, A, Shimomura, T, Irie, K, Kaneko, R, Yanagawa, Y, Fujiyoshi, Y, Kobayashi, K, Ochiya, T, Sugimachi, M

Nat. Neurosci.   22 ( 8 )   1289 - 1305   2019.8（ ISSN:1097-6256 ）

ラット側坐核におけるドーパミンD2受容体発現ニューロンの遠心性投射

清水 朋子, 加藤 成樹, 小林 和人, 崔 翼龍

形態・機能   18 ( 1 )   66 - 66   2019.8（ ISSN:1347-7145 ）

A note on retrograde gene transfer efficiency and inflammatory response of lentiviral vectors pseudotyped with FuG-E vs. FuG-B2 glycoproteins.

Soshi Tanabe, Shiori Uezono, Hitomi Tsuge, Maki Fujiwara, Miki Miwa, Shigeki Kato, Katsuki Nakamura, Kazuto Kobayashi, Ken-Ichi Inoue, Masahiko Takada

Scientific reports   9 ( 1 )   3567 - 3567   2019.3

Motor skills mediated through cerebellothalamic tracts projecting to the central lateral nucleus.

Sakayori N, Kato S, Sugawara M, Setogawa S, Fukushima H, Ishikawa R, Kida S, Kobayashi K

Molecular brain   12 ( 1 )   13   2019.2

融合糖タンパク質E型変異体を用いた神経特異的逆行性ウイルスベクターによるマーモセット脳内への遺伝子導入効率の向上

菅原正晃, 加藤成樹, 木村 慧, 井上 謙一, 高田 昌彦, 小林 和人

第8回日本マーモセット研究会大会(日本橋ライフサイエンスハブ、東京都中央区)   2019.2

Retrograde gene transfer efficacy and inflammatory response of lentiviral vectors pseudotyped with FuG-E vs. FuG-B2 glycoproteins in the striatal input system of primates and rodents.

Otsuka Y, Tsuge H, Uezono S, Tanabe S, Fujiwara M, Miwa M, Kato S, Nakamura K, Kobayashi K, Inoue K, Takada M

2019.2

Retrograde gene transfer efficacy and inflammatory response of HiRet vs. NeuRet lentiviral vectors

Otsuka Y, Tsuge H, Uezono S, Tanabe S, Fujiwara M, Miwa M, Kato S, Nakamura K, Kobayashi K, Inoue K, Takada M

第8回日本マーモセット研究会大会(日本橋ライフサイエンスハブ、東京都中央区)   2019.2

Motor skills mediated through cerebellothalamic tracts projecting to the central lateral nucleus.

Sakayori, N, Kato, S, Sugawara, M, Setogawa, S, Fukushima, H, Ishikawa, R, Kida, S, Kobayashi, K

Mol. Brain   12 ( 1 )   13   2019.2

Ipsilateral-Dominant Control of Limb Movements in Rodent Posterior Parietal Cortex

Shogo Soma, Junichi Yoshida, Shigeki Kato, Yukari Takahashi, Satoshi Nonomura, Yae K. Sugimura, Alain Ríos, Masanori Kawabata, Kazuto Kobayashi, Fusao Kato, Yutaka Sakai, Yoshikazu Isomura

The Journal of Neuroscience   39 ( 3 )   485 - 502   2019.1（ ISSN:0270-6474 ）

Enhancement of the transduction efficiency of a lentiviral vector for neuron-specific retrograde gene delivery through the point mutation of fusion glycoprotein type E

Shigeki Kato, Masateru Sugawara, Kenta Kobayashi, Kei Kimura, Ken-Ichi Inoue, Masahiko Takada, Kazuto Kobayashi

Journal of neuroscience methods   311   147 - 155   2019.1（ ISSN:0165-0270 ）

Monitoring and Updating of Action Selection for Goal-Directed Behavior through the Striatal Direct and Indirect Pathways.

Nonomura S, Nishizawa K, Sakai Y, Kawaguchi Y, Kato S, Uchigashima M, Watanabe M, Yamanaka K, Enomoto K, Chiken S, Sano H, Soma S, Yoshida J, Samejima K, Ogawa M, Kobayashi K, Nambu A, Isomura Y, Kimura M

Neuron   99 ( 6 )   1302 - 1314.e5   2018.9（ ISSN:0896-6273 ）

Copy number elevation of 22q11.2 genes arrests the developmental maturation of working memory capacity and adult hippocampal neurogenesis

Boku S., Izumi T., Abe S., Takahashi T., Nishi A., Nomaru H., Naka Y., Kang G., Nagashima M., Hishimoto A., Enomoto S., Duran-Torres G., Tanigaki K., Zhang J., Ye K., Kato S., Männistö P., Kobayashi K., Hiroi N.

Molecular Psychiatry   23 ( 4 )   985 - 992   2018.4（ ISSN:13594184 ）

Gene therapy approaches in the non-human primate model of Parkinson’s disease

Pignataro D., Sucunza D., Rico A., Dopeso-Reyes I., Roda E., Rodríguez-Perez A., Labandeira-Garcia J., Broccoli V., Kato S., Kobayashi K., Lanciego J.

Journal of Neural Transmission   125 ( 3 )   575 - 589   2018.3（ ISSN:03009564 ）

Action selection and flexible switching controlled by the intralaminar thalamic neurons.

Kato, S., Fukabori, R., Nishizawa, K., Okada, K., Yoshioka, N., Sugawara, M., Maejima, Y., Shimomura, K., Okamoto, M., Eifuku, S. and Kobayashi, K.

Cell Rep.   22 ( 9 )   2370 - 2382   2018.2

Genetic manipulation of specific neural circuits by use of a viral vector system.

Kobayashi K, Kato S, Kobayashi K

Journal of neural transmission (Vienna, Austria : 1996)   125 ( 1 )   67 - 75   2018.1（ ISSN:0300-9564 ）

Anatomical Evidence for a Direct Projection from Purkinje Cells in the Mouse Cerebellar Vermis to Medial Parabrachial Nucleus.

Hashimoto M, Yamanaka A, Kato S, Tanifuji M, Kobayashi K, Yaginuma H

Frontiers in neural circuits   12   6   2018（ ISSN:16625110 ）

Segregated Excitatory-Inhibitory Recurrent Subnetworks in Layer 5 of the Rat Frontal Cortex.

Morishima M, Kobayashi K, Kato S, Kobayashi K, Kawaguchi Y

Cerebral cortex (New York, N.Y. : 1991)   27 ( 12 )   5846 - 5857   2017.12（ ISSN:1047-3211 ）

Neuronal cytoskeletal gene dysregulation and mechanical hypersensitivity in a rat model of Rett syndrome.

Bhattacherjee A, Mu Y, Winter MK, Knapp JR, Eggimann LS, Gunewardena SS, Kobayashi K, Kato S, Krizsan-Agbas D, Smith PG

Proceedings of the National Academy of Sciences of the United States of America   114 ( 33 )   E6952 - E6961   2017.8（ ISSN:0027-8424 ）

Pseudotyped Lentiviral Vectors for Retrograde Gene Delivery into Target Brain Regions.

Kobayashi, K., Inoue, K., Tanabe, S., Kato, S., Takada, M. and Kobayashi, K.

Front. Neuoanat.   11   65   2017.8

The use of an optimized chimeric envelope glycoprotein enhances the efficiency of retrograde gene transfer of a pseudotyped lentiviral vector in the primate brain.

Tanabe, S., Inoue, K., Tsuge, H., Uezono, S., Nagaya, K., Fujiwara, M., Kato, S., Kobayashi, K. and Takada, M.

Neurosci. Res.   120   45 - 52   2017.7（ ISSN:0168-0102 ）

最適化されたキメラエンベロープ糖蛋白質の使用は、霊長類の脳にシュードタイプレンチウイルスベクターの逆行性遺伝子輸送効率を増強させる(The use of an optimized chimeric envelope glycoprotein enhances the efficiency of retrograde gene transfer of a pseudotyped lentiviral vector in the primate brain)

Tanabe Soshi, Inoue Ken-ichi, Tsuge Hitomi, Uezono Shiori, Nagaya Kiyomi, Fujiwara Maki, Kato Shigeki, Kobayashi Kazuto, Takada Masahiko

Neuroscience Research   120   45 - 52   2017.7（ ISSN:0168-0102 ）

Pseudotyped lentiviral vectors for retrograde gene delivery into target brain regions.

Kobayashi, K., Inoue, K., Tanabe, S., Kato, S., Takada, M. and Kobayashi, K.

Front. Neuoanat.   11   65   2017

Survival of corticostriatal neurons by Rho/Rho-kinase signaling pathway.

Kobayashi, K., Sano, H., Kato, S., Kuroda, K., Nakamuta, S., Isa, T., Nambu, A., Kaibuchi, K. and Kobayashi, K.

Neurosci. Lett.   630   45 - 52   2016.9（ ISSN:0304-3940 ）

Involvement of mesolimbic dopaminergic network in neuropathic pain relief by treadmill exercise: A study for specific neural control with Gi-DREADD in mice.

Wakaizumi, K., Kondo, T., Hamada, Y., Narita, M., Kawabe, R., Narita, H., Watanabe, M., Kato, S., Senba, E., Kobayashi, K., Kuzumaki, N., Yamanaka, A., Morisaki, H. and Narita, M.

Mol. Pain.   12   1 - 11   2016

Altering Entry Site Preference of Lentiviral Vectors into Neuronal Cells by Pseudotyping with Envelope Glycoproteins.

Kobayashi, K., Kato, S., Inoue, K., Takada, M. and Kobayashi, K.

Methods Mol. Biol.   1382   175 - 86   2016（ ISSN:1064-3745 ）

Lgr4 controls specialization of female gonads.

Koizumi, M., Oyama, K., Yamakami, Y., Kida, T., Satoh, R., Kato, S., Hidema, S., Oe, T., Goto, T., Clevers, H., Nawa, A. and Nishimori, K.

Biol. Reprod.   93 ( 4 )   90   2015.10

Double Virus Vector Infection to the Prefrontal Network of the Macaque Brain.

Oguchi, M., Okajima, M., Tanaka, S., Koizumi, M., Kikusui, T., Ichihara, N., Kato, S., Kobayashi, K., and Sakagami, M.

PLoS ONE   10 ( 7 )   e0132825   2015.7

An avian sarcoma leukosis virus receptor-envelope system for simultaneous dissection of multiple neural circuits in mammalian brain.

Matsuyama, M., Ohashi, Y., Tsubota, T., Yaguchi, M., Kato, S., Kobayashi, K., and Miyashita, Y.

PNAS   112 ( 22 )   E2947 - 56   2015.6（ ISSN:0027-8424 ）

Double Virus Vector Infection to the Prefrontal Network of the Macaque Brain.

Oguchi, M., Okajima, M., Tanaka, S., Koizumi, M., Kikusui, T., Ichihara, N., Kato, S., Kobayashi, K., and Sakagami, M.

PLoS ONE   10 ( 7 )   e0132825   2015

局所神経回路の機能制御による行動解析

加藤 成樹

上原記念生命科学財団研究報告集   28   1 - 4   2014.12

Improved transduction efficiency of a lentiviral vector for neuron-specific retrograde gene transfer by optimizing the junction of fusion envelope glycoprotein.

Kato, S., Kobayashi, K., and Kobayashi, K.

J Neurosci. Methods   227   151 - 8   2014.4（ ISSN:0165-0270 ）

Simultaneous visualization of extrinsic and intrinsic axon collaterals in Golgi-like detail for mouse corticothalamic and corticocortical cells: a double viral infection method.

Watakabe, A., Takaji, M., Kato, S., Kobayashi, K., Mizukami, H., Ozawa, K., Ohsawa, S., Matsui, R., Watanabe, D., and Yamamori, T.

Front. Neural Circuits   8   110   2014（ ISSN:16625110 ）

Viral vector-mediated selective and reversible blockade of the pathway for visual orienting in mice

Sooksawate T., Isa K., Matsui R., Kato S., Kinoshita M., Kobayashi K., Watanabe D., Kobayashi K., Isa T.

Frontiers in Neural Circuits   7 ( OCT )   2013.10（ ISSN:16625110 ）

Elucidating information processing in primate basal ganglia circuitry: a novel technique for pathway-selective ablation mediated by immunotoxin.

Takada, M., Inoue, K., Koketsu, D., Kato, S., Kobayashi, K., and Nambu, A.

Front. Neural Circuits   7 ( SEP )   140   2013.9（ ISSN:16625110 ）

Highly efficient retrograde gene transfer into motor neurons by a lentiviral vector pseudotyped with fusion glycoprotein.

Hirano, M., Kato, S., Kobayashi, K., Okada, T., Yaginuma, H., and Kobayashi, K.

PLoS ONE   8 ( 9 )   e75896   2013

Dissecting circuit mechanisms by genetic manipulation of specific neural pathways.

Kato, S., Kobayashi, K., and Kobayashi, K.

Rev. Nuerosci.   24 ( 1 )   1 - 8   2013（ ISSN:0334-1763 ）

ウイルスベクター技術によって脳神経回路の仕組みに迫る

小林　和人, 加藤 成樹, 小林　憲太

脳21   15 ( 4 )   125 - 132   2012.12

Visualization of cortical projection neurons with retrograde TET-Off lentiviral vector.

Watakabe, A., Kato, S., Kobayashi, K., Takaji, M., Nakagami, Y., Sadakane, O., Ohtsuka, M., Hioki, H, Kaneko, T., Okuno, H, Kawashima, T., Bito, H., Kitamura, Y., and Yamamori, T.

PLoS ONE   7 ( 10 )   e46157   2012.10

Immunotoxin-mediated tract targeting in the primate brain: Selective elimination of the cortico-subthalamic "Hyperdirect" pathway.

Inoue, K., Koketsu, D., Kato, S., Kobayashi, K., Nambu, A., and Takada, M.

PLoS ONE   7 ( 6 )   e39149   2012.6

Genetic dissection of the circuit for hand dexterity in primates.

Kinoshita, M., Matsui, R., Kato, S., Hasegawa, T., Kasahara, H., Isa, K., Watakabe, A., Yamamori, T., Nishimura, Y., Alstermark, B., Watanabe, D., Kobayashi, K., and Isa, T.

Nature   487 ( 7406 )   235 - 238   2012.6

Neuron-specific gene transfer through retrograde transport of lentiviral vector pseudotyped with a novel type of fusion envelope glycoprotein.

Kato, S., Kuramochi, M., Takasumi, K., Kobayashi, K., Inoue, K., Takahara, D., Hitoshi, S., Ikenaka, K., Shimada, T., Takada, M., and Kobayashi, K.

Hum. Gene Ther.   22 ( 12 )   1511 - 1523   2011.12

Selective neural pathway targeting reveals key roles of thalamostriatal projection in the control of visual discrimination.

Kato, S., Kuramochi, M., Kobayashi, K., Fukabori, R., Okada, K., Uchigashima, M., Watanabe, M., Tsutsui, Y., and Kobayashi, K.

J Neurosci.   31 ( 47 )   17169 - 17179   2011.11

Dynamic expression of cadherins regulates vocal development in a songbird.

Matsunaga, E., Suzuki, K., Kato, S., Kurotani, T., Kobayashi, K., and Okanoya, K.

PLoS ONE   6 ( 9 )   e25272   2011.9

Lgr4-deficient mice showed premature differentiation of ureteric bud with reduced expression of Wnt effector Lef1 and Gata3.

Mohri, Y., Oyama, K., Akamatsu, A., Kato, S., and Nishimori, K.

Dev. Dyn.   240 ( 6 )   1626 - 1634   2011.6

A lentiviral strategy for highly efficient retrograde gene transfer by pseudotyping with fusion envelope glycoprotein.

Kato, S., Kobayashi, K., Inoue, K., Kuramochi, M., Okada, T., Yaginuma, H., Morimoto, K., Shimada, T., Takada, M., and Kobayashi, K.

Hum. Gene Ther.   22 ( 2 )   197 - 206   2011.2

Reduced sterility with impairment of early-stage embryos observed in mice lacking Lgr4 in epithelial tissues.

Mohri, Y., Umezu, T., Hidema, S., Tomisawa, H., Akamatsu, A., Kato, S., Nawa, A., and Nishimori, K.

Fertil. Steril.   97 ( 7 )   2878 - 2881   2010.12

Impaired hair placode formation with reduced expression of hair follicle-related genes in mice lacking Lgr4.

Mohri, Y., Kato, S., Umezawa, A., Okuyama, R., and Nishimori, K.

Dev. Dyn.   238 ( 8 )   2235 - 2242   2008.8

Efficient gene transfer via retrograde transport in rodent and primate brains by an HIV-1-based vector pseudotyped with rabies virus glycoprotein.

Kato, S., Inoue, K., Kobayashi, K., Yasoshima, Y., Miyachi, S., Inoue, S., Hanawa, H., Shimada, T., Takada, M., and Kobayashi, K.

Hum. Gene Ther.   18 ( 11 )   1141 - 1151   2007.11

Eye-open at birth phenotype with reduced keratinocyte motility in LGR4 null mice.

Kato, S., Mohri, Y., Matsuo, T., Ogawa, E., Umezawa, A., Okuyama, R., and Nishimori, K.

FEBS Lett.   581 ( 24 )   4685 - 4690   2007.10

Highly induced DNA recombination mediated by membrane permeabilized recombinant Cre protein in mouse primary cells.

Hidema, S., Maruyama, T., Kato, S., and Nishimori, K.

Biosci. Biotechnol. Biochem.   71 ( 3 )   817 - 820   2007.3

Leucine-rich repeat-containing G protein-coupled receptor-4 (LGR4, Gpr48) is essential for renal development in mice.

Kato, S., Matsubara, M., Matsuo, T., Mohri, Y., Kazama, I., Hatano, R., Umezawa, A., and Nishimori, K.

Nephron Exp. Nephrol.   104 ( 2 )   e63-e75   2006.6

遺伝子欠損マウスが語る生殖関連GPCRの生体機能解析

西森 克彦, 加藤 成樹, 川又 理樹, 高柳 友紀.

臨床化学   33 ( 3 )   154 - 162   2004.12

Development and application of new type vector for neural circuitry labeling.

Intralaminar thalamic neuron plays the action selection and flexible behavioral controls.

Neuroscience 2019  

Behavioral regulation through molecular genetic manipulation of selective neural circuit.

Neural circuitry system of the response selection and switching flexibility

Behavioral selection and switching flexibility via thalamostriatal circuit

Neural circuitry functional analysis of behavioral selection and switching flexibility

Behavioral selection and switching flexibility regulated by thalamostriatal circuit.

Behavioral selection and switching flexibility regulated by thalamostriatal circuit.  

Behavioral selection and switching flexibility via thalamostriatal circuit

Consortium of Biological Science 2017  

経路選択的な回路操作技術の応用：行動制御機構の解明に迫る

生理学研究所研究会  

経路選択的な回操作技術の応用：行動制御機構解明に迫る

生理学研究所研究会@東北  

Thalamostriatal circuit controls action selection and flexible switching in learning behavior.

大脳基底核機能研究会  

Behavioral selection and flexible switching through thalamostriatal circuit.

International Workshop on Basal Ganglia Functions 2017  

Optimizing the junction of chimeric fusion glycoprotein of a lentiviral vector for highly neuron-specific retrograde gene transfer.

第40回日本神経科学大会  

特定神経回路の機能制御を可能とする高頻度逆行性導入 ウイルスベクターの開発

平成28年度 京都大学霊長類研究所 共同利用研究会  

Pathway-selective manipulation of neural function by using HiRet/NeuRet vector system.

The International Workshop for Strategy for Neuroscience  

Comparative study of gene transduction efficiency for retrograde gene transfer lentiviral vector with novel fusion envelope glycoproteins.

Neuroscience 2016  

特定神経回路を標的とした機能制御システムの開発と応用

第7回福島運動器疼痛セミナー  

Comparative study of gene transduction efficiency for retrograde gene transfer lentiviral vector with novel fusion envelope glycoprotein.

International Symposium on Adaptive Circuit Shift 2016  

Optimizing the junction of fusion glycoprotein for the transduction efficiency of a lentiviral vector for neuron-specific retrograde gene transfer.

第37回日本神経科学大会  

刺激弁別学習における2種類の主要な視床線条体路の行動生理学的役割

第36回日本分子生物学会  

Functional control of specific neural pathways in basal ganglia circuit by HiRet.

Neuroscience 2013  

Comparative analysis for behavioral roles of the central lateral and parafascicular nuclear groups projecting to the dorsolateral striatum.

Distinct behavioral roles of thalamostriatal pathways arising from the central lateral and parafascicular nuclear groups in basal ganglia function.

Molecular and Cellular Cognition Society-Asia 2013  

神経回路特異的な機能改変技術を用いた刺激弁別学習における視床線条体神経路の行動生理学的役割の解明

第35回日本分子生物学会  

Selective neural pathway targeting reveals key roles of thalamostriatal projection in the control of conditional response association

第35回日本神経科学大会  

学習行動に関わる視床-線条体神経路の機能解析

第27回日本大脳基底核研究会  

新規融合糖タンパク質組換え体レンチウイルスベクター系による神経細胞特異的逆行性遺伝子導入

第34回日本分子生物学会  

Behavioral role of thalamostriatal neural pathway in conditional discrimination paradigm.

第34回日本神経科学大会  

脳神経回路研究のための融合糖タンパク質組換え体レンチウイルスベクター系による高頻度逆行性遺伝子導入

第33回日本分子生物学会  

Analysis of behavioral role of the thalamostriatal neural pathway by using the highly efficient retrograde transport vector.

第33回日本神経科学大会  

HIGHLY EFFICIENT GENE DELIVERY SYSTEM INTO THE BRAIN THROUGH RETROGRADE AXONAL TRANSPORT BY USING LENTIVIRAL VECTORS PSEUDOTYPED WITH RABIES VIRUS GLYCOPROTEIN AND ITS DERIVATIVES.

Development of the efficient gene transfer system through a lentiviral vector with retrograde axonal transport for specific neural circuit labeling.

Immunotoxin targeting of the thalamostriatal neural pathway labeled by the retrograde gene transfer

逆行輸送を介して特定神経路を標識する新規レンチウイルスベクター系の開発

BMB2008(第31回日本分子生物学会年会・第81回日本生化学会大会合同大会)  

Efficient gene transfer system through retrograde axonal transport with a human immunodeficiency virus type 1-based vector pseudotyped with rabies virus glycoprotein.

Neuroscience 2008  

Development of a Pseudotyped HIV-1-based Lentiviral Vector Capable of Retrograde Axonal Transport.

Identification of CRF neurons in the hypothalamic paraventricular nucleus that are involved in feeding inhibition

Grant number：20K06918  2020.4 - 2024.3

Grant-in-Aid for Scientific Research (C)

視床線条体ネットワークの構造・機能マッピングと認知行動機能における役割の解明

2020.4 - 2024.3

越シナプス多重標識による特定出入力神経機能制御システムの開発

2019.9 - 2020.7

Shigeki KATO

香気および味覚による嗜好性の認知と好き嫌いを生む神経基盤の解明

2019.4 - 2022.3

香気および味覚による嗜好性の認知と好き嫌いを生む神経基盤の解明

2019.4 - 2021.3

Shigeki KATO

全脳的コネクトーム解析のための新しい越シナプス多重標識システムの開発

2018.9 - 2019.7

全脳的コネクトーム解析のための新しい越シナプス多重標識システムの開発

2018.9 - 2019.7

Shigeki KATO

Neural circuit mechanisms underlying behavioral control through corticostriatal pathways in an area- and input-specific manner

Grant number：18H02545  2018.4 - 2021.3

Grant-in-Aid for Scientific Research (B)

Kobayashi Kazuto

領野・入力特異的な皮質線条体経路を介する行動制御の神経回路メカニズム

2018.4 - 2021.3

小林　和人、加藤　成樹

脳機能ネットワーク解明のための多重経シナプス標識システムの開発

2017.8 - 2018.6

大脳基底核回路を介した行動を制御する神経機構の解明

2014.12 - 2015.12

エンベロープタンパク質の改良による特定神経路への逆行性遺伝子導入ベクターの開発

2014.4 - 2014.9

不安障害・うつ様情動系行動を自律するための扁桃体出入力系神経路特異的な機能制御の試み

2014.1 - 2016.12

記憶・学習を介する神経回路の機能制御と優れた学習モデル動物作出の試み

2013.4 - 2017.3

局所神経回路の機能制御による行動解析

2013.1 - 2014.4

大脳基底核ループを形成する局所神経回路の機能制御と行動生理学的解析

2012.9 - 2015.3

神経回路研究のための新しい性質を持つ逆行性レンチウイルスベクターの開発

2012.4 - 2014.3

逆行性レンチウイルスベクターによる局所神経回路の機能制御と行動生理学的解析

2012.4 - 2013.3

特定神経路標識する逆行性レンチウイルスベクターを用いた視床-線条体経路の機能解明

2009.4 - 2012.3